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List of works by Benjamin Tycko

A DNA hypomethylating drug alters the tumor microenvironment and improves the effectiveness of immune checkpoint inhibitors in a mouse model of pancreatic cancer

scientific article published on 14 August 2020

A blueprint for an international cancer epigenome consortium. A report from the AACR Cancer Epigenome Task Force.

scientific article

A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes

article

A pathologic link between Wilms tumor suppressor gene, WT1, and IFI16.

scientific article published on January 2008

A single nucleotide polymorphism chip-based method for combined genetic and epigenetic profiling: validation in decitabine therapy and tumor/normal comparisons

scientific article published in April 2006

APOE and APOC1 promoter polymorphisms and the risk of Alzheimer disease in African American and Caribbean Hispanic individuals.

scientific article published in September 2004

Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease

scientific article published on 17 October 2007

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs

scientific article published on 29 June 2020

Allele-specific DNA methylation: beyond imprinting

scientific article published on 20 September 2010

Altered DNA methylation in leukocytes with trisomy 21

scientific article

Altered PET functional brain responses in cognitively intact elderly persons at risk for Alzheimer disease (carriers of the epsilon4 allele)

scientific article

Apolipoprotein E epsilon4 and age at onset of sporadic and familial Alzheimer disease in Caribbean Hispanics

scientific article published in November 2006

Biallelic expression of HRAS and MUCDHL in human and mouse

scientific article (publication date: April 2003)

Bone marrow-derived myofibroblasts contribute to the mesenchymal stem cell niche and promote tumor growth.

scientific article

Breast Cancer Family History and Allele-Specific DNA Methylation in the Legacy Girls Study

scientific article published on 13 February 2018

CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors

scientific article

Cancer epigenetics and targeted therapies

scientific article published on March 1, 2011

Candidate gene analysis for Alzheimer's disease in adults with Down syndrome.

scientific article published on 3 May 2017

Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome.

scientific article

Cell type-specific over-expression of chromosome 21 genes in fibroblasts and fetal hearts with trisomy 21.

scientific article

Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome

scientific article published on 11 February 2007

Chromosome arm 16q in Wilms tumors: unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene

scientific article published in October 2002

CloudASM: an ultra-efficient cloud-based pipeline for mapping allele-specific DNA methylation

scientific article published on 02 March 2020

Comparative anatomy of chromosomal domains with imprinted and non-imprinted allele-specific DNA methylation

scientific article

Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1)

scientific article published on 25 October 2012

DNA Methylation Changes in Barrett’s Epithelium and Adjacent Normal Mucosa ⬇️

scholarly article

Detecting methylation quantitative trait loci using a methylation random field method

scientific article published in 2021

Distinct epigenetic profiles in children with perinatally-acquired HIV on antiretroviral therapy

scientific article published on 19 July 2019

Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal Neurobehavior

scientific article published on 25 March 2016

Down syndrome and Alzheimer's disease: Common pathways, common goals

scientific article published on 12 December 2014

Epidemiology of estrogen and dementia in women with Down syndrome

scientific article

Epigenetic Alterations Affecting Transcription Factors and Signaling Pathways in Stromal Cells of Endometriosis

scientific article

Epigenomic insights into common disease ⬇️

scientific article published on November 23, 2011

Erratum to: Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models.

scientific article published on 9 June 2016

Estrogen receptor-Beta variants are associated with increased risk of Alzheimer's disease in women with down syndrome.

scientific article published on 8 December 2011

Estrogen receptor-alpha variants increase risk of Alzheimer's disease in women with Down syndrome.

scientific article published on 14 April 2008

Expanded Genomewide Scan Implicates a Novel Locus at 3q28 Among Caribbean Hispanics With Familial Alzheimer Disease

Faithful tissue-specific expression of the human chromosome 21-linked COL6A1 gene in BAC-transgenic mice.

scientific article published on 28 February 2007

Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE.

scientific article published on January 2002

Folic acid increases global DNA methylation and reduces inflammation to prevent Helicobacter-associated gastric cancer in mice.

scientific article published on 13 January 2012

Gene expression in Wilms' tumor mimics the earliest committed stage in the metanephric mesenchymal-epithelial transition

scientific article published in June 2002

Genetic and Epigenetic Mosaicism in Cancer Precursor Tissues ⬇️

scientific article published on March 1, 2003

Genetic and epigenetic pathways in Down syndrome: Insights to the brain and immune system from humans and mouse models

scientific article published on 24 October 2019

Genetic epidemiology and nonsyndromic structural birth defects: from candidate genes to epigenetics

scientific article

Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era

scientific article

Genome-wide divergence of DNA methylation marks in cerebral and cerebellar cortices

scientific article

Genomic profiling maps loss of heterozygosity and defines the timing and stage dependence of epigenetic and genetic events in Wilms' tumors.

scientific article published in September 2005

Genomic surveys by methylation-sensitive SNP analysis identify sequence-dependent allele-specific DNA methylation

scientific article published on 22 June 2008

Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.

scientific article published on December 2008

HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL ⬇️

scientific article published on July 19, 2011

Histone Deacetylase Inhibitors Synergistically Enhance the Cytotoxic Effect of Hypomethylating Agents in Models of Diffuse Large B-Cell Lymphoma. ⬇️

scholarly article

Hypomethylating therapy in an aggressive stroma-rich model of pancreatic carcinoma.

scientific article published on 29 November 2012

Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys

scientific article (publication date: September 2002)

Immunohistochemistry for the imprinted gene product IPL/PHLDA2 for facilitating the differential diagnosis of complete hydatidiform mole.

scientific article published in August 2004

Inhibition of NF-κB-Dependent Signaling Enhances Sensitivity and Overcomes Resistance to BET Inhibition in Uveal Melanoma

scientific article published on 18 March 2019

Integrative epigenomic and genomic filtering for methylation markers in hepatocellular carcinomas

scientific article published on 10 June 2015

Intramuscular therapeutic vaccination targeting HPV16 induces T cell responses that localize in mucosal lesions

scientific article

Mapping allele-specific DNA methylation: a new tool for maximizing information from GWAS.

scientific article

Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease

scientific article published in 2021

Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes

scientific article published on 14 October 2019

Mechanisms and Disease Associations of Haplotype-Dependent Allele-Specific DNA Methylation

scientific article published on May 2016

Mesenchymal Stem Cells Derived Myofibroblasts Function as Niche Cells in the Normal Bone Marrow and Expand During Carcinogenesis to Promote Tumor Growth

scholarly article published in May 2011

Methods in DNA methylation profiling

scientific article

Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy?

scientific article published on 17 October 2009

Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome.

scientific article published on 24 August 2005

Mouse-based genetic modeling and analysis of Down syndrome

scientific article

NPTX2 and cognitive dysfunction in Alzheimer's Disease.

scientific article

Onset of dementia is associated with age at menopause in women with Down's syndrome

scientific article published on October 2003

Oral Rigosertib (ON 01910.Na) Treatment Produces An Encouraging Rate Of Transfusion Independence In Lower Risk Myelodysplastic Syndromes (MDS) Patients; A Genomic Methylation Profile Is Associated With Responses ⬇️

scholarly article

PCDH10 promoter hypermethylation is frequent in most histologic subtypes of mature lymphoid malignancies and occurs early in lymphomagenesis

scientific article

PEG10 is a c-MYC target gene in cancer cells

scientific article

PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression

scholarly article

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

scientific article

Phosphoinositide binding by the pleckstrin homology domains of Ipl and Tih1

scientific article (publication date: 20 December 2002)

Physiological functions of imprinted genes.

scientific article

Piece of cake

scientific article published in Nature

Placental growth retardation due to loss of imprinting of Phlda2

scientific article published on 01 October 2004

Placental overgrowth in mice lacking the imprinted gene Ipl

scientific article

Plasma Total-Tau and Neurofilament Light Chain as Diagnostic Biomarkers of Alzheimer's Disease Dementia and Mild Cognitive Impairment in Adults with Down Syndrome

scientific article published on 16 December 2020

Polymorphisms in the promoter of the human APP gene: functional evaluation and allele frequencies in Alzheimer disease

scientific article published in November 2002

Polymorphisms inHSD17B1: Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome ⬇️

scientific article published on March 4, 2012

Preservation of cognitive and functional ability as markers of longevity

scientific article published in October 2004

Proteomic profiles for Alzheimer's disease and mild cognitive impairment among adults with Down syndrome spanning serum and plasma: An Alzheimer's Biomarker Consortium-Down Syndrome (ABC-DS) study

scientific article published on 30 June 2020

Random field modeling of multi-trait multi-locus association for detecting methylation quantitative trait loci

scientific article published in 2022

Regulation of supply and demand for maternal nutrients in mammals by imprinted genes.

scientific article

Sex differences in the associations of placental epigenetic aging with fetal growth

scientific article published on 08 August 2019

Stromal protein Ecm1 regulates ureteric bud patterning and branching

scientific article

Successful aging in a 70-year-old man with down syndrome: a case study

scientific article published in June 2008

Synergistic Combinations of Histone Deacetylase Inhibitors and Decitabine Induce a Unique Gene Expression and Epigenetic Profile In Models of Diffuse Large B-Cell Lymphoma ⬇️

scholarly article

TP73 allelic expression in human brain and allele frequencies in Alzheimer's disease

scientific article

The Effect of Folate Supplementation on Global Methylation and Progression of Gastric Cancer in the Transgenic Hypergastrinemic Murine Model

scholarly article published in May 2011

The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts.

scientific article published in August 2003

The Tnfrh1 (Tnfrsf23) gene is weakly imprinted in several organs and expressed at the trophoblast-decidua interface

scientific article

The Wnt/beta-catenin pathway in Wilms tumors and prostate cancers

scientific article published on August 2007

The caBIG® Life Science Business Architecture Model ⬇️

scientific article (publication date: 15 May 2011)

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

scientific article published on 3 July 2017

Thirtyfold multiplex genotyping of the p53 gene using solid phase capturable dideoxynucleotides and mass spectrometry

scientific article published in May 2004

Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models

scientific article

Trans-acting epigenetic effects of chromosomal aneuploidies: lessons from Down syndrome and mouse models

scientific article published on 2 December 2016

Two somatic biallelic lesions within and near SMAD4 in a human breast cancer cell line

scientific article published on April 2005

Variants in CYP17 and CYP19 Cytochrome P450 Genes are Associated with Onset of Alzheimer's Disease in Women with Down Syndrome ⬇️

scientific article published on January 1, 2012

Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2

scientific article

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