List of works - Glenn C. Telling

Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene

scientific article

Accelerated high fidelity prion amplification within and across prion species barriers.

scientific article

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein

scientific article

Aerosol and nasal transmission of chronic wasting disease in cervidized mice

scientific article published on 17 February 2010

Alteration of the chronic wasting disease species barrier by in vitro prion amplification

scientific article

Anchors away--of plaques and pathology in prion disease

scientific article

Application of PMCA to screen for prion infection in a human cell line used to produce biological therapeutics

Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy

scientific article

B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease

scientific article

Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse

scientific article published on 3 February 2013

Breakthroughs in antemortem diagnosis of neurodegenerative diseases ⬇️

scientific article published on 30 October 2019

Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation

scientific article published on 16 March 2004

Calpastatin overexpression protects against excitotoxic hippocampal injury and traumatic spinal cord injury

scientific article published on 27 July 2020

Cell-based quantification of chronic wasting disease prions

scientific article

Characterization of conformation-dependent prion protein epitopes

scientific article

Chronic wasting disease (CWD) in cervids

scientific article published in January 2017

Chronic wasting disease prion infection of differentiated neurospheres

scientific article

Chronic wasting disease prion trafficking via the autonomic nervous system

scientific article

Chronic wasting disease prions in elk antler velvet

scientific article

Chronic wasting disease: an evolving prion disease of cervids

scientific article published on 01 January 2018

Clay Components in Soil Dictate Environmental Stability and Bioavailability of Cervid Prions in Mice

scientific article

Co-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selection

scientific article published on 23 August 2013

Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids

scientific article published on 26 March 2018

Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis

scientific article

Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease

scientific article published on 13 September 2013

Dehydration of prions on environmentally relevant surfaces protects them from inactivation by freezing and thawing

scientific article published on 31 January 2018

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

scientific article published on 11 August 2017

Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay

scientific article

Detection of PrPCWD in feces from naturally exposed Rocky Mountain elk (Cervus elaphus nelsoni) using protein misfolding cyclic amplification

scientific article published in April 2012

Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission

scientific article

Detection of prion protein in the cerebrospinal fluid of elk (Cervus canadensis nelsoni) with chronic wasting disease using protein misfolding cyclic amplification

scientific article published on 23 May 2012

Detection of protease-resistant cervid prion protein in water from a CWD-endemic area

scientific article

Detection of sub-clinical CWD infection in conventional test-negative deer long after oral exposure to urine and feces from CWD+ deer

scientific article

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

scientific article published on 23 October 2019

Dissociation of prion protein amyloid seeding from transmission of a spongiform encephalopathy

scientific article published on 11 September 2013

Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells

scientific article published on 7 January 2017

Efficient in vitro amplification of chronic wasting disease PrPRES.

scientific article

Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source

scientific article published on 05 August 2009

Environmentally-relevant forms of the prion protein

scientific article published on September 2008

Epigenetic dominance of prion conformers

scientific article

GFP-tagged PrP supports compromised prion replication in transgenic mice

scientific article published on 28 December 2005

Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions

scientific article

Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease

scientific article

Grass plants bind, retain, uptake, and transport infectious prions

scientific article

Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice

scientific article

In Vitro detection of Chronic Wasting Disease (CWD) prions in semen and reproductive tissues of white tailed deer bucks (Odocoileus virginianus)

scientific article published on 30 December 2019

In vitro amplification of misfolded prion protein using lysate of cultured cells

scientific article

In vitro strain adaptation of CWD prions by serial protein misfolding cyclic amplification

scientific article published on 25 October 2008

Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination

scientific article published on 08 June 2020

Incunabular immunological events in prion trafficking

scientific article

Infectious prions in the saliva and blood of deer with chronic wasting disease

scientific article

Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion

scientific article

Insights into Mechanisms of Transmission and Pathogenesis from Transgenic Mouse Models of Prion Diseases

scientific article

Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay

scientific article

Minor Oral Lesions Facilitate Transmission of Chronic Wasting Disease ⬇️

scientific article published on November 17, 2010

Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting

scientific article

Molecular Mechanisms of Chronic Wasting Disease Prion Propagation

scientific article

Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc

scholarly article

Motor behavioral and neuropathological deficits in mice deficient for normal prion protein expression

scientific article

Neurodegeneration: Evolved protection against human prions

scientific article published on 10 June 2015

Nucleic acid-free mutation of prion strains ⬇️

scientific article published on October 19, 2010

Pathogenesis of chronic wasting disease in cervidized transgenic mice

scientific article

PrP conformational transitions alter species preference of a PrP-specific antibody.

scientific article

PrPC expression and prion seeding activity in the alimentary tract and lymphoid tissue of deer

scientific article published on 7 September 2017

Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice.

scientific article published on 30 May 2019

Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70)

scientific article published on 18 July 2019

Prion disease tempo determined by host-dependent substrate reduction

scientific article published on 16 January 2014

Prion protein expression and functional importance in skeletal muscle

scientific article

Prion replication without host adaptation during interspecies transmissions.

scientific article

Prion strain mutation determined by prion protein conformational compatibility and primary structure

scientific article

Prions in skeletal muscle

scientific article

Prions in skeletal muscles of deer with chronic wasting disease

scientific article published on 26 January 2006

Properties of the cellular prion protein expressed in Xenopus oocytes

scientific article published in July 2002

Quinacrine promotes replication and conformational mutation of chronic wasting disease prions

scientific article published on 07 April 2014

Reply to Kascsak: Definition of the PrP 3F4 Epitope Revisited

scientific article published in Journal of Biological Chemistry

Role of prion protein glycosylation in replication of human prions by protein misfolding cyclic amplification

scientific article published on 27 June 2019

Scientific opinion on chronic wasting disease (II)

scientific article published on 17 January 2018

Sensitivity of protein misfolding cyclic amplification versus immunohistochemistry in ante-mortem detection of chronic wasting disease

scientific article published on 25 January 2012

Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

scientific article

Special issue: prion-related disorders

scientific article published on 01 June 2007

Structural effects of PrP polymorphisms on intra- and interspecies prion transmission.

scientific article

Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America

scientific article published on 23 November 2020

Study of prion types questions classification system

scientific article published on 01 December 2005

The cellular prion protein promotes neuronal regeneration after acute nasotoxic injury

scientific article published on 01 December 2020

The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis.

scientific article published on 22 March 2018

The elk PRNP codon 132 polymorphism controls cervid and scrapie prion propagation

scientific article

The importance of prions

scientific article

The mechanism of prion strain propagation

scientific article

Trans-species amplification of PrP(CWD) and correlation with rigid loop 170N.

scientific article published on 9 March 2009

Transgenic mouse models and prion strains

scientific article published on January 2011

Transgenic mouse models of prion diseases

scientific article published on January 2008

Transmission of prions from mule deer and elk with chronic wasting disease to transgenic mice expressing cervid PrP.

scientific article published on December 2004

Unaltered prion protein expression in Alzheimer disease patients

scientific article

Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease

scientific article published on 15 November 2019

List of works by Glenn C. Telling

Abbreviated incubation times for human prions in mice expressing a chimeric mouse-human prion protein transgene

Accelerated high fidelity prion amplification within and across prion species barriers.

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein

Aerosol and nasal transmission of chronic wasting disease in cervidized mice

Alteration of the chronic wasting disease species barrier by in vitro prion amplification

Anchors away--of plaques and pathology in prion disease

Application of PMCA to screen for prion infection in a human cell line used to produce biological therapeutics

Assessing the susceptibility of transgenic mice overexpressing deer prion protein to bovine spongiform encephalopathy

B cells and platelets harbor prion infectivity in the blood of deer infected with chronic wasting disease

Brain injury-induced proteolysis is reduced in a novel calpastatin-overexpressing transgenic mouse

Breakthroughs in antemortem diagnosis of neurodegenerative diseases ⬇️

Calpain-dependent endoproteolytic cleavage of PrPSc modulates scrapie prion propagation

Calpastatin overexpression protects against excitotoxic hippocampal injury and traumatic spinal cord injury

Cell-based quantification of chronic wasting disease prions

Characterization of conformation-dependent prion protein epitopes

Chronic wasting disease (CWD) in cervids

Chronic wasting disease prion infection of differentiated neurospheres

Chronic wasting disease prion trafficking via the autonomic nervous system

Chronic wasting disease prions in elk antler velvet

Chronic wasting disease: an evolving prion disease of cervids

Clay Components in Soil Dictate Environmental Stability and Bioavailability of Cervid Prions in Mice

Co-existence of distinct prion types enables conformational evolution of human PrPSc by competitive selection

