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List of works by Hiroshi Akazawa

"Change can happen" by PKA: proteasomes in in vivo hearts

scientific article published on 31 December 2008

A Case of Multiple Coronary Artery-Left Ventricular Micro Fistulae Complicated With Hepatic Arteriovenous Fistulae.

scientific article published on 6 January 2016

A DPP-4 inhibitor suppresses fibrosis and inflammation on experimental autoimmune myocarditis in mice

scientific article

A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure

scientific article

A novel LIM protein Cal promotes cardiac differentiation by association with CSX/NKX2-5

scientific article

A novel mechanism of mechanical stress-induced angiotensin II type 1-receptor activation without the involvement of angiotensin II.

scientific article

A peptide vaccine targeting angiotensin II attenuates the cardiac dysfunction induced by myocardial infarction

scientific article published on 07 March 2017

ARB and cardioprotection

scientific article published on April 2013

Abdominal aortic pseudoaneurysm caused by prolonged methicillin-resistant Staphylococcus aureus sepsis

scientific article published on 24 October 2007

Activated β-catenin in Foxp3 regulatory T cells links inflammatory environments to autoimmunity

scientific article published on 29 October 2018

Activation of endothelial β-catenin signaling induces heart failure.

scientific article

Adult cardiac Sca-1-positive cells differentiate into beating cardiomyocytes

scientific article

Agonist-independent constitutive activity of angiotensin II receptor promotes cardiac remodeling in mice

scientific article published on 30 January 2012

An EP4 Receptor Agonist Inhibits Cardiac Fibrosis Through Activation of PKA Signaling in Hypertrophied Heart

scientific article published on 9 November 2016

Angiogenesis and cardiac hypertrophy: maintenance of cardiac function and causative roles in heart failure

scientific article published on January 2014

Angiotensin II receptor blockade promotes repair of skeletal muscle through down-regulation of aging-promoting C1q expression

scientific article

Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure.

scientific article

Angiotensin II type 1 and type 2 receptor-induced cell signaling

scientific article published on January 2013

Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus

scientific article published on 27 April 2011

Angiotensin II type 1a receptor signals are involved in the progression of heart failure in MLP-deficient mice

scientific article

Assessment of inverse agonism for the angiotensin II type 1 receptor

scientific article published on January 2010

Author Correction: Activation of endothelial β-catenin signaling induces heart failure

scientific article published in Scientific Reports

Autoregulation of human cardiac homeobox gene CSX1: mediation by the enhancer element in the first intron

scientific article published on January 1, 1997

Beating is necessary for transdifferentiation of skeletal muscle‐derived cells into cardiomyocytes ⬇️

scientific article published on May 8, 2003

Cacao polyphenols ameliorate autoimmune myocarditis in mice

scientific article published on 10 December 2015

Calpain-dependent cleavage of N-cadherin is involved in the progression of post-myocardial infarction remodeling

scientific article published on 2 June 2014

Cancer Therapeutics-Related Cardiac Dysfunction　- Insights From Bench and Bedside of Onco-Cardiology

scientific article published on 29 July 2020

Cardiac Sarcoidosis Diagnosed by Incidental Lymph Node Biopsy

scientific article published on 24 January 2017

Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts

scientific article published on 21 December 2009

Cardiac nonmyocytes in the hub of cardiac hypertrophy

scientific article

Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo

scientific article

Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases

scientific article

Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure

scientific article published in Nature Communications

Cardiomyocytes fuse with surrounding noncardiomyocytes and reenter the cell cycle

scientific article published on 18 October 2004

Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes

scientific article

Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling

scientific article published on 26 February 2015

Conformational switch of angiotensin II type 1 receptor underlying mechanical stress-induced activation

scientific article

Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats

scientific article

Coronary Artery Aneurysm Caused by a Stent Fracture

scientific article published in January 2018

Coronary aneurysm reduced after coronary stenting

scientific article published on 13 November 2006

Correct Diagnosis of Wild-Type Transthyretin-Related Amyloidosis Followed by the Introduction of a Novel Therapy in a Patient With Cardiac Wall Thickening of Unknown Cause

