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List of works by Emmanuel J H J Wiertz

A Broad-Spectrum Antiviral Peptide Blocks Infection of Viruses by Binding to Phosphatidylserine in the Viral Envelope

scientific article published on 29 August 2020

A CD8+ T cell immune evasion protein specific to Epstein-Barr virus and its close relatives in Old World primates

scientific article

A Flow Cytometry-Based Approach to Unravel Viral Interference with the MHC Class I Antigen Processing and Presentation Pathway

scientific article published on 01 January 2019

A combinational CRISPR/Cas9 gene-editing approach can halt HIV replication and prevent viral escape.

scientific article published on 8 February 2017

A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation

scientific article

Adenoviral vectors stimulate glucagon transcription in human mesenchymal stem cells expressing pancreatic transcription factors.

scientific article

Amino acid composition of alpha1/alpha2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11-mediated down-regulation.

scientific article published on June 2003

Bovine herpesvirus 1 UL49.5 protein inhibits the transporter associated with antigen processing despite complex formation with glycoprotein M.

scientific article published in June 2006

CD8+ T cell responses against TAP-inhibited cells are readily detected in the human population

scientific article published on 27 October 2010

CRISPR/Cas9-Mediated Genome Editing of Herpesviruses Limits Productive and Latent Infections

scientific article

Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines.

scientific article

Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.

scientific article

Distinct kinetics and dynamics of cross-presentation in liver sinusoidal endothelial cells compared to dendritic cells.

scientific article published in September 2009

EBV BILF1 Evolved To Downregulate Cell Surface Display of a Wide Range of HLA Class I Molecules through Their Cytoplasmic Tail ⬇️

scientific article published on January 11, 2013

EBV MicroRNA BART16 Suppresses Type I IFN Signaling.

scientific article published on 17 April 2017

EBV protein BNLF2a exploits host tail-anchored protein integration machinery to inhibit TAP.

scientific article published on 4 February 2011

Endogenous HLA class II epitopes that are immunogenic in vivo show distinct behavior toward HLA-DM and its natural inhibitor HLA-DO.

scientific article published on 13 August 2012

Endoplasmic reticulum-associated degradation of a degron-containing polytopic membrane protein

scientific article published on December 2009

Epstein-Barr virus evasion of CD8(+) and CD4(+) T cell immunity via concerted actions of multiple gene products.

scientific article published on 25 October 2008

Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion.

scientific article

Epstein-Barr virus isolates retain their capacity to evade T cell immunity through BNLF2a despite extensive sequence variation

scientific article published on 19 October 2011

Erratum: Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM.

scientific article published in April 2016

Evaluation of Viral Interference with MHC Class I-Restricted Antigen Processing and Presentation Using a Flow Cytometry-Based Approach ⬇️

scientific article published on January 1, 2013

Exploitation of herpesvirus immune evasion strategies to modify the immunogenicity of human mesenchymal stem cell transplants

scientific article

Exploiting human herpesvirus immune evasion for therapeutic gain: potential and pitfalls ⬇️

scientific article published on 08 February 2011

Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM.

scientific article published on February 2016

Fluorescent TAP as a Platform for Virus-Induced Degradation of the Antigenic Peptide Transporter

scientific article published on 07 December 2019

Genetic Variability among Complete Human Respiratory Syncytial Virus Subgroup A Genomes: Bridging Molecular Evolutionary Dynamics and Epidemiology ⬇️

scientific article published on December 7, 2012

Herpesviruses and immunity: the art of evasion

scientific article published on 25 February 2010

Host shutoff during productive Epstein-Barr virus infection is mediated by BGLF5 and may contribute to immune evasion

scholarly article

Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation

scientific article published on 10 August 2005

Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation

scientific article published on December 2003

Immune Evasion by Epstein-Barr Virus

scientific article published on January 2015

Impaired transporter associated with antigen processing-dependent peptide transport during productive EBV infection

scientific article

In cis inhibition of antigen processing by the latency-associated nuclear antigen I of Kaposi sarcoma herpes virus

scientific article published on 7 July 2006

Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination

scientific article published on 01 September 2007

Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses

scientific article published on 2 February 2011

Interference with T cell receptor–HLA-DR interactions by Epstein–Barr virus gp42 results in reduced T helper cell recognition ⬇️

