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List of works by Mario Soberón

A Bacillus thuringiensis S-layer protein involved in toxicity against Epilachna varivestis (Coleoptera: Coccinellidae)

scientific article published on January 2006

A GPI-anchored alkaline phosphatase is a functional midgut receptor of Cry11Aa toxin in Aedes aegypti larvae.

scientific article published on February 2006

A Single Point Mutation Resulting in Cadherin Mislocalization Underpins Resistance against Bacillus thuringiensis Toxin in Cotton Bollworm.

scientific article published on 12 January 2017

A Tenebrio molitor GPI-anchored alkaline phosphatase is involved in binding of Bacillus thuringiensis Cry3Aa to brush border membrane vesicles.

scientific article

A single amino acid polymorphism in ABCC2 loop 1 is responsible for differential toxicity of Bacillus thuringiensis Cry1Ac toxin in different Spodoptera (Noctuidae) species

scientific article published on 30 June 2018

A system for the directed evolution of the insecticidal protein from Bacillus thuringiensis

scientific article

ABCC2 is associated with Bacillus thuringiensis Cry1Ac toxin oligomerization and membrane insertion in diamondback moth

scientific article

Addendum: Bedoya-Pérez, L.P. et al. Role of UPR Pathway in Defense Response of Aedes aegypti against Cry11Aa Toxin from Bacillus thuringiensis. Int. J. Mol. Sci. 2013, 14, 8467–8478.

scientific article published on 2 December 2016

Aedes aegypti alkaline phosphatase ALP1 is a functional receptor of Bacillus thuringiensis Cry4Ba and Cry11Aa toxins.

scientific article

Aedes aegypti cadherin serves as a putative receptor of the Cry11Aa toxin from Bacillus thuringiensis subsp. israelensis

scientific article published on 11 November 2009

An Intramolecular Salt Bridge in Bacillus thuringiensis Cry4Ba Toxin Is Involved in the Stability of Helix α-3, Which Is Needed for Oligomerization and Insecticidal Activity.

scientific article published on 11 August 2017

An alpha-amylase is a novel receptor for Bacillus thuringiensis ssp. israelensis Cry4Ba and Cry11Aa toxins in the malaria vector mosquito Anopheles albimanus (Diptera: Culicidae)

scientific article published on 4 December 2009

Assembling of Holotrichia parallela (dark black chafer) midgut tissue transcriptome and identification of midgut proteins that bind to Cry8Ea toxin from Bacillus thuringiensis.

scientific article

Bacillus thuringiensis Cry and Cyt mutants useful to counter toxin action in specific environments and to overcome insect resistance in the field

article by Mario Soberón et al published October 2012 in Pesticide Biochemistry and Physiology

Bacillus thuringiensis Cry1A toxins are versatile proteins with multiple modes of action: two distinct pre-pores are involved in toxicity

scientific article published on April 2014

Bacillus thuringiensis Cry1Ab domain III β-16 is involved in binding to prohibitin which correlates with toxicity against Helicoverpa armigera (Lepidoptera: Noctuidae)

scientific article published on 30 October 2020

Bacillus thuringiensis Cry1Ab domain III β-22 mutants with enhanced toxicity to Spodoptera frugiperda (J. E. Smith)

scientific article published on 04 September 2020

Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non-toxic to Manduca sexta larvae.

scientific article published on 30 May 2007

Bacillus thuringiensis Cry1Ab mutants affecting oligomer formation are non-toxic to Manduca sexta larvae.

scientific article

Bacillus thuringiensis Cry1AbMod toxin counters tolerance associated with low cadherin expression but not that associated with low alkaline phosphatase expression in Manduca sexta

scientific article published on 17 September 2014

Bacillus thuringiensis cry toxin triggers autophagy activity that may enhance cell death

scientific article published on 16 October 2020

Bacillus thuringiensis insecticidal three-domain Cry toxins: mode of action, insect resistance and consequences for crop protection.

