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List of works by Nobuyoshi Kosaka

A Challenge to Aging Society by microRNA in Extracellular Vesicles: microRNA in Extracellular Vesicles as Promising Biomarkers and Novel Therapeutic Targets in Multiple Myeloma

scientific article published on 12 March 2018

A paradigm shift for extracellular vesicles as small RNA carriers: from cellular waste elimination to therapeutic applications

scientific article published on January 2014

A robust screening method for dietary agents that activate tumour-suppressor microRNAs

scientific article published on October 2015

Altered biodistribution of deglycosylated extracellular vesicles through enhanced cellular uptake

scientific article published on 13 January 2020

An Insight into the Roles of MicroRNAs and Exosomes in Sarcoma

An integrative genomic analysis revealed the relevance of microRNA and gene expression for drug-resistance in human breast cancer cells

scientific article

Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo

scientific article published on 22 July 2004

Bovine milk exosomes contain microRNA and mRNA and are taken up by human macrophages

scientific article

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier

scientific article

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A.

scientific article published on 12 February 2018

Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis

scientific article

Clinical relevance and therapeutic significance of microRNA-133a expression profiles and functions in malignant osteosarcoma-initiating cells

scientific article published in April 2014

Commitment of Annexin A2 in recruitment of microRNAs into extracellular vesicles

scientific article published on 26 November 2015

Comparative marker analysis of extracellular vesicles in different human cancer types

scientific article published on 18 June 2013

Competitive interactions of cancer cells and normal cells via secretory microRNAs

scientific article published on 28 November 2011

Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease

scientific article

Cross-talk between cancer cells and their neighbors via miRNA in extracellular vesicles: an emerging player in cancer metastasis

Dark side of the exosome: the role of the exosome in cancer metastasis and targeting the exosome as a strategy for cancer therapy.

scientific article published on March 2014

Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer

scientific article published on 24 July 2015

Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment

scientific article

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells.

scientific article

Exploiting the message from cancer: the diagnostic value of extracellular vesicles for clinical applications

scientific article published in 2019

Expression Level of Urinary MicroRNA-146a-5p Is Increased in Patients With Bladder Cancer and Decreased in Those After Transurethral Resection

scientific article published on 9 April 2016

Expression of erythropoietin receptor-like molecule in Xenopus laevis and erythrocytopenia upon administration of its recombinant soluble form

scientific article published in August 2005

Extracellular vesicles as biomarkers and therapeutic targets for cancer

scientific article published on 06 November 2019

Extracellular vesicles in lung microenvironment and pathogenesis

scientific article published on 28 July 2015

Extracellular vesicles: Toward a clinical application in urological cancer treatment

scientific article published on 03 May 2018

FGF-4 regulates neural progenitor cell proliferation and neuronal differentiation

scientific article published on 24 May 2006

Functional analysis of exosomal microRNA in cell-cell communication research

scientific article published on January 2013

Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes

scientific article

Identification of erythropoietin-induced microRNAs in haematopoietic cells during erythroid differentiation.

scientific article

Latest advances in extracellular vesicles: from bench to bedside

scientific article published on 17 June 2019

MicroRNA-143 Regulates Human Osteosarcoma Metastasis by Regulating Matrix Metalloprotease-13 Expression ⬇️

scientific article published on March 22, 2011

MicroRNA-500 as a potential diagnostic marker for hepatocellular carcinoma.

scientific article

Micromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins

scientific article

Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis

scientific article published on 25 February 2013

On-chip immunoelectrophoresis of extracellular vesicles released from human breast cancer cells

scientific article published on 30 April 2015

Physiological and pathological relevance of secretory microRNAs and a perspective on their clinical application

scientific article published on April 2014

Pleiotropic function of FGF-4: its role in development and stem cells

scientific article published on February 2009

Profiling of circulating microRNAs for prostate cancer biomarker discovery.

scientific article published on February 2014

Purification of RNA from milk whey

scientific article published in January 2013

RPN2 Gene Confers Osteosarcoma Cell Malignant Phenotypes and Determines Clinical Prognosis

scientific article

RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy

scientific article

Secretory mechanisms and intercellular transfer of microRNAs in living cells

scientific article

Secretory microRNAs as a versatile communication tool

scientific article

Stilbene derivatives promote Ago2-dependent tumour-suppressive microRNA activity ⬇️

scientific article published on March 15, 2012

Structural and biological properties of erythropoietin in Xenopus laevis

scientific article

Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis

scientific article

Systemic delivery of synthetic microRNA-16 inhibits the growth of metastatic prostate tumors via downregulation of multiple cell-cycle genes

scientific article

The clinical relevance of the miR-197/CKS1B/STAT3-mediated PD-L1 network in chemoresistant non-small-cell lung cancer

scientific article

The miR-1908/SRM regulatory axis contributes to extracellular vesicle secretion in prostate cancer

scientific article published on 18 June 2020

The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families

scientific article

The roles of extracellular vesicles in cancer biology: toward the development of novel cancer biomarkers

scientific article published on March 2014

The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment

scientific article published on 13 December 2017

The therapeutic potential of mesenchymal stem cell‐derived extracellular vesicles ⬇️

scientific article published on February 26, 2013

Therapeutic Effects of MicroRNA-582-5p and -3p on the Inhibition of Bladder Cancer Progression ⬇️

scientific article published on January 8, 2013

Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey

scientific article

Trash or Treasure: extracellular microRNAs and cell-to-cell communication

scientific article published in 2013

UBL3 modification influences protein sorting to small extracellular vesicles

scientific article published in Nature Communications

Ultra-sensitive liquid biopsy of circulating extracellular vesicles using ExoScreen

scientific article

Unraveling the Mystery of Cancer by Secretory microRNA: Horizontal microRNA Transfer between Living Cells ⬇️

scientific article published on January 3, 2012

Versatile Applications of microRNA in Anti-Cancer Drug Discovery: From Therapeutics to Biomarkers ⬇️

scientific article published on June 1, 2010

Versatile roles of extracellular vesicles in cancer

scientific article published on 14 March 2016

miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma.

scientific article

miR-148a plays a pivotal role in the liver by promoting the hepatospecific phenotype and suppressing the invasiveness of transformed cells

scientific article published on 30 July 2013

miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1

scientific article published on 29 April 2020

microRNA as a new immune-regulatory agent in breast milk

scientific article

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