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List of works by Elizabeth P Henske

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

scientific article published on 8 May 2017

A genome-wide association study implicates NR2F2 in lymphangioleiomyomatosis pathogenesis

scientific article published on 27 June 2019

Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation

scientific article published on 15 February 2017

Abstract A64: The development of novel cell culture models and preclinical models of lymphangioleiomyomatosis

scientific article published in 2011

Activation of the mTOR signaling pathway in renal clear cell carcinoma

scientific article published on 01 January 2007

Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference

scientific article published on 02 April 2016

Allosteric and ATP-Competitive Inhibitors of mTOR Effectively Suppress Tumor Progression-Associated Epithelial-Mesenchymal Transition in the Kidneys of Tsc2+/- Mice

scientific article published on 14 June 2019

Alterations in Polyamine Metabolism in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex 2-Deficient Cells

scientific article published on 09 July 2019

Altered gene expression in phenotypically normal renal cells from carriers of tumor suppressor gene mutations

scientific article

Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide

scientific article

Celecoxib in LAM: Results of a Phase I Clinical Trial

scientific article published on 20 February 2020

Chromophobe renal cell carcinoma: New genetic and metabolic insights

scientific article published on 19 May 2020

Circulating Biomarkers From the Phase 1 trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis

scientific article published on 23 August 2018

Correction: p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis

scientific article published on 01 December 2020

ETV2 regulates PARP-1 binding protein to induce ER stress-mediated death in tuberin-deficient cells

scientific article published on 18 February 2022

Emerging biomarkers of lymphangioleiomyomatosis

scientific article published on 24 November 2017

Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells

scholarly article

Evidence Supporting a Lymphatic Endothelium Origin for Angiomyolipoma, a TSC2(-) Tumor Related to Lymphangioleiomyomatosis

scientific article published on 02 June 2016

Familial pneumothorax: towards precision medicine

scientific article

Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis.

scientific article published on July 2013

Filling the holes in cystic kidney disease research

scientific article

Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells.

scientific article

Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion

scientific article

Frequent [corrected] hyperphosphorylation of ribosomal protein S6 [corrected] in lymphangioleiomyomatosis-associated angiomyolipomas

scientific article published in June 2006

Generalised mosaicism for TSC2 mutation in isolated lymphangioleiomyomatosis

scientific article published on 10 October 2019

Getting to the finish line with mTORC1-targeted therapy ⬇️

scientific article published on May 24, 2012

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

HEF1-dependent Aurora A activation induces disassembly of the primary cilium

scientific article

Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner

scientific article

Haploinsufficiency in tumor predisposition syndromes: altered genomic transcription in morphologically normal cells heterozygous for VHL or TSC mutation

scientific article

High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting.

scientific article

Human Pluripotent Stem Cell-Derived TSC2-Haploinsufficient Smooth Muscle Cells Recapitulate Features of Lymphangioleiomyomatosis.

scientific article

Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11

scientific article published in 2022

IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex

scientific article published on 09 April 2020

Immunotherapy for Lymphangioleiomyomatosis and Tuberous Sclerosis: Progress and Future Directions

scientific article published on 19 August 2019

Impairment of gamma-glutamyl transferase 1 activity in the metabolic pathogenesis of chromophobe renal cell carcinoma.

scientific article published on 11 June 2018

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization

scientific article published on 18 October 2016

Loss of FLCN inhibits canonical WNT signaling via TFE3

scientific article published on 01 October 2019

Lymphangioleiomyomatosis - a wolf in sheep's clothing.

scientific article

Lymphangioleiomyomatosis: calling it what it is: a low-grade, destructive, metastasizing neoplasm

scientific article published on December 2012

Lysosomal regulation of cholesterol homeostasis in tuberous sclerosis complex is mediated via NPC1 and LDL-R

scientific article published on 27 April 2017

MITF is a driver oncogene and potential therapeutic target in kidney angiomyolipoma tumors through transcriptional regulation of CYR61

scientific article published on 20 October 2020

Mechanisms of pulmonary cyst pathogenesis in Birt-Hogg-Dube syndrome: The stretch hypothesis

scientific article published on 10 February 2016

Mesenchymal folliculin is required for alveolar development: implications for cystic lung disease in Birt-Hogg-Dubé syndrome

scientific article published on 01 April 2020

Metabolic reprogramming in polycystic kidney disease

scientific article published on 01 April 2013

MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM).

scientific article

Modeling tuberous sclerosis with organoids

scientific article published on 28 January 2022

Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma

scientific article published on 2 March 2016

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma ⬇️

scientific article published on April 19, 2003

New Developments in the Pathogenesis of Pulmonary Cysts in Birt-Hogg-Dubé Syndrome

scientific article published on 12 April 2020

New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex

scientific article

Notch transactivates Rheb to maintain the multipotency of TSC-null cells

scientific article published on 29 November 2017

Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management

scientific article published in September 2016

Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis

scientific article

Pulmonary manifestations in tuberous sclerosis complex

scientific article published on 28 July 2018

Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells

scientific article published on 4 August 2017

Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ)

scientific article published on 16 August 2019

Real-Time Monitoring of Tumorigenesis, Dissemination, & Drug Response in a Preclinical Model of Lymphangioleiomyomatosis/Tuberous Sclerosis Complex ⬇️

scientific article published on June 15, 2012

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex

scientific article

Renal cell carcinoma in tuberous sclerosis complex

scientific article

Renal disease in tuberous sclerosis complex: pathogenesis and therapy

scientific article published on 01 November 2018

Reply: Characterization of lymphangioleiomyomatosis as a neoplastic disease

scientific article published on August 2013

Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis

scientific article published on 29 March 2019

Sirolimus and Autophagy Inhibition in Lymphangioleiomyomatosis: Results of a Phase I Clinical Trial

scientific article published on 10 February 2017

Spontaneous Pneumothoraces in Patients with Birt-Hogg-Dubé Syndrome.

scientific article

TORC1 signaling is governed by two negative regulators in fission yeast

scientific article published on 09 August 2013

TSC2 regulates microRNA biogenesis via mTORC1 and GSK3β.

scientific article published on 2 March 2018

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

scientific article published on 19 April 2018

Targeted deletion of Tsc1 causes fatal cardiomyocyte hyperplasia independently of afterload

scientific article published on 7 November 2014

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

scientific article published in April 2018

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The Codon 72 TP53 Polymorphism Contributes to TSC Tumorigenesis through the Notch-Nodal Axis

scientific article published on 14 May 2019

The Genetics of Pneumothorax

scientific article published on 01 June 2019

The International LAM Registry: a component of an innovative web-based clinician, researcher, and patient-driven rare disease research platform.

scientific article published on March 2010

The Verge of Collapse.

scientific article published in March 2018

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

scientific journal article

The next breakthrough in LAM clinical trials may be their design: challenges in design and execution of future LAM clinical trials

scientific article

The p53 target Plk2 interacts with TSC proteins impacting mTOR signaling, tumor growth and chemosensitivity under hypoxic conditions

scientific article

The somatic genomic landscape of chromophobe renal cell carcinoma

scientific article (publication date: 8 September 2014)

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

scientific article published on 9 October 2008

Towards personalised therapy for lymphangioleiomyomatosis: lessons from cancer

scientific article published on March 2014

Tuberin, the tuberous sclerosis complex 2 tumor suppressor gene product, regulates Rho activation, cell adhesion and migration

scientific article published on December 2002

Tuberous Sclerosis Complex and Lymphangioleiomyomatosis: Miles to Go, Promises to Keep

scientific article published on June 21, 2011

Tuberous sclerosis complex

scientific article published on 26 May 2016

Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis.

scientific article

Tuberous sclerosis complex, mTOR, and the kidney: report of an NIDDK-sponsored workshop.

scientific article

Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease

scientific article published in November 2005

Tuberous sclerosis-associated lesions of the kidney, brain, and skin are angiogenic neoplasms

scientific article published on 01 March 2002

Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion

scientific article published on 10 September 2019

Tumour predisposition and cancer syndromes as models to study gene-environment interactions

scientific article published on 29 May 2020

Unjamming and cell shape in the asthmatic airway epithelium.

scientific article

Use of RNA amplification in the optimal characterization of global gene expression using cDNA microarrays

scientific article published on 01 December 2004

Vitamin D binding protein: a new biomarker of disease severity in lymphangioleiomyomatosis

scientific article published on 01 November 2018

Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis

scientific article published in Scientific Reports

Whole Exome Sequencing Identifies TSC1/TSC2 Biallelic Loss as the Primary and Sufficient Driver Event for Renal Angiomyolipoma Development

scientific article

mTOR is activated in the majority of malignant melanomas

scientific article

mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

scientific article

mTORC1 Hyperactivation in LAM Leads to ACE2 Upregulation in Type II Pneumocytes: Implications for COVID-19

scientific article published on 15 October 2020

p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis.

scientific article published on 16 May 2017

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