List of works - Ruben J Boado

A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease

scientific article published on 05 December 2019

A Rapid Two-Step Iduronate-2-Sulfatatse Enzymatic Activity Assay for MPSII Pharmacokinetic Assessment

scientific article published on 23 June 2017

A new generation of neurobiological drugs engineered to overcome the challenges of brain drug delivery

scientific article

AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys

scientific article published on 06 September 2009

Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes

scientific article

Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology

scientific article

Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery

scientific article published on 09 December 2019

Blood-Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer's Disease.

scientific article published on 17 May 2017

Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor

scientific article published on 27 September 2018

Blood-brain barrier genomics

scientific article published on 01 January 2003

Blood-brain barrier genomics and cloning of a novel organic anion transporter

scientific article

Blood-brain barrier molecular trojan horse enables imaging of brain uptake of radioiodinated recombinant protein in the rhesus monkey.

scientific article published on 3 October 2013

Blood-brain barrier transport of non-viral gene and RNAi therapeutics

scientific article published on 8 June 2007

Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease

article

Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein

scientific article published on 9 March 2017

Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse

scientific article published on 26 January 2011

Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein

scientific article

Brain-penetrating IgG-iduronate 2-sulfatase fusion protein for the mouse

scientific article

Brain-penetrating tumor necrosis factor decoy receptor in the mouse

scientific article

CHO cell expression, long-term stability, and primate pharmacokinetics and brain uptake of an IgG-paroxonase-1 fusion protein

scientific article published in January 2011

Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein

scientific article

Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins

scientific article published on 18 February 2013

Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey

scientific article published on 09 September 2009

Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes

scientific article published in July 2007

Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation

scientific article published on 21 June 2006

Delivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein

scientific article

Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein

scientific article published on 5 February 2004

Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide

scientific article published on 20 August 2013

Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse

scientific article published on 16 March 2010

Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

scientific article published on March 2009

Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein

scientific article

Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation

scientific article published on 22 February 2007

GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier

scientific article published on June 2008

Gene therapy of the brain: the trans-vascular approach

scientific article published on April 2004

Genetic engineering of IgG-glucuronidase fusion proteins

scientific article published on April 2010

Genetic engineering of a bifunctional IgG fusion protein with iduronate-2-sulfatase

scientific article published in January 2010

Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier

scientific article published in February 2008

Genetic engineering, expression, and activity of a chimeric monoclonal antibody-avidin fusion protein for receptor-mediated delivery of biotinylated drugs in humans

scientific article published on 16 February 2008

Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier

scientific article published on August 2007

Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element

scientific article published on February 2002

Glycemic control and chronic dosing of rhesus monkeys with a fusion protein of iduronidase and a monoclonal antibody against the human insulin receptor

scientific article

Hematologic safety of chronic brain-penetrating erythropoietin dosing in APP/PS1 mice

scientific article published on 17 October 2019

Human LAT1 single nucleotide polymorphism N230K does not alter phenylalanine transport

scientific article published in December 2004

Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier

scientific article published on February 2007

Hypoxia induces de-stabilization of the LAT1 large neutral amino acid transporter mRNA in brain capillary endothelial cells

scientific article published on May 2003

IgG-enzyme fusion protein: pharmacokinetics and anti-drug antibody response in rhesus monkeys

scientific article published on 31 December 2012

IgG-paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier

scientific article

IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

scientific article

Imaging amyloid plaque in Alzheimer's disease brain with a biotinylated Aβ peptide radiopharmaceutical conjugated to an IgG-avidin fusion protein

scientific article

Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology.

scientific article

Imaging gene expression in the brain in vivo in a transgenic mouse model of Huntington's disease with an antisense radiopharmaceutical and drug-targeting technology.

scientific article published in July 2002

Immunologic privilege in the central nervous system and the blood-brain barrier

scientific article published on 17 October 2012

In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats

scientific article published in December 2003

Insulin Receptor Antibody-α-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts

scientific article published on 24 February 2016

Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys

scientific article published on 5 August 2014

Insulin receptor antibody-sulfamidase fusion protein penetrates the primate blood-brain barrier and reduces glycosoaminoglycans in Sanfilippo type A cells

scientific article

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

scientific article published on June 2004

Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

scientific article published on March 2008

Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

scientific article

Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology

scientific article

Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier

scientific article published on 30 June 2010

Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer

scientific article published on 30 June 2007

Marked enhancement in gene expression by targeting the human insulin receptor

scientific article published on February 2003

Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse

scientific article

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 t

Neuroprotection in experimental stroke in the rat with an IgG–erythropoietin fusion protein

article

Neuroprotection in stroke in the mouse with intravenous erythropoietin–Trojan horse fusion protein

article

Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor

scientific article

Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter

scientific article published in April 2004

Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice

article

Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer

scientific article published on 3 October 2003

Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

scientific article published on 25 December 2012

Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor

scientific article

Pharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in mice

scientific article published on 28 February 2013

Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery

scientific article published on 17 July 2009

Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice

scientific article published on 27 June 2019

Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I.

