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List of works by Roméo Cecchelli

3HBHDP as a novel and selective ligand for σ1 receptors in liver mitochondria and brain synaptosomes of the rat ⬇️

scientific article published on October 9, 2003

A New Function for the LDL Receptor: Transcytosis of LDL across the Blood–Brain Barrier ⬇️

scientific article published on August 25, 1997

A differential proteomic approach identifies structural and functional components that contribute to the differentiation of brain capillary endothelial cells.

scientific article published on 23 September 2011

A large-scale electrophoresis- and chromatography-based determination of gene expression profiles in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties ⬇️

scientific article published on November 15, 2010

A nanoformulation for the preferential accumulation in adult neurogenic niches

scientific article published on 15 June 2018

A new angle on blood-CNS interfaces: a role for connexins?

scientific article published on 12 March 2014

A polarized localization of amino acid/carnitine transporter B(0,+) (ATB(0,+)) in the blood-brain barrier.

scientific article

A simple method for assessing free brain/free plasma ratios using an in vitro model of the blood brain barrier

scientific article (publication date: 2013)

A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells

scientific article (publication date: 2014)

Accelerated Caco-2 cell permeability model for drug discovery ⬇️

scientific article published on August 3, 2013

Actin, gelsolin and filamin-A are dynamic actors in the cytoskeleton remodelling contributing to the blood brain barrier phenotype.

scientific article published in March 2009

Adamantoylated monosaccharides: new compounds for modification of the properties of cyclodextrin-containing materials.

scientific article published in June 2005

An easier, reproducible, and mass-production method to study the blood-brain barrier in vitro

scientific article published in May 1990

An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening

scientific article

Apical-to-basolateral transport of amyloid-β peptides through blood-brain barrier cells is mediated by the receptor for advanced glycation end-products and is restricted by P-glycoprotein

scientific article published on 01 January 2010

Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with a loss of tight junction proteins from the cellular contacts

scientific article published on 13 November 2003

Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood-brain barrier endothelial cells in vitro ⬇️

scientific article published on September 1, 1998

Behavior of alpha-, beta-, and gamma-cyclodextrins and their derivatives on an in vitro model of blood-brain barrier.

scientific article published on 13 April 2004

Blood-brain barrier in vitro models and their application in toxicology. The report and recommendations of ECVAM Workshop 49.

scientific article

Blood-brain barrier pericytes are the main source of gamma-glutamyltranspeptidase activity in brain capillaries

scientific article published on February 1, 1992

Blood-brain barrier proteomics: towards the understanding of neurodegenerative diseases

scientific article

Blood-brain interfaces: relevance to cerebral drug metabolism.

scientific article published on December 1995

Bovine brain endothelial cells express tight junctions and monoamine oxidase activity in long-term culture.

scientific article

Brain pericytes ABCA1 expression mediates cholesterol efflux but not cellular amyloid-β peptide accumulation.

scientific article

Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro ⬇️

scientific article published on June 29, 2012

Ca(2+) regulation of connexin 43 hemichannels in C6 glioma and glial cells

scientific article published on 4 August 2009

Carnitine: transport and physiological functions in the brain.

scientific article published in October 2004

Case study: adapting in vitro blood–brain barrier models for use in early-stage drug discovery ⬇️

scientific article published on October 20, 2011

Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: an in vitro study.

scientific article published on 23 July 2009

Characterization of angiogenin receptors on bovine brain capillary endothelial cells

scientific article

Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability

scientific article

Contribution of glial cells and pericytes to the mRNA profiles of P-glycoprotein and multidrug resistance-associated proteins in an in vitro model of the blood-brain barrier

scientific article

Derivation of Brain Capillary-like Endothelial Cells from Human Pluripotent Stem Cell-Derived Endothelial Progenitor Cells

scientific article published on 05 September 2019

Development and validation of a LC-MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood-brain barrier models

scientific article published on 27 May 2014

Differential expression of selectins by mouse brain capillary endothelial cells in vitro in response to distinct inflammatory stimuli

scientific article

Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium

scientific article published on 22 September 2010

Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy.

scientific article published on January 2004

Drug transfer across the blood-brain barrier: comparison of in vitro and in vivo models

scientific article published in January 1993

Drug transfer across the blood-brain barrier: correlation between in vitro and in vivo models

scientific article published on May 1992

Effects of gamma- and hydroxypropyl-gamma-cyclodextrins on the transport of doxorubicin across an in vitro model of blood-brain barrier.

scientific article published on 27 July 2004

Effects of tumor necrosis factor on receptor-mediated endocytosis and barrier functions of bovine brain capillary endothelial cell monolayers

scientific article

Endothelial calcium dynamics, connexin channels and blood-brain barrier function.

scientific article published on 10 July 2013

Endothelial cells and astrocytes: a concerto en duo in ischemic pathophysiology

scientific article

Endothelin-1 as a mediator of endothelial cell-pericyte interactions in bovine brain capillaries

scientific article

Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models

scientific article

Evaluation of effect of charge and lipid coating on ability of 60-nm nanoparticles to cross an in vitro model of the blood-brain barrier

scientific article published on 01 December 1999

Evidence of lowest brain penetration of an antiemetic drug, metopimazine, compared to domperidone, metoclopramide and chlorpromazine, using an in vitro model of the blood-brain barrier

scientific article published on 19 December 2006

Exposure of tumor necrosis factor-α to luminal membrane of bovine brain capillary endothelial cells cocultured with astrocytes induces a delayed increase of permeability and cytoplasmic stress fiber formation of actin

scientific article published on 01 August 1995

Fatty acid composition of brain capillary endothelial cells: effect of the coculture with astrocytes

scientific article published on 01 November 1995

Glial-cell-mediated re-induction of the blood-brain barrier phenotype in brain capillary endothelial cells: a differential gel electrophoresis study.

scientific article published in April 2013

HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator

scientific article published on 24 May 2011

Heparin Oligosaccharides that Pass the Blood‐Brain Barrier Inhibit β‐Amyloid Precursor Protein Secretion and Heparin Binding to β‐Amyloid Peptide ⬇️

scientific article published on February 1, 1998

High transcytosis of melanotransferrin (P97) across the blood-brain barrier

scientific article (publication date: November 2002)

Highly purified lipoteichoic acid from gram-positive bacteria induces in vitro blood-brain barrier disruption through glia activation: role of pro-inflammatory cytokines and nitric oxide

scientific article

Histamine induces a selective albumin permeation through the blood-brain barrierin vitro

scientific article published on 01 April 1995

How cyclodextrins can mask their toxic effect on the blood-brain barrier.

scientific article published on 25 January 2006

Hypoxia Increases the Susceptibility to Oxidant Stress and the Permeability of the Blood‐Brain Barrier Endothelial Cell Monolayer ⬇️

scientific article published on 01 November 1995

Hypoxia dramatically increases the nonspecific transport of blood-borne proteins to the brain

scientific article

In vitro blood-brain barrier permeability and cerebral endothelial cell uptake of the neuroprotective nitrone compound NXY-059 in normoxic, hypoxic and ischemic conditions

scientific article published in November 2002

In vitro blood-brain barrier permeability predictions for GABAA receptor modulating piperine analogs.

scientific article published on 24 March 2016

In vitro blood–brain barrier model adapted to repeated-dose toxicological screening ⬇️

scientific article published on 09 July 2013

In vitro model for evaluating drug transport across the blood-brain barrier

scientific article

In vitro models for the blood-brain barrier.

scientific article published on April 2005

Increased transendothelial permeability of anti-cancer agent carboplatin with the aid of hyperbaric oxygenation

scientific article

Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity

scientific article published in 1999

Induction of blood-brain barrier properties in cultured brain capillary endothelial cells: comparison between primary glial cells and C6 cell line

scientific article

Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier.

scientific article

Interactions of high-density lipoprotein 3 with brain capillary endothelial cells

scientific article published on October 1989

Intercommunications between brain capillary endothelial cells and glial cells increase the transcellular permeability of the blood-brain barrier during ischaemia.

scientific article published in November 2002

Involvement of OCTN2 and B0,+ in the transport of carnitine through an in vitro model of the blood-brain barrier.

scientific article published in November 2004

In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use.

scientific article published on 11 February 2016

Lessons from CADASIL.

scientific article

Localization of organic cation/carnitine transporter (OCTN2) in cells forming the blood-brain barrier

scientific article

Low extracellular Ca2+ conditions induce an increase in brain endothelial permeability that involves intercellular Ca2+ waves

scientific article published on 10 July 2012

Low-density lipoprotein receptor on endothelium of brain capillaries

scientific article published on 01 August 1989

Maternal calorie restriction modulates placental mitochondrial biogenesis and bioenergetic efficiency: putative involvement in fetoplacental growth defects in rats

scientific article published on 23 October 2012

Methylated beta-cyclodextrin as P-gp modulators for deliverance of doxorubicin across an in vitro model of blood-brain barrier

scientific article published on 7 February 2006

MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery

scientific article published on 23 October 2015

Modelling of the blood-brain barrier in drug discovery and development.

scientific article

Modelling the neurovascular unit and the blood-brain barrier with the unique function of pericytes.

scientific article published in November 2011

Monoacylation of ribonuclease A enables its transport across an in vitro model of the blood-brain barrier.

scientific article published in December 1998

Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium.

scientific article published in June 2005

Mycobacterium tuberculosis heparin-binding haemagglutinin adhesin (HBHA) triggers receptor-mediated transcytosis without altering the integrity of tight junctions

scientific journal article

Neuroprotective properties of tianeptine: interactions with cytokines

scientific article published in May 2003

New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment

scientific article

Oxygen glucose deprivation switches the transport of tPA across the blood-brain barrier from an LRP-dependent to an increased LRP-independent process

scientific article published on 7 April 2005

P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins.

scientific article published in November 2003

PPACK-Desmodus rotundus salivary plasminogen activator (cDSPAα1) prevents the passage of tissuetype plasminogen activator (rt-PA) across the blood-brain barrier and neurotoxicity

scientific article published on 01 September 2009

Penetration of small molecular weight substances through cultured bovine brain capillary endothelial cell monolayers: the early effects of cyclic adenosine 3',5'-monophosphate

scientific article published in July 1995

Peroxisome proliferator-activated receptor-alpha activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment.

scientific article published in July 2003

Peroxisome-proliferator-activated receptor-alpha activation protects brain capillary endothelial cells from oxygen-glucose deprivation-induced hyperpermeability in the blood-brain barrier.

scientific article

Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin

scientific article published on 19 April 2016

Physiological pathway for low-density lipoproteins across the blood-brain barrier: transcytosis through brain capillary endothelial cells in vitro.

scientific article

Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models.

scientific article published on July 2002

Preferential transfer of 2-docosahexaenoyl-1-lysophosphatidylcholine through an in vitro blood-brain barrier over unesterified docosahexaenoic acid.

scientific article

Protective effect of glial cells against lipopolysaccharide-mediated blood-brain barrier injury

scientific article published in April 2003

Protein kinase C restricts transport of carnitine by amino acid transporter ATB(0,+) apically localized in the blood-brain barrier.

scientific article

Protein transport in cerebral endothelium. In vitro transcytosis of transferrin.

scientific article published in January 2003

Receptor-mediated transcytosis of cyclophilin B through the blood-brain barrier.

scientific article published on July 1999

Receptor-mediated transcytosis of lactoferrin through the blood-brain barrier.

scientific article published on March 1999

Receptor-mediated transcytosis of transferrin through blood-brain barrier endothelial cells

scientific article published in April 1996

Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects

scientific article

ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier.

scientific article published on 11 August 2016

Schistosoma mansoni activates host microvascular endothelial cells to acquire an anti-inflammatory phenotype

scientific article published on July 1999

Selection of a Relevant In Vitro Blood-Brain Barrier Model to Investigate Pro-Metastatic Features of Human Breast Cancer Cell Lines

scientific article

Selective drug transport and P-glycoprotein activity in an in vitro blood-brain barrier model

scientific article published on 01 August 1995

Specific AHNAK expression in brain endothelial cells with barrier properties.

scientific article

Stem Cell-Based Human Blood-Brain Barrier Models for Drug Discovery and Delivery.

scientific article published on 30 January 2016

Stroke-induced brain parenchymal injury drives blood-brain barrier early leakage kinetics: a combined in vivo/in vitro study.

scientific article

Structural determination of the novel fragmentation routes of morphine opiate receptor antagonists using electrospray ionization quadrupole time-of-flight tandem mass spectrometry

scientific article

Synthesis of chacotriose analogues.

scientific article

TNAP and EHD1 are over-expressed in bovine brain capillary endothelial cells after the re-induction of blood-brain barrier properties

scientific article

The MAP kinase pathway mediates transcytosis induced by TNF-alpha in an in vitro blood-brain barrier model

scientific article

The neuroprotective activity of 8-alkylamino-1,4-benzoxazine antioxidants

scientific article published in July 2001

The value of selected in vitro and in silico methods to predict acute oral toxicity in a regulatory context: results from the European Project ACuteTox

scientific article published on 16 August 2012

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

scientific article published on 25 April 2005

Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood-brain barrier: use of an in vitro model.

scientific article

Transport of cationized anti-tetanus Fab'2 fragments across an in vitro blood-brain barrier model: involvement of the transcytosis pathway

scientific article published on 01 November 1999

Transport screening of drug cocktails through an in vitro blood-brain barrier: is it a good strategy for increasing the throughput of the discovery pipeline?

scientific article

Tumor necrosis factor-alpha increases lactoferrin transcytosis through the blood-brain barrier

scientific article published on 01 December 1999

Understanding the blood-brain barrier using gene and protein expression profiling technologies.

scientific article published on 19 September 2009

Upregulation of the low density lipoprotein receptor at the blood-brain barrier: intercommunications between brain capillary endothelial cells and astrocytes

scientific article

VEGF-Induced BBB Permeability is Associated with an MMP-9 Activity Increase in Cerebral ischemia: Both Effects Decreased by ANG-1

scientific article published on 01 November 2005

[Cerebral transfer and neuroprotection]

scientific article published on 01 March 2004

[Dysfunction of the blood-brain barrier during ischaemia: a therapeutic concern]

scientific article published on 22 November 2012

[Role of the blood-brain barrier in Alzheimer's disease]

scientific article published on 30 November 2011

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