List of works by Jean-Michel Scherrmann

1-Methyl-4-phenylpyridinium (MPP+) does not exhibit paraquat-like immunoreactivity

scientific article published on October 1990

A case report of transient but clinically relevant interaction between methadone and duloxetine: a reply to McCance-Katz et al.

scientific article published on September 2010

A critical review of antidotal immunotherapy for low molecular weight toxins. Current antidotes and perspectives

scientific article published on January 1997

A functional in vitro model of rat blood-brain barrier for molecular analysis of efflux transporters

scientific article published on 12 March 2007

A physiologically based modeling strategy during preclinical CNS drug development.

scientific article published on 29 January 2014

A polyspecific drug/proton antiporter mediates diphenhydramine and clonidine transport at the mouse blood-retinal barrier.

scientific article

ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas

scientific article published on 23 December 2019

ABC transporters and cytochromes P450 in the human central nervous system: influence on brain pharmacokinetics and contribution to neurodegenerative disorders

scientific article published on October 2010

ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells.

scientific article

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier.

scientific article

ABCG2- and ABCG4-mediated efflux of amyloid-β peptide 1-40 at the mouse blood-brain barrier

scientific article

Affinity and dose-dependent digoxin Na+K+ATPase dissociation by monoclonal digoxin-specific antibodies.

scientific article published in November 1995

Age-Dependent Regulation of the Blood-Brain Barrier Influx/Efflux Equilibrium of Amyloid-β Peptide in a Mouse Model of Alzheimer's Disease (3xTg-AD).

scientific article published on 09 October 2015

Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's disease

scientific article published on 12 March 2014

Antibodies proposed as therapeutic agents

scientific article published on January 1996

Apparent lack of Mrp1-mediated efflux at the luminal side of mouse blood-brain barrier endothelial cells

scientific article

Aryl hydrocarbon receptor regulates CYP1B1 but not ABCB1 and ABCG2 in hCMEC/D3 human cerebral microvascular endothelial cells after TCDD exposure

scientific article

Aryl hydrocarbon receptor-dependent upregulation of Cyp1b1 by TCDD and diesel exhaust particles in rat brain microvessels

scientific article

Association constants of monoclonal antibodies for hapten: heterogeneity of frequency distribution and possible relationship with hapten molecular weight

scientific article published in June 1994

Binding of colchicine and thiocolchicoside to human serum proteins and blood cells.

scientific article

Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier

scientific article published on 27 October 2015

Brain drug delivery technologies: novel approaches for transporting therapeutics

scientific article

Brain microdialysis in the mouse

scientific article published on 01 February 1995

Brief report: treatment of severe colchicine overdose with colchicine-specific Fab fragments

scientific article published on 01 March 1995

CNS delivery via adsorptive transcytosis

scientific article

Carrier-mediated cocaine transport at the blood-brain barrier as a putative mechanism in addiction liability.

scientific article published on 31 October 2014

Carrier-mediated processes at several rat brain interfaces determine the neuropharmacokinetics of morphine and morphine-6-beta-D-glucuronide

scientific article published on 23 November 2005

Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of 99mTechnetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2.

scientific article published on 4 December 2008

Clonidine transport at the mouse blood-brain barrier by a new H+ antiporter that interacts with addictive drugs.

scientific article published on 20 May 2009

Coexistence of passive and proton antiporter-mediated processes in nicotine transport at the mouse blood-brain barrier.

scientific article published on 5 December 2012

Colchicine concentration in leukocytes of patients with familial Mediterranean fever

scientific article

Colchicine in tear fluid of treated patients with familial Mediterranean fever

scientific article published on April 2003

Colchicine nonresponsiveness in familial Mediterranean fever: clinical, genetic, pharmacokinetic, and socioeconomic characterization

scientific article published on February 2004

Colchicine poisoning apropos of a pediatric case

scientific article published on July 1994

Colchicine today

scientific article published on September 2006

Colchicine-specific Fab fragments alter colchicine disposition in rabbits ⬇️

scientific article published on 01 March 1992

Combined ursodeoxycholic acid plus colchicine--treatment of primary biliary cirrhosis: results of a placebo-controlled double-blind study

scientific article published on 01 March 1992

Comment on: Rationale of a loading dose initiation for hydroxychloroquine treatment in COVID-19 infection in the DisCoVeRy trial

scientific article published on 07 August 2020

Commentary: current advances and future directions for CNS delivery

scientific article published on 12 December 2008

Comparing translational population-PBPK modelling of brain microdialysis with bottom-up prediction of brain-to-plasma distribution in rat and human

scientific article published on 17 September 2014

Comparison of colchicine toxicity on different dysmyelinating mutant models.

