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List of works by Donald Lavelle

A new target for fetal hemoglobin reactivation

scientific article published on 01 December 2019

Clinical effectiveness of decitabine in severe sickle cell disease

scientific article published in April 2008

Cord blood stem cell expansion is permissive to epigenetic regulation and environmental cues.

scientific article published on 6 June 2009

Cytokine-free rapid red cell regeneration

scientific article published in February 2015

DNA hypo-methylating agents and sickle cell disease

scientific article published in September 2004

DNA methylation and mechanism of action of 5-azacytidine

scientific article published in February 2008

Decitabine increases fetal hemoglobin in Papio anubis by increasing γ-globin gene transcription

scientific article

Decitabine induces cell cycle arrest at the G1 phase via p21(WAF1) and the G2/M phase via the p38 MAP kinase pathway

scientific article

Developmental changes in DNA methylation and covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin gene promoters in Papio anubis

scientific article published on 9 March 2006

Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells

scientific article published on 26 December 2013

Effect of 5-aza-2'-deoxycytidine (Dacogen) on covalent histone modifications of chromatin associated with the epsilon-, gamma-, and beta-globin promoters in Papio anubis

scientific article published on 01 March 2006

Effect of AGM and Fetal Liver-Derived Stromal Cell Lines on Globin Expression in Adult Baboon (P. anubis) Bone Marrow-Derived Erythroid Progenitors ⬇️

scientific article published on May 31, 2012

Effects of tetrahydrouridine on pharmacokinetics and pharmacodynamics of oral decitabine

scientific article published on 7 December 2011

Efficacy and safety of long-term RN-1 treatment to increase HbF in baboons

scientific article published in December 2016

Fetal Hemoglobin Induction by Epigenetic Drugs

scholarly article by Donald Lavelle et al published April 2018 in Seminars in Hematology

Hydroxymethylcytosine and demethylation of the γ-globin gene promoter during erythroid differentiation

scientific article published on January 2015

Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia

scientific article

Modification of hematopoietic stem cell fate by 5aza 2'deoxycytidine and trichostatin A.

scientific article published on 19 February 2004

Oral administration of the LSD1 inhibitor ORY-3001 increases fetal hemoglobin in sickle cell mice and baboons

scientific article published on 17 August 2018

Oral decitabine reactivates expression of the methylated gamma-globin gene in Papio anubis

scientific article published on 01 November 2007

Oral tetrahydrouridine and decitabine for non-cytotoxic epigenetic gene regulation in sickle cell disease: A randomized phase 1 study.

scientific article published on 7 September 2017

Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

scientific article published on 23 February 2017

Potential role of LSD1 inhibitors in the treatment of sickle cell disease: a review of preclinical animal model data

scientific article published on 01 August 2018

RN-1, a potent and selective lysine-specific demethylase 1 inhibitor, increases γ-globin expression, F reticulocytes, and F cells in a sickle cell disease mouse model

scientific article published on 27 April 2015

Regulation of myeloma cell growth through Akt/Gsk3/forkhead signaling pathway

scientific article published on October 2002

S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

scientific article published on 8 October 2010

Selenium Deficiency in a Mouse Model of Sickle Cell Disease Resulted in Increased Oxygen Consumption and Aberrant Mitochondrial Retention (OR11-05-19)

Standard clinical practice underestimates the role and significance of erythropoietin deficiency in sickle cell disease ⬇️

scientific article published on March 21, 2011

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

scientific article published in June 2015

The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis).

scientific article published on 8 February 2016

The gamma-globin gene promoter progressively demethylates as the hematopoietic stem progenitor cells differentiate along the erythroid lineage in baboon fetal liver and adult bone marrow

scientific article published in January 2007

The mRNA-Binding Protein IGF2BP1 Restores Fetal Hemoglobin in Cultured Erythroid Cells from Patients with β-Hemoglobin Disorders

scientific article published on 31 January 2020

The molecular mechanism of fetal hemoglobin reactivation

scientific article

Transcriptional activation of the gamma-globin gene in baboons treated with decitabine and in cultured erythroid progenitor cells involves different mechanisms.

scientific article

siDNMT1 increases γ-globin expression in chemical inducer of dimerization (CID)−dependent mouse βYAC bone marrow cells and in baboon erythroid progenitor cell cultures ⬇️

scientific article published on October 23, 2010

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