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List of works by Robert E Sinden

A GFP-actin reporter line to explore microfilament dynamics across the malaria parasite lifecycle

scientific article published on 25 November 2011

A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle

scientific article

A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle

scientific article

A Research Agenda to Underpin Malaria Eradication

scientific article

A clinical trial of prime-boost immunisation with the candidate malaria vaccines RTS,S/AS02A and MVA-CS.

scientific article

A comprehensive survey of the Plasmodium life cycle by genomic, transcriptomic, and proteomic analyses

scientific article

A high throughput screen for next-generation leads targeting malaria parasite transmission

scientific article published in Nature Communications

A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines

scientific article published on 27 September 2012

A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine

scientific article

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A malaria membrane skeletal protein is essential for normal morphogenesis, motility, and infectivity of sporozoites

scientific article (publication date: 8 November 2004)

A malaria scavenger receptor-like protein essential for parasite development.

scientific article published in September 2002

A semi-automated method for counting fluorescent malaria oocysts increases the throughput of transmission blocking studies

scientific article

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

scientific article published on 24 May 2017

A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion

scientific article

A viral vectored prime-boost immunization regime targeting the malaria Pfs25 antigen induces transmission-blocking activity

scientific article (publication date: 2011)

Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery

scientific article published on 05 October 2016

An antigen specific to the liver stage of rodent malaria recognized by a monoclonal antibody

scientific article published in September 1990

An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission

scientific article (publication date: February 2015)

Anopheles arabiensis and An. funestus are equally important vectors of malaria in Matola coastal suburb of Maputo, southern Mozambique

scientific article published in June 2000

Anopheles gambiae laminin interacts with the P25 surface protein of Plasmodium berghei ookinetes

scientific article published in February 2001

Anopheles mortality is both age- and Plasmodium-density dependent: implications for malaria transmission

scientific article published on 12 October 2009

Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity ⬇️

scientific article published on January 1, 2011

Assessing transmission blockade in Plasmodium spp.

scientific article published in January 2013

Azadirachtin disrupts formation of organised microtubule arrays during microgametogenesis of Plasmodium berghei

scientific article

Baculovirus-vectored multistage Plasmodium vivax vaccine induces both protective and transmission-blocking immunities against transgenic rodent malaria parasites

scientific article

Both mosquito-derived xanthurenic acid and a host blood-derived factor regulate gametogenesis of Plasmodium in the midgut of the mosquito

scientific article published in August 2001

C-reactive protein and the liver stage of Plasmodium vivax and P. berghei

scientific article published in November 1990

ChAd63-MVA-vectored blood-stage malaria vaccines targeting MSP1 and AMA1: assessment of efficacy against mosquito bite challenge in humans

scientific article

Characterisation of Plasmodium invasive organelles; an ookinete microneme proteome

scientific article (publication date: March 2009)

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

scientific article

Characterization of the modes of action of anti-Pbs21 malaria transmission-blocking immunity: ookinete to oocyst differentiation in vivo

scientific article published in November 1994

Clinical Evaluation Of New Viral Vectored Vaccines Targeting The Plasmodium Falciparum Blood-Stage Antigens; Msp1 And Ama1

scientific article published in 2011

Cloning and expression of the thrombospondin related adhesive protein gene of Plasmodium berghei

scientific article published in January 1997

Close association of invading Plasmodium berghei and beta integrin in the Anopheles gambiae midgut

scientific article published in September 2005

Complete development of mosquito phases of the malaria parasite in vitro

scientific article published on January 2002

Contrasts in antigen expression in the erythrocytic and exoerythrocytic stages of rodent malaria

scientific article published in October 1989

Correction: Evidence of Blood Stage Efficacy with a Virosomal Malaria Vaccine in a Phase IIa Clinical Trial.

scientific article published on 26 February 2011

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article published on 25 May 2016

Determination of mosquito bloodmeal pH in situ by ion-selective microelectrode measurement: implications for the regulation of malarial gametogenesis

scientific article published in June 2000

Determining the protein repertoire of Cryptosporidium parvum sporozoites ⬇️

scientific article

Developing transmission-blocking strategies for malaria control

scientific article

Development of malaria transmission-blocking vaccines: from concept to product

scientific article published on 08 May 2015

Direct processing and presentation of antigen from malaria sporozoites by professional antigen-presenting cells in the induction of CD8 T-cell responses

scientific article published in June 2005

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

scientific article published on 10 September 2016

Distinct roles for pbs21 and pbs25 in the in vitro ookinete to oocyst transformation of Plasmodium berghei.

scientific article published on October 2000

Effects of hormones and cysteine protease modulators on infection of HepG2 cells by Plasmodium berghei sporozoites in vitro determined by ELISA immunoassay

scientific article published on June 1994

Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes

scientific article published in January 2002

Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus

scientific article published in March 2004

Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara

scientific article

Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans

scientific article published on 25 May 2003

Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing circumsporozoite protein and ME-TRAP against controlled human malaria infection in malaria-naive individuals

scientific article

Evidence of blood stage efficacy with a virosomal malaria vaccine in a phase IIa clinical trial

scientific article

Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions

scientific article published on 23 December 2014

Expression of circumsporozoite proteins revealed in situ in the mosquito stages of Plasmodium berghei by the Lowicryl-immunogold technique

scientific article published in April 1988

Expression of the Plasmodium berghei ookinete protein Pbs21 in a baculovirus-insect cell system produces an efficient transmission blocking immunogen

scientific article published in April 1995

Expression of the precursor of the major merozoite surface antigens during the hepatic stage of malaria

scientific article published in April 1989

Factors regulating natural transmission of Plasmodium berghei to the mosquito vector, and the cloning of a transmission-blocking immunogen

scientific article published on July 1, 1993

Failure of in vitro differentiation of Plasmodium falciparum gametocytes into ookinetes arises because of poor gamete fertilisation

Female inheritance of malarial lap genes is essential for mosquito transmission

scientific article

Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages

scientific article published on 13 September 2019

Functional characterization of an LCCL-lectin domain containing protein family in Plasmodium berghei

scientific article published in October 2004

Generation of gene targeting constructs for Plasmodium berghei by a PCR-based method amenable to high throughput applications

scientific article published on 24 October 2005

Generation of quinolone antimalarials targeting the Plasmodium falciparum mitochondrial respiratory chain for the treatment and prophylaxis of malaria

scientific article

Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii

scientific article

Hemolytic C-type lectin CEL-III from sea cucumber expressed in transgenic mosquitoes impairs malaria parasite development

scientific article published in December 2007

Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

scientific article published on 14 August 2017

Histone methyltransferase inhibitors are orally bioavailable, fast-acting molecules with activity against different species causing malaria in humans

scientific article

Hundreds of dual-stage antimalarial molecules discovered by a functional gametocyte screen

scientific article

Identification of differentially regulated genes of Plasmodium by suppression subtractive hybridization

scientific article published in August 2000

Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation

scientific article published on 23 March 2015

Immunisation against a serine protease inhibitor reduces intensity of Plasmodium berghei infection in mosquitoes

scientific article published on 18 July 2013

Immunoelectron microscopic localization of circumsporozoite antigen in the differentiating exoerythrocytic trophozoite of Plasmodium berghei

scientific article published in February 1988

Immunological detection of cytoskeletal proteins in the exoerythrocytic stages of malaria by fluorescence and confocal laser scanning microscopy

scientific article published on January 1993

In situ detection of Pbs21 mRNA during sexual development of Plasmodium berghei

scientific article published in December 1994

Inhibition of the mosquito transmission of Plasmodium berghei by Malarone (atovaquone-proguanil).

scientific article published in July 2000

Inhibitory action of the anti-malarial compound atovaquone (566C80) against Plasmodium berghei ANKA in the mosquito, Anopheles stephensi

scientific article published in May 1994

Inhibitory activity of the anti-malarial atovaquone (566C80) against ookinetes, oocysts, and sporozoites of Plasmodium berghei.

scientific article published in June 1995

Innate immune responses to human malaria: heterogeneous cytokine responses to blood-stage Plasmodium falciparum correlate with parasitological and clinical outcomes

scientific article published on October 2006

Interaction between host complement and mosquito-midgut-stage Plasmodium berghei

scientific article

Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission

scientific article published on 14 July 2010

Intranuclear development of Plasmodium berghei in liver cells

scientific article published in December 1986

Invariant Valpha14 chain NKT cells promote Plasmodium berghei circumsporozoite protein-specific gamma interferon- and tumor necrosis factor alpha-producing CD8+ T cells in the liver after poxvirus vaccination of mice

scientific article

Isonicotinic acid hydrazide: an anti-tuberculosis drug inhibits malarial transmission in the mosquito gut.

scientific article published on January 2004

Kinetics of expression of two major Plasmodium berghei antigens in the mosquito vector, Anopheles stephensi

scientific article published in September 1993

LCCL proteins of apicomplexan parasites.

scientific article

Laboratory maintenance of rodent malaria parasites

scientific article

Localisation and timing of expression of putative Plasmodium berghei rhoptry proteins in merozoites and sporozoites

scientific article (publication date: July 2009)

Localization of ribosomal RNA and Pbs21-mRNA in the sexual stages of Plasmodium berghei using electron microscope in situ hybridization

scientific article published on November 1996

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

scientific article published on 20 March 2019

Maintenance of the Plasmodium berghei life cycle

scientific article published in January 2002

Malaria control with genetically manipulated insect vectors

scientific article published in October 2002

Malaria: new ideas, old problems, new technologies

scientific article published in February 2000

Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs

scientific article published on 29 April 2013

Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection

scientific article published on 23 November 2020

Measuring the blockade of malaria transmission--an analysis of the Standard Membrane Feeding Assay

scientific article published on 27 September 2012

Measuring the blockade of malaria transmission: analyzing the results of mosquito feeding assays.

scientific article

Nitric oxide synthase activity in malaria‐infected mice ⬇️

scientific article published on October 1, 1996

Nucleotide sequence of the Plasmodium berghei circumsporozoite protein gene from the ANKA clone 2.34L.

scientific article published on January 1990

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

PCR-based detection of Plasmodium in Anopheles mosquitoes: a comparison of a new high-throughput assay with existing methods

scientific article published on 15 September 2008

Paternal effect of the nuclear formin-like protein MISFIT on Plasmodium development in the mosquito vector

scientific article (publication date: August 2009)

PbGEST mediates malaria transmission to both mosquito and vertebrate host

scientific article (publication date: October 2011)

Persistence of atovaquone in human sera following treatment: inhibition of Plasmodium falciparum development in vivo and in vitro.

scientific article published in January 2003

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro

scientific article published on 09 July 2009

Plasmodium berghei calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion

scientific article

Plasmodium berghei ookinetes bind to Anopheles gambiae and Drosophila melanogaster annexins

scientific article published in July 2005

Plasmodium berghei: infectivity of mice to Anopheles stephensi mosquitoes

scientific article published in December 1996

Plasmodium berghei: ionic regulation and the induction of gametogenesis

scientific article published in January 1991

Plasmodium berghei: plasmodium perforin-like protein 5 is required for mosquito midgut invasion in Anopheles stephensi

scientific article (publication date: August 2007)

Plasmodium berghei: routine production of pure gametocytes, extracellular gametes, zygotes, and ookinetes

scientific article published in May 2002

Plasmodium berghei: serum-mediated inhibition of infectivity of infected mice to Anopheles stephensi mosquitoes

scientific article published in February 1994

Plasmodium male development gene-1 (mdv-1) is important for female sexual development and identifies a polarised plasma membrane during zygote development

scientific article published on 24 December 2008

Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs.

scientific article

Population biology of malaria within the mosquito: density-dependent processes and potential implications for transmission-blocking interventions

scientific article

Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts

scientific article

Progression of Plasmodium berghei through Anopheles stephensi is density-dependent

scientific article

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation

scientific article published on January 2013

Proteome analysis of rhoptry-enriched fractions isolated from Plasmodium merozoites

scientific article published in September 2004

Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.

scientific article

Proteomic comparison of four Eimeria tenella life-cycle stages: unsporulated oocyst, sporulated oocyst, sporozoite and second-generation merozoite

scientific article

Quantitative analysis of Plasmodium ookinete motion in three dimensions suggests a critical role for cell shape in the biomechanics of malaria parasite gliding motility

scientific article

Quinolone-3-diarylethers: a new class of antimalarial drug.

scientific article published in March 2013

Regulation of infectivity of Plasmodium to the mosquito vector

scientific article published on January 1996

Reverse genetics screen identifies six proteins important for malaria development in the mosquito

scientific article (publication date: October 2008)

Routine in vitro culture of P. falciparum gametocytes to evaluate novel transmission-blocking interventions.

scientific article published on 18 August 2016

SOAP, a novel malaria ookinete protein involved in mosquito midgut invasion and oocyst development

scientific article (publication date: July 2003)

Safety and High Level Efficacy of the Combination Malaria Vaccine Regimen of RTS,S/AS01B With Chimpanzee Adenovirus 63 and Modified Vaccinia Ankara Vectored Vaccines Expressing ME-TRAP.

scientific article published on 15 June 2016

Safety and efficacy of novel malaria vaccine regimens of RTS,S/AS01B alone, or with concomitant ChAd63-MVA-vectored vaccines expressing ME-TRAP

scientific article published on 09 October 2018

Safety, immunogenicity and efficacy of a pre-erythrocytic malaria candidate vaccine, ICC-1132 formulated in Seppic ISA 720.

scientific article published on January 2005

Safety, immunogenicity, and efficacy of prime-boost immunization with recombinant poxvirus FP9 and modified vaccinia virus Ankara encoding the full-length Plasmodium falciparum circumsporozoite protein

scientific article published on May 2006

Sexual development in malarial parasites: gametocyte production, fertility and infectivity to the mosquito vector

scientific article published in June 1990

Sexual development of malaria parasites is inhibited in vitro by the Neem extract Azadirachtin, and its semi-synthetic analogues

article

Sexual development of malaria parasites is inhibited in vitro by the neem extract azadirachtin, and its semi-synthetic analogues

scientific article published in July 1994

Spatial localisation of actin filaments across developmental stages of the malaria parasite

scientific article (publication date: 2012)

Stage-specific depletion of myosin A supports an essential role in motility of malarial ookinetes

scientific article published on 28 September 2011

Studies on the immunogenicity of a recombinant ookinete surface antigen Pbs21 from Plasmodium berghei expressed in Escherichia coli

scientific article published in January 1994

Substituted Aminoacetamides as Novel Leads for Malaria Treatment

scientific article published on 03 July 2019

Survival and antigenic profile of irradiated malarial sporozoites in infected liver cells

scientific article

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points

scientific article

Targeting the parasite in the mosquito: rationale and practicality.

scientific article published on 15 October 2012

The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes

scientific article

The Matola Malaria Project: a Temporal and Spatial Study of Malaria Transmission and Disease in a Suburban Area of Maputo, Mozambique ⬇️

scientific article published on November 1, 1997

The SCID mouse as a laboratory model for development of the exoerythrocytic stages of human and rodent malaria

scientific article published in September 1993

The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites

scientific article

The biology of sexual development of Plasmodium: the design and implementation of transmission-blocking strategies ⬇️

scientific article published on March 16, 2012

The biosynthesis and post-translational modification of Pbs21 an ookinete-surface protein of Plasmodium berghei

scientific article published on January 1999

The causal prophylactic activity of the novel hydroxynaphthoquinone 566C80 against Plasmodium berghei infections in rats.

scientific article published in January 1989

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

scientific article published on 26 March 2008

The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium

scientific article published on 11 September 2012

The development and routine application of high-density exoerythrocytic-stage cultures of Plasmodium berghei

scientific article published on January 1990

The differing impact of chloroquine and pyrimethamine/sulfadoxine upon the infectivity of malaria species to the mosquito vector ⬇️

scientific article published on February 1, 1998

The dynamics of interactions between Plasmodium and the mosquito: a study of the infectivity of Plasmodium berghei and Plasmodium gallinaceum, and their transmission by Anopheles stephensi, Anopheles gambiae and Aedes aegypti

scientific article published in August 2003

The in vitro cultivation of P. falciparum ookinetes, and their enrichment on Nycodenz density gradients

scientific article published in August 1987

The mosquito transmission of malaria: the effects of atovaquone-proguanil (Malarone) and chloroquine

scientific article published on January 2000

The novel hydroxynaphthoquinone 566C80 inhibits the development of liver stages of Plasmodium berghei cultured in vitro

scientific article published on January 1993

The proteome of Toxoplasma gondii: integration with the genome provides novel insights into gene expression and annotation

scientific article published on 21 July 2008

The rhoptry proteome of Eimeria tenella sporozoites

scientific article published on 20 December 2012

The role of metacaspase 1 in Plasmodium berghei development and apoptosis.

scientific article

The roles of temperature, pH and mosquito factors as triggers of male and female gametogenesis of Plasmodium berghei in vitro

scientific article published in July 1997

The roles of the glycosylphosphatidylinositol anchor on the production and immunogenicity of recombinant ookinete surface antigen Pbs21 of Plasmodium berghei when prepared in a baculovirus expression system

scientific article

The temporal dynamics of Plasmodium density through the sporogonic cycle within Anopheles mosquitoes

scientific article published on 5 April 2009

The use of transgenic Plasmodium berghei expressing the Plasmodium vivax antigen P25 to determine the transmission-blocking activity of sera from malaria vaccine trials

scientific article published on 20 September 2006

Transcriptome analysis of Anopheles stephensi-Plasmodium berghei interactions.

scientific article published on 12 April 2005

Upregulation of TGF-beta, FOXP3, and CD4+CD25+ regulatory T cells correlates with more rapid parasite growth in human malaria infection

scientific article published on September 2005

Use of a selective inhibitor to define the chemotherapeutic potential of the plasmodial hexose transporter in different stages of the parasite's life cycle

scientific article

Viral vectored transmission blocking vaccines against Plasmodium falciparum.

scientific article

Vital functions of the malarial ookinete protein, CTRP, reside in the A domains

scientific article

Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae

scientific article

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