scientific article published on 11 June 2012

Bacillus thuringiensis ssp. israelensis Cyt1Aa enhances activity of Cry11Aa toxin by facilitating the formation of a pre-pore oligomeric structure.

scientific article published on 2 August 2007

Bacillus thuringiensis subsp. israelensis Cyt1Aa synergizes Cry11Aa toxin by functioning as a membrane-bound receptor

scientific article

Bacillus thuringiensis targets the host intestinal epithelial junctions for successful infection of Caenorhabditis elegans

scientific article published on 14 February 2019

Bacillus thuringiensis: A story of a successful bioinsecticide

scientific article published on 02 March 2011

Bacterial Toxins Active against Mosquitoes: Mode of Action and Resistance

publication published on 27 July 2021

Binding and Oligomerization of Modified and Native Bt Toxins in Resistant and Susceptible Pink Bollworm

scientific article published on 3 December 2015

Binding of Bacillus thuringiensis subsp. israelensis Cry4Ba to Cyt1Aa has an important role in synergism.

scientific article

Cadherin binding is not a limiting step for Bacillus thuringiensis subsp. israelensis Cry4Ba toxicity to Aedes aegypti larvae.

scientific article published on May 2012

Cadherin, alkaline phosphatase, and aminopeptidase N as receptors of Cry11Ba toxin from Bacillus thuringiensis subsp. jegathesan in Aedes aegypti

scientific article

Cadherin-like receptor binding facilitates proteolytic cleavage of helix alpha-1 in domain I and oligomer pre-pore formation of Bacillus thuringiensis Cry1Ab toxin

scientific article published in February 2002

Can microbial‐based insecticides replace chemical pesticides in agricultural production?

scientific article published in 2023

Cell lines as models for the study of Cry toxins from Bacillus thuringiensis

scientific article published on 18 December 2017

Characterization of Two Novel Bacillus thuringiensis Cry8 Toxins Reveal Differential Specificity of Protoxins or Activated Toxins against Chrysomeloidea Coleopteran Superfamily

scientific article published on 05 October 2020

Characterization of the Cry1Ah resistance in Asian corn Borer and its cross-resistance to other Bacillus thuringiensis toxins.

scientific article published on 10 January 2018

Characterization of the mechanism of action of the genetically modified Cry1AbMod toxin that is active against Cry1Ab-resistant insects

scientific article published on 24 June 2009

Cloning and epitope mapping of Cry11Aa-binding sites in the Cry11Aa-receptor alkaline phosphatase from Aedes aegypti

scientific article published on September 2009

Coexistence of cry9 with the vip3A Gene in an Identical Plasmid of Bacillus thuringiensis Indicates Their Synergistic Insecticidal Toxicity

scientific article published on 12 November 2020

Comparative proteomic analysis of Aedes aegypti larval midgut after intoxication with Cry11Aa toxin from Bacillus thuringiensis

scientific article

Comprehensive analysis of Cry1Ac protoxin activation mediated by midgut proteases in susceptible and resistant Plutella xylostella (L.).

scientific article published on 23 October 2019

Correction: Dominant Negative Mutants of Bacillus thuringiensis Cry1Ab Toxin Function as Anti-Toxins: Demonstration of the Role of Oligomerization in Toxicity

scientific article

Corrigendum to “The mitogen-activated protein kinase p38 is involved in insect defense against Cry toxins from Bacillus thuringiensis” [Insect Biochem. Mol. Biol. 40 (1) (2010) 58–63]

scholarly article published in Insect Biochemistry and Molecular Biology

Cry11Aa toxin from Bacillus thuringiensis binds its receptor in Aedes aegypti mosquito larvae through loop alpha-8 of domain II.

scientific article published in July 2005

Cry64Ba and Cry64Ca, two ETX/MTX2 Bacillus thuringiensis insecticidal proteins against hemipteran pests

scientific article published on 17 November 2017

Cryptic endotoxic nature of Bacillus thuringiensis Cry1Ab insecticidal crystal protein

scientific article published in July 2004

Cyt toxins produced by Bacillus thuringiensis: a protein fold conserved in several pathogenic microorganisms

scientific article published on 09 June 2012

Defense and death responses to pore forming toxins

scientific article published on January 2010

Defense and death responses to pore forming toxins

article

Differential role of Manduca sexta aminopeptidase-N and alkaline phosphatase in the mode of action of Cry1Aa, Cry1Ab, and Cry1Ac toxins from Bacillus thuringiensis.

scientific article published on 17 May 2013

Domain II loop 3 of Bacillus thuringiensis Cry1Ab toxin is involved in a "ping pong" binding mechanism with Manduca sexta aminopeptidase-N and cadherin receptors.

scientific article published on 06 October 2009

Domains II and III of Bacillus thuringiensis Cry1Ab toxin remain exposed to the solvent after insertion of part of domain I into the membrane

scientific article published on 4 April 2011

Domains II and III of Bacillus thuringiensis Cry1Ab toxin remain exposed to the solvent after insertion of part of domain I into the membrane

scientific article

Dominant negative mutants of Bacillus thuringiensis Cry1Ab toxin function as anti-toxins: demonstration of the role of oligomerization in toxicity

scientific article published on 14 May 2009

Dominant negative phenotype of Bacillus thuringiensis Cry1Ab, Cry11Aa and Cry4Ba mutants suggest hetero-oligomer formation among different Cry toxins

scientific article (publication date: 2011)

Dual mode of action of Bt proteins: protoxin efficacy against resistant insects

scientific article

Efficacy of genetically modified Bt toxins against insects with different genetic mechanisms of resistance

scientific article published on 9 October 2011

Efficacy of genetically modified Bt toxins alone and in combinations against pink bollworm resistant to Cry1Ac and Cry2Ab

scientific article published on 7 November 2013

Efficient production of Bacillus thuringiensis Cry1AMod toxins under regulation of cry3Aa promoter and single cysteine mutations in the protoxin region.

scientific article published on 6 September 2013

Employing phage display to study the mode of action of Bacillus thuringiensis Cry toxins.

scientific article

Engineering Bacillus thuringiensis Cyt1Aa toxin specificity from dipteran to lepidopteran toxicity.

scientific article published on 21 March 2018

Engineering modified Bt toxins to counter insect resistance.

scientific article published on November 2007

Enhancement of Bacillus thuringiensis Cry1Ab and Cry1Fa Toxicity to Spodoptera frugiperda by Domain III Mutations Indicates There Are Two Limiting Steps in Toxicity as Defined by Receptor Binding and Protein Stability

article

Enhancement of insecticidal activity of Bacillus thuringiensis Cry1A toxins by fragments of a toxin-binding cadherin correlates with oligomer formation.

scientific article published on 20 August 2008

Evaluation of the Impact of Genetically Modified Cotton After 20 Years of Cultivation in Mexico.

scientific article published on 22 June 2018

Evidence of field-evolved resistance of Spodoptera frugiperda to Bt corn expressing Cry1F in Brazil that is still sensitive to modified Bt toxins

scientific article

Evolution of Bacillus thuringiensis Cry toxins insecticidal activity.

scientific article published on 29 March 2012

FOXA transcriptional factor modulates insect susceptibility to Bacillus thuringiensis Cry1Ac toxin by regulating the expression of toxin-receptor ABCC2 and ABCC3 genes.

scientific article published on 20 July 2017

Functional Bacillus thuringiensis Cyt1Aa Is Necessary To Synergize Lysinibacillus sphaericus Binary Toxin (Bin) against Bin-Resistant and -Refractory Mosquito Species

scientific article published on 18 March 2020

Functional display of Bacillus thuringiensis Cry1Ac toxin on T7 phage.

scientific article published on 17 April 2006

GATAe transcription factor is involved in Bacillus thuringiensis Cry1Ac toxin receptor gene expression inducing toxin susceptibility

scientific article published on 13 December 2019

Genetic Basis of Cry1F-Resistance in a Laboratory Selected Asian Corn Borer Strain and Its Cross-Resistance to Other Bacillus thuringiensis Toxins.

scientific article

Genetic variability of Spodoptera frugiperda Smith (Lepidoptera: Noctuidae) populations from Latin America is associated with variations in susceptibility to Bacillus thuringiensis cry toxins.

scientific article published on 25 August 2006

Heliothis virescens and Manduca sexta lipid rafts are involved in Cry1A toxin binding to the midgut epithelium and subsequent pore formation

scientific article published on 8 February 2002

Helix α-3 inter-molecular salt bridges and conformational changes are essential for toxicity of Bacillus thuringiensis 3D-Cry toxin family.

scientific article published on 9 July 2018

Holotrichia oblita Midgut Proteins That Bind to Bacillus thuringiensis Cry8-Like Toxin and Assembly of the H. oblita Midgut Tissue Transcriptome.

scientific article published on 07 April 2017

How to cope with insect resistance to Bt toxins?

scientific article published on 14 August 2008

Hydropathic complementarity determines interaction of epitope (869)HITDTNNK(876) in Manduca sexta Bt-R(1) receptor with loop 2 of domain II of Bacillus thuringiensis Cry1A toxins

scientific article

Identification of ABCC2 as a binding protein of Cry1Ac on brush border membrane vesicles from Helicoverpa armigera by an improved pull-down assay

scientific article published on April 2016

Identification of Aminopeptidase-N2 as a Cry2Ab binding protein in Manduca sexta.

scientific article published on 17 January 2017

Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda.

scientific article

Identification of Bacillus thuringiensis Cry3Aa toxin domain II loop 1 as the binding site of Tenebrio molitor cadherin repeat CR12.

scientific article published on 17 February 2015

Identification of Cry1Ah-binding proteins through pull down and gene expression analysis in Cry1Ah-resistant and susceptible strains of Ostrinia furnacalis

scientific article published on 20 November 2019

Identification of an alkaline phosphatase as a putative Cry1Ac binding protein in Ostrinia furnacalis (Guenée).

scientific article

Identification of midgut membrane proteins from different instars of Helicoverpa armigera (Lepidoptera: Noctuidae) that bind to Cry1Ac toxin

scientific article published in PLoS ONE

Improvement and efficient display of Bacillus thuringiensis toxins on M13 phages and ribosomes

scientific article published on 25 November 2015

Induction ofManduca sextaLarvae Caspases Expression in Midgut Cells byBacillus thuringiensisCry1Ab Toxin

article

Insect Hsp90 Chaperone Assists Bacillus thuringiensis Cry Toxicity by Enhancing Protoxin Binding to the Receptor and by Protecting Protoxin from Gut Protease Degradation

scientific article published on 26 November 2019

Insecticidal Specificity of Cry1Ah to Helicoverpa armigera Is Determined by Binding of APN1 via Domain II Loops 2 and 3

scientific article published on 9 December 2016

Membrane binding and oligomer membrane insertion are necessary but insufficient for Bacillus thuringiensis Cyt1Aa toxicity

scientific article published on 25 October 2013

Microorganisms in the biological control of insects and phytopathogens

scientific article published in April 2006

Mode of Action ofBacillus thuringiensis-Genetically Modified Cry1AbMod and Cry1AcMod Toxins: Role of Alkaline pH in Toxin Oligomerization

Mode of action of Bacillus thuringiensis Cry and Cyt toxins and their potential for insect control

scientific article

Mode of action of mosquitocidal Bacillus thuringiensis toxins

scientific article published on 21 November 2006

Modified Bacillus thuringiensis toxins and a hybrid B. thuringiensis strain counter greenhouse-selected resistance in Trichoplusia ni

scientific article published on 10 July 2009

Molecular Cloning, Expression, and Identification of Bre Genes Involved in Glycosphingolipids Synthesis in Helicoverpa armigera (Lepidoptera: Noctuidae).

scientific article published on 17 May 2016

Molecular basis for Bacillus thuringiensis Cry1Ab toxin specificity: two structural determinants in the Manduca sexta Bt-R1 receptor interact with loops alpha-8 and 2 in domain II of Cy1Ab toxin.

scientific article

Molecular basis of gene regulation by the THI-box riboswitch

scientific article published on 19 December 2007

Multiple receptors as targets of Cry toxins in mosquitoes

scientific article published on 06 January 2011

New Insights into the Mode of Action of Cry1Ab Toxin used in Transgenic Insect-Resistant Crops

scientific article published in October 2010

Nitric oxide participates in the toxicity of Bacillus thuringiensis Cry1Ab toxin to kill Manduca sexta larvae.

scientific article published on 23 July 2014

Nutrient conditions determine the localization of Bacillus thuringiensis Vip3Aa protein in the mother cell compartment

scientific article published on 30 November 2020

Oligomerization is a key step for Bacillus thuringiensis Cyt1Aa insecticidal activity but not for toxicity against red blood cells

scientific article published on 21 January 2020

Oligomerization is a key step in Cyt1Aa membrane insertion and toxicity but not necessary to synergize Cry11Aa toxicity in Aedes aegypti larvae.

scientific article published on 24 September 2013

Oligomerization of Cry11Aa from Bacillus thuringiensis Has an Important Role in Toxicity against Aedes aegypti.

scientific article published in March 2013

Oligomerization of Cry11Aa from Bacillus thuringiensis has an important role in toxicity against Aedes aegypti.

scientific article published on 9 October 2009

Oligomerization of Cry9Aa in solution without receptor binding, is not related with insecticidal activity

scholarly article by Longfa Fang et al published May 2016 in Electronic Journal of Biotechnology

Pore formation activity of Cry1Ab toxin from Bacillus thuringiensis in an improved membrane vesicle preparation from Manduca sexta midgut cell microvilli

scientific article published on May 2002

Pore formation by Cry toxins

scientific article published on January 2010

RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design.

scientific article

Rearrangement of N-Terminal α-Helices of Bacillus thuringiensis Cry1Ab Toxin Essential for Oligomer Assembly and Toxicity

scientific article published on 08 October 2020

Reduced Expression of a Novel Midgut Trypsin Gene Involved in Protoxin Activation Correlates with Cry1Ac Resistance in a Laboratory-Selected Strain of Plutella xylostella (L.).

scientific article published on 23 January 2020

Resistance to Bacillus thuringiensis Mediated by an ABC Transporter Mutation Increases Susceptibility to Toxins from Other Bacteria in an Invasive Insect ⬇️

scientific article published on 12 February 2016

Role of MAPK p38 in the cellular responses to pore-forming toxins.

scientific article published on 25 June 2010

Role of UPR pathway in defense response of Aedes aegypti against Cry11Aa toxin from Bacillus thuringiensis

scientific article published on 17 April 2013

Role of alkaline phosphatase from Manduca sexta in the mechanism of action of Bacillus thuringiensis Cry1Ab toxin

scientific article

Role of tryptophan residues in toxicity of Cry1Ab toxin from Bacillus thuringiensis.

scientific article published on January 2006

Single amino acid mutations in the cadherin receptor from Heliothis virescens affect its toxin binding ability to Cry1A toxins

scientific article published on 30 November 2004

Single concentration tests show synergism among Bacillus thuringiensis subsp. israelensis toxins against the malaria vector mosquito Anopheles albimanus.

scientific article published on 31 March 2010

Specific binding between Bacillus thuringiensis Cry9Aa and Vip3Aa toxins synergizes their toxicity against Asiatic rice borer (Chilo suppressalis)

scientific article published on 01 June 2018

Specific epitopes of domains II and III of Bacillus thuringiensis Cry1Ab toxin involved in the sequential interaction with cadherin and aminopeptidase-N receptors in Manduca sexta

scientific article

Spodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin

scientific article published on 17 August 2018

Structural and functional analysis of the pre-pore and membrane-inserted pore of Cry1Ab toxin.

scientific article published on 14 June 2006

Structural changes of the Cry1Ac oligomeric pre-pore from bacillus thuringiensis induced by N-acetylgalactosamine facilitates toxin membrane insertion.

scientific article published on August 2006

Susceptible and mCry3A resistant corn rootworm larvae killed by a non-hemolytic Bacillus thuringiensis Cyt1Aa mutant

scientific article published in Scientific Reports

Synergistic activity of Bacillus thuringiensis toxins against Simulium spp. larvae

scientific article published on 19 July 2014

Systematic characterization of Bacillus Genetic Stock Center Bacillus thuringiensis strains using Multi-Locus Sequence Typing

scientific article published on 30 April 2018

Systemic mitochondrial disruption is a key event in the toxicity of bacterial pore-forming toxins to Caenorhabditis elegans

scientific article published on 23 December 2020

The C-terminal protoxin domain of Bacillus thuringiensis Cry1Ab toxin has a functional role in binding to GPI-anchored receptors in the insect midgut

scientific article published in Journal of Biological Chemistry

The CRISPR-Cas systems were selectively inactivated during evolution of Bacillus cereus group for adaptation to diverse environments

scientific article published on 04 March 2020

The Cadherin Cry1Ac Binding-Region is Necessary for the Cooperative Effect with ABCC2 Transporter Enhancing Insecticidal Activity of Bacillus thuringiensis Cry1Ac Toxin

scientific article published on 14 September 2019

The Cadherin Protein Is Not Involved in Susceptibility to Bacillus thuringiensis Cry1Ab or Cry1Fa Toxins in Spodoptera frugiperda

scientific article published on 06 June 2020

The Cyt1Aa toxin from Bacillus thuringiensis inserts into target membranes via different mechanisms in insects, red blood cells, and lipid liposomes

scientific article published on 22 May 2020

The amino- and carboxyl-terminal fragments of the Bacillus thuringensis Cyt1Aa toxin have differential roles in toxin oligomerization and pore formation

scientific article

The mitogen-activated protein kinase p38 is involved in insect defense against Cry toxins from Bacillus thuringiensis.

scientific article published on 28 December 2009

The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host

scientific article published on 08 September 2021

Thiamine limitation determines the transition from aerobic to fermentative-like metabolism in Rhizobium etli CE3.

scientific article published in February 2008

Tobacco plants expressing the Cry1AbMod toxin suppress tolerance to Cry1Ab toxin of Manduca sexta cadherin-silenced larvae.

scientific article published on 23 May 2011

Toxicity and mode of action of insecticidal Cry1A proteins from Bacillus thuringiensis in an insect cell line, CF-1.

scientific article published on November 2013

Toxicity of Cry1A toxins from Bacillus thuringiensis to CF1 cells does not involve activation of adenylate cyclase/PKA signaling pathway.

scientific article published on 17 November 2016

Transcriptional cellular responses in midgut tissue of Aedes aegypti larvae following intoxication with Cry11Aa toxin from Bacillus thuringiensis.

scientific article published on 9 December 2015

Transgenic cotton co-expressing chimeric Vip3AcAa and Cry1Ac confers effective protection against Cry1Ac-resistant cotton bollworm

scientific article published on 15 November 2017

Tryptophan spectroscopy studies and black lipid bilayer analysis indicate that the oligomeric structure of Cry1Ab toxin from Bacillus thuringiensis is the membrane-insertion intermediate

scientific article published on January 2004

Two ABC transporters are differentially involved in the toxicity of two Bacillus thuringiensis Cry1 toxins to the invasive crop-pest Spodoptera frugiperda (J. E. Smith)

scientific article published on 04 November 2020

Unfolding events in the water-soluble monomeric Cry1Ab toxin during transition to oligomeric pre-pore and membrane-inserted pore channel.

scientific article published on 21 October 2004

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