scientific article published on 13 February 2018

RNA interference and nonviral targeted gene therapy of experimental brain cancer

scientific article

Rat blood-brain barrier genomics. II.

scientific article

Re-engineering erythropoietin as an IgG fusion protein that penetrates the blood-brain barrier in the mouse

scientific article

Receptor-mediated abeta amyloid antibody targeting to Alzheimer's disease mouse brain

scientific article published on 21 December 2010

Receptor-mediated delivery of an antisense gene to human brain cancer cells

scientific article

Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse-Sulfamidase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse

scientific article published on 18 December 2017

Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier

scientific article

Reversal of lysosomal storage in brain of adult MPS-I mice with intravenous Trojan horse-iduronidase fusion protein

scientific article published on 17 June 2011

Selective plasma pharmacokinetics and brain uptake in the mouse of enzyme fusion proteins derived from species-specific receptor-targeted antibodies

scientific article published in September 2012

Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein

scientific article

Site-directed mutagenesis of cysteine residues of large neutral amino acid transporter LAT1.

scientific article published in September 2005

Site-directed mutagenesis of rabbit LAT1 at amino acids 219 and 234.

scientific article

Subtractive expression cloning reveals high expression of CD46 at the blood-brain barrier

scientific article

The Ro52/SS-A autoantigen has elevated expression at the brain microvasculature

scientific article

The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier

scientific article published on 16 November 2011

Tumor necrosis factor receptor-IgG fusion protein for targeted drug delivery across the human blood-brain barrier

scientific article

Vascular genomics of the human brain

scientific article published in March 2002

Vascular proteomics and subtractive antibody expression cloning

scientific article

Very High Plasma Concentrations of a Monoclonal Antibody against the Human Insulin Receptor Are Produced by Subcutaneous Injection in the Rhesus Monkey

scientific article published on 11 August 2016

List of works by Ruben J Boado

A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease

A Rapid Two-Step Iduronate-2-Sulfatatse Enzymatic Activity Assay for MPSII Pharmacokinetic Assessment

A new generation of neurobiological drugs engineered to overcome the challenges of brain drug delivery

AGT-181: expression in CHO cells and pharmacokinetics, safety, and plasma iduronidase enzyme activity in Rhesus monkeys

Absence of toxicity of chronic weekly intravenous gene therapy with pegylated immunoliposomes

Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology

Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery

Blood-Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer's Disease.

Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor

Blood-brain barrier genomics

Blood-brain barrier genomics and cloning of a novel organic anion transporter

Blood-brain barrier molecular trojan horse enables imaging of brain uptake of radioiodinated recombinant protein in the rhesus monkey.

Blood-brain barrier transport of non-viral gene and RNAi therapeutics

Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer's Disease

Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein

Brain penetrating IgG-erythropoietin fusion protein is neuroprotective following intravenous treatment in Parkinson's disease in the mouse

Brain protection from stroke with intravenous TNFα decoy receptor-Trojan horse fusion protein

Brain-penetrating IgG-iduronate 2-sulfatase fusion protein for the mouse

Brain-penetrating tumor necrosis factor decoy receptor in the mouse

CHO cell expression, long-term stability, and primate pharmacokinetics and brain uptake of an IgG-paroxonase-1 fusion protein

Chronic dosing of mice with a transferrin receptor monoclonal antibody-glial-derived neurotrophic factor fusion protein

Combination stroke therapy in the mouse with blood-brain barrier penetrating IgG-GDNF and IgG-TNF decoy receptor fusion proteins

Comparison of blood-brain barrier transport of glial-derived neurotrophic factor (GDNF) and an IgG-GDNF fusion protein in the rhesus monkey

Comparison of cDNA and genomic forms of tyrosine hydroxylase gene therapy of the brain with Trojan horse liposomes

Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation

Delivery of a peptide radiopharmaceutical to brain with an IgG-avidin fusion protein

Developmental regulation of the rabbit blood-brain barrier LAT1 large neutral amino acid transporter mRNA and protein

Disaggregation of amyloid plaque in brain of Alzheimer's disease transgenic mice with daily subcutaneous administration of a tetravalent bispecific antibody that targets the transferrin receptor and the Abeta amyloid peptide

