List of works - Sevgi Keles

A novel approach in allergen-specific immunotherapy: combination of sublingual and subcutaneous routes.

scientific article published on 8 June 2011

A rare cause of preseptal cellulitis: anthrax.

scientific article published in May 2007

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

scientific article published on 01 June 2018

Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency

scientific article published on 22 June 2019

Chilaiditi syndrome as a cause of respiratory distress

scientific article

Clinical spectrum of LIG4 deficiency is broadened with severe dysmaturity, primordial dwarfism, and neurological abnormalities

scientific article published on 18 September 2013

Clinical, Immunological and Genetic Spectrum of 696 Patients with Combined Immunodeﬁciency.

scientific article published on 12 September 2017

Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

scientific article published on 01 June 2020

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Conten

scientific article published on 10 October 2017

DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency.

scientific article

DOCK8 Deficiency Presenting as an IPEX-Like Disorder.

scientific article

DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.

scientific article published on 4 September 2017

DOCK8 deficiency: Insights into pathophysiology, clinical features and management.

scientific article

DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients

scientific article

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

scientific article

Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.

scientific article published on 24 May 2016

Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

scientific article

Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome

scientific article

Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: implications for pathogenesis and potential detection by newborn screening.

scientific article

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

scientific article published on 01 June 2020

Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation

scientific article published on 5 September 2014

Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency.

scientific article

Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation.

scientific article published on 7 June 2017

F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects

scientific article published on 26 February 2019

Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency.

scientific article published in April 2014

Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency

scientific article published on 6 April 2016

Human genetic and immunological determinants of critical COVID-19 pneumonia

scientific article published on 28 January 2022

ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients

scientific article published on 09 October 2019

Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder

scientific article published on 2 November 2012

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome associated with neonatal epidermolysis bullosa acquisita.

scientific article published on 17 March 2015

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

scientific article published on 24 September 2020

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

scientific article published on June 2015

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

scientific article

Late-presenting congenital diaphragmatic hernia associated with ectopic thoracic kidney

scientific article published on 19 April 2006

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content

scientific article

Neonatal BCG vaccination induces IL-10 production by CD4+ CD25+ T cells

scientific article published on 01 November 2010

Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function

scientific article published on 13 April 2018

Picture of the month: Coughing paroxysms associated with subconjunctival hemorrhage and dellen

scientific article published in January 2006

Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy

scientific article

Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA.

scientific article

Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder

scientific article published on 25 April 2015

Sublingual immunotherapy in children with allergic rhinoconjunctivitis mono-sensitized to house-dust-mites: a double-blind-placebo-controlled randomised trial

scientific article published on 23 July 2013

Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency.

scientific article

Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency

scientific article

Systemic onset juvenile rheumatoid arthritis presenting with absence of B lymphocytes.

scientific article published on 25 January 2007

The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency

scientific article

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

scientific article published on 16 May 2022

Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'.

scientific article published in July 2010

Type I IFN related NETosis in Ataxia Telangiectasia and Artemis deficiency

scientific article

Variable presentation of primary immune deficiency: two cases with CD3 gamma deficiency presenting with only autoimmunity

scientific article published in May 2013

Would mean platelet volume/platelet count ratio be used as a novel formula to predict 22q11.2 deletion syndrome?

scientific article published on 24 March 2016

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19

scholarly article by Takaki Asano published in 2021

List of works by Sevgi Keles

A novel approach in allergen-specific immunotherapy: combination of sublingual and subcutaneous routes.

A rare cause of preseptal cellulitis: anthrax.

A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

Abatacept as a Long-Term Targeted Therapy for LRBA Deficiency

Chilaiditi syndrome as a cause of respiratory distress

Clinical spectrum of LIG4 deficiency is broadened with severe dysmaturity, primordial dwarfism, and neurological abnormalities

Clinical, Immunological and Genetic Spectrum of 696 Patients with Combined Immunodeﬁciency.

Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Corrigendum: Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Conten

DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency.

DOCK8 Deficiency Presenting as an IPEX-Like Disorder.

DOCK8 and STAT3 dependent inhibition of IgE isotype switching by TLR9 ligation in human B cells.

DOCK8 deficiency: Insights into pathophysiology, clinical features and management.

DOCK8 deficiency: clinical and immunological phenotype and treatment options - a review of 136 patients

DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

Dedicator of cytokinesis 8 regulates signal transducer and activator of transcription 3 activation and promotes TH17 cell differentiation.

Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells

Defects along the T(H)17 differentiation pathway underlie genetically distinct forms of the hyper IgE syndrome

Deficient T Cell Receptor Excision Circles (TRECs) in autosomal recessive hyper IgE syndrome caused by DOCK8 mutation: implications for pathogenesis and potential detection by newborn screening.

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

Efficacy of intravenous immunoglobulin treatment in immunocompromised children with H1N1 influenza: a clinical observation

Evaluation of Clinical and Immunological Characteristics of Children with Common Variable Immunodeficiency.

Exaggerated follicular helper T-cell responses in patients with LRBA deficiency caused by failure of CTLA4-mediated regulation.

F-BAR domain only protein 1 (FCHO1) deficiency is a novel cause of combined immune deficiency in human subjects

Flow cytometry diagnosis of dedicator of cytokinesis 8 (DOCK8) deficiency.

Hematopoietic stem cell transplantation outcomes for 11 patients with dedicator of cytokinesis 8 deficiency

Human genetic and immunological determinants of critical COVID-19 pneumonia

ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients

Identification of a novel mutation in ZAP70 and prenatal diagnosis in a Turkish family with severe combined immunodeficiency disorder

Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome associated with neonatal epidermolysis bullosa acquisita.

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

Inherited DOCK2 Deficiency in Patients with Early-Onset Invasive Infections

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

Late-presenting congenital diaphragmatic hernia associated with ectopic thoracic kidney

Natural Killer Cells from Patients with Recombinase-Activating Gene and Non-Homologous End Joining Gene Defects Comprise a Higher Frequency of CD56bright NKG2A+++ Cells, and Yet Display Increased Degranulation and Higher Perforin Content

Neonatal BCG vaccination induces IL-10 production by CD4+ CD25+ T cells

Patients with CD3G mutations reveal a role for human CD3γ in Treg diversity and suppressive function

Picture of the month: Coughing paroxysms associated with subconjunctival hemorrhage and dellen

Plasmacytoid dendritic cell depletion in DOCK8 deficiency: rescue of severe herpetic infections with IFN-α 2b therapy

Regulatory T-cell deficiency and immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like disorder caused by loss-of-function mutations in LRBA.

Renal involvement in the immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) disorder

Sublingual immunotherapy in children with allergic rhinoconjunctivitis mono-sensitized to house-dust-mites: a double-blind-placebo-controlled randomised trial

Successful engraftment of donor marrow after allogeneic hematopoietic cell transplantation in autosomal-recessive hyper-IgE syndrome caused by dedicator of cytokinesis 8 deficiency.

Successful interferon-alpha 2b therapy for unremitting warts in a patient with DOCK8 deficiency

Systemic onset juvenile rheumatoid arthritis presenting with absence of B lymphocytes.

The extended clinical phenotype of 64 patients with dedicator of cytokinesis 8 deficiency

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Transient hypogammaglobulinemia and unclassified hypogammaglobulinemia: 'similarities and differences'.

Type I IFN related NETosis in Ataxia Telangiectasia and Artemis deficiency

Variable presentation of primary immune deficiency: two cases with CD3 gamma deficiency presenting with only autoimmunity

Would mean platelet volume/platelet count ratio be used as a novel formula to predict 22q11.2 deletion syndrome?

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19