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List of works by Joshua A Bittker

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

scientific article published in November 2017

A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay

scientific article

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

scientific article

An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines

scientific article

An economic framework to prioritize confirmatory tests after a high-throughput screen.

scientific article published on 14 June 2010

An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries

scientific article

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

scientific article

Automatically detecting workflows in PubChem.

scientific article

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

scientific article

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

scientific article

Directed evolution of protein enzymes using nonhomologous random recombination

scientific article

Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

scientific article published on 20 January 2020

Discovery of Inhibitors of Anti-Apoptotic Protein A1 ⬇️

scientific article published on July 27, 2012

Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Enhancing the rate of scaffold discovery with diversity-oriented prioritization ⬇️

scientific article published on June 17, 2011

Evolving BioAssay Ontology (BAO): modularization, integration and applications

scientific article

Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection

scientific article published in July 2005

Genetic and transcriptional evolution alters cancer cell line drug response

scientific article published in August 2018

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

scientific article

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

scientific article published on 28 August 2018

High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding.

scientific article

High‐Throughput RT‐PCR for Small‐Molecule Screening Assays ⬇️

scientific article published on March 1, 2012

Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.

scientific article published on 19 February 2017

Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3 ⬇️

scientific article published on July 27, 2012

Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe

scholarly article published 4 April 2015

Identification of a small molecule that selectively activates alpha-synuclein translational expression

scientific article published on 3 June 2011

Identification of a small molecule that selectively inhibits alpha-synuclein translational expression ⬇️

scientific article published on June 3, 2011

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence ⬇️

scientific article published on June 14, 2013

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2 ⬇️

scientific article published on July 27, 2012

Identification of small-molecule inhibitors of Trypansoma cruzi replication

scientific article

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans ⬇️

scientific article published on July 26, 2013

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

scientific article

Nucleic acid evolution and minimization by nonhomologous random recombination

scientific article

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

scientific article

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

scientific article

Recent advances in the in vitro evolution of nucleic acids

scientific article

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1 ⬇️

scientific article published on June 3, 2011

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2 ⬇️

scientific article published on July 27, 2012

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

scientific article published on March 2017

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

scientific article

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

scientific article

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

scientific article

The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity

scientific article published on 01 April 2019

The Drug Repurposing Hub: a next-generation drug library and information resource

scientific article (publication date: 7 April 2017)

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

scientific article

Utility-aware screening with clique-oriented prioritization.

scientific article

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