scientific article published on 20 January 2017

Correction

scholarly article published in Journal of Cell Biology

Corrigendum: Cacao polyphenols ameliorate autoimmune myocarditis in mice

scientific article published on November 2016

Cost-Effectiveness Analysis of Cardiovascular Disease Treatment in Japan

scientific article published on 17 November 2017

Critical roles of muscle-secreted angiogenic factors in therapeutic neovascularization.

scientific article

Csx/Nkx2-5 is required for homeostasis and survival of cardiac myocytes in the adult heart

scientific article

Current therapies and investigational drugs for peripheral arterial disease

scientific article

Cytokine therapy prevents left ventricular remodeling and dysfunction after myocardial infarction through neovascularization

scientific article published on 4 March 2004

DNA single-strand break-induced DNA damage response causes heart failure

scientific article published on 24 April 2017

Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations

scientific journal article

Detrimental effects of specific Periodontopathic bacterial infection on tachyarrhythmia compared to Bradyarrhythmia

scientific article published on 17 October 2017

Developmental stage-specific biphasic roles of Wnt/beta-catenin signaling in cardiomyogenesis and hematopoiesis

scholarly article

Direct measurement of Ca2+ concentration in the SR of living cardiac myocytes

scientific article published in February 2004

Dual effects of the homeobox transcription factor Csx/Nkx2-5 on cardiomyocytes

scientific article published on November 2002

Dysbiosis and compositional alterations with aging in the gut microbiota of patients with heart failure

scientific article

Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents

scientific article published on 19 April 2010

Excitation propagation in three-dimensional engineered hearts using decellularized extracellular matrix

scientific article published on 20 June 2014

Heart Failure Complicated by Alveolar Hemorrhage due to Vascular Collapse and Amyloid Deposits in Wild-Type Transthyretin Amyloidosis.

scientific article

High incidence and severity of periodontitis in patients with Marfan syndrome in Japan

scientific article

High incidence of Aggregatibacter actinomycetemcomitans infection in patients with cerebral infarction and diabetic renal failure: a cross-sectional study

scientific article

High incidence of periodontitis in Japanese patients with abdominal aortic aneurysm.

scientific article

Identification of a novel compound that inhibits both mitochondria-mediated necrosis and apoptosis

scientific article published on 8 October 2015

Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia

scientific article

Inhibitory molecules in signal transduction pathways of cardiac hypertrophy

scientific article

Integrins play a critical role in mechanical stress-induced p38 MAPK activation

scientific article published in February 2002

Japanese Cardiovascular Disease Patients with Diabetes Mellitus Suffer Increased Tooth Loss in Comparison to Those without Diabetes Mellitus -A Cross-sectional Study

scientific article published on 20 November 2017

Leukemia Inhibitory Factor Enhances Endogenous Cardiomyocyte Regeneration after Myocardial Infarction

scientific article

Leukemia inhibitory factor enhances survival of cardiomyocytes and induces regeneration of myocardium after myocardial infarction

scientific article published on 14 July 2003

Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II.

scientific article

Mechanisms and functions of agonist-independent activation in the angiotensin II type 1 receptor

scientific article

Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice

scientific article

Molecular and cellular mechanisms of mechanical stress-induced cardiac hypertrophy

scientific article

Monitoring β-arrestin recruitment via β-lactamase enzyme fragment complementation: purification of peptide E as a low-affinity ligand for mammalian bombesin receptors

scientific article published on June 2015

Monocyte-derived extracellular Nampt-dependent biosynthesis of NAD(+) protects the heart against pressure overload

scientific article published on 2 November 2015

Multivalent ligand-receptor interactions elicit inverse agonist activity of AT(1) receptor blockers against stretch-induced AT(1) receptor activation

