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List of works by Hiroyasu Esumi

"S'ils n'ont pas de pain, qu'ils mangent de la brioche." Focus on "anaerobic respiration sustains mitochondrial membrane potential in a prolyl hydroxylase pathway-activated cancer cell line in a hypoxic microenvironment".

scientific article published on 11 December 2013

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death

scientific article published on 18 December 2013

5-Amino-4-imidazolecarboxamide Riboside Confers Strong Tolerance to Glucose Starvation in a 5′-AMP-Activated Protein Kinase-Dependent Fashion ⬇️

scientific article published on January 11, 2002

A pull-down assay for 5' AMP-activated protein kinase activity using the GST-fused protein

scientific article published on January 2006

ARK5 expression in colorectal cancer and its implications for tumor progression

scientific article

ARK5 is a tumor invasion-associated factor downstream of Akt signaling

scientific article

ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma

scientific article

ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation

scientific article

Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines

scientific article

An anticancer agent, pyrvinium pamoate inhibits the NADH–fumarate reductase system—a unique mitochondrial energy metabolism in tumour microenvironments

scientific article published on 23 April 2012

Analysis of promoter region of X-linked pgk-1 gene polymorphisms: evidence for polyclonality of adult mouse gastric glands.

scientific article published in February 2004

Angelmarin, a novel anti-cancer agent able to eliminate the tolerance of cancer cells to nutrient starvation

scientific article published on 08 November 2005

Antiausterity activity of arctigenin enantiomers: importance of (2R,3R)-absolute configuration

scientific article published on January 2014

Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation

scientific article

Antitumor effect of kigamicin D on mouse tumor models.

scientific article published on April 2006

Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways

scientific article (publication date: 2014)

Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer

scientific article published in October 2002

Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues

scientific article

Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation

scientific article

Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome

scientific article published on 04 July 2008

Biased discordance of KRAS mutation detection in archived colorectal cancer specimens between the ARMS-Scorpion method and direct sequencing

scientific article

Bioactive secondary metabolites from Boesenbergia pandurata of Myanmar and their preferential cytotoxicity against human pancreatic cancer PANC-1 cell line in nutrient-deprived medium.

scientific article

Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer

scientific article published in June 2018

Characterization of cancer omics and drug perturbations in panels of lung cancer cells

scientific article published on 20 December 2019

Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line.

scientific article published on 28 July 2016

Chemical constituents of propolis from Myanmar and their preferential cytotoxicity against a human pancreatic cancer cell line

scientific article

Chemopreventive effect of peroxisome proliferator-activated receptor gamma on gastric carcinogenesis in mice

scientific article published in June 2005

Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal antibody treatment in patients with pretreated metastatic colorectal cancer: the Biomarker Research for anti-EGFR monoclonal Antibodies by Comprehen

scientific article published on 3 October 2017

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

scientific article published on 2 March 2018

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition.

scientific article published on 5 October 2007

Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line

scientific article published on 18 January 2017

Critical role of H2O2 generated by NOX4 during cellular response under glucose deprivation

scientific article

Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation

scientific article published in September 2002

Cytotoxic constituents of Soymida febrifuga from Myanmar.

scientific article published in September 2009

Development of Highly Selective Fluorescent Probe Enabling Flow-Cytometric Isolation of ALDH3A1-Positive Viable Cells.

scientific article published on 15 December 2016

Differential regulation of tumor angiogenesis by distinct ErbB homo- and heterodimers

scientific article

Diterpenes from "Pini Resina" and their preferential cytotoxic activity under nutrient-deprived condition

scientific article published on 10 August 2006

Effect of a poly(ADP-ribose) polymerase-1 inhibitor against esophageal squamous cell carcinoma cell lines

scientific article

Effects of nitric oxide donors on vascular endothelial growth factor gene induction.

scientific article published in August 2002

Epidermal growth factor receptor (EGFR) signaling regulates global metabolic pathways in EGFR-mutated lung adenocarcinoma

scientific article

Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines.

scientific article published on 11 July 2005

Feasibility and robustness of amplification refractory mutation system (ARMS)-based KRAS testing using clinically available formalin-fixed, paraffin-embedded samples of colorectal cancers

scientific article published on 09 August 2010

Genome-wide identification and annotation of HIF-1α binding sites in two cell lines using massively parallel sequencing

scientific article

Highly oxygenated antiausterity agents from the leaves of Uvaria dac.

scientific article

Histopathological factors affecting the extraction of high quality genomic DNA from tissue sections for next-generation sequencing

scientific article published on 21 August 2019

Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

scientific article

Hypoglycemic/hypoxic condition in vitro mimicking the tumor microenvironment markedly reduced the efficacy of anticancer drugs

scientific article published on 7 March 2011

Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner

scientific article (publication date: 6 September 2002)

Hypoxia imaging endoscopy equipped with laser light source from preclinical live animal study to first-in-human subject research

scientific article (publication date: 2014)

Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation

scientific article

Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers

scientific article

IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner

scientific article

Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts

scientific article

Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo

scientific article published on 12 May 2013

Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein

scientific article

Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation ⬇️

scientific article published on February 2006

Identification of chrysoplenetin from Vitex negundo as a potential cytotoxic agent against PANC-1 and a panel of 39 human cancer cell lines (JFCR-39).

scientific article published on 6 April 2011

Immunohistochemical expression of inducible nitric oxide synthase (iNOS) in human brain tumors: relationships of iNOS to superoxide dismutase (SOD) proteins (SOD1 and SOD2), Ki-67 antigen (MIB-1) and p53 protein

scientific article published on 19 December 2002

Impact of inducible nitric oxide synthase gene on tumor progression

scientific article

Improvement of radiation-induced healing delay by etanercept treatment in rat arteries

scientific article

Improvement of the breaking strength of wound by combined treatment with recombinant human G-CSF, recombinant human M-CSF, and a TGF-beta1 receptor kinase inhibitor in rat skin

scientific article published in May 2008

Inducible nitric oxide synthase activity induced by sodium chloride solution prolongs luminal pH elevation in rat and mouse stomachs

scientific article published in September 2003

Induction of cell–cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family ⬇️

scientific article published on November 7, 2003

Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP-1 gene induction in human melanoma cell lines

scientific article published in January 2003

Induction of necrosis in human myeloma cells by kigamicin

scientific article

Involvement of transforming growth factor-beta 1 signaling in hypoxia-induced tolerance to glucose starvation

scientific article published on 13 July 2005

Kigamicin D, a novel anticancer agent based on a new anti-austerity strategy targeting cancer cells' tolerance to nutrient starvation

scientific article published on June 2004

Kigamicins, novel antitumor antibiotics. I. Taxonomy, isolation, physico-chemical properties and biological activities

scientific article published on December 2003

Kigamicins, novel antitumor antibiotics. II. Structure determination.

scientific article published in December 2003

Loss of HGF activator inhibits foveolar hyperplasia induced by oxyntic atrophy without altering gastrin levels.

scientific article published on 11 October 2012

Massive transcriptional start site analysis of human genes in hypoxia cells

scientific article

Measurement and verification of positron emitter nuclei generated at each treatment site by target nuclear fragment reactions in proton therapy

scientific article published on 01 August 2010

Metabolic Determinants of Sensitivity to Phosphatidylinositol 3-Kinase Pathway Inhibitor in Small-Cell Lung Carcinoma.

scientific article published on 28 February 2018

Metabolomic profiling of lung and prostate tumor tissues by capillary electrophoresis time-of-flight mass spectrometry.

scientific article published on 2 November 2012

Mitochondrial fumarate reductase as a target of chemotherapy: from parasites to cancer cells

scientific article published on 29 December 2011

Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions.

scientific article

Molecular analysis of the TSC1 gene in adenocarcinoma of the lung

scientific article

Muscle contractions, AICAR, and insulin cause phosphorylation of an AMPK-related kinase

scientific article

Muscle-specific Knock-out of NUAK Family SNF1-like Kinase 1 (NUAK1) Prevents High Fat Diet-induced Glucose Intolerance ⬇️

scientific article published on March 14, 2012

NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling

scientific article

Nitric oxide as an endogenous mutagen for Sendai virus without antiviral activity

scientific article published on August 2004

Non-Hodgkin's lymphoma in a patient with probable hereditary nonpolyposis colon cancer: report of a case and review of the literature

scientific article

Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar.

scientific article

Novel anticancer agents, kayeassamins C-I from the flower of Kayea assamica of Myanmar

scientific article

Nuclear localization of SNARK; its impact on gene expression

scientific article

Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in gastrointestinal stromal tumours.

scientific article published on 28 November 2017

Oncogenic Kit signals on endolysosomes and endoplasmic reticulum are essential for neoplastic mast cell proliferation

scientific article

Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human

scientific article

Panduratins D-I, novel secondary metabolites from rhizomes of Boesenbergia pandurata ⬇️

scientific article

Phase I trial of GBS-01 for advanced pancreatic cancer refractory to gemcitabine

scientific article published on 29 September 2016

Phenotypic reversion in analbuminemic rats due to an altered splicing mechanism

scientific article published on May 2007

Provision of a voluntary exercise environment enhances running activity and prevents obesity in Snark-deficient mice

scientific article published on 10 March 2009

Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry.

scientific article

Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis.

scientific article

Regulation of caspase-6 and FLIP by the AMPK family member ARK5.

scientific article

Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit

scientific article

Report of the 16th International Symposium of the Foundation for Promotion of Cancer Research: Recent advances in pancreatic cancer

scientific article published in May 2003

Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region

scientific article

Role of nitric oxide (NO) in interferon-alpha therapy for hepatitis C.

scientific article published in July 2005

Roles of inducible nitric oxide synthase in the development and healing of experimentally induced gastric ulcers

scientific article published in October 2003

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

scientific article published on 28 May 2015

Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation

scientific article

Squamous cell carcinoma in situ at oropharyngeal and hypopharyngeal mucosal sites

scientific article published in September 2004

Study on the constituents of Mexican propolis and their cytotoxic activity against PANC-1 human pancreatic cancer cells

scientific article published on April 2010

Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle.

scientific article

Sucrose nonfermenting AMPK-related kinase (SNARK) regulates exercise-stimulated and ischemia-stimulated glucose transport in the heart

scientific article published on 07 September 2018

Susceptibility of Snark-deficient mice to azoxymethane-induced colorectal tumorigenesis and the formation of aberrant crypt foci

scientific article published on 27 February 2007

Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population

scientific article published on 01 July 2007

Synthesis and antitumor evaluation of arctigenin derivatives based on antiausterity strategy.

scientific article

Synthesis and evaluation of anticancer natural product analogues based on angelmarin: targeting the tolerance towards nutrient deprivation.

scientific article

Synthesis of new tricyclic thiolactams as potent antitumor agent for pancreatic cancer

scientific article published on 16 April 2016

The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments

scientific article published on July 2010

The development and clinical use of a beam ON-LINE PET system mounted on a rotating gantry port in proton therapy

scientific article published in January 2010

Therapeutic priority of the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed by a comprehensive genomic analysis

scientific article

Therapeutic strategies targeting cancer--specific metabolism

scientific article

Thymidine Catabolism as a Metabolic Strategy for Cancer Survival.

scientific article published in May 2017

Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells.

scientific article published on 30 April 2018

c-Maf expression in angioimmunoblastic T-cell lymphoma

scientific article published in November 2007

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