scientific article

Concepts for toxicokinetic-toxicodynamic modelling in clinical toxicology: application to acute cardiac glycoside intoxications

scientific article published on January 1, 1992

Covalent modifications of antitetanus F(ab')2 fragments with natural and synthetic polyamines and their effects on the antibody endocytosis in cultured HL60 cells

scientific article published on 17 July 2008

Design of cocaethylene and cocaine conjugates to produce highly selective polyclonal antibodies

scientific article published on February 2006

Determination of 3,4-methylenedioxymethamphetamine and its five main metabolites in rat urine by solid-phase extraction and high performance liquid chromatography with on line mass spectrometry ⬇️

scientific article published on August 21, 2010

Development and validation of an antigen-binding capture ELISA for native and putrescine-modified anti-tetanus F(ab')2 fragments for the assessment of the cellular uptake and plasma kinetics of the antibodies

scientific article published on 4 November 2005

Development of a physiologically based pharmacokinetic model for the rat central nervous system and determination of an in vitro-in vivo scaling methodology for the blood-brain barrier permeability of two transporter substrates, morphine and oxycodo

scientific article published in August 2012

Discrepancies in the P-glycoprotein-mediated transport of (18)F-MPPF: a pharmacokinetic study in mice and non-human primates.

scientific article published on 30 May 2012

Dose-dependent delivery of colchicine to the rat hippocampus by microdialysis

scientific article published on February 1996

Dose-dependent reversal of acute murine colchicine poisoning by goat colchicine-specific Fab fragments

scientific article

Dose-dependent reversal of digoxin-inhibited activity of an in vitro Na+K+ATPase model by digoxin-specific antibody

scientific article

Doxorubicin-peptide conjugates overcome multidrug resistance

scientific article

Effect of Long-term In Vitro Lithium Exposure on mRNA Levels of Claudin-3, CYP1A1, ABCG2 and GSTM3 Genes in the hCMEC/D3 Human Brain Endothelial Cell Line

scientific article

Effect of a Roux-en-Y gastric bypass on the pharmacokinetics of oral morphine using a population approach

scientific article published in October 2014

Effect of antivenom on venom pharmacokinetics in experimentally envenomed rabbits: toward an optimization of antivenom therapy

scientific article published on 01 April 1997

Effect of chronic exposure to morphine on the rat blood-brain barrier: focus on the P-glycoprotein

scientific article published on 30 August 2008

Effect of colchicine-specific Fab fragments on the hepatic clearance of colchicine

scientific article published on 01 November 1993

Effect of social isolation on the metabolism of morphine and its passage through the blood-brain barrier and on consumption of sucrose solutions

scientific article

Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.

scientific article published on 4 August 2010

Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells

scientific article

Effects of selected OATP and/or ABC transporter inhibitors on the brain and whole-body distribution of glyburide

scientific article published on 02 August 2013

Efflux of intracellular colchicine in lymphocytes with colchicine-specific Fab fragments

scientific article published on 01 September 1995

Elimination of paraquat

scientific article

Elimination of paraquat

scientific article published on 01 January 1986

Enhanced cellular uptake and transport of polyclonal immunoglobulin G and fab after their cationization

scientific article published on 01 January 2000

Evidence for an active transport of morphine-6-beta-d-glucuronide but not P-glycoprotein-mediated at the blood-brain barrier.

scientific article published in September 2003

Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide

scientific article published on 17 October 2017

Expression and function of multidrug resistance transporters at the blood-brain barriers

scientific article

Expression and induction by dexamethasone of ABC transporters and nuclear receptors in a human T-lymphocyte cell line

scientific article published on February 2012

Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells.

scientific article

Expression of P-glycoprotein (ABCB1) and Mrp1 (ABCC1) in adult rat brain: focus on astrocytes.

scientific article

Expression of drug transporters at the blood-brain barrier using an optimized isolated rat brain microvessel strategy.

scientific article published on 28 December 2006

Expression, up-regulation, and transport activity of the multidrug-resistance protein Abcg2 at the mouse blood-brain barrier.

scientific article

Extrahepatic metabolism of morphine occurs in humans

scientific article published in December 1990

Fab-bound colchicine appears to adopt Fab fragment disposition in rats

scientific article published on December 1, 1992

Facilitation of imipramine efflux from the brain by systemic specific antibodies

scientific article published on August 1996

Heterogeneity in the rat brain vasculature revealed by quantitative confocal analysis of endothelial barrier antigen and P-glycoprotein expression

scientific article published on 27 July 2011

How to obtain DNA from injection drug users?

scientific article published on 17 June 2011

Human ABC transporters at blood-CNS interfaces as determinants of CNS drug penetration

scientific article published on January 2014

Hurdles with using in vitro models to predict human blood-brain barrier drug permeability: a special focus on transporters and metabolizing enzymes

scientific article published on January 2013

Hydroxychloroquine and Azithromycin to Treat Patients With COVID-19: Both Friends and Foes?

scientific article published on 20 May 2020

Hypoxia interferes with aryl hydrocarbon receptor pathway in hCMEC/D3 human cerebral microvascular endothelial cells.

scientific article

Ibogaine labeling with 99mTc-tricarbonyl: synthesis and transport at the mouse blood-brain barrier.

scientific article published in December 2009

Immunoreactivity and pharmacokinetics of horse anti-scorpion venom F(ab')2-scorpion venom interactions

scientific article published on 01 November 1996

Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties

scientific article published on 5 April 2014

Improved brain delivery of benzylpenicillin with a peptide-vector-mediated strategy

scientific article published in June 2002

Improved brain uptake and pharmacological activity of dalargin using a peptide-vector-mediated strategy

scientific article published on 7 April 2003

Improved brain uptake and pharmacological activity profile of morphine-6-glucuronide using a peptide vector-mediated strategy

scientific article published on 12 January 2005

In situ mouse carotid perfusion model: glucose and cholesterol transport in the eye and brain.

scientific article published on 30 April 2008

In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier

scientific article published in August 2004

In vivo saturation of the transport of vinblastine and colchicine by P-glycoprotein at the rat blood-brain barrier

scientific article published in October 2003

Induction of P-glycoprotein and Bcrp at the rat blood-brain barrier following a subchronic morphine treatment is mediated through NMDA/COX-2 activation

scientific journal article

Influence of P-Glycoprotein Inhibition or Deficiency at the Blood-Brain Barrier on (18)F-2-Fluoro-2-Deoxy-D-glucose ( (18)F-FDG) Brain Kinetics

scientific article published on 26 February 2015

Influence of breast cancer resistance protein (Abcg2) and p-glycoprotein (Abcb1a) on the transport of imatinib mesylate (Gleevec® ) across the mouse blood-brain barrier

Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes

scientific article published on 16 October 2009

Influence of goat colchicine specific antibodies on murine colchicine disposition

scientific article published on November 1989

Influence of hydroxyurea on imatinib mesylate (gleevec) transport at the mouse blood-brain barrier

scientific article published on 25 August 2006

Influence of various combinations of specific antibody dose and affinity on tissue imipramine redistribution ⬇️

scientific article published in September 1998

Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART® Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

scientific article published on 20 February 2018

Interaction of drugs of abuse and maintenance treatments with human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2).

scientific article

Interplay of drug metabolizing CYP450 enzymes and ABC transporters in the blood-brain barrier

scientific article published on October 2011

Interspecies scaling of clearance and volume of distribution for digoxin-specific Fab.

scientific article published in May 1996

Is P-glycoprotein (ABCB1) a phase 0 or a phase 3 colchicine transporter depending on colchicine exposure conditions?

scientific article published on 10 August 2006

KCNH2 polymorphism and methadone dosage interact to enhance QT duration

scientific article published on 14 May 2014

LC-MS/MS-based quantification of efflux transporter proteins at the BBB

scientific article published on 08 November 2018

Mechanistic modeling of hepatic transport from cells to whole body: application to napsagatran and fexofenadine

scientific article published in November 2009

Methadone dose in heroin-dependent patients: role of clinical factors, comedications, genetic polymorphisms and enzyme activity

scientific article published on June 2015

Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research

scientific article published on 26 June 2013

Model-independent pharmacokinetics of colchicine after oral administration to healthy volunteers

scientific article published on 01 January 1989

Modulation of MDMA-induced behavioral and transcriptional effects by the delta opioid antagonist naltrindole in mice.

scientific article published on July 2009

Modulation of the brain distribution of imatinib and its metabolites in mice by valspodar, zosuquidar and elacridar

scientific article published on 23 March 2007

Molecular and functional MDR1-Pgp and MRPs expression in human glioblastoma multiforme cell lines

scientific article published on March 2002

Morphine pharmacokinetics and pain assessment after intracerebroventricular administration in patients with terminal cancer

scientific article published on April 1991

Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat.

scientific article

Nonlinear accumulation in the brain of the new taxoid TXD258 following saturation of P-glycoprotein at the blood-brain barrier in mice and rats.

scientific article

Oatp1a4 and an L-thyroxine-sensitive transporter mediate the mouse blood-brain barrier transport of amyloid-β peptide.

scientific article

Opioid transport by ATP-binding cassette transporters at the blood-brain barrier: implications for neuropsychopharmacology

scientific article published on January 2011

Optimisation of digoxin posology (author's transl)

scientific article published on 01 March 1981

Oral Morphine Pharmacokinetic in Obesity: The Role of P-Glycoprotein, MRP2, MRP3, UGT2B7, and CYP3A4 Jejunal Contents and Obesity-Associated Biomarkers.

scientific article published on 22 January 2016

Oral absorption characteristics and pharmacokinetics of colchicine in healthy volunteers after single and multiple doses

scientific article published on October 1996

P-glycoprotein (ABCB1) but not multidrug resistance-associated protein 1 (ABCC1) is induced by doxorubicin in primary cultures of rat astrocytes

scientific journal article

P2-002 S 18986, a positive modulator of AMPA receptors, crosses the blood brain barrier and it mainly distributes into brain hippocampal cells in rat

Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors

scientific article

Peptide vectors as drug carriers.

scientific article published on January 2003

Peptide-vector strategy bypasses P-glycoprotein efflux, and enhances brain transport and solubility of paclitaxel

scientific article

Pharmacokinetics and organ distribution of cationized colchicine-specific IgG and Fab fragments in rat

scientific article published on 01 January 1999

Pharmacokinetics of Vipera aspis venom after experimental envenomation in rabbits

scientific article published on 01 March 1994

Pharmacokinetics of colchicine: a review of experimental and clinical data

scientific article published in March 1992

Pharmacokinetics of digoxin‐specific Fab: effects of decreased renal function and age ⬇️

scientific article published on August 1, 1997

Pharmacokinetics of lithium in plasma and red blood cells in acute and chronic intoxicated patients

scientific article published on 01 June 1995

Pharmacokinetics of oral digoxin. Influence of congestive heart failure and age of patients (author's transl)

scientific article published on 01 March 1981

Pharmacokinetics of total and free digoxin and Fab fragments in 5 intoxicated patients after administration of specific anti-digoxin Fab fragments

scientific article published on 01 January 1991

Pharmacokinetics of unchanged morphine in normal and cirrhotic subjects.

scientific article published in April 1987

Pharmacology of morphine in obese patients: clinical implications

scientific article published on January 2009

Pharmacophore-based discovery of inhibitors of a novel drug/proton antiporter in human brain endothelial hCMEC/D3 cell line

scientific article

Physiologically based pharmacokinetic modelling of drug penetration across the blood-brain barrier--towards a mechanistic IVIVE-based approach

scientific article published on 20 June 2013

Plasma concentration of digoxin and digitoxin in elderly : correlation with clinical toxicity (author's transl)

scientific article published on 01 January 1981

Population pharmacokinetics of 3,4-methylenedioxymethamphetamine and main metabolites in rats.

scientific article published on 14 December 2009

Possible role of ABCB1 in lysosomal accumulation of azithromycin in COVID-19 therapy

scientific article published on 17 August 2020

Preclinical assessment of immunoreactivity of a new purified equine F(ab')2 against European viper venom

scientific article published on 01 February 1998

Prognosis and treatment of paraquat poisoning: a review of 28 cases

scientific article published on July 1982

Prognostic value of plasma and urine paraquat concentration

scientific article published in January 1987

Quantitative Atlas of Cytochrome P450, UDP-Glucuronosyltransferase, and Transporter Proteins in Jejunum of Morbidly Obese Subjects.

scientific article published on 27 June 2016

Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model

scientific article

Radioimmunoassay for Colchicine: Synthesis and Properties of Three Haptens ⬇️

scientific article published on 01 January 1980

Respiratory toxicity of buprenorphine results from the blockage of P-glycoprotein-mediated efflux of norbuprenorphine at the blood-brain barrier in mice.

scientific article published in December 2012

Reversal of murine colchicine toxicity by colchicine-specific Fab fragments

scientific article published on October 1991

Role of ABC transporters in the chemoresistance of human gliomas.

scientific article published on August 2006

Role of P-170 glycoprotein in colchicine brain uptake ⬇️

scientific article published on July 1, 1997

Role of P-glycoprotein in colchicine and vinblastine cellular kinetics in an immortalized rat brain microvessel endothelial cell line ⬇️

scientific article published on June 1, 1997

Simultaneous microdialysis in brain and blood of the mouse: extracellular and intracellular brain colchicine disposition

scientific article published in March 1998

Simultaneous pharmacokinetics/pharmacodynamics modeling of recombinant human erythropoietin upon multiple intravenous dosing in rats

scientific article

Single- and repeated-dose pharmacokinetics of intramuscular thiocolchicoside in healthy volunteers

scientific article published on 01 October 1999

Sprague-Dawley rats display metabolism-mediated sex differences in the acute toxicity of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy).

scientific article

Sprague-Dawley rats display sex-linked differences in the pharmacokinetics of 3,4-methylenedioxymethamphetamine (MDMA) and its metabolite 3,4-methylenedioxyamphetamine (MDA).

scientific article published on 23 September 2009

Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity

scientific article published in December 2004

Targeted unlabeled multiple reaction monitoring analysis of cell markers for the study of sample heterogeneity in isolated rat brain cortical microvessels.

scientific article

The effect of colchicine-specific active immunization on colchicine toxicity and disposition in the rabbit

scientific article

The effect of morbid obesity on morphine glucuronidation

scientific article published on 5 September 2016

The effect of morbid obesity on morphine glucuronidation

scientific article published on 28 September 2016

The human and rat recombinant receptors for advanced glycation end products have a high degree of homology but different pharmacokinetic properties in rats.

scientific article published in September 1999

Time-dependent clearance and hematological pharmacodynamics upon erythropoietin multiple dosing in rats

scientific article published in July 2010

Transcriptomic and quantitative proteomic analysis of transporters and drug metabolizing enzymes in freshly isolated human brain microvessels

scientific article published on 8 July 2011

Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2

scientific article

Transport of selected PET radiotracers by human P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2): an in vitro screening.

scientific article published on 14 February 2011

Transporters in absorption, distribution, and elimination

scientific article

Vector-mediated drug delivery to the brain

scientific article

[Endogenous or "digoxin-like" digitalis compounds. Physiopathological, analytical and pharmacokinetic impact]

scientific article published on 01 May 1988

[Immunotherapy of drug poisoning]

scientific article published on 01 January 1994

[Immunotoxicotherapy: protective effect of anti-colchicine antibodies in acute colchicine poisoning in rabbits and mice]

scientific article published on 01 January 1986

[Optimization of the dosage of digoxin. Proposal for a minimal exploratory protocol]

[Prognostic factors in acute digitalis poisoning]

scientific article published on 01 August 1982

[Recent advances in quantitative proteomics as a sensitive tool to quantify drug transporters and drug metabolizing enzymes at the human blood-brain barrier]

scientific article published on 22 November 2012

[Reversibility of severe digitoxin poisoning with antidigoxin antibodies]

scientific article published on 01 January 1983

[¹¹C]befloxatone brain kinetics is not influenced by Bcrp function at the blood-brain barrier: a PET study using Bcrp TGEM knockout rats

scientific article

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