scientific article published on September 22, 2003

Manipulation of the immune response by Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus: consequences for tumor development

scientific article published on 31 October 2008

Multiple E2 ubiquitin-conjugating enzymes regulate human cytomegalovirus US2-mediated immunoreceptor downregulation

scientific article

Mutagenic repair of double-stranded DNA breaks in vaccinia virus genomes requires cellular DNA ligase IV activity in the cytosol

scientific article published on 20 April 2018

New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins

scientific article published on 29 March 2018

Noncytotoxic inhibition of cytomegalovirus replication through NK cell protease granzyme M-mediated cleavage of viral phosphoprotein 71

scientific article published on 08 November 2010

Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression

scientific article

Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.

scientific article published on 24 June 2015

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

scientific article published on 24 July 2020

Quality Control of ER Membrane Proteins by the RNF185/Membralin Ubiquitin Ligase Complex

scientific article published on 01 October 2020

RNA accessibility impacts potency of Tough Decoy microRNA inhibitors

scientific article published on 07 November 2018

Rat cytomegalovirus induces a temporal downregulation of major histocompatibility complex class I cell surface expression

scientific article published on January 2005

Signaling of a varicelloviral factor across the endoplasmic reticulum membrane induces destruction of the peptide-loading complex and immune evasion

scientific article

Specific targeting of the EBV lytic phase protein BNLF2a to the transporter associated with antigen processing results in impairment of HLA class I-restricted antigen presentation

scientific article

Stage-specific inhibition of MHC class I presentation by the Epstein-Barr virus BNLF2a protein during virus lytic cycle

scientific article

Structural and functional analysis of the TAP-inhibiting UL49.5 proteins of varicelloviruses.

scientific article

Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation

scientific article published on 16 December 2005

Synthesis and biological evaluation of a chitobiose-based peptide N-glycanase inhibitor library

scientific article

TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I.

scientific article published on 11 November 2013

TAP-inhibiting proteins US6, ICP47 and UL49.5 differentially affect minor and major histocompatibility antigen-specific recognition by cytotoxic T lymphocytes

scientific article published on September 2007

The "Bridge" in the Epstein-Barr virus alkaline exonuclease protein BGLF5 contributes to shutoff activity during productive infection

scientific article

The DNase of gammaherpesviruses impairs recognition by virus-specific CD8+ T cells through an additional host shutoff function

scientific article published on 19 December 2007

The E3 Ubiquitin Ligase TMEM129 Is a Tri-Spanning Transmembrane Protein

scientific article

The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells

scientific article

The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation

scientific article

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

scientific article

The capacity of UL49.5 proteins to inhibit TAP is widely distributed among members of the genus Varicellovirus.

scientific article

The comparative genomics of human respiratory syncytial virus subgroups A and B: genetic variability and molecular evolutionary dynamics

scientific article published on 22 May 2013

The nested open reading frame in the Epstein-Barr virus nuclear antigen-1 mRNA encodes a protein capable of inhibiting antigen presentation in cis.

scientific article published on 20 April 2007

The transporter associated with antigen processing (TAP) is active in a post-ER compartment

scientific article published on 23 November 2010

The varicellovirus UL49.5 protein blocks the transporter associated with antigen processing (TAP) by inhibiting essential conformational transitions in the 6+6 transmembrane TAP core complex

scientific journal article

The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1.

scientific article published on January 2007

Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking

scientific article published on 29 January 2019

Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells

scientific article

Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates

scientific article

Ubiquitination of serine, threonine, or lysine residues on the cytoplasmic tail can induce ERAD of MHC-I by viral E3 ligase mK3

scientific article

Varicellovirus UL 49.5 proteins differentially affect the function of the transporter associated with antigen processing, TAP.

scientific article

Varicelloviruses avoid T cell recognition by UL49.5-mediated inactivation of the transporter associated with antigen processing

scientific journal article

Viral evasion of T cell immunity: ancient mechanisms offering new applications ⬇️

scientific article published on 09 December 2010

Viral immune evasion: Lessons in MHC class I antigen presentation

scientific article published on March 2015

Viral immune evasion: a masterpiece of evolution

scientific article

Viral inhibition of the transporter associated with antigen processing (TAP): a striking example of functional convergent evolution

scientific article

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