Comparative analysis of prions in nervous and lymphoid tissues of chronic wasting disease-infected cervids

Complement Regulatory Protein Factor H Is a Soluble Prion Receptor That Potentiates Peripheral Prion Pathogenesis

Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease

Dehydration of prions on environmentally relevant surfaces protects them from inactivation by freezing and thawing

Destabilizing polymorphism in cervid prion protein hydrophobic core determines prion conformation and conversion efficiency

Detection of CWD prions in urine and saliva of deer by transgenic mouse bioassay

Detection of PrPCWD in feces from naturally exposed Rocky Mountain elk (Cervus elaphus nelsoni) using protein misfolding cyclic amplification

Detection of chronic wasting disease prions in salivary, urinary, and intestinal tissues of deer: potential mechanisms of prion shedding and transmission

Detection of prion protein in the cerebrospinal fluid of elk (Cervus canadensis nelsoni) with chronic wasting disease using protein misfolding cyclic amplification

Detection of protease-resistant cervid prion protein in water from a CWD-endemic area

Detection of sub-clinical CWD infection in conventional test-negative deer long after oral exposure to urine and feces from CWD+ deer

Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies

Dissociation of prion protein amyloid seeding from transmission of a spongiform encephalopathy

Effect of poly-L-arginine in inhibiting scrapie prion protein of cultured cells

Efficient in vitro amplification of chronic wasting disease PrPRES.

Enhancement of protein misfolding cyclic amplification by using concentrated cellular prion protein source

Environmentally-relevant forms of the prion protein

Epigenetic dominance of prion conformers

GFP-tagged PrP supports compromised prion replication in transgenic mice

Generation of a new form of human PrP(Sc) in vitro by interspecies transmission from cervid prions

Genetic depletion of complement receptors CD21/35 prevents terminal prion disease in a mouse model of chronic wasting disease

Grass plants bind, retain, uptake, and transport infectious prions

Immunodetection of disease-associated mutant PrP, which accelerates disease in GSS transgenic mice

In Vitro detection of Chronic Wasting Disease (CWD) prions in semen and reproductive tissues of white tailed deer bucks (Odocoileus virginianus)

In vitro amplification of misfolded prion protein using lysate of cultured cells

In vitro strain adaptation of CWD prions by serial protein misfolding cyclic amplification

Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination

Incunabular immunological events in prion trafficking

Infectious prions in the saliva and blood of deer with chronic wasting disease

Insights into Chronic Wasting Disease and Bovine Spongiform Encephalopathy Species Barriers by Use of Real-Time Conversion

Insights into Mechanisms of Transmission and Pathogenesis from Transgenic Mouse Models of Prion Diseases

Intranasal inoculation of white-tailed deer (Odocoileus virginianus) with lyophilized chronic wasting disease prion particulate complexed to montmorillonite clay

Minor Oral Lesions Facilitate Transmission of Chronic Wasting Disease ⬇️

Mitigation of prion infectivity and conversion capacity by a simulated natural process--repeated cycles of drying and wetting

Molecular Mechanisms of Chronic Wasting Disease Prion Propagation

Motif-grafted antibodies containing the replicative interface of cellular PrP are specific for PrPSc

Motor behavioral and neuropathological deficits in mice deficient for normal prion protein expression

Neurodegeneration: Evolved protection against human prions

Nucleic acid-free mutation of prion strains ⬇️

Pathogenesis of chronic wasting disease in cervidized transgenic mice

PrP conformational transitions alter species preference of a PrP-specific antibody.

PrPC expression and prion seeding activity in the alimentary tract and lymphoid tissue of deer

Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice.

Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70)

Prion disease tempo determined by host-dependent substrate reduction

Prion protein expression and functional importance in skeletal muscle

Prion replication without host adaptation during interspecies transmissions.

Prion strain mutation determined by prion protein conformational compatibility and primary structure

Prions in skeletal muscle

Prions in skeletal muscles of deer with chronic wasting disease

Properties of the cellular prion protein expressed in Xenopus oocytes

Quinacrine promotes replication and conformational mutation of chronic wasting disease prions

Reply to Kascsak: Definition of the PrP 3F4 Epitope Revisited

Role of prion protein glycosylation in replication of human prions by protein misfolding cyclic amplification

Scientific opinion on chronic wasting disease (II)

Sensitivity of protein misfolding cyclic amplification versus immunohistochemistry in ante-mortem detection of chronic wasting disease

Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).