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List of works by Michelle H Rich

A giant leap in sequence space reveals the intracellular complexities of evolving a new function

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

scientific article published on 25 March 2023

Directed evolution of the B. subtilis nitroreductase YfkO improves activation of the PET-capable probe SN33623 and CB1954 prodrug

scientific article published on 26 August 2020

Discovery and directed evolution of nitroreductase enzymes for activation of prodrugs and PET imaging compounds

2017 doctoral thesis by Michelle Hedley Rich at Victoria University of Wellington

Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy

scientific article published on 20 August 2019

Engineering the <i>Escherichia coli</i> Nitroreductase NfsA to Create a Flexible Enzyme-Prodrug Activation System

scientific article published on 07 June 2021

Evaluation of NfsA-like nitroreductases from Neisseria meningitidis and Bartonella henselae for enzyme-prodrug therapy, targeted cellular ablation, and dinitrotoluene bioremediation.

scientific article published on 17 November 2017

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

scientific article published on 13 November 2020

Mechanism of Two-/Four-Electron Reduction of Nitroaromatics by Oxygen-Insensitive Nitroreductases: The Role of a Non-Enzymatic Reduction Step

scientific article published on 09 July 2018

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

scientific article published on 15 September 2020

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

scientific article published on 25 April 2020

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

scientific article published on October 2015

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