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List of works by Giuseppe Bianchi

?-ADDUCIN MAY CONTROL BLOOD PRESSURE BOTH IN RATS AND HUMANS

A primer on the genetics of hypertension ⬇️

scientific article published on August 1, 1998

A renal abnormality as a possible cause of "essential" hypertension ⬇️

scientific article published on January 27, 1979

ACE and α-Adducin Polymorphism as Markers of Individual Response to Diuretic Therapy

article

Adducin and hypertension

scientific article

Adducin polymorphism: detection and impact on hypertension and related disorders

scientific article

Adducin, Renal Intermediate Phenotypes, and Hypertension

Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies

scientific article published on November 2010

Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies

scientific article published on November 2010

Angiotensin-converting enzyme I/D and alpha-adducin Gly460Trp polymorphisms: from angiotensin-converting enzyme activity to cardiovascular outcome

scientific article published on 23 April 2007

Antidiuretic effect of bremazocine and U-50,488 in rats after α2-adrenoceptor blockade ⬇️

scientific article published on March 1, 1991

Are the new single nucleotide polymorphisms (SNPs) relevant for hypertensive populations?

scientific article published on 01 December 2002

Arterial properties in relation to genetic variations in the adducin subunits in a white population

scientific article

Association between aldosterone synthase (CYP11B2) polymorphism and left ventricular mass in human essential hypertension

scientific article

Association between hypertension and variation in the alpha- and beta-adducin genes in a white population

scientific article published in December 2002

Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ventricular mass in human essential hypertension.

scientific article published on 12 July 2006

Association of echocardiographic left ventricular structure with the ACE D/I polymorphism: a meta-analysis

scientific article published on 27 January 2011

Association of peripheral and central arterial wave reflections with the CYP11B2 -344C allele and sodium excretion.

scientific article published in December 2004

Blocking the salt-inducible kinase 1 network prevents the increases in cell sodium transport caused by a hypertension-linked mutation in human alpha-adducin

scientific article

Blood Pressure Changes Produced by Kidney Cross-Transplantation between Spontaneously Hypertensive Rats and Normotensive Rats ⬇️

scientific article published on 01 November 1974

Blood pressure and plasma angiotensin II concentration after renal artery constriction and angiotensin infusion in the dog. (5-Isoleucine)angiotensin II and its breakdown fragments in dog blood ⬇️

scientific article published on 01 April 1976

Blood pressure in relation to three candidate genes in a Chinese population.

scientific article published in May 2004

Blood pressure phenotypes in relation to the ??-adducin C1797T polymorphism in the European Project on Genes in Hypertension(EPOGH)

article

Cardiovascular control in the Milan strain of spontaneously hypertensive rat (MHS) at "rest" and during acute mental "stress"

scientific article published on February 1, 1977

Cardiovascular risk in relation to alpha-adducin Gly460Trp polymorphism and systolic pressure: a prospective population study

scientific article published on 25 July 2005

Carotid and femoral intima–media thickness in relation to three candidate genes in a Caucasian population

article

Clinical impact of adducin polymorphism

scientific article

Common genetic variants and haplotypes in renal CLCNKA gene are associated to salt-sensitive hypertension

scientific article

Context-Dependency of Relations Between Cardiovascular Phenotypes and Genes Involved in Sodium Homeostasis: Findings from the European Project on Genes in Hypertension

article

Critical review on the methods employed for circulating immune complexes detection ⬇️

scientific article published on August 1, 1979

Differences in ouabain-induced natriuresis between isolated kidneys of Milan hypertensive and normotensive rats

scientific article published on February 1, 1992

Effect of Add1 gene transfer on blood pressure in reciprocal congenic strains of Milan rats

scientific article published on 01 November 2004

Effect of amiloride analogues on sodium transport in renal brush border membrane vesicles from Milan hypertensive rats

scientific article published on February 28, 1992

Effects of Intravenous Endothelin on Hemodynamics and Cardiac Contractility in Conscious Milan Normotensive Rats ⬇️

scientific article published on April 1, 1991

Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population.

scientific article

Endogenous ouabain and the renin-angiotensin-aldosterone system: distinct effects on Na handling and blood pressure in human hypertension

scientific article

Endogenous ouabain in cardiovascular function and disease

scientific article published on January 2009

Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans

scientific article published in May 2005

Essential hypertension

scientific article published in The Lancet

Expression analysis of the human adducin gene family and evidence of ADD2 beta4 multiple splicing variants

scientific article (publication date: 19 September 2003)

Familial Hypertension and Hormonal Profile, Renal Haemodynamics and Body Fluids of Young Normotensive Subjects ⬇️

scientific article published on December 1, 1978

Genetic aspects of ion transport systems in hypertension

scientific article published on December 1, 1990

Genetic variation in CYP11B2 and AT1R influences heart rate variability conditional on sodium excretion

scientific article published on 6 July 2004

Genetics of essential hypertension: from families to genes

scientific article

Genetics of primary hypertension: the clinical impact of adducin polymorphisms.

scientific article published on 08 April 2010

Genome sequencing reveals loci under artificial selection that underlie disease phenotypes in the laboratory rat

scientific article published on 25 July 2013

Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Ménière's syndrome.

scientific article

Haematological phenotypes in relation to the C1797T beta-adducin polymorphism in a Caucasian population

scientific article published in April 2003

Haplotype analysis of carnitine transporters and left ventricular mass in human essential hypertension

scientific article published in January 2005

High circulating levels of endogenous ouabain in the offspring of hypertensive and normotensive individuals

scientific article published on 01 September 2005

Hypertension-linked mutation in the adducin alpha-subunit leads to higher AP2-mu2 phosphorylation and impaired Na+,K+-ATPase trafficking in response to GPCR signals and intracellular sodium

scientific article

Independent and incremental prognostic value of endogenous ouabain in idiopathic dilated cardiomyopathy

article

Influence of Calcium-Sensing Receptor Gene on Urinary Calcium Excretion in Stone-Forming Patients

article

Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition.

scientific article published in August 2013

Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure

scientific article published on 25 September 2006

Left ventricular geometry and endogenous ouabain in a Flemish population

article

Left ventricular mass in relation to genetic variation in angiotensin II receptors, renin system genes, and sodium excretion

scientific article published on 18 October 2004

Left ventricular radial function associated with genetic variation in the cGMP-dependent protein kinase.

scientific article

Left ventricular structure and function in relation to steroid biosynthesis genes in a white population.

scientific article published on 7 June 2012

Low-salt diet and diuretic effect on blood pressure and organ damage

scientific article published on January 2004

Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin

scientific article

Mechanisms involved in renal hypertension

scientific article published on 01 September 1975

Na+, kidney, hypertension and genes

article

Na+/K+/Cl- cotransport in resealed ghosts from erythrocytes of the Milan hypertensive rats

scientific article published on October 19, 1992

OASIS-HT: design of a pharmacogenomic dose-finding study

scientific article

OXIDATION OF CHOLINE IN RAT LIVER MITOCHONDRIA

scientific article published in November 1964

Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238.

scientific article

Ouabain and Serum Sodium

Ouabainlike factor in Milan hypertensive rats

scientific article published on October 1, 1992

PST 2238: a new antihypertensive compound that modulates renal Na-K pump function without diuretic activity in Milan hypertensive rats

scientific article

PST2238: a new antihypertensive compound that antagonizes the long-term pressor effect of ouabain ⬇️

scientific article published on 01 April 1998

Personalized Therapy of Hypertension: the Past and the Future

scientific article published on March 2016

Pharmacogenomics and genetics of primary hypertension ⬇️

scientific article published on 01 December 2001

Pharmacogenomics and pharmacogenetics of hypertension: update and perspectives--the adducin paradigm

scientific article

Pharmacogenomics of primary hypertension--the lessons from the past to look toward the future

scientific article

Physiological Interaction Between α-Adducin and WNK1-NEDD4L Pathways on Sodium-Related Blood Pressure Regulation

