List of works - Julio Scharfstein

1 H, 15 N and 13C assignments of the cysteine protease inhibitor Chagasin from Trypanosoma cruzi

A new cruzipain-mediated pathway of human cell invasion by Trypanosoma cruzi requires trypomastigote membranes ⬇️

scientific article published on October 2004

A recombinant form of chagasin from Trypanosoma cruzi: inhibitory activity on insect cysteine proteinases

scientific article published in July 2008

Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway

scientific article published on August 2008

Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research.

scientific article published on July 2009

Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

scientific article

Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses

scientific article

Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells.

scientific article

C5a and bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma cruzi infection

scientific article published on 3 September 2014

Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells

scientific article published on 15 February 2005

Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzi and functional complementation of a Saccharomyces cerevisiae PGM null mutant.

scientific article published on 21 July 2005

Computer-aided quantification of microvascular networks: Application to alterations due to pathological angiogenesis in the hamster

scientific article published on 12 March 2017

Congopain from Trypanosoma congolense: drug target and vaccine candidate.

scientific article

Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.

scientific article published in November 2006

Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization.

scientific article published in June 2003

Ecotin-like ISP of L. major promastigotes fine-tunes macrophage phagocytosis by limiting the pericellular release of bradykinin from surface-bound kininogens: a survival strategy based on the silencing of proinflammatory G-protein coupled kinin B2 a

scientific article published on 10 September 2014

G Protein-Coupled Kinin Receptors and Immunity Against Pathogens

scientific article published on 23 August 2017

Heparan Sulfate Modulates Kinin Release by Trypanosoma cruzi through the Activity of Cruzipain ⬇️

scientific article published on November 28, 2001

IL-18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection

scientific article published on 25 May 2020

Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection.

scientific article published in July 2002

Infection-associated vasculopathy in experimental chagas disease pathogenic roles of endothelin and kinin pathways

scientific article published on January 2011

Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex

scientific article

Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.

scientific article published on 17 August 2009

Kinins Released by Erythrocytic Stages of Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors

scientific article published on 16 April 2019

Mast Cell Coupling to the Kallikrein-Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease.

scientific article published on 2 August 2017

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

scientific article published on 18 September 2020

Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway

scientific article published on 19 October 2011

Novel Family of Insect Salivary Inhibitors Blocks Contact Pathway Activation by Binding to Polyphosphate, Heparin, and Dextran Sulfate

scientific article

Oral infection of mice with Fusobacterium nucleatum results in macrophage recruitment to the dental pulp and bone resorption

scientific article published on 01 June 2018

P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation

scientific article published on 02 November 2018

P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation

scientific article published in February 2021

Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids

scientific article

Perspectives on the Trypanosoma cruzi-host cell receptor interactions

scientific article published on 13 March 2009

Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion.

scientific article

Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells

scientific article published on 21 July 2009

Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors

scientific article published on 17 March 2009

Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors ⬇️

scientific article published on November 14, 2012

Review of the World Class Parasites Book Series

scientific article

Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa

scientific article

Role of vasoactive mediators in the pathogenesis of Chagas disease

scientific article published on May 1, 2003

Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi.

scientific article published on January 2008

Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation.

scientific article published on 29 January 2009

Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin

scientific article

Subverting bradykinin-evoked inflammation by co-opting the contact system: lessons from survival strategies of Trypanosoma cruzi

scientific article published on 01 September 2018

The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi ⬇️

scientific article published on January 25, 2013

The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F.

scientific article published on March 2007

The role of conserved residues of chagasin in the inhibition of cysteine peptidases

scientific article published on 15 January 2008

The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family

scientific article

The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi

scientific article published on 01 June 2006

Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes

scientific article published in November 2002

Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy.

scientific article

List of works by Julio Scharfstein

1 H, 15 N and 13C assignments of the cysteine protease inhibitor Chagasin from Trypanosoma cruzi

A new cruzipain-mediated pathway of human cell invasion by Trypanosoma cruzi requires trypomastigote membranes ⬇️

A recombinant form of chagasin from Trypanosoma cruzi: inhibitory activity on insect cysteine proteinases

Angiotensin-converting enzyme limits inflammation elicited by Trypanosoma cruzi cysteine proteases: a peripheral mechanism regulating adaptive immunity via the innate kinin pathway

Back to the future in Chagas disease: from animal models to patient cohort studies, progress in immunopathogenesis research.

Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease

Bradykinin B2 Receptors of dendritic cells, acting as sensors of kinins proteolytically released by Trypanosoma cruzi, are critical for the development of protective type-1 responses

Bradykinin enhances Sindbis virus infection in human brain microvascular endothelial cells.

C5a and bradykinin receptor cross-talk regulates innate and adaptive immunity in Trypanosoma cruzi infection

Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cells

Cloning and characterization of the phosphoglucomutase of Trypanosoma cruzi and functional complementation of a Saccharomyces cerevisiae PGM null mutant.

