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List of works by Joshua A Bittker

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A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

scientific article published in November 2017
An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

scientific article
Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset

scientific article
Correlating chemical sensitivity and basal gene expression reveals mechanism of action

scientific article
The Drug Repurposing Hub: a next-generation drug library and information resource

scientific article (publication date: 7 April 2017)
Genetic and transcriptional evolution alters cancer cell line drug response

scientific article published in August 2018
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)
Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

scientific article
Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

scientific article
Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

scientific article
Evolving BioAssay Ontology (BAO): modularization, integration and applications

scientific article
Small-molecule inducers of insulin expression in pancreatic alpha-cells.

scientific article
Development of small-molecule probes that selectively kill cells induced to express mutant RAS

scientific article
Nucleic acid evolution and minimization by nonhomologous random recombination

scientific article
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

scientific article published on March 2017
Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

scientific article
Recent advances in the in vitro evolution of nucleic acids

scientific article
Directed evolution of protein enzymes using nonhomologous random recombination

scientific article
An Overview of the Challenges in Designing, Integrating, and Delivering BARD: A Public Chemical-Biology Resource and Query Portal for Multiple Organizations, Locations, and Disciplines

scientific article
An economic framework to prioritize confirmatory tests after a high-throughput screen.

scientific article published on 14 June 2010
A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay

scientific article
Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

scientific article
Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

scientific article published on October 9, 2017
Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

scientific article
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling

scientific article published on 20 January 2020
High Throughput Screens to Identify Autophagy Inducers that Function by Disrupting Beclin 1/Bcl-2 Binding.

scientific article
ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

scientific article published on July 26, 2013
High‐Throughput RT‐PCR for Small‐Molecule Screening Assays

scientific article published on March 1, 2012
Identification of small-molecule inhibitors of Trypansoma cruzi replication

scientific article
Enhancing the rate of scaffold discovery with diversity-oriented prioritization

scientific article published on June 17, 2011
Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection

scientific article published in July 2005
An informatic pipeline for managing high-throughput screening experiments and analyzing data from stereochemically diverse libraries

scientific article
Automatically detecting workflows in PubChem.

scientific article
Utility-aware screening with clique-oriented prioritization.

scientific article
The Carcinogenome Project: In Vitro Gene Expression Profiling of Chemical Perturbations to Predict Long-Term Carcinogenicity

scientific article published on 01 April 2019
High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

scientific article published on 28 August 2018
Identification of Highly Specific Diversity-Oriented Synthesis-Derived Inhibitors of Clostridium difficile.

scientific article published on 19 February 2017
Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3

scientific article published on July 27, 2012
Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe

scientific article published on January 16, 2015
Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1

scientific article published on June 3, 2011
Identification of a small molecule that selectively inhibits alpha-synuclein translational expression

scientific article published on June 3, 2011
Identification of a small molecule that selectively activates alpha-synuclein translational expression

scientific article published on 3 June 2011
Discovery of Inhibitors of Anti-Apoptotic Protein A1

scientific article published on July 27, 2012
Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2

scientific article published on July 27, 2012
Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence

scientific article published on June 14, 2013
Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition

scientific article published on January 16, 2015
Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2

scientific article published on July 27, 2012

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