List of works - Nicholas Kwiatkowski

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.

scientific article

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations

scientific article published in February 2018

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

article

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

scientific article published on 29 April 2020

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

scientific article published on 26 December 2019

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

scientific article

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

scientific article

Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes

scientific article published on June 2017

Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

scientific article published on 20 February 2017

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

scientific article published on 29 August 2016

Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure

scientific article

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8

scientific article published on 18 March 2018

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype

scientific article published on 21 March 2019

Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13

scientific article published on 05 June 2020

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1.

scientific article published on 12 January 2011

Discovery of selective aminothiazole aurora kinase inhibitors

scientific article

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

scientific article published on 19 December 2017

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

scientific article published on 18 January 2018

Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs

scientific article published on 12 August 2013

High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma.

scientific article

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors

scientific article

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML

scientific article published on 27 December 2018

Identification of small molecule inhibitors targeting the Zika virus envelope protein

scientific article published on 13 February 2019

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

scientific article published on October 2012

MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51

scientific journal article

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

scientific article published on 15 December 2017

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

scientific article

Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen

scientific article

Small genomic insertions form enhancers that misregulate oncogenes

scientific article published on 09 February 2017

Small molecules targeting the flavivirus E protein with broad-spectrum activity and antiviral efficacy in vivo

scientific article published on 14 January 2019

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

scientific article

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.

scientific article

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

scientific article published on 30 January 2017

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

scientific article

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

scientific article

Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines

scientific article published on 29 August 2014

List of works by Nicholas Kwiatkowski

Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.

Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations

CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

CDK7-dependent transcriptional addiction in triple-negative breast cancer.

Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes

Corrigendum: THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors

Cut homeobox 1 causes chromosomal instability by promoting bipolar division after cytokinesis failure

Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8

Development of a Selective CDK7 Covalent Inhibitor Reveals Predominant Cell-Cycle Phenotype

Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13

Discovery of a benzo[e]pyrimido-[5,4-b][1,4]diazepin-6(11H)-one as a Potent and Selective Inhibitor of Big MAP Kinase 1.

Discovery of selective aminothiazole aurora kinase inhibitors

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma

Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs

High MITF Expression is Associated with Super-enhancers and Suppressed by CDK7 Inhibition in Melanoma.

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML

Identification of small molecule inhibitors targeting the Zika virus envelope protein

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

MT FdR: a ferredoxin reductase from M. tuberculosis that couples to MT CYP51

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors

Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation.

Selective Aurora Kinase Inhibitors Identified Using a Taxol-Induced Checkpoint Sensitivity Screen

Small genomic insertions form enhancers that misregulate oncogenes

Small molecules targeting the flavivirus E protein with broad-spectrum activity and antiviral efficacy in vivo

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.

THZ1 targeting CDK7 suppresses STAT transcriptional activity and sensitizes T-cell lymphomas to BCL2 inhibitors

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

Tivantinib (ARQ 197) efficacy is independent of MET inhibition in non-small-cell lung cancer cell lines