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List of works by Blake Pepinsky

A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble

scientific article

A cell-free electrochemiluminescence assay for measuring beta1-integrin-ligand interactions

scientific article published on July 2002

A dimeric form of lipocortin-1 in human placenta

scientific article

A direct binding assay for the vascular cell adhesion molecule-1 (VCAM1) interaction with alpha 4 integrins

scientific article published on 01 December 1995

A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice

scientific article published on 3 October 2006

A mouse homolog to the avian sarcoma virus src protein is a member of a protein kinase cascade ⬇️

scientific article published on July 1, 1981

A neutralizing anti-Nogo66 receptor monoclonal antibody reverses inhibition of neurite outgrowth by central nervous system myelin.

scientific article published on 5 August 2004

A novel platform for engineering blood-brain barrier-crossing bispecific biologics

scientific article

A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence

scientific article published on 23 May 2003

A small molecule very late antigen-4 antagonist can inhibit ovalbumin-induced lung inflammation

scientific article

Alpha 4-integrins mediate antigen-induced late bronchial responses and prolonged airway hyperresponsiveness in sheep

scientific article

Amino-terminal amino acid sequence of p10, the fifth major gag polypeptide of avian sarcoma and leukemia viruses ⬇️

scientific article published on February 1, 1983

An assessment of the mechanistic differences between two integrin alpha 4 beta 1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental autoimmune encephalomyelitis

scientific article published on 6 March 2003

An immunoassay to detect human müllerian inhibiting substance in males and females during normal development

scientific article published on January 1990

Analysis of Rous sarcoma virus Gag protein by mass spectrometry indicates trimming by host exopeptidase

scientific article

Anti-müllerian hormone: the Jost factor.

scientific article

Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework

scientific article

Artemin crystal structure reveals insights into heparan sulfate binding

scientific article (publication date: 6 June 2006)

Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush

scientific article published on 27 April 2015

Assay and purification of phospholipase A2 from human synovial fluid in rheumatoid arthritis

scientific article published in January 1991

Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody ⬇️

scientific article published on July 1, 1993

Autoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythematosus

scientific article

Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury.

scientific article published in November 2004

Blockade of signaling via the very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) causes increased T cell apoptosis in experimental autoimmune neuritis

scientific article published on 31 October 2001

Blocking LINGO-1 function promotes retinal ganglion cell survival following ocular hypertension and optic nerve transection.

scientific article

Blocking LINGO-1 in vivo reduces degeneration and enhances regeneration of the optic nerve

scientific article

Characterization of a secretable phospholipase A2 from human platelets

scientific article published on January 1990

Characterization of trisulfide modification in antibodies

scientific article published on 18 January 2010

Chemical crosslinking of proteins in avian sarcoma and leukemia viruses ⬇️

scientific article published on April 15, 1980

Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.

scientific article published in June 2002

Comparative biological responses to human Sonic, Indian, and Desert hedgehog

scientific article published on August 2001

Constitutive negative regulation in the processing of the anti-Müllerian hormone receptor II.

scientific article published on 6 February 2015

Crystal structure of the alpha1beta1 integrin I-domain: insights into integrin I-domain function

scientific article

Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination ⬇️

scientific article published on July 3, 2011

Design, synthesis, and analysis of a polyethelene glycol-modified (PEGylated) small molecule inhibitor of integrin {alpha}4{beta}1 with improved pharmaceutical properties

scientific article published on 14 October 2004

Determination of the Disulfide Structure of Murine Meteorin, a Neurotrophic Factor, by LC-MS and Electron Transfer Dissociation-High-Energy Collisional Dissociation Analysis of Proteolytic Fragments.

scientific article published on 28 February 2017

Development and validation of immunoassays to quantify the half-antibody exchange of an IgG4 antibody, natalizumab (Tysabri®) with endogenous IgG4 ⬇️

scientific article published on January 19, 2011

Development of an aggregate-selective, human-derived α-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models

article

Differential proteolytic processing leads to multiple forms of the CA protein in avian sarcoma and leukemia viruses.

scientific article published in October 1995

Disulfide structure of the leucine-rich repeat C-terminal cap and C-terminal stalk region of Nogo-66 receptor

scientific article

Divalent cations stabilize the alpha 1 beta 1 integrin I domain

scientific article published on 01 June 1999

Dynamic structural changes are observed upon collagen and metal ion binding to the integrin α1 I domain.

scientific article

Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury

scientific article

Endothelial cell lymphocyte function-associated antigen-3 and an unidentified ligand act in concert to provide costimulation to human peripheral blood CD4+ T cells ⬇️

scientific article published on 01 October 1991

Engineering potent long-acting variants of the Wnt inhibitor DKK2

scientific article

Enhanced potency of human Sonic hedgehog by hydrophobic modification.

scientific article published on April 2001

Epidermal growth factor-dependent phosphorylation of lipocortin

scientific article

Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium

scientific article published on 25 July 2001

Exposure Levels of Anti-LINGO-1 Li81 Antibody in the Central Nervous System and Dose-Efficacy Relationships in Rat Spinal Cord Remyelination Models after Systemic Administration ⬇️

scientific article published on August 1, 2011

Expression, purification and biochemical comparison of natural and recombinant human non-pancreatic phospholipase A2

scientific article published on August 31, 1992

Expression, purification, and characterization of rat interferon-beta, and preparation of an N-terminally PEGylated form with improved pharmacokinetic parameters

scientific article published in April 2004

Fine-structure analyses of lipid-protein and protein-protein interactions of gag protein p19 of the avian sarcoma and leukemia viruses by cyanogen bromide mapping ⬇️

scientific article published on October 1, 1984

Five distinct calcium and phospholipid binding proteins share homology with lipocortin I

scientific article

Functional activity of anti-LINGO-1 antibody opicinumab requires target engagement at a secondary binding site

scientific article published on 01 January 2020

Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity.

scientific article

Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins

scientific article

Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test

scientific article

IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice

scientific article published on 27 June 2009

Identification of Ligand Binding Sites on Integrin α4β1 through Chemical Cross-Linking ⬇️

scientific article published on June 16, 1998

Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog ⬇️

scientific article published on May 29, 1998

Identification of retrovirus matrix proteins by lipid-protein cross-linking ⬇️

scientific article published on July 15, 1979

Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity.

scientific article

Improving the solubility of anti-LINGO-1 monoclonal antibody Li33 by isotype switching and targeted mutagenesis

scientific article

Infusion of an antialpha4 integrin antibody is associated with less neoadventitial formation after balloon injury of porcine coronary arteries

scientific article published on 01 February 2000

Inhibition of LINGO-1 promotes functional recovery after experimental spinal cord demyelination

scientific article published on 11 February 2015

Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models

scientific article

Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS.

scientific article published on 21 October 2009

LINGO-1 Regulates Oligodendrocyte Differentiation through the Cytoplasmic Gelsolin Signaling Pathway.

scientific article published on 13 February 2017

LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury

scientific article published on 29 September 2006

LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis

scientific article published on 30 September 2007

LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex

scientific article

LINGO-1 negatively regulates myelination by oligodendrocytes

scientific journal article

LINGO-1 regulates oligodendrocyte differentiation by inhibiting ErbB2 translocation and activation in lipid rafts

scientific article published on 28 February 2014

Location of sites in human lipocortin I that are phosphorylated by protein tyrosine kinases and protein kinases A and C

scientific article

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model

scientific article published on February 2002

Mapping sonic hedgehog-receptor interactions by steric interference

scientific article published on 14 April 2000

Meteorin reverses hypersensitivity in rat models of neuropathic pain ⬇️

scientific article published on July 2, 2012

Monoclonal antibodies to lipocortin-1 as probes for biological function.

scientific article published on February 1990

Most Cleaved Anti-Müllerian Hormone Binds Its Receptor in Human Follicular Fluid but Little Is Competent in Serum

scientific article published on 13 September 2016

Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily

scientific article published in February 1993

Multiple actions of systemic artemin in experimental neuropathy ⬇️

scientific article (publication date: November 2003)

Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand

scientific article published on 01 May 1999

Mutations of the anti-mullerian hormone gene in patients with persistent mullerian duct syndrome: biosynthesis, secretion, and processing of the abnormal proteins and analysis using a three-dimensional model

scientific article published on 12 December 2003

N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model.

scientific article published on January 2006

NGF regulates the expression of axonal LINGO-1 to inhibit oligodendrocyte differentiation and myelination

scientific article published on 01 January 2007

Oligodendrocyte differentiation and myelination defects in OMgp null mice ⬇️

scientific article published on February 23, 2011

Pathophysiologic role of alpha 4 integrins in the lung

scientific article published on October 1996

Primary structure of p19 species of avian sarcoma and leukemia viruses

scientific article published on October 1985

Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-beta.

scientific article

Production of a PEGylated Fab′ of the anti-LINGO-1 Li33 Antibody and Assessment of Its Biochemical and Functional Properties in Vitro and in a Rat Model of Remyelination ⬇️

scientific article published on January 21, 2011

Production of multimeric forms of CD4 through a sugar-based cross-linking strategy.

scientific article published in September 1991

Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells

scientific article (publication date: March 2009)

Proteolytic processing of mullerian inhibiting substance produces a transforming growth factor-beta-like fragment

scientific article published on 01 December 1988

Purification and characterization of proteolytic fragments of lipocortin I that inhibit phospholipase A2

scientific article published on 01 June 1987

Purification and partial sequence analysis of a 37-kDa protein that inhibits phospholipase A2 activity from rat peritoneal exudates

scientific article

Purification and properties of a fifth major viral gag protein from avian sarcoma and leukemia viruses ⬇️

scientific article published on February 1, 1983

Purifying the hedgehog protein and its variants

scientific article

Randomized phase I clinical trial of anti-α-synuclein antibody BIIB054

scientific article published on 17 June 2019

Rational design of potent and selective VLA-4 inhibitors and their utility in the treatment of asthma

scientific article

Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cells

scientific article

Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung.

scientific article published in July 1987

Resistance of primary isolates of human immunodeficiency virus type 1 to neutralization by soluble CD4 is not due to lower affinity with the viral envelope glycoprotein gp120 ⬇️

scientific article published on February 15, 1992

Resolution of disulfide heterogeneity in Nogo receptor 1 fusion proteins by molecular engineering ⬇️

scientific article published on September 1, 2010

Role of lipocortin I in the glucocorticoid induction of the terminal differentiation of a human squamous carcinoma

scientific article published on January 1990

Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses

scientific article

Sequences flanking the core DNA-binding domain of bovine papillomavirus type 1 E2 contribute to DNA-binding function.

scientific article

Specific inhibition of a human papillomavirus E2 trans-activator by intracellular delivery of its repressor

scientific article published on October 1994

Sphingosine 1-phosphate receptor modulator fingolimod (FTY720) does not promote remyelination in vivo ⬇️

scientific article published on June 24, 2011

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.

scientific article published on 23 April 2018

Structure and processing of the p2 region of avian sarcoma and leukemia virus gag precursor polyproteins

scientific article published on April 1986

Structure and properties of a human non-pancreatic phospholipase A2

scientific journal article

Structure and properties of a secretable phospholipase A2 from human platelets

scientific article

Structure of the LINGO-1-anti-LINGO-1 Li81 antibody complex provides insights into the biology of LINGO-1 and the mechanism of action of the antibody therapy

scientific article

Structure/function studies on vascular cell adhesion molecule-1 ⬇️

scientific article published on September 5, 1992

Suppression of sodium dodecyl sulfate-polyacrylamide gel electrophoresis sample preparation artifacts for analysis of IgG4 half-antibody

scientific article published on 9 March 2006

TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration

scientific article

Tat-mediated delivery of heterologous macromolecules into living cells ⬇️

scientific article published on 01 January 1995

Tat-mediated protein delivery can facilitate MHC class I presentation of antigens

scientific article published on October 1996

Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice

scientific article published in November 2005

The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin

scientific article published in December 2000

The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction

scientific article

The increased potency of cross-linked lymphocyte function-associated antigen-3 (LFA-3) multimers is a direct consequence of changes in valency ⬇️

scientific article published on September 25, 1991

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

scientific article published on 01 June 2001

The plasma and cytoplasmic forms of human gelsolin differ in disulfide structure

scientific article published on July 1996

The role of the very late antigen-4 and its counterligand vascular cell adhesion molecule-1 in the pathogenesis of experimental autoimmune neuritis of the Lewis rat ⬇️

scientific article published on July 1, 1998

The tryptophan bridge is a critical feature of the papillomavirus E2 DNA binding domain.

scientific article

Tissue distribution of 35S-metabolically labeled neublastin (BG00010) in rats

scientific article published on 06 February 2020

Ubiquitin in avian leukosis virus particles

scientific article published in June 1990

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