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List of works by Francesca Tonelli

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

scientific article published on 06 November 2018

Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson's disease

scientific article published on 29 June 2020

Genome-wide screen reveals Rab12 GTPase as a critical activator of pathogenic LRRK2 kinase

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

scientific article published on 30 October 2019

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

scientific journal article

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

scientific article published on 6 December 2017

Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2

scientific article published on 21 December 2023

Sphingosine 1-phosphate signalling in cancer ⬇️

scientific article published on February 1, 2012

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

scientific article published on 10 November 2017

Targeting sphingosine kinase 1 in cancer ⬇️

scientific article published on January 1, 2012

The Sphingosine Kinase 1 Inhibitor 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole Induces Proteasomal Degradation of Sphingosine Kinase 1 in Mammalian Cells ⬇️

scientific article published on October 6, 2010

The sphingosine kinase inhibitor 2‐(p‐hyroxyanilino)‐4‐(p‐chlorophenyl)thiazole reduces androgen receptor expression via an oxidative stress‐dependent mechanism ⬇️

scientific article published on March 1, 2013

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