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List of works by Srinivasan Yegnasubramanian

A Novel Two-Stage, Transdisciplinary Study Identifies Digoxin as a Possible Drug for Prostate Cancer Treatment ⬇️

scientific article published on June 1, 2011

A conserved intratumoral regulatory T cell signature identifies 4-1BB as a pan-cancer target

scientific article published on 01 March 2020

A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs

A mouse model of chronic prostatic inflammation using a human prostate cancer-derived isolate of Propionibacterium acnes.

scientific article published on 6 February 2013

A novel functional splice variant of AKT3 defined by analysis of alternative splice expression in HPV-positive oropharyngeal cancers

scientific article

A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts.

scientific article

AIM1 is an actin-binding protein that suppresses cell migration and micrometastatic dissemination

scientific article published on 26 July 2017

Abnormal DNA methylation, epigenetics, and prostate cancer

scientific article published on May 2007

Abstract 2482: Key tumor suppressor genes inactivated by promoter methylation and somatic mutations in head and neck cancer

article

Accurate genome-scale percentage DNA methylation estimates from microarray data

scientific article

Alterations in nucleolar structure and gene expression programs in prostatic neoplasia are driven by the MYC oncogene

scientific article

An in situ atlas of mitochondrial DNA in mammalian tissues reveals high content in stem/progenitor cells

scientific article published on 15 April 2020

Androgen Receptor Splice Variants Are Not Substrates of Nonsense-Mediated Decay

scientific article published on 22 February 2017

Androgen-Regulated SPARCL1 in the Tumor Microenvironment Inhibits Metastatic Progression

scientific article

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

scientific article published on 4 July 2010

Anti-inflammatory drugs, antioxidants, and prostate cancer prevention.

scientific article published on July 2009

Beefing up Prostate Cancer Therapy with Performance-Enhancing (Anti-) Steroids ⬇️

scientific article published on July 12, 2011

Biobanking of derivatives from radical retropubic and robot-assisted laparoscopic prostatectomy tissues as part of the prostate cancer biorepository network

scientific article published on 21 September 2013

Bisulfite-converted duplexes for the strand-specific detection and quantification of rare mutations

scientific article

CD38 is methylated in prostate cancer and regulates extracellular NAD

scientific article published on 21 September 2018

Characterization of novel cell lines derived from a MYC-driven murine model of lethal metastatic adenocarcinoma of the prostate

scientific article published on 30 May 2018

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

scientific article published on 16 May 2019

Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences

scientific article

Combination of methylated-DNA precipitation and methylation-sensitive restriction enzymes (COMPARE-MS) for the rapid, sensitive and quantitative detection of DNA methylation

scientific article

Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer

scientific article

Comprehensive Evaluation of Programmed Death-Ligand 1 Expression in Primary and Metastatic Prostate Cancer

scientific article published on 22 March 2018

Consequences of interleukin 1β-triggered chronic inflammation in the mouse prostate gland: Altered architecture associated with prolonged CD4+ infiltration mimics human proliferative inflammatory atrophy

scientific article published on 22 March 2019

Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

scientific article

Correction: Dietary Chemoprevention of PhIP Induced Carcinogenesis in Male Fischer 344 Rats with Tomato and Broccoli

scientific article (publication date: 7 January 2014)

Correction: Dietary Chemoprevention of PhIP Induced Carcinogenesis in Male Fischer 344 Rats with Tomato and Broccoli.

scientific article published on 7 January 2014

Correction: Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines

scientific article published on 21 July 2020

CpG island hypermethylation profile in the serum of men with clinically localized and hormone refractory metastatic prostate cancer

scientific article published on February 2008

DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity.

scientific article

DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases

scientific article published on January 2013

Decreased 5-Hydroxymethylcytosine Is Associated with Neural Progenitor Phenotype in Normal Brain and Shorter Survival in Malignant Glioma ⬇️

scientific article published on July 19, 2012

Diagnostic challenges of clonal heterogeneity in prostate cancer

scientific article published on 17 March 2014

Dickkopf-1 Can Lead to Immune Evasion in Metastatic Castration-Resistant Prostate Cancer

scientific article published on 29 September 2020

Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli

scientific article

Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer.

scientific article

Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth ⬇️

scientific article published on August 31, 2010

ETS2 is a prostate basal cell marker and is highly expressed in prostate cancers aberrantly expressing p63.

scientific article published on 15 May 2018

Effect of bipolar androgen therapy for asymptomatic men with castration-resistant prostate cancer: results from a pilot clinical study

scientific article

Epigenetic DNA methylation of antioxidative stress regulator NRF2 in human prostate cancer

scientific article

Epigenetic alterations in human prostate cancers.

scientific article published on 11 June 2009

Erratum: Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

article

GSTP1 CpG island hypermethylation as a molecular biomarker for prostate cancer

scientific article

Genetic and epigenetic inactivation of LPL gene in human prostate cancer

scientific article published on February 2009

Genetic landscape of extreme responders with anaplastic oligodendroglioma

scientific article

Genome-wide comparison of the transcriptomes of highly enriched normal and chronic myeloid leukemia stem and progenitor cell populations ⬇️

scientific article published on May 1, 2013

Global 5-Hydroxymethylcytosine Levels Are Profoundly Reduced in Multiple Genitourinary Malignancies

scientific article published on 19 January 2016

Global 5-hydroxymethylcytosine content is significantly reduced in tissue stem/progenitor cell compartments and in human cancers.

scientific article published on August 2011

Global DNA hypomethylation in intratubular germ cell neoplasia and seminoma, but not in nonseminomatous male germ cell tumors

scientific article

Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer.

