Search filters

List of works by Stanley H Appel

"Individual and health-related quality of life assessment in amyotrophic lateral sclerosis patients and their caregivers" by Lo Coco G, Lo Coco D, Cicero V, Oliveri A, Lo Verso G, Piccolo F, La Bella V.

scientific article published on 26 August 2005

2D gel blood serum biomarkers reveal differential clinical proteomics of the neurodegenerative diseases

scientific article

A robust, good manufacturing practice-compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy

scientific article published on 3 August 2016

A study comparing patients with amyotrophic lateral sclerosis and their caregivers on measures of quality of life, depression, and their attitudes toward treatment options

scientific article published on May 2003

AALSS.

scientific article

ALS patients' regulatory T lymphocytes are dysfunctional, and correlate with disease progression rate and severity

scientific article published on 09 March 2017

ALSFRS and appel ALS scores: discordance with disease progression

scientific article published on 01 May 2008

Abnormal serum concentrations of proteins in Parkinson's disease.

scientific article published on 31 August 2009

Activated microglia initiate motor neuron injury by a nitric oxide and glutamate-mediated mechanism

scientific article published in September 2004

Amyotrophic lateral sclerosis, frontotemporal lobar dementia, and p62: a functional convergence?

scientific article published on 12 September 2012

Amyotrophic lateral sclerosis: early predictors of prolonged survival

scientific article published on 13 June 2006

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

scientific article published on 29 March 2013

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

scientific article published on 8 January 2018

An open-label multicenter study to assess the safety of dextromethorphan/quinidine in patients with pseudobulbar affect associated with a range of underlying neurological conditions

scientific article published on 28 July 2014

Association between dysarthria and cognitive impairment in ALS: A prospective study

article

Blood–spinal cord barrier breakdown and pericyte reductions in amyotrophic lateral sclerosis ⬇️

scientific article published on September 1, 2012

CD4+ T cells mediate cytotoxicity in neurodegenerative diseases

scientific article published in January 2009

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS.

scholarly article

Calpain activation in apoptosis of ventral spinal cord 4.1 (VSC4.1) motoneurons exposed to glutamate: calpain inhibition provides functional neuroprotection

scientific article published in August 2005

Characterization of Gene Expression Phenotype in Amyotrophic Lateral Sclerosis Monocytes.

scientific article published on 24 April 2017

Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis

scientific article published in May 2017

Complement C3c and related protein biomarkers in amyotrophic lateral sclerosis and Parkinson's disease

scientific article published on 20 February 2006

Deciphering amyotrophic lateral sclerosis: What phenotype, neuropathology and genetics are telling us about pathogenesis ⬇️

scientific article published on May 1, 2013

Design using historical controls.

scientific article published in September 2004

Dipeptide repeat (DPR) pathology in the skeletal muscle of ALS patients with C9ORF72 repeat expansion

scientific article published on 02 August 2019

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis ⬇️

scientific article published on May 1, 2011

Epigallocatechin gallate prevents oxidative-stress-induced death of mutant Cu/Zn-superoxide dismutase (G93A) motoneuron cells by alteration of cell survival and death signals

scientific article published on October 2004

Euthanasia and physician-assisted suicide in ALS: a commentary

scientific article published on 01 November 2004

Excess Circulating Alternatively Activated Myeloid (M2) Cells Accelerate ALS Progression While Inhibiting Experimental Autoimmune Encephalomyelitis ⬇️

scientific article published on November 3, 2011

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

scientific article published on 19 February 2015

Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study.

scientific article

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

scientific article published on January 2010

Functional alterations of myeloid cells during the course of Alzheimer's disease

scholarly article by Aaron D Thome published in November 2018

Head-to-head comparison of 11C-PBR28 and 11C-ER176 for quantification of the translocator protein in the human brain

scientific article published on 31 May 2019

Head-to-head comparison of 11C-PBR28 and 18F-GE180 for the quantification of TSPO in the human brain

scientific article published on 18 January 2018

Human Bone Marrow Endothelial Progenitor Cell Transplantation into Symptomatic ALS Mice Delays Disease Progression and Increases Motor Neuron Survival by Repairing Blood-Spinal Cord Barrier

scientific article published on 27 March 2019

Immune dysregulation in amyotrophic lateral sclerosis: mechanisms and emerging therapies

scientific article published on 01 February 2019

Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis

scientific article published on 25 July 2013

Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons

scientific article

Incidence and characteristics of spinal decompression surgery after the onset of symptoms of amyotrophic lateral sclerosis

scientific article published in November 2005

Increased activation ability of monocytes from ALS patients

scientific article published on 24 February 2020

Inflammation in Parkinson's disease: Cause or consequence? ⬇️

scientific article published on July 13, 2012

Introduction to supplement: the current status of treatment for ALS.

scientific article published in October 2017

Is ALS a systemic disorder? Evidence from muscle mitochondria

scientific article published on 03 February 2006

Major stressors facing patients with amyotrophic lateral sclerosis (ALS): a survey to identify their concerns and to compare with those of their caregivers

scientific article

Mechanisms of disease pathogenesis in amyotrophic lateral sclerosis. A central role for calcium

scientific article

Microglia in ALS: the good, the bad, and the resting

scientific article published on December 2009

Multimodal 18F-AV-1451 and MRI Findings in Nonfluent Variant of Primary Progressive Aphasia: Possible Insights on Nodal Propagation of Tau Protein Across the Syntactic Network

scientific article published on 26 July 2019

Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia

scientific article published on 07 June 2007

Mutant genes responsible for Parkinson's disease

scientific article (publication date: February 2004)

Mutations in NR4A2 associated with familial Parkinson disease

scientific article

Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice ⬇️

scientific article published on December 19, 2010

Neuroinflammatory mechanisms in amyotrophic lateral sclerosis pathogenesis

scientific article published on 01 October 2018

Neuroprotective activities of regulatory T cells ⬇️

scientific article published on October 11, 2011

Novel therapeutic targets in neurodegenerative diseases: lessons from amyotrophic lateral sclerosis

scientific article published on September 2008

Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis.

scientific article published on November 2003

PARP expression is increased in astrocytes but decreased in motor neurons in the spinal cord of sporadic ALS patients

scientific article published in January 2003

Peripheral nerve inflammation in ALS mice: cause or consequence ⬇️

scientific article published on February 29, 2012

Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability

scientific article published on 29 June 2017

Phenotypic characteristics of human bone marrow-derived endothelial progenitor cells in vitro support cell effectiveness for repair of the blood-spinal cord barrier in ALS

scientific article published on 04 September 2019

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis.

scientific article published on 13 April 2018

Predictability of disease progression in amyotrophic lateral sclerosis

scientific article published on 01 December 2006

Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue

scientific article published in February 2004

Promoting excellence in end-of-life care in ALS.

scientific article

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

scientific article published on April 2015

Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia

scientific article published on 02 October 2006

Pyrimethamine significantly lowers cerebrospinal fluid Cu/Zn superoxide dismutase in amyotrophic lateral sclerosis patients with SOD1 mutations

scientific article

Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms ⬇️

scientific article published on July 17, 2012

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival

scientific article published on 9 November 2012

Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival.

scientific article published on 4 February 2013

Role of Fcgamma receptors in nigral cell injury induced by Parkinson disease immunoglobulin injection into mouse substantia nigra

scientific article published in August 2002

Role of nitric oxide in rotenone-induced nigro-striatal injury

scientific article published in September 2003

Seeking a measure of clinically meaningful change in ALS.

scientific article published on 15 August 2014

Serum C-Reactive Protein as a Prognostic Biomarker in Amyotrophic Lateral Sclerosis

scientific article published on 3 April 2017

Serum anti-Fas antibody levels in amyotrophic lateral sclerosis ⬇️

scientific article published on September 1, 2003

Slower disease progression and prolonged survival in contemporary patients with amyotrophic lateral sclerosis: is the natural history of amyotrophic lateral sclerosis changing?

scientific article published on 01 August 2006

Special issue: A tribute to Jenny S. Henkel, Ph.D. (1955-2013).

scientific article published on 31 July 2013

Stem cells in amyotrophic lateral sclerosis: Ready for prime time?

scientific article published on 29 June 2016

Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo

scientific article published on 3 June 2005

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

scientific article published on 31 October 2009

TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss

scientific article

TDP-43 activates microglia through NF-κB and NLRP3 inflammasome

scientific article published on 26 July 2015

TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis

scientific article published on 24 December 2014

TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis

scientific article

The Role of Regulatory T Lymphocytes in Amyotrophic Lateral Sclerosis

scientific article published on 01 June 2018

The chemokine MCP-1 and the dendritic and myeloid cells it attracts are increased in the mSOD1 mouse model of ALS

scientific article published on 05 December 2005

The immune system continues to knock at the ALS door.

scientific article published on 19 April 2016

Toward more efficient clinical trials for amyotrophic lateral sclerosis

scientific article published on May 2010

Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS ⬇️

scientific article published on June 23, 2012

Transplantation of human bone marrow stem cells into symptomatic ALS mice enhances structural and functional blood-spinal cord barrier repair

scientific article published on 30 August 2018

Trauma, TDP‐43, and amyotrophic lateral sclerosis ⬇️

scientific article published on 01 December 2010

Whole-genome analysis of sporadic amyotrophic lateral sclerosis

scientific article

Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis

scholarly article

Paulina is supported by:

About Paulina

Help