scientific article published on 7 August 2009

Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice

scientific article

Navigational error in the heart leads to premature ventricular excitation

scientific article published on 25 January 2011

Notch activation mediates angiotensin II-induced vascular remodeling by promoting the proliferation and migration of vascular smooth muscle cells

scientific article published on 30 May 2013

Novel Concept of a Heart-Gut Axis in the Pathophysiology of Heart Failure

scientific article published on 23 August 2017

Oxidative stress-induced signal transduction pathways in cardiac myocytes: involvement of ROS in heart diseases

scientific article published on December 2003

PDK1 coordinates survival pathways and beta-adrenergic response in the heart

scientific journal article

Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys-Dietz Syndromes

scientific article published on 13 May 2016

Periodontitis May Deteriorate Sinus of Valsalva Dilatation in Marfan Syndrome Patients

scientific article

Periodontitis and myocardial hypertrophy

scientific article published on 10 November 2016

Periodontitis deteriorates peripheral arterial disease in Japanese population via enhanced systemic inflammation

scientific article published on 31 May 2017

Periodontitis in cardiovascular disease patients with or without Marfan syndrome--a possible role of Prevotella intermedia

scientific article

Phosphatidylinositol 3-kinase-Akt pathway plays a critical role in early cardiomyogenesis by regulating canonical Wnt signaling

scientific article published on 30 June 2005

Pirfenidone exhibits cardioprotective effects by regulating myocardial fibrosis and vascular permeability in pressure-overloaded hearts.

scientific article

Pleiotropic Effects of Angiotensin II Receptor Signaling in Cardiovascular Homeostasis and Aging

scientific article published on 27 April 2015

Pleiotropic effects of cytokines on acute myocardial infarction: G-CSF as a novel therapy for acute myocardial infarction

scientific article

Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease

scientific article published on 05 October 2020

Porphyromonas gingivalis, a periodontal pathogen, enhances myocardial vulnerability, thereby promoting post-infarct cardiac rupture

scientific article published on 11 April 2016

Promotion of CHIP-mediated p53 degradation protects the heart from ischemic injury

scientific article published on 22 April 2010

Quantitative Measurement of GPCR Endocytosis via Pulse-Chase Covalent Labeling

scientific article published on 28 May 2015

Right ventricular dysplasia with complete atrioventricular block: Necessity and limitation of left ventricular epicardial pacing ⬇️

scientific article published on 01 August 1998

Role of Na+-Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+-Ca2+ exchanger knockout mouse model

scientific article published in February 2004

Roles of cardiac transcription factors in cardiac hypertrophy

scientific article (publication date: 30 May 2003)

Roles of renin-angiotensin system and Wnt pathway in aging-related phenotypes

scientific article published on 9 August 2016

Specific periodontopathic bacterial infection affects hypertension in male cardiovascular disease patients

scientific article published on 12 August 2017

Stretch-modulation of second messengers: effects on cardiomyocyte ion transport ⬇️

scientific article published on May 1, 2003

Takayasu arteritis evaluated by multi-slice computed tomography in an old man.

scientific article published on 24 August 2007

The physiological and pathological function of Ca(2 +) -dependent cysteine protease (Calpain)

scientific article published in April 2013

Toll-like receptor 4 signaling has a critical role in Porphyromonas gingivalis-accelerated neointimal formation after arterial injury in mice

scientific article published on 26 May 2016

Transethnic Meta-analysis of Genome-wide Association Studies Identifies Three New Loci and Characterizes Population-specific Differences for Coronary Artery Disease

scientific article published on 29 May 2020

Understanding Vascular Diseases: Lessons From Premature Aging Syndromes

scientific article published on 13 December 2015

Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes

scientific article

Wnt/β-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O.

scientific article published on 2 June 2015

[Pharmacological therapeutics based on molecular mechanisms].

scientific article

[Phospholamban].

scientific article published in April 2007

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

scientific article published in Nature

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