scientific article

Humanizing π-class glutathione S-transferase regulation in a mouse model alters liver toxicity in response to acetaminophen overdose

scientific article

Hypermethylation of CpG islands in primary and metastatic human prostate cancer.

scientific article

Hypomethylation, endogenous retrovirus expression, and interferon signaling in testicular germ cell tumors

article published in the Proceedings of the National Academy of Sciences of the United States of America

Identification of Replication Competent Murine Gammaretroviruses in Commonly Used Prostate Cancer Cell Lines ⬇️

scientific article published on June 17, 2011

If this is true, what does it imply? How end-user antibody validation facilitates insights into biology and disease

scientific article published on 12 December 2018

Immunogenicity of prostate cancer is augmented by BET bromodomain inhibition

scientific article published on 25 October 2019

Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.

scientific article published on 8 March 2005

Inflammation, Microbiota, and Prostate Cancer

scientific article

Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines

scientific article published on 04 May 2020

Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer

scientific article

Lactoferrin CpG Island Hypermethylation and Decoupling of mRNA and Protein Expression in the Early Stages of Prostate Carcinogenesis

scientific article published on 06 September 2019

Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

scientific article

MDR1 promoter hypermethylation in MCF-7 human breast cancer cells: changes in chromatin structure induced by treatment with 5-Aza-cytidine

scientific article published on 10 June 2004

MYC and Prostate Cancer

scientific article published on June 2010

MYC drives overexpression of telomerase RNA (hTR/TERC) in prostate cancer.

scientific article published on 9 September 2017

MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells

scientific article

Metabolic programs define dysfunctional immune responses in severe COVID-19 patients

scientific article

Methylation of the PMEPA1 gene, a negative regulator of the androgen receptor in prostate cancer

scientific article

Molecular Pathology of High-Grade Prostatic Intraepithelial Neoplasia: Challenges and Opportunities

scientific article published on 01 April 2019

Molecular alterations in prostate cancer as diagnostic, prognostic, and therapeutic targets

scientific article

Molecular biomarker in prostate cancer: the role of CpG island hypermethylation

scientific article

Molecular evidence that invasive adenocarcinoma can mimic prostatic intraepithelial neoplasia (PIN) and intraductal carcinoma through retrograde glandular colonization

scientific article

Molecular profiling and classification of sporadic renal cell carcinoma by quantitative methylation analysis.

scientific article published in November 2004

Myc enforces overexpression of EZH2 in early prostatic neoplasia via transcriptional and post-transcriptional mechanisms

scientific article published on September 2011

Nucleotide resolution analysis of TMPRSS2 and ERG rearrangements in prostate cancer ⬇️

scientific article published on June 1, 2013

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers

scientific article published on 28 May 2020

Premalignancy in Prostate Cancer: Rethinking What we Know

scientific article published on 26 January 2016

Preoperative serum DNA GSTP1 CpG island hypermethylation and the risk of early prostate-specific antigen recurrence following radical prostatectomy

scientific article published in June 2005

Procainamide is a specific inhibitor of DNA methyltransferase 1.

scientific article

Profiling the Urinary Microbiome in Men with Positive versus Negative Biopsies for Prostate Cancer

scientific article published on 7 August 2017

Prognostic value of preoperative serum cell-free circulating DNA in men with prostate cancer undergoing radical prostatectomy

scientific article published on 01 September 2007

Progressive spreading of DNA methylation in the GSTP1 promoter CpG island across transitions from precursors to invasive prostate cancer

scientific article published in 2023

Prostate Cancer Epigenetics: From Basic Mechanisms to Clinical Implications

scientific article published on 01 April 2019

Prostate adenocarcinomas aberrantly expressing p63 are molecularly distinct from usual-type prostatic adenocarcinomas

scientific article

Prostate cancer: New answers prompt new questions regarding cell of origin.

scientific article published on December 2010

Publisher Correction: Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers.

scientific article published on 29 May 2019

RNA-Seq of the nucleolus reveals abundant SNORD44-derived small RNAs

scientific article

Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy

scientific article published on 17 September 2018

Resistance emerges to second-generation antiandrogens in prostate cancer

scientific article

Should Gleason 6 be labeled as cancer?

scientific article published on May 2015

Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors

scientific article published on 21 March 2016

The inflammatory microenvironment and microbiome in prostate cancer development

scientific article published on 31 October 2017

The structure of the nucleus in normal and neoplastic prostate cells: untangling the role of type 2 DNA topoisomerases

scientific article published in April 2018

Tight correlation of 5-hydroxymethylcytosine and Polycomb marks in health and disease ⬇️

scientific article published on May 15, 2013

Time-Resolved Fluorescence Resonance Energy Transfer Assay for Discovery of Small-Molecule Inhibitors of Methyl-CpG Binding Domain Protein 2.

scientific article

Tracking the clonal origin of lethal prostate cancer

scientific article published on 25 October 2013

Transcription-Induced DNA Double Strand Breaks: Both Oncogenic Force and Potential Therapeutic Target? ⬇️

scientific article published on March 8, 2011

Transcriptional profiling identifies novel regulators of macrophage polarization

scientific article published in PLoS ONE

Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers

USP2a Activation of MYC in Prostate Cancer ⬇️

scientific article published on March 1, 2012

Update on Systemic Prostate Cancer Therapies: Management of Metastatic Castration-resistant Prostate Cancer in the Era of Precision Oncology

scientific article published on 16 April 2018

c-Myc Antagonises the Transcriptional Activity of the Androgen Receptor in Prostate Cancer Affecting Key Gene Networks

scientific article

miR-21: an androgen receptor-regulated microRNA that promotes hormone-dependent and hormone-independent prostate cancer growth

scientific article

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