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List of works by Paul P Van Veldhoven

(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1

scientific article

1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase

scientific article

2-Methylacyl racemase: a coupled assay based on the use of pristanoyl-CoA oxidase/peroxidase and reinvestigation of its subcellular distribution in rat and human liver ⬇️

scientific article published on July 12, 1997

5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids

scientific article published on 28 October 2004

A Nonradioactive Fluorimetric SPE-Based Ceramide Kinase Assay Using NBD-C(6)-Ceramide

scientific article published on 26 July 2012

Abolition of peroxiredoxin-5 mitochondrial targeting during canid evolution

scientific article

Absence of functional peroxisomes from mouse CNS causes dysmyelination and axon degeneration

scientific article published in April 2008

Absence of peroxisomes in mouse hepatocytes causes mitochondrial and ER abnormalities

scientific journal article

Acyl-CoA thioesterase 9 (ACOT9) in mouse may provide a novel link between fatty acid and amino acid metabolism in mitochondria.

scientific article

Adipose tissue protects against sepsis-induced muscle weakness in mice: from lipolysis to ketones

scientific article published on 01 July 2019

Aging, age-related diseases and peroxisomes

scientific article published on January 2013

Allostery between two binding sites in the ion channel subunit TRIP8b confers binding specificity to HCN channels.

scientific article published on 8 September 2017

Alpha‐oxidation of 3‐methyl‐substituted fatty acids and its thiamine dependence ⬇️

scientific article published on April 1, 2003

Alterations in phosphatidylethanolamine levels affect the generation of Aβ.

scientific article published on 28 November 2011

Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis

scientific article

Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay

scientific article

Anomalous surface distribution of glycosyl phosphatidyl inositol-anchored proteins in neurons lacking acid sphingomyelinase

scientific article

Beta-oxidation in hepatocyte cultures from mice with peroxisomal gene knockouts

scientific journal article

Bifunctional Sphingosine for Cell-Based Analysis of Protein-Sphingolipid Interactions

scientific article published on 11 November 2015

Biochemistry and genetics of inherited disorders of peroxisomal fatty acid metabolism

scientific article

Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids

scientific article

Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression

scientific article published on 14 October 2011

Central nervous system pathology in MFP2 deficiency: insights from general and conditional knockout mouse models.

scientific article published on 19 August 2013

Ceramide-dependent release of ceramide kinase from cultured cells

scientific article published on 4 October 2007

Cholesterol-Lowering Gene Therapy Counteracts the Development of Non-ischemic Cardiomyopathy in Mice

scientific article

Coconut Oil Aggravates Pressure Overload-Induced Cardiomyopathy without Inducing Obesity, Systemic Insulin Resistance, or Cardiac Steatosis

scientific article published on 18 July 2017

Combined deficiency of peroxisomal beta-oxidation and ether lipid synthesis in mice causes only minor cortical neuronal migration defects but severe hypotonia

scientific article published on 12 February 2010

Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b

scientific article

Coordinate induction of PPAR alpha and SREBP2 in multifunctional protein 2 deficient mice

scientific article

De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation

scientific article published on 28 September 2010

Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting

scientific article published on 24 May 2019

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

scientific article

Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process

scientific article published on 19 June 2008

Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice

scientific article

Determination of sphingosine-1-phosphate lyase activity by gas chromatography coupled to electron impact mass spectrometry

scientific article published on 12 January 2012

Developmental changes of bile acid composition and conjugation in L- and D-bifunctional protein single and double knockout mice

scientific article

Differential activities of peroxisomes along the mouse intestinal epithelium

scientific article

Differential distribution of peroxisomal proteins points to specific roles of peroxisomes in the murine retina

scientific article published on 02 January 2019

Differential regulation by a peroxisome proliferator of the different multifunctional proteins in guinea pig: cDNA cloning of the guinea pig D-specific multifunctional protein 2 ⬇️

scientific article published on March 15, 1998

Discontinued postnatal thymocyte development in sphingosine 1-phosphate-lyase-deficient mice.

scientific article published on 11 September 2009

Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation

scientific article

Distinct Mechanisms for Visual and Motor-Related Astrocyte Responses in Mouse Visual Cortex

scientific article published on 05 September 2019

Editorial Expression of Concern: Glial β-Oxidation regulates Drosophila Energy Metabolism

scientific article published on 31 July 2020

Enhanced Ca2+ storage in sphingosine-1-phosphate lyase-deficient fibroblasts

scientific article published on March 2010

Enzymatic Quantitation of Cholesterol Esters in Lipid Extracts ⬇️

scientific article published on April 10, 1998

Erratum: Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells

scientific article published in Nature

Evidence for the existence of a pristanoyl-CoA oxidase gene in man ⬇️

scientific article published on August 1, 1997

Evidence that multifunctional protein 2, and not multifunctional protein 1, is involved in the peroxisomal β-oxidation of pristanic acid ⬇️

scientific article published on July 15, 1997

Exercise-induced, but not creatine-induced, decrease in intramyocellular lipid content improves insulin sensitivity in rats

scientific article published on 17 February 2011

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

scientific article

Fatty acid carbon is essential for dNTP synthesis in endothelial cells

scientific article published on April 2015

Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains

scientific article

Functional peroxisomes are required for β-cell integrity in mice

scientific article published on 08 February 2019

Functional studies on human Pex7p: subcellular localization and interaction with proteins containing a peroxisome-targeting signal type 2 and other peroxins

scientific article

Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies

scientific article

Further studies on the substrate spectrum of phytanoyl-CoA hydroxylase: implications for Refsum disease?

scientific article published on 16 August 2003

Gender affects liver desaturase expression in a rat model of n-3 fatty acid repletion

scientific article published on 20 January 2009

Generalised and conditional inactivation of Pex genes in mice

scientific article published on 25 August 2006

Glial β-oxidation regulates Drosophila energy metabolism

scientific article

Hematopoietic sphingosine 1-phosphate lyase deficiency decreases atherosclerotic lesion development in LDL-receptor deficient mice

scientific article

Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice.

scientific article published on 7 November 2012

Hepatic dysfunction in peroxisomal disorders

scientific article published on 07 October 2015

Hepatosteatosis in peroxisome deficient liver despite increased β-oxidation capacity and impaired lipogenesis.

scientific article

Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

scientific article published on 2 January 2016

Identification and characterization of new long chain acyl-CoA dehydrogenases

scientific article

Identification of a Novel Human Peroxisomal 2,4-Dienoyl-CoA Reductase Related Protein Using the M13 Phage Protein VI Phage Display Technology ⬇️

scientific article published on November 1, 2001

Identification of a novel PEX14 mutation in Zellweger syndrome

scientific article published on 23 January 2009

Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative

scientific journal article

Intellectual disability, muscle weakness and characteristic face in three siblings: A newly described recessive syndrome mapping to 3p24.3-p25.3.

scientific article published on 20 July 2015

Intracellular Growth Hormone Receptors in Chicken Liver ⬇️

scientific article published on May 15, 1998

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

scientific article published on 3 March 2011

Lessons from knockout mice. I: Phenotypes of mice with peroxisome biogenesis disorders.

scientific article published on January 2003

Leukodystrophy caused by plasmalogen deficiency rescued by glyceryl 1-myristyl ether treatment

scientific article published on 20 February 2019

Lipase‐based quantitation of triacylglycerols in cellular lipid extracts: Requirement for presence of detergent and prior separation by thin‐layer chromatography ⬇️

scientific article published on 01 December 1997

Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency

scientific article

Localization of 1-deoxysphingolipids to mitochondria induces mitochondrial dysfunction.

scientific article published on 23 November 2016

Loss of HIF-2alpha and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

scientific journal article

Mass spectrometric analysis of ceramide perturbations in brain and fibroblasts of mice and human patients with peroxisomal disorders

scientific article

Metabolism of dolichol, dolichoic acid and nordolichoic acid in cultured cells ⬇️

scientific article published on July 12, 1997

Microarray-based discovery of highly expressed olfactory mucosal genes: potential roles in the various functions of the olfactory system

scientific article published on 16 December 2003

Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells

scientific article published on 27 August 2013

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

scientific article published on 20 November 2014

Mitochondrial disruption in peroxisome deficient cells is hepatocyte selective but is not mediated by common hepatic peroxisomal metabolites

scientific article published on 30 August 2017

Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus

scientific article published on 08 July 2011

Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies

scientific article

N-acyl migration in ceramides

scientific article

Neuronal migration depends on intact peroxisomal function in brain and in extraneuronal tissues

scientific journal article

Neutropenia with Impaired Immune Response to Streptococcus pneumoniae in Ceramide Kinase-Deficient Mice

scientific article published on 01 March 2008

Nuclear Sphingosine-1-phosphate Lyase Generated ∆2-hexadecenal is A Regulator of HDAC Activity and Chromatin Remodeling in Lung Epithelial Cells

scientific article published on 03 June 2021

Odd Chain Fatty Acids; New Insights of the Relationship Between the Gut Microbiota, Dietary Intake, Biosynthesis and Glucose Intolerance

scientific article published on 23 March 2017

On the presence of C2-ceramide in mammalian tissues: possible relationship to etherphospholipids and phosphorylation by ceramide kinase

scientific article published in March 2007

Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal b ⬇️

scientific article published on September 18, 2003

PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein

scientific article published on 31 October 2013

PPARα-mediated peroxisome induction compensates PPARγ-deficiency in bronchiolar club cells

scientific article published in PLoS ONE

Peroxisomal 2-Hydroxyacyl-CoA Lyase Is Involved in Endogenous Biosynthesis of Heptadecanoic Acid.

scientific article

Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk

scientific article published on 01 January 2020

Peroxisomal Multifunctional Protein 2 Deficiency Perturbs Lipid Homeostasis in the Retina and Causes Visual Dysfunction in Mice

scientific article published on 02 February 2021

Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility in mice

scientific journal article

Peroxisomal multifunctional protein-2 deficiency causes motor deficits and glial lesions in the adult central nervous system

scientific article

Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation

scientific article published on 15 June 2013

Peroxisomal multifunctional protein-2: the enzyme, the patients and the knockout mouse model

scientific article (publication date: September 2006)

Peroxisome deficiency but not the defect in ether lipid synthesis causes activation of the innate immune system and axonal loss in the central nervous system

scientific article published on 29 March 2012

Peroxisome deficient aP2-Pex5 knockout mice display impaired white adipocyte and muscle function concomitant with reduced adrenergic tone

scientific article published on 22 October 2012

Peroxisome deficient invertebrate and vertebrate animal models

scientific article

Peroxisome dynamics in cultured mammalian cells.

scientific article published on 4 August 2009

Peroxisome proliferator-activated receptor alpha-retinoid X receptor agonists induce beta-cell protection against palmitate toxicity

scientific article published on 26 October 2007

Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System.

scientific article

Pharmacological reversion of sphingomyelin-induced dendritic spine anomalies in a Niemann Pick disease type A mouse model

scientific article published on 21 January 2014

Phytol-induced pathology in 2-hydroxyacyl-CoA lyase (HACL1) deficient mice. Evidence for a second non-HACL1-related lyase

scientific article published on 16 June 2017

Potential role for Pex19p in assembly of PTS-receptor docking complexes

scientific article (publication date: 26 March 2004)

Presence of thiamine pyrophosphate in mammalian peroxisomes

scientific article

Quantitative lipidomic analysis of mouse lung during postnatal development by electrospray ionization tandem mass spectrometry

scientific article published in PLoS ONE

RP-HPLC-fluorescence analysis of aliphatic aldehydes: application to aldehyde-generating enzymes HACL1 and SGPL1.

scientific article published on 09 December 2013

Redox interplay between mitochondria and peroxisomes

scientific article

Regulation of high-density lipoprotein on hematopoietic stem/progenitor cells in atherosclerosis requires scavenger receptor type BI expression

scientific article

Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging

scientific article published on 07 January 2011

Role of PFKFB3-driven glycolysis in vessel sprouting

scientific article

Role of alpha-methylacyl coenzyme A racemase in the degradation of methyl-branched alkanes by Mycobacterium sp. strain P101

scientific article (publication date: November 2004)

Role of thiamine pyrophosphate in oligomerisation, functioning and import of peroxisomal 2-hydroxyacyl-CoA lyase

scientific article

Roux-en-y gastric bypass attenuates hepatic mitochondrial dysfunction in mice with non-alcoholic steatohepatitis.

scientific article published on 10 June 2014

S1P-lyase independent clearance of extracellular sphingosine 1-phosphate after dephosphorylation and cellular uptake

scientific article published on June 2008

Slc25a17 Gene Trapped Mice: PMP34 Plays a Role in the Peroxisomal Degradation of Phytanic and Pristanic Acid

scientific article published on 24 March 2020

Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.

scientific article published on 17 August 2009

Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis

scientific article published in April 2011

Sphingosine-1-phosphate lyase mutations cause primary adrenal insufficiency and steroid-resistant nephrotic syndrome

scientific article published on 06 February 2017

Sphingosine-1-phosphate lyase regulates sensitivity of human cells to select chemotherapy drugs in a p38-dependent manner.

scientific article

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.

scientific article published on 24 August 2003

Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.

scientific article published on 5 May 2007

Subcellular origin of sphingosine 1-phosphate is essential for its toxic effect in lyase-deficient neurons

scientific article published on 27 February 2009

Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase

scientific article

Synaptic vesicle docking: sphingosine regulates syntaxin1 interaction with Munc18

scientific article

Synthesis of a fluorogenic analogue of sphingosine-1-phosphate and its use to determine sphingosine-1-phosphate lyase activity

scientific article published in March 2009

Thapsigargin affinity purification of intracellular P(2A)-type Ca(2+) ATPases

scientific article published on 4 January 2011

The acyl-CoA oxidases from the yeast Yarrowia lipolytica: characterization of Aox2p

scientific article published in November 2002

The oxysterol and cholestenoic acid profile of mouse cerebrospinal fluid.

scientific article published on 7 March 2015

Thiamine pyrophosphate: an essential cofactor in the mammalian metabolism of 3-methyl-branched fatty acids--implications for thiamine deficiencies?

scientific article

Training in the fasted state improves glucose tolerance during fat-rich diet

scientific article published on November 2010

Upregulation of ABC transporters contributes to chemoresistance of sphingosine 1-phosphate lyase-deficient fibroblasts.

scientific article published on 10 November 2014

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