Drug targeting of erythropoietin across the primate blood-brain barrier with an IgG molecular Trojan horse

Engineering and expression of a chimeric transferrin receptor monoclonal antibody for blood-brain barrier delivery in the mouse

Expression in CHO cells and pharmacokinetics and brain uptake in the Rhesus monkey of an IgG-iduronate-2-sulfatase fusion protein

Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation

GDNF fusion protein for targeted-drug delivery across the human blood-brain barrier

Gene therapy of the brain: the trans-vascular approach

Genetic engineering of IgG-glucuronidase fusion proteins

Genetic engineering of a bifunctional IgG fusion protein with iduronate-2-sulfatase

Genetic engineering of a lysosomal enzyme fusion protein for targeted delivery across the human blood-brain barrier

Genetic engineering, expression, and activity of a chimeric monoclonal antibody-avidin fusion protein for receptor-mediated delivery of biotinylated drugs in humans

Genetic engineering, expression, and activity of a fusion protein of a human neurotrophin and a molecular Trojan horse for delivery across the human blood-brain barrier

Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element

Glycemic control and chronic dosing of rhesus monkeys with a fusion protein of iduronidase and a monoclonal antibody against the human insulin receptor

Hematologic safety of chronic brain-penetrating erythropoietin dosing in APP/PS1 mice

Human LAT1 single nucleotide polymorphism N230K does not alter phenylalanine transport

Humanization of anti-human insulin receptor antibody for drug targeting across the human blood-brain barrier

Hypoxia induces de-stabilization of the LAT1 large neutral amino acid transporter mRNA in brain capillary endothelial cells

IgG-enzyme fusion protein: pharmacokinetics and anti-drug antibody response in rhesus monkeys

IgG-paraoxonase-1 fusion protein for targeted drug delivery across the human blood-brain barrier

IgG-single chain Fv fusion protein therapeutic for Alzheimer's disease: Expression in CHO cells and pharmacokinetics and brain delivery in the rhesus monkey

Imaging amyloid plaque in Alzheimer's disease brain with a biotinylated Aβ peptide radiopharmaceutical conjugated to an IgG-avidin fusion protein

Imaging endogenous gene expression in brain cancer in vivo with 111In-peptide nucleic acid antisense radiopharmaceuticals and brain drug-targeting technology.

Imaging gene expression in the brain in vivo in a transgenic mouse model of Huntington's disease with an antisense radiopharmaceutical and drug-targeting technology.

Immunologic privilege in the central nervous system and the blood-brain barrier

In vivo knockdown of gene expression in brain cancer with intravenous RNAi in adult rats

Insulin Receptor Antibody-α-N-Acetylglucosaminidase Fusion Protein Penetrates the Primate Blood-Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type B Fibroblasts

Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys

Insulin receptor antibody-sulfamidase fusion protein penetrates the primate blood-brain barrier and reduces glycosoaminoglycans in Sanfilippo type A cells

Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain cancer

Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

Intravenous nonviral gene therapy causes normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism.

Intravenous siRNA of brain cancer with receptor targeting and avidin-biotin technology

Intravenous treatment of experimental Parkinson's disease in the mouse with an IgG-GDNF fusion protein that penetrates the blood-brain barrier

Lysosomal enzyme replacement of the brain with intravenous non-viral gene transfer

Marked enhancement in gene expression by targeting the human insulin receptor

Monoclonal antibody-glial-derived neurotrophic factor fusion protein penetrates the blood-brain barrier in the mouse

Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 t

Neuroprotection in experimental stroke in the rat with an IgG–erythropoietin fusion protein

Neuroprotection in stroke in the mouse with intravenous erythropoietin–Trojan horse fusion protein

Neuroprotection with a brain-penetrating biologic tumor necrosis factor inhibitor

Normalization of striatal tyrosine hydroxylase and reversal of motor impairment in experimental parkinsonism with intravenous nonviral gene therapy and a brain-specific promoter

Organ-specific expression of the lacZ gene controlled by the opsin promoter after intravenous gene administration in adult mice

Organ-specific gene expression in the rhesus monkey eye following intravenous non-viral gene transfer

Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor

Pharmacokinetics and brain uptake of a genetically engineered bifunctional fusion antibody targeting the mouse transferrin receptor

Pharmacokinetics and brain uptake of an IgG-TNF decoy receptor fusion protein following intravenous, intraperitoneal, and subcutaneous administration in mice

Pharmacokinetics and safety in rhesus monkeys of a monoclonal antibody-GDNF fusion protein for targeted blood-brain barrier delivery

Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice

Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I.

RNA interference and nonviral targeted gene therapy of experimental brain cancer

Rat blood-brain barrier genomics. II.