Polymorphism of γ-Adducin Gene in Genetic Hypertension and Mapping of the Gene to Rat Chromosome 1q55 ⬇️

scientific article published on August 28, 1997

Preoperative endogenous ouabain predicts acute kidney injury in cardiac surgery patients

scientific article published on March 2013

Registration of trials and protocols ⬇️

scientific article published on September 27, 2003

Relationship between left ventricular mass and the ACE D/I polymorphism varies according to sodium intake

scientific article published in February 2004

Relationships among endogenous ouabain, alpha-adducin polymorphisms and renal sodium handling in primary hypertension.

scientific article

Renal function in relation to three candidate genes in a Chinese population.

scientific article published on 18 September 2004

Renal genetic mechanisms of essential hypertension

scientific article published on July 1, 1997

Renal haemodynamics are not related to genotypes in offspring of parents with essential hypertension.

scientific article

Renal micropuncture study of normotensive and Milan hypertensive rats before and after development of hypertension

scientific article published on June 1, 1978

Role of The Ouabain-Like Factor and Na-K Pump in Rat and Human Genetic Hypertension ⬇️

scientific article published on July 1, 1998

Role of rat alpha adducin in angiogenesis: null effect of the F316Y polymorphism

scientific journal article

Role of the Kidney in ‘Salt and Water Dependent Hypertension’ of End-Stage Renal Disease ⬇️

scientific article published on 01 January 1972

Role of the adducin family genes in human essential hypertension

scientific article (publication date: March 2005)

Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain

scientific article published on 3 September 2014

Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension

scientific article

Salt, endogenous ouabain and blood pressure interactions in the general population

scientific article published in August 2003

Sodium excretion as a modulator of genetic associations with cardiovascular phenotypes in the European Project on Genes in Hypertension

scientific article

Sodium pump alpha2 subunits control myogenic tone and blood pressure in mice

scientific article published on 15 September 2005

Spasmolytic and cholinergic blocking properties and toxicity of levomepate, I-tropine α-methyltropate ⬇️

scientific article

Stem cells and the kidney: a new therapeutic tool?

scientific article

Steroid biosynthesis and renal excretion in human essential hypertension: association with blood pressure and endogenous ouabain.

scientific article

Strontium absorption and excretion in normocalciuric subjects: relation to calcium metabolism ⬇️

scientific article published on March 1, 1998

Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach

scientific article published on 9 November 2006

The Value of Plasma Renin Concentration Per Se, and in Relation to Plasma and Extracellular Fluid Volume in Diagnosis and Prognosis of Human Renovascular Hypertension ⬇️

scientific article published on 01 November 1970

The amytal and the cold pressor tests in relation to the aetiology and to the therapy of arterial hypertension

scientific article published on 01 July 1970

The calpain-calpastatin system in obsessive-compulsive disorder ⬇️

scientific article published on August 1, 1997

The endogenous ouabain: molecular basis of its role in hypertension and cardiovascular complications

scientific article

The kidney in the pathogenesis of hypertension

scientific article published on September 1, 1991

The role of adducin in hypertension

Tissue-specific modulation of beta-adducin transcripts in Milan hypertensive rats

scientific article published in March 2003

Urinary kallikrein excretion in a spontaneously hypertensive strain of rats ⬇️

scientific article published on 01 September 1975

alpha- and beta-Adducin polymorphisms affect podocyte proteins and proteinuria in rodents and decline of renal function in human IgA nephropathy

scientific article

beta-Adducin polymorphisms, blood pressure, and sodium excretion in three European populations

scientific article (publication date: October 2003)

cGMP-dependent protein kinase 1 polymorphisms underlie renal sodium handling impairment

scientific article

α-Adducin 460Trp Allele Is Associated With Erythrocyte Na Transport Rate in North Sardinian Primary Hypertensives

scientific article published on 01 February 2002

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