List of works - Lance L Munn

A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.

scientific article

A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents

scientific article published on January 2008

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

scientific article published on 4 April 2016

Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas

scientific article

Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model

scientific article

Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling?

scientific article published on 13 May 2013

Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors

scientific article published on 13 May 2011

Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors

scientific article published on 01 December 2002

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

scientific article

Combining microenvironment normalization strategies to improve cancer immunotherapy

scientific article published on 03 February 2020

Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure

scientific article published on July 2014

Consensus guidelines for the use and interpretation of angiogenesis assays

article

Differential gene expression in metastasizing cells shed from kidney tumors

scientific article published in April 2004

Differential transplantability of tumor-associated stromal cells.

scientific article

Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation

scientific article

Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions

scientific article

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

scientific article published on 25 January 2004

Dissecting tumour pathophysiology using intravital microscopy

scientific article

Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice

scientific article

Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model

scientific article published on March 2007

Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis

scientific article published on 11 August 2011

Impaired lymphatic contraction associated with immunosuppression

scientific article published on 7 November 2011

In vivo compression and imaging in mouse brain to measure the effects of solid stress

scientific article published on 17 July 2020

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

scientific article

In vivo imaging of tumors

scientific article

Is vasculogenesis crucial for the regrowth of irradiated tumours?

scientific article published on 24 June 2011

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

scientific article

Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line

scientific article published on July 2005

Liver tumor preparation in mice

scientific article published on 01 December 2012

Lung window preparation in mice

scientific article published on 01 January 2013

Lymphangiography of the mouse ear.

scientific article published in November 2012

Lymphangiography of the mouse tail

scientific article published on 01 November 2012

Lymphatic metastasis in the absence of functional intratumor lymphatics

scientific article published on 25 April 2002

Mammary fat pad chamber preparation in mice

scientific article published in October 2012

Mammary fat pad tumor preparation in mice

scientific article published on 01 October 2012

Measuring angiogenesis and hemodynamics in mice

scientific article

Measuring interstitial diffusion, convection, and binding parameters in mouse tumors

scientific article

Measuring interstitial pH and pO2 in mouse tumors

scientific article published on 01 July 2013

Measuring leukocyte-endothelial interactions in mice

scientific article

Measuring vascular permeability in mice

scientific article

Mechanical compression drives cancer cells toward invasive phenotype

scientific article published on 27 December 2011

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

scientific article published in January 2018

Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells

scientific article (publication date: 2009)

Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers

scientific article

NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels

scientific article published on 9 June 2005

Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?

scientific article

Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion

scientific article published on 11 September 2007

Normalization of the vasculature for treatment of cancer and other diseases

scientific article

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment

scientific article

Pancreatic tumor preparation in mice

scientific article published on 01 December 2012

Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo

scientific article published on 28 May 2009

Physical traits of cancer

scientific article published on 01 October 2020

Quantifying solid stress and elastic energy from excised or in situ tumors.

scientific article published on 19 April 2018

Rabbit ear chambers

July 2012 scholarly article in Cold Spring Harbor Protocols

Red blood cells augment leukocyte rolling in a virtual blood vessel.

scientific article

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.

scientific article published on 13 March 2018

Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.

scientific article

Scaling rules for diffusive drug delivery in tumor and normal tissues

scientific article

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks

scientific article

Solid stress and elastic energy as measures of tumour mechanopathology

Solid stress generated by spheroid growth estimated using a linear poroelasticity model.

scientific article

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

scientific article published on 07 January 2019

Stress granule-associated protein G3BP2 regulates breast tumor initiation.

scientific article published on 17 January 2017

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients

scientific article published in November 2005

Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model

scientific article

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

scientific article

Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models

scientific article

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

scientific article

Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment

scientific article

List of works by Lance L Munn

A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy.

A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas

Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model

Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling?

Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors

Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Combining microenvironment normalization strategies to improve cancer immunotherapy

Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure

Consensus guidelines for the use and interpretation of angiogenesis assays

Differential gene expression in metastasizing cells shed from kidney tumors

Differential transplantability of tumor-associated stromal cells.

Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation

Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

Dissecting tumour pathophysiology using intravital microscopy

Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice

Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model

Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis

Impaired lymphatic contraction associated with immunosuppression

In vivo compression and imaging in mouse brain to measure the effects of solid stress

In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts

In vivo imaging of tumors

Is vasculogenesis crucial for the regrowth of irradiated tumours?

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.

Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line

Liver tumor preparation in mice

Lung window preparation in mice

Lymphangiography of the mouse ear.

Lymphangiography of the mouse tail

Lymphatic metastasis in the absence of functional intratumor lymphatics

Mammary fat pad chamber preparation in mice

Mammary fat pad tumor preparation in mice

Measuring angiogenesis and hemodynamics in mice

Measuring interstitial diffusion, convection, and binding parameters in mouse tumors

Measuring interstitial pH and pO2 in mouse tumors

Measuring leukocyte-endothelial interactions in mice

Measuring vascular permeability in mice

Mechanical compression drives cancer cells toward invasive phenotype

Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction

Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells

Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers

NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels

Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors?

Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion

Normalization of the vasculature for treatment of cancer and other diseases

PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment

Pancreatic tumor preparation in mice

Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo

Physical traits of cancer

Quantifying solid stress and elastic energy from excised or in situ tumors.

Rabbit ear chambers

Red blood cells augment leukocyte rolling in a virtual blood vessel.

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside.

Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy.

Scaling rules for diffusive drug delivery in tumor and normal tissues

Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks

Solid stress and elastic energy as measures of tumour mechanopathology

Solid stress generated by spheroid growth estimated using a linear poroelasticity model.

Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium

Stress granule-associated protein G3BP2 regulates breast tumor initiation.

Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients

Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models

Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy

Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment