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List of works by Merit E Cudkowicz

7‐T MRI of the spinal cord can detect lateral corticospinal tract abnormality in amyotrophic lateral sclerosis ⬇️

scientific article published on March 29, 2013

A High-Density Genome-Wide Association Screen of Sporadic ALS in US Veterans ⬇️

scientific article published on March 28, 2012

A phase I, pharmacokinetic, dosage escalation study of creatine monohydrate in subjects with amyotrophic lateral sclerosis

scientific article

A phase III trial of tirasemtiv as a potential treatment for amyotrophic lateral sclerosis

scientific article published on 01 January 2019

A pilot trial of RNS60 in amyotrophic lateral sclerosis

scientific article published on 26 December 2018

A post hoc analysis of subgroup outcomes and creatinine in the phase III clinical trial (EMPOWER) of dexpramipexole in ALS

article

A randomized controlled trial of resistance and endurance exercise in amyotrophic lateral sclerosis

scientific article published on 30 November 2017

A randomized trial of mexiletine in ALS: Safety and effects on muscle cramps and progression

scientific article published on 24 February 2016

A randomized, double-blind, placebo-controlled trial of coenzyme Q10 in Huntington disease

scientific article published on 02 December 2016

ALS drug development: reflections from the past and a way forward

scientific article published on October 2008

ALS/SURV: a modification of the CAFS statistic

scientific article published on 23 July 2019

Abstracts from the ASENT 2010 annual meeting March 4–6, 2010.

scientific article published in July 2010

Addressing heterogeneity in amyotrophic lateral sclerosis CLINICAL TRIALS

scientific article published on 03 January 2020

Advanced statistical methods to study the effects of gastric tube and non-invasive ventilation on functional decline and survival in amyotrophic lateral sclerosis ⬇️

scientific article published on May 9, 2011

Amyotrophic Lateral Sclerosis Care and Research in the USA During the COVID-19 Pandemic: Challenges and Opportunities

scientific article published on 23 May 2020

Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery

scientific article

An antisense oligonucleotide against SOD1 delivered intrathecally for patients with SOD1 familial amyotrophic lateral sclerosis: a phase 1, randomised, first-in-man study

scientific article published on 29 March 2013

An open label study of a novel immunosuppression intervention for the treatment of amyotrophic lateral sclerosis

scientific article published on 8 January 2018

Analysis of Participant Withdrawal in Huntington Disease Clinical Trials

scientific article

Analysis of Participant Withdrawal in Huntington Disease Clinical Trials

scientific article published on 01 January 2017

Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS)

article

Analysis of start-up, retention, and adherence in ALS clinical trials

scientific article published on 04 September 2013

Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis

scientific article

Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models

scientific article published on 16 July 2018

Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis

scientific article

Arimoclomol: a potential therapy under development for ALS.

scientific article

Baseline Variables Associated with Functional Decline in 2CARE, A Randomized Clinical Trial in Huntington's Disease

scientific article published on 01 January 2020

Baseline results of the NeuroNEXT spinal muscular atrophy infant biomarker study.

scientific article published on 21 January 2016

Being PRO-ACTive: What can a Clinical Trial Database Reveal About ALS?

scientific article

Biochemical alterations associated with ALS.

scientific article published on 25 November 2011

Biomarkers for amyotrophic lateral sclerosis

scientific article

Body mass index, not dyslipidemia, is an independent predictor of survival in amyotrophic lateral sclerosis

scientific article

Ciliary neurotrophic factor genotype does not influence clinical phenotype in amyotrophic lateral sclerosis

article

Clinical Trial Designs in Amyotrophic Lateral Sclerosis: Does One Design Fit All?

scientific article

Clinical significance in the change of decline in ALSFRS-R

scientific article

Clinical trials in amyotrophic lateral sclerosis: the tenuous past and the promising future

scientific article

Clinical trials in progressive neurological diseases. Recruitment, enrollment, retention and compliance

scientific article published on 19 March 2009

Coenzyme Q treatment of neurodegenerative diseases of aging

scientific article published on 27 March 2007

Combination therapy using minocycline and coenzyme Q10 in R6/2 transgenic Huntington's disease mice

scientific article published on 5 December 2005

Combined riluzole and sodium phenylbutyrate therapy in transgenic amyotrophic lateral sclerosis mice

scientific article published in April 2009

Comparison of incremental with multipoint MUNE methods in transgenic ALS mice ⬇️

scientific article published on 01 January 2002

Cortical Hyperexcitability in Amyotrophic Lateral Sclerosis: C9orf72 Repeats

scientific article published on 8 September 2015

Cromolyn sodium delays disease onset and is neuroprotective in the SOD1G93A Mouse Model of amyotrophic lateral sclerosis

scientific article published on 27 November 2019

Crowdsourced analysis of clinical trial data to predict amyotrophic lateral sclerosis progression

scientific article

Defining survival as an outcome measure in amyotrophic lateral sclerosis.

scientific article

Depression in amyotrophic lateral sclerosis

scientific article

Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis

scientific article

Design of phase II ALS clinical trials

scientific article published in January 2008

Design, rationale, and baseline characteristics of the randomized double-blind phase II clinical trial of ibudilast in progressive multiple sclerosis

scientific article

Developing multidisciplinary clinics for neuromuscular care and research.

scientific article

Developing normalized strength scores for neuromuscular research ⬇️

scientific article published on November 21, 2012

Dexpramipexole effects on functional decline and survival in subjects with amyotrophic lateral sclerosis in a Phase II study: Subgroup analysis of demographic and clinical characteristics ⬇️

scientific article published on September 17, 2012

Dexpramipexole versus placebo for patients with amyotrophic lateral sclerosis (EMPOWER): a randomised, double-blind, phase 3 trial

scientific article published on 23 September 2013

Diagnostic timelines and delays in diagnosing amyotrophic lateral sclerosis (ALS).

scientific article published on July 2014

Discovery and verification of amyotrophic lateral sclerosis biomarkers by proteomics

scientific article

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS.

scientific article

Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS.

scientific article

Disease burden in upper motor neuron syndromes: a survey of patient perspectives.

scientific article

Electrical impedance myography to assess outcome in amyotrophic lateral sclerosis clinical trials

scientific article

Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis

scientific article published on May 2007

Emerging targets and treatments in amyotrophic lateral sclerosis

scientific article published on May 2011

Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial.

scientific article published on 9 January 2017

Enhancing clinical trials in neurodegenerative disorders: lessons from amyotrophic lateral sclerosis

scientific article published on December 2012

Erratum to: Enhanced Bulbar Function in Amyotrophic Lateral Sclerosis: The Nuedexta Treatment Trial

scientific article published on 10 March 2017

Expanded autologous regulatory T-lymphocyte infusions in ALS: A phase I, first-in-human study.

scientific article

Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen

scientific article published on 07 January 2019

Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

scientific article published on 24 January 2017

Functional Decline is Associated with Hopelessness in Amyotrophic Lateral Sclerosis (ALS).

scientific article

Galectin-3 is a candidate biomarker for amyotrophic lateral sclerosis: discovery by a proteomics approach

scientific article

Gender-based effect of statins on functional decline in amyotrophic lateral sclerosis

scientific article

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

scientific article published in March 2018

Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis.

scientific article published on 11 November 2016

How common are ALS plateaus and reversals?

scientific article

Hypercaloric enteral nutrition in patients with amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled phase 2 trial

scientific article

IL6 receptor358Ala variant and trans-signaling are disease modifiers in amyotrophic lateral sclerosis

scientific article published on 14 October 2019

Imaging of glia activation in people with primary lateral sclerosis.

scientific article

Improving the responsiveness of rating scales: the challenge of stepping twice into the same river

scientific article published on 01 May 2004

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28.

scientific article

Increased incidence of deep venous thrombosis in ALS

scientific article published on 01 January 2007

Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease

scientific article published in August 2003

Initial Identification of a Blood-Based Chromosome Conformation Signature for Aiding in the Diagnosis of Amyotrophic Lateral Sclerosis.

scientific article published on 23 June 2018

Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial

scientific article

Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons

scientific article published on 3 April 2014

Is erythropoietin a potential therapy for amyotrophic lateral sclerosis?

scientific article published on 11 April 2007

Is it too soon for mesenchymal stem cell trials in people with ALS?

scientific article published on December 2008

Is pentoxifylline safe and effective in patients with amyotrophic lateral sclerosis?

scientific article published on 01 July 2006

Job-related formaldehyde exposure and ALS mortality in the USA

scientific article

Lithium therapy in ALS

Locked in, but not out?

scientific article published on 30 April 2014

Lyme disease serology in amyotrophic lateral sclerosis

scientific article published in October 2009

Maximum voluntary isometric contraction (MVIC).

scientific article published in September 2004

Measures and markers in amyotrophic lateral sclerosis

scientific article

Medications and laboratory parameters as prognostic factors in amyotrophic lateral sclerosis

scientific article published on December 2008

Metabolomic analysis and signatures in motor neuron disease

scientific article published on January 2005

Mexiletine for muscle cramps in amyotrophic lateral sclerosis: A randomized, double-blind crossover trial.

scientific article published on 6 March 2018

Military Service and Amyotrophic Lateral Sclerosis in a Population-based Cohort

scientific article

Mitochondrial DNA from platelets of sporadic ALS patients restores normal respiratory functions in rho(0) cells

scientific article published in February 2003

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS.

scientific article

Motor unit number estimation predicts disease onset and survival in a transgenic mouse model of amyotrophic lateral sclerosis

scientific article published on 01 November 2006

Motor, cognitive, and functional declines contribute to a single progressive factor in early HD.

scientific article

Natural history of infantile-onset spinal muscular atrophy.

scientific article published on 17 November 2017

Neuroprotective agents target molecular mechanisms of disease in ALS.

scientific article published on 06 September 2014

New considerations in the design of clinical trials for amyotrophic lateral sclerosis ⬇️

scientific article published on October 1, 2011

North East ALS Study Group

NurOwn, phase 2, randomized, clinical trial in patients with ALS: Safety, clinical, and biomarker results

scientific article published on 18 November 2019

Nutritional counseling with or without mobile health technology: a randomized open-label standard-of-care-controlled trial in ALS

scientific article published on 29 May 2019

Opinion and Special Articles: Challenges and opportunities in defining career identity in academic neurology

scientific article published on 01 October 2018

Opportunities for improving therapy development in ALS.

scientific article

Oral repeated-dose toxicity studies of coenzyme Q10 in beagle dogs

scientific article published on 20 January 2012

Outcome measures in amyotrophic lateral sclerosis clinical trials

scientific article published on January 2014

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

scientific article published on 01 August 2018

Phase 2 study of sodium phenylbutyrate in ALS.

scientific article published in April 2009

Pilot trial of inosine to elevate urate levels in amyotrophic lateral sclerosis

Plasma metabolomic biomarker panel to distinguish patients with amyotrophic lateral sclerosis from disease mimics

scientific article published in July 2014

Post-lumbar puncture headache is reduced with use of atraumatic needles in ALS.

scientific article published on 8 July 2013

Pre-morbid type 2 diabetes mellitus is not a prognostic factor in amyotrophic lateral sclerosis

scientific article

Preclinical Rodent Toxicity Studies for Long Term Use of Ceftriaxone

scientific article

Predicting success: optimizing phase II ALS trials for the transition to phase III.

scientific article published on March 2014

Primary Lateral Sclerosis and Early Upper Motor Neuron Disease: Characteristics of a Cross-Sectional Population

scientific article published on March 2016

Profound muscle weakness and pain after one dose of actonel

scientific article published on 11 October 2009

Proposed BioRepository platform solution for the ALS research community ⬇️

scientific article published on December 6, 2010

Prospective natural history study of C9orf72 ALS clinical characteristics and biomarkers

scientific article published on 02 October 2019

Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis

scientific article

Quantitative strength testing in ALS clinical trials

scientific article published on 6 July 2016

Race/ethnicity, socioeconomic status, and ALS mortality in the United States

scientific article published on 14 October 2016

Randomized phase 2 trial of NP001-a novel immune regulator: Safety and early efficacy in ALS.

scientific article

Randomized, double-blind, placebo-controlled trial of arimoclomol in rapidly progressive SOD1 ALS.

scientific article published on 24 January 2018

Recruitment & retention program for the NeuroNEXT SMA Biomarker Study: Super Babies for SMA!

article by Amy Bartlett et al published September 2018 in Contemporary clinical trials communications

Reply: To PMID 25900666

scientific article published on 19 August 2015

Respiratory measures in amyotrophic lateral sclerosis

scientific article published on 23 March 2018

Risk factors for suicidality in Huntington disease: An analysis of the 2CARE clinical trial

scientific article published on 08 March 2019

Roadmap and standard operating procedures for biobanking and discovery of neurochemical markers in ALS.

scientific article published on January 2012

SOD1 in Cerebral Spinal Fluid as a Pharmacodynamic Marker for Antisense Oligonucleotide Therapy ⬇️

scientific article published on February 1, 2013

Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial

scientific article

Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial

scientific article

Safety and tolerability of high-dosage coenzyme Q10 in Huntington's disease and healthy subjects

scientific article

Safety, pharmacokinetic, and functional effects of the nogo-a monoclonal antibody in amyotrophic lateral sclerosis: a randomized, first-in-human clinical trial

scientific article (publication date: 2014)

Safety, tolerability and pharmacodynamics of a skeletal muscle activator in amyotrophic lateral sclerosis

article

Scrutinizing enrollment in ALS clinical trials: room for improvement?

scientific article published on October 2008

Seeking a measure of clinically meaningful change in ALS.

scientific article published on 15 August 2014

Selecting Patients for Intra-Arterial Therapy in the Context of a Clinical Trial for Neuroprotection

scientific article

Selection design phase II trial of high dosages of tamoxifen and creatine in amyotrophic lateral sclerosis

scientific article published on 14 October 2019

Serum Nogo-A levels are not elevated in amyotrophic lateral sclerosis patients

scientific article

Serum ferritin and metal levels as risk factors for amyotrophic lateral sclerosis

scientific article published on 12 September 2008

Serum urate at trial entry and ALS progression in EMPOWER.

scientific article published on 28 September 2016

Seven-Year Experience From the National Institute of Neurological Disorders and Stroke-Supported Network for Excellence in Neuroscience Clinical Trials

scientific article published on 23 March 2020

Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice

scientific article published in June 2005

Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach

scientific article published in Scientific Reports

Stratification of amyotrