List of works by John Nemunaitis

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

943. Prognostic Determinants Associated with Efficacy of Adenoviral p53 Gene Therapy in Patients with Recurrent Squamous Cell Carcinoma of the Head and Neck

article

<i>BRCA1/2</i> Mutation Status Impact on Autophagy and Immune Response: Unheralded Target

scientific article published on 24 August 2020

A First-in-Human, Phase I, Dose-Escalation Study of TAK-117, a Selective PI3Kα Isoform Inhibitor, in Patients with Advanced Solid Malignancies.

scientific article published on 10 May 2017

A Phase 1 Study to Assess the Relative Bioavailability of Two Capsule Formulations of Ixazomib, an Oral Proteasome Inhibitor, in Patients With Advanced Solid Tumors or Lymphoma

scientific article

A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses.

scientific article published on 2 March 2018

A Phase I trial of TNFerade biologic in patients with soft tissue sarcoma in the extremities

scientific article published on September 2004

A Phase II study of Viagenpumatucel-l (HS-110) in combination with low-dose Cyclophosphamide versus physician's choice in patients with advanced non-small cell lung cancer.

scientific article published on 6 November 2014

A Randomized Phase II Trial of Epigenetic Priming with Guadecitabine and Carboplatin in Platinum-resistant, Recurrent Ovarian Cancer

scientific article published on 12 December 2019

A live-attenuated Listeria vaccine (ANZ-100) and a live-attenuated Listeria vaccine expressing mesothelin (CRS-207) for advanced cancers: phase I studies of safety and immune induction

scientific article published on 6 December 2011

A novel synthetic human insulin super promoter for targeting PDX-1-expressing pancreatic cancer

scientific article published on 5 January 2018

A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms

scientific article published on 17 September 2019

A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors

scientific article

A randomized, phase 2 trial of Docetaxel with or without PX-866, an irreversible oral phosphatidylinositol 3-kinase inhibitor, in patients with relapsed or metastatic non-small-cell lung cancer.

scientific article

A review of contusugene ladenovec (Advexin) p53 therapy.

scientific article published on February 2009

AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer

scientific article

Allogeneic granulocyte macrophage colony-stimulating factor-secreting tumor immunotherapy alone or in sequence with cyclophosphamide for metastatic pancreatic cancer: a pilot study of safety, feasibility, and immune activation

scientific article

Antitumor activity of an oncolytic adenovirus-delivered oncogene small interfering RNA.

scientific article published on October 2006

BIRC5 is a target for molecular imaging and detection of human pancreatic cancer

scientific article published on 03 May 2019

Bifidobacterium spp: the promising Trojan Horse in the era of precision oncology

scientific article published on 31 October 2019

Bifunctional short hairpin RNA (bi-shRNA): design and pathway to clinical application

scientific article published in January 2013

Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck

scientific article published in December 2009

Bromodomain and extra-terminal motif inhibitors: a review of preclinical and clinical advances in cancer therapy

Case Report: Immune-mediated Complete Response in a Patient With Recurrent Advanced Ewing Sarcoma (EWS) After Vigil Immunotherapy

scientific article published on 23 March 2017

Characterization of a novel prostate-specific antigen-activated peptide-doxorubicin conjugate in patients with prostate cancer

scientific article published on 01 April 2002

Chimeric Antigen Receptor T-Cell Therapy: Reach to Solid Tumor Experience

scientific article published on 01 July 2019

Clinical Activity, Tolerability, and Long-Term Follow-Up of Durvalumab in Patients With Advanced NSCLC

scientific article published on 20 June 2019

Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study

scientific article published on 01 January 2005

Current Ovarian Cancer Maintenance Strategies and Promising New Developments

scientific article published on 01 January 2021

Defining the cancer master switch

scientific article published on August 2011

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.

scientific article

EUS or percutaneously guided intratumoral TNFerade biologic with 5-fluorouracil and radiotherapy for first-line treatment of locally advanced pancreatic cancer: a phase I/II study

scientific article

Effect of CYP3A inhibitors on the pharmacokinetics of pevonedistat in patients with advanced solid tumours

scientific article published on 17 May 2019

Effect of alisertib, an investigational aurora a kinase inhibitor on the QTc interval in patients with advanced malignancies

scientific article published on 18 August 2017

Effect of the cytochrome P450 2C19 inhibitor omeprazole on the pharmacokinetics and safety profile of bortezomib in patients with advanced solid tumours, non-Hodgkin's lymphoma or multiple myeloma

scientific article

Effects of Strong CYP3A Inhibition and Induction on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor: Results of Drug-Drug Interaction Studies in Patients With Advanced Solid Tumors or Lymphoma and a Physiologically Based Pharmacokinet

scientific article

Effects of rifampin, itraconazole and esomeprazole on the pharmacokinetics of alisertib, an investigational aurora a kinase inhibitor in patients with advanced malignancies.

scientific article

Emergency use regulatory approval process for experimental gene-based therapy

scientific article published on 20 October 2008

Emerging new therapies for chemotherapy-resistant cancer using adenoviral vectors

scientific article

Enhanced oncolytic potency of replicative adenovirus expressing p53

scientific article published on 01 February 2003

Ewing's Sarcoma: Development of RNA Interference-Based Therapy for Advanced Disease

scientific article published on 11 March 2012

FDA efficiency for approval process of COVID-19 therapeutics

scientific article published on 01 December 2020

First-In-Human Phase I Study Of A Dual mTOR Kinase And DNA-PK Inhibitor (CC-115) In Advanced Malignancy

scientific article published on 13 December 2019

Gemogenovatucel-T (Vigil) immunotherapy as maintenance in frontline stage III/IV ovarian cancer (VITAL): a randomised, double-blind, placebo-controlled, phase 2b trial

scientific article published on 01 December 2020

Granulocyte macrophage colony-stimulating factor--secreting allogeneic cellular immunotherapy for hormone-refractory prostate cancer

scientific article

Granulocyte-macrophage colony-stimulating factor gene-modified autologous tumor vaccines in non-small-cell lung cancer

scientific article published in February 2004

Harnessing the immune response to target tumors

scientific article

Hereditary Inclusion Body Myopathy (HIBM2)

scientific article

Hereditary inclusion body myopathy: single patient response to GNE gene Lipoplex therapy

scientific article published on May 2010

Hereditary inclusion body myopathy: single patient response to intravenous dosing of GNE gene lipoplex

scientific article published on 25 April 2011

In vivo safety and antitumor efficacy of bifunctional small hairpin RNAs specific for the human Stathmin 1 oncoprotein.

scientific article published on 25 May 2011

Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer

scientific article

Interleukin 10-Mediated Response and Correlated Anemia in a Patient with Advanced Non-Small Cell Lung Carcinoma

Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients

scientific article

Intrigue: Phase III study of ripretinib versus sunitinib in advanced gastrointestinal stromal tumor after imatinib

scientific article published on 22 November 2019

KRAS mutant allele-specific expression knockdown in pancreatic cancer model with systemically delivered bi-shRNA KRAS lipoplex.

scientific article published on 31 May 2018

Letter to the editor: Does dicer expression affect shRNA processing?

scientific article published on 19 June 2009

Long-term follow-up of Phase 2A trial results involving advanced ovarian cancer patients treated with Vigil® in frontline maintenance

scientific article published on 17 September 2020

MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma.

scientific article published in June 2012

Melanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma

scientific article published on 23 November 2006

Molecular mechanisms underlying rheumatoid arthritis and cancer development and treatment

scientific article published on 26 February 2020

Natural killer cells: a review of biology, therapeutic potential and challenges in treatment of solid tumors

scientific article published on 14 August 2019

Notch1 activation up-regulates pancreatic and duodenal homeobox-1.

scientific article published on 19 July 2013

Oncolytic viruses for induction of anti-tumor immunity

scientific article

Overview of the development of personalized genomic medicine and surgery

scientific article published on August 2011

PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform

scientific article

PDX-1: demonstration of oncogenic properties in pancreatic cancer ⬇️

scientific article published on September 30, 2010

PDX1 associated therapy in translational medicine

scientific article

PIK3CA gene aberrancy and role in targeted therapy of solid malignancies

scientific article published on 28 January 2020

Pancreatic cancer actionable genes in precision medicine and personalized surgery

scientific article

Personalized cancer approach: using RNA interference technology

scientific article published on August 2011

Pharmacokinetics of ixazomib, an oral proteasome inhibitor, in solid tumour patients with moderate or severe hepatic impairment

scientific article published on 28 April 2016

Pharmacokinetics of the Investigational Aurora A Kinase Inhibitor Alisertib in Adult Patients With Advanced Solid Tumors or Relapsed/Refractory Lymphoma With Varying Degrees of Hepatic Dysfunction

scientific article published on 15 April 2019

Phase 1 Trial of Bi-shRNA STMN1 BIV in Refractory Cancer

scientific article published on 26 January 2015

Phase 1 clinical and pharmacokinetics evaluation of oral CI-1033 in patients with refractory cancer

scientific article published on 01 May 2005

Phase 1 dose escalation of ONT-10, a therapeutic MUC1 vaccine, in patients with advanced cancer

scientific article published on 7 November 2013

Phase 1b study of lenvatinib (E7080) in combination with temozolomide for treatment of advanced melanoma

scientific article published on 15 October 2015

Phase 2 trial of Allovectin-7 in advanced metastatic melanoma

scientific article published in December 2006

Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma ⬇️

scientific article published on 13 July 2015

Phase I Trial of sequential administration of recombinant DNA and adenovirus expressing L523S protein in early stage non-small-cell lung cancer

scientific article published on 11 April 2006

Phase I study of CT-2103, a polymer-conjugated paclitaxel, and carboplatin in patients with advanced solid tumors

scientific article

Phase I study of a systemically delivered p53 nanoparticle in advanced solid tumors

scientific article published on 23 April 2013

Phase I study of oral CI-994 in combination with carboplatin and paclitaxel in the treatment of patients with advanced solid tumors

scientific article

Phase I trial of "bi-shRNAi(furin)/GMCSF DNA/autologous tumor cell" vaccine (FANG) in advanced cancer

scientific article

Phase I trial of PT-100 (PT-100), a cytokine-inducing small molecule, following chemotherapy for solid tumor malignancy

scientific article published in October 2006

Phase I trial of TGF-beta 2 antisense GM-CSF gene-modified autologous tumor cell (TAG) vaccine

scientific article published on 01 January 2011

Phase I trial of an all-oral combination chemotherapy regimen: topotecan and capecitabine in solid tumor patients

scientific article

Phase I trial of topotecan in combination with gemcitabine in refractory solid tumor patients

scientific article published in January 2004

Phase I/II trial of custirsen (OGX-011), an inhibitor of clusterin, in combination with a gemcitabine and platinum regimen in patients with previously untreated advanced non-small cell lung cancer

scientific article published on 01 March 2012

Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma

scientific article

Phase II study of Vigil® DNA engineered immunotherapy as maintenance in advanced stage ovarian cancer.

scientific article published on 24 September 2016

Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer

scientific article published on 11 September 2006

Phase IIIb safety results from an expanded-access protocol of talimogene laherparepvec for patients with unresected, stage IIIB-IVM1c melanoma

scientific article published on 22 November 2017

Pilot Trial of FANG Immunotherapy in Ewing's Sarcoma

scientific article published on 19 March 2015

Pilot trial of genetically modified, attenuated Salmonella expressing the E. coli cytosine deaminase gene in refractory cancer patients ⬇️

scientific article published on October 1, 2003

Pilot trial of intravenous infusion of a replication-selective adenovirus (ONYX-015) in combination with chemotherapy or IL-2 treatment in refractory cancer patients ⬇️

scientific article published on May 1, 2003

Potential use of RNA interference in cancer therapy

scientific article published on 18 August 2010

Preclinical Biodistribution and Safety Evaluation of a pbi-shRNA STMN1 Lipoplex after Subcutaneous Delivery

scientific article published on 4 November 2016

Preclinical Justification of pbi-shRNA EWS/FLI1 Lipoplex (LPX) Treatment for Ewing's Sarcoma

scientific article published on 11 May 2016

Preclinical assessment of wt GNE gene plasmid for management of hereditary inclusion body myopathy 2 (HIBM2)

scientific article

Procoagulant inhibitory properties of paclitaxel poliglumex.

scientific article

RNA Interference and Cancer Therapy

scientific article (publication date: 19 October 2011)

Randomized, double-blind, phase two study of ruxolitinib plus regorafenib in patients with relapsed/refractory metastatic colorectal cancer

scientific article published on 19 August 2018

Recombinant Hematopoietic Growth Factors in Bone Marrow Transplantation ⬇️

scientific article published on January 1, 1995

Repurposing metformin, simvastatin and digoxin as a combination for targeted therapy for pancreatic ductal adenocarcinoma

scientific article published on 20 August 2020

Resident Memory T Cells and Their Effect on Cancer

scientific article published on 01 October 2020

RhGM-CSF in bone marrow transplantation: Experience in pediatric patients ⬇️

scientific article published on January 1, 1992

STAT3 antisense oligonucleotide AZD9150 in a subset of patients with heavily pretreated lymphoma: results of a phase 1b trial

scholarly article by Matthew J Reilley et al published 16 November 2018 in Journal for Immunotherapy of Cancer

Safety and Efficacy in Advanced Solid Tumors of a Targeted Nanocomplex Carrying the p53 Gene Used in Combination with Docetaxel: A Phase 1b Study

scientific article published on 30 June 2016

Safety and activity of varlilumab, a novel and first-in-class agonist anti-CD27 antibody, for hematologic malignancies

scientific article published on 01 May 2020

Safety and in vivo expression of a GNE-transgene: a novel treatment approach for hereditary inclusion body myopathy-2.

scientific article published on 08 May 2009

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection: let the virus be its own demise

scientific article

Shedding New Light on the Use of Imaging Technology for Glioblastoma Tumor Resection

scientific article published on July 2015

Small interfering RNA for experimental cancer therapy.

scientific article

Stathmin 1: a novel therapeutic target for anticancer activity

scientific article published on September 2008

Summary of bi-shRNA/GM-CSF augmented autologous tumor cell immunotherapy (FANG™) in advanced cancer of the liver

scientific article

Systemic therapeutic gene delivery for cancer: crafting Paris' arrow

scientific article published on February 2009

Systemic versus local responses in melanoma patients treated with talimogene laherparepvec from a multi-institutional phase II study.

scientific article published on 15 March 2016

TG4010 immunotherapy combined with first-line therapy in advanced non-small cell lung cancer (NSCLC): phase IIb results of the TIME study.

scientific article

TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials

scientific article published on 28 April 2020

TNFerade biologic, an adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene: a phase I study in patients with solid tumors

scientific article published on 15 January 2004

TNFerade, an adenovector carrying the transgene for human tumor necrosis factor alpha, for patients with advanced solid tumors: surgical experience and long-term follow-up

scientific article published on 9 August 2005

The Effect of a High-Fat Meal on the Pharmacokinetics of Ixazomib, an Oral Proteasome Inhibitor, in Patients With Advanced Solid Tumors or Lymphoma

scientific article published on 13 February 2016

Three-year Follow up of GMCSF/bi-shRNA(furin) DNA-transfected Autologous Tumor Immunotherapy (Vigil) in Metastatic Advanced Ewing's Sarcoma

scientific article published on 25 April 2016

Treatment of biochemical recurrence of prostate cancer with granulocyte-macrophage colony-stimulating factor secreting, allogeneic, cellular immunotherapy

scientific article published on 17 September 2008

Tumor vaccines and cellular immunotherapies

scientific article published on October 2016

mda-7/IL-24: exploiting cancer's Achilles' heel

scientific article

miRNA profiling for diagnosis and prognosis of human cancer

scientific article published on May 2007

p53 therapy in a patient with Li-Fraumeni syndrome

scientific article published on 4 May 2007

siRNA vs. shRNA: similarities and differences

scientific article published on 20 April 2009

Paulina is supported by:

About Paulina

Help