Computer-aided quantification of microvascular networks: Application to alterations due to pathological angiogenesis in the hamster

Congopain from Trypanosoma congolense: drug target and vaccine candidate.

Cooperative activation of TLR2 and bradykinin B2 receptor is required for induction of type 1 immunity in a mouse model of subcutaneous infection by Trypanosoma cruzi.

Cutting edge: bradykinin induces IL-12 production by dendritic cells: a danger signal that drives Th1 polarization.

Ecotin-like ISP of L. major promastigotes fine-tunes macrophage phagocytosis by limiting the pericellular release of bradykinin from surface-bound kininogens: a survival strategy based on the silencing of proinflammatory G-protein coupled kinin B2 a

G Protein-Coupled Kinin Receptors and Immunity Against Pathogens

Heparan Sulfate Modulates Kinin Release by Trypanosoma cruzi through the Activity of Cruzipain ⬇️

IL-18R signaling is required for γδ T cell response and confers resistance to Trypanosoma cruzi infection

Induction of B- and T-cell responses to cruzipain in the murine model of Trypanosoma cruzi infection.

Infection-associated vasculopathy in experimental chagas disease pathogenic roles of endothelin and kinin pathways

Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex

Kinin danger signals proteolytically released by gingipain induce Fimbriae-specific IFN-gamma- and IL-17-producing T cells in mice infected intramucosally with Porphyromonas gingivalis.

Kinins Released by Erythrocytic Stages of Enhance Adhesion of Infected Erythrocytes to Endothelial Cells and Increase Blood Brain Barrier Permeability via Activation of Bradykinin Receptors

Mast Cell Coupling to the Kallikrein-Kinin System Fuels Intracardiac Parasitism and Worsens Heart Pathology in Experimental Chagas Disease.

Mast Cells in Alveolar Septa of COVID-19 Patients: A Pathogenic Pathway That May Link Interstitial Edema to Immunothrombosis

Maxadilan, the Lutzomyia longipalpis vasodilator, drives plasma leakage via PAC1-CXCR1/2-pathway

Novel Family of Insect Salivary Inhibitors Blocks Contact Pathway Activation by Binding to Polyphosphate, Heparin, and Dextran Sulfate

Oral infection of mice with Fusobacterium nucleatum results in macrophage recruitment to the dental pulp and bone resorption

P2X7 receptor-mediated leukocyte recruitment and Porphyromonas gingivalis clearance requires IL-1β production and autocrine IL-1 receptor activation

P2Y14 Receptor as a Target for Neutrophilia Attenuation in Severe COVID-19 Cases: From Hematopoietic Stem Cell Recruitment and Chemotaxis to Thrombo-inflammation

Parasite cysteine proteinase interactions with alpha 2-macroglobulin or kininogens: differential pathways modulating inflammation and innate immunity in infection by pathogenic trypanosomatids

Perspectives on the Trypanosoma cruzi-host cell receptor interactions

Porphyromonas gingivalis fimbriae dampen P2X7-dependent interleukin-1β secretion.

Protease activated receptor signaling is required for African trypanosome traversal of human brain microvascular endothelial cells

Proteolytic generation of kinins in tissues infected by Trypanosoma cruzi depends on CXC chemokine secretion by macrophages activated via Toll-like 2 receptors

Resistance to visceral leishmaniasis is severely compromised in mice deficient of bradykinin B2-receptors ⬇️

Review of the World Class Parasites Book Series

Role of chagasin-like inhibitors as endogenous regulators of cysteine proteases in parasitic protozoa

Role of vasoactive mediators in the pathogenesis of Chagas disease

Roles of naturally occurring protease inhibitors in the modulation of host cell signaling and cellular invasion by Trypanosoma cruzi.

Salivary gland homogenates of Lutzomyia longipalpis and its vasodilatory peptide maxadilan cause plasma leakage via PAC1 receptor activation.

Solution structure and backbone dynamics of the Trypanosoma cruzi cysteine protease inhibitor chagasin

Subverting bradykinin-evoked inflammation by co-opting the contact system: lessons from survival strategies of Trypanosoma cruzi

The kallikrein-kinin system in experimental Chagas disease: a paradigm to investigate the impact of inflammatory edema on GPCR-mediated pathways of host cell invasion by Trypanosoma cruzi ⬇️

The propeptide of cruzipain--a potent selective inhibitor of the trypanosomal enzymes cruzipain and brucipain, and of the human enzyme cathepsin F.

The role of conserved residues of chagasin in the inhibition of cysteine peptidases

The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family

The substrate specificity of cruzipain 2, a cysteine protease isoform from Trypanosoma cruzi

Trypanosoma cruzi induces edematogenic responses in mice and invades cardiomyocytes and endothelial cells in vitro by activating distinct kinin receptor (B1/B2) subtypes

Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy.