List of works - Sam Possemiers

A Critical Evaluation of In Vitro Hesperidin 2S Bioavailability in a Model Combining Luminal (Microbial) Digestion and Caco-2 Cell Absorption in Comparison to a Randomized Controlled Human Trial

scientific article published on 16 February 2018

A comparison of the anticancer properties of isoxanthohumol and 8-prenylnaringenin using in vitro models of colon cancer

scientific article published on 30 January 2013

A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach

scientific article published on 19 September 2013

A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial

scientific article published on 4 September 2017

Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin

scientific article published in August 2005

Administration of equol-producing bacteria alters the equol production status in the Simulator of the Gastrointestinal Microbial Ecosystem (SHIME).

scientific article published in April 2006

An exploratory study into the putative prebiotic activity of fructans isolated from Agave angustifolia and the associated anticancer activity ⬇️

scientific article published on May 25, 2013

Arabinogalactan and fructo-oligosaccharides have a different fermentation profile in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME ®).

scientific article

Arabinoxylan in wheat is more responsible than cellulose for promoting intestinal barrier function in weaned male piglets

scientific article

Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats

scientific article published on 30 August 2011

Arabinoxylans, inulin and Lactobacillus reuteri 1063 repress the adherent-invasive Escherichia coli from mucus in a mucosa-comprising gut model

scientific article published on 27 July 2016

Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines

scientific article published on 25 April 2011

Barcoded pyrosequencing analysis of the microbial community in a simulator of the human gastrointestinal tract showed a colon region-specific microbiota modulation for two plant-derived polysaccharide blends

scientific article

Characterization of the bactericidal effect of dietary sphingosine and its activity under intestinal conditions

scientific article

Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents

scientific article published on 28 October 2009

Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice

scientific article published on 15 March 2011

Different human gut models reveal the distinct fermentation patterns of Arabinoxylan versus inulin

scientific article

Disposition of hop prenylflavonoids in human breast tissue

scientific article

Disposition of soy isoflavones in normal human breast tissue

scientific article published on 17 February 2010

Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial

scientific article

Effects of wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal parameters in healthy preadolescent children

scientific article

Egg-derived bioactive peptides with ACE-inhibitory properties: a literature update

scientific article published on 25 September 2017

Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine

scientific article

Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.

scientific article published on 15 June 2017

Gut Microbial Metabolism of Polyphenols from Black Tea and Red Wine/Grape Juice Is Source-Specific and Colon-Region Dependent ⬇️

scientific article published on November 14, 2012

Gut metabotypes govern health effects of dietary polyphenols

scientific article published on 04 October 2012

Human faecal microbiota display variable patterns of glycerol metabolism

scientific article published on 14 October 2010

Implication of fermentable carbohydrates targeting the gut microbiota on conjugated linoleic acid production in high-fat-fed mice

scientific article published on 18 March 2013

In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability.

scientific article

Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli

scientific article published on 12 October 2011

Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice

scientific article published on 05 November 2010

Metabolic fate of polyphenols in the human superorganism

scientific article

Metabolism of isoflavones, lignans and prenylflavonoids by intestinal bacteria: producer phenotyping and relation with intestinal community

scientific article published on 16 May 2007

Metabolism of the lignan macromolecule into enterolignans in the gastrointestinal lumen as determined in the simulator of the human intestinal microbial ecosystem

scientific article published on 22 May 2008

Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women

scientific article published in October 2007

Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women

scientific article published on 23 May 2007

Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX

scientific article

Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria

scientific article published on 02 February 2009

Prebiotic approach alleviates hepatic steatosis: implication of fatty acid oxidative and cholesterol synthesis pathways

scientific article

Prebiotic effects of chicory inulin in the simulator of the human intestinal microbial ecosystem

scientific article

Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice

scientific article

Prebiotics to manage the microbial control of energy homeostasis ⬇️

scientific article published on December 1, 2011

Quantification of egg ovalbumin hydrolysate-derived anti-hypertensive peptides in an in vitro model combining luminal digestion with intestinal Caco-2 cell transport.

scientific article published on 8 June 2017

Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals

scientific article

Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial: Arabinoxylans in gut barrier

scientific article published on 3 February 2017

Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice

scientific article

The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro

scientific article

The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept

scientific article published on 18 March 2011

The intestinal environment in health and disease - recent insights on the potential of intestinal bacteria to influence human health

scientific article published on January 2009

The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals

scientific article published on 23 July 2010

The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine

scientific article

Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding

scientific article

List of works by Sam Possemiers

A Critical Evaluation of In Vitro Hesperidin 2S Bioavailability in a Model Combining Luminal (Microbial) Digestion and Caco-2 Cell Absorption in Comparison to a Randomized Controlled Human Trial

A comparison of the anticancer properties of isoxanthohumol and 8-prenylnaringenin using in vitro models of colon cancer

A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach

A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial

Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; conversion of isoxanthohumol into 8-prenylnaringenin

Administration of equol-producing bacteria alters the equol production status in the Simulator of the Gastrointestinal Microbial Ecosystem (SHIME).

An exploratory study into the putative prebiotic activity of fructans isolated from Agave angustifolia and the associated anticancer activity ⬇️

Arabinogalactan and fructo-oligosaccharides have a different fermentation profile in the Simulator of the Human Intestinal Microbial Ecosystem (SHIME ®).

Arabinoxylan in wheat is more responsible than cellulose for promoting intestinal barrier function in weaned male piglets

Arabinoxylans and inulin differentially modulate the mucosal and luminal gut microbiota and mucin-degradation in humanized rats

Arabinoxylans, inulin and Lactobacillus reuteri 1063 repress the adherent-invasive Escherichia coli from mucus in a mucosa-comprising gut model

Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines

Barcoded pyrosequencing analysis of the microbial community in a simulator of the human gastrointestinal tract showed a colon region-specific microbiota modulation for two plant-derived polysaccharide blends

Characterization of the bactericidal effect of dietary sphingosine and its activity under intestinal conditions

Cosupplementation of isoflavones, prenylflavonoids, and lignans alters human exposure to phytoestrogen-derived 17beta-estradiol equivalents

Dietary modulation of clostridial cluster XIVa gut bacteria (Roseburia spp.) by chitin-glucan fiber improves host metabolic alterations induced by high-fat diet in mice

Different human gut models reveal the distinct fermentation patterns of Arabinoxylan versus inulin

Disposition of hop prenylflavonoids in human breast tissue

Disposition of soy isoflavones in normal human breast tissue

Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over trial

Effects of wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal parameters in healthy preadolescent children

Egg-derived bioactive peptides with ACE-inhibitory properties: a literature update

Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine

Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.

Gut Microbial Metabolism of Polyphenols from Black Tea and Red Wine/Grape Juice Is Source-Specific and Colon-Region Dependent ⬇️

Gut metabotypes govern health effects of dietary polyphenols

Human faecal microbiota display variable patterns of glycerol metabolism

Implication of fermentable carbohydrates targeting the gut microbiota on conjugated linoleic acid production in high-fat-fed mice

In vitro bioconversion of polyphenols from black tea and red wine/grape juice by human intestinal microbiota displays strong interindividual variability.

Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli

Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice

Metabolic fate of polyphenols in the human superorganism

Metabolism of isoflavones, lignans and prenylflavonoids by intestinal bacteria: producer phenotyping and relation with intestinal community

Metabolism of the lignan macromolecule into enterolignans in the gastrointestinal lumen as determined in the simulator of the human intestinal microbial ecosystem

Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women

Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women

Microbial community development in a dynamic gut model is reproducible, colon region specific, and selective for Bacteroidetes and Clostridium cluster IX

Oestrogenicity of prenylflavonoids from hops: activation of pro-oestrogens by intestinal bacteria

Prebiotic approach alleviates hepatic steatosis: implication of fatty acid oxidative and cholesterol synthesis pathways

Prebiotic effects of chicory inulin in the simulator of the human intestinal microbial ecosystem

Prebiotic effects of wheat arabinoxylan related to the increase in bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice

Prebiotics to manage the microbial control of energy homeostasis ⬇️

Quantification of egg ovalbumin hydrolysate-derived anti-hypertensive peptides in an in vitro model combining luminal digestion with intestinal Caco-2 cell transport.

Randomized clinical trial on the efficacy of hesperidin 2S on validated cardiovascular biomarkers in healthy overweight individuals

Reinforcement of intestinal epithelial barrier by arabinoxylans in overweight and obese subjects: A randomized controlled trial: Arabinoxylans in gut barrier

Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice

The HMI™ module: a new tool to study the Host-Microbiota Interaction in the human gastrointestinal tract in vitro

The host selects mucosal and luminal associations of coevolved gut microorganisms: a novel concept

The intestinal environment in health and disease - recent insights on the potential of intestinal bacteria to influence human health

The intestinal microbiome: a separate organ inside the body with the metabolic potential to influence the bioactivity of botanicals

The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine

Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding