List of works - Rona K Graham

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

scientific article

Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity

scientific article

Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice

scientific article published on 27 July 2016

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

scientific article published on September 2002

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

scientific article published in June 2006

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

scientific article published on February 2009

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

scientific journal article

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

scientific article

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

scientific article published on 11 February 2016

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

scientific article published on 17 October 2005

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells

scientific article

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease

scientific article

Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process

scientific article published on 15 July 2016

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

scientific article

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

scientific article published on October 2010

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

scientific article published in July 2003

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

scientific article published on 13 September 2005

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

scientific article published on May 2015

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

scientific article

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin

scientific article published in January 2012

Wild-type huntingtin protects neurons from excitotoxicity

scientific article published on 17 January 2006

List of works by Rona K Graham

Absence of behavioral abnormalities and neurodegeneration in vivo despite widespread neuronal huntingtin inclusions

Activation of caspase-6 and cleavage of caspase-6 substrates is an early event in NMDA receptor-mediated excitotoxicity

Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

Elevated brain 3-hydroxykynurenine and quinolinate levels in Huntington disease mice

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

Mutant huntingtin N-terminal fragments of specific size mediate aggregation and toxicity in neuronal cells

N-terminal proteolysis of full-length mutant huntingtin in an inducible PC12 cell model of Huntington's disease

Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

Phosphorylation of huntingtin at Ser421 in YAC128 neurons is associated with protection of YAC128 neurons from NMDA-mediated excitotoxicity and is modulated by PP1 and PP2A.

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease

Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin

Wild-type huntingtin protects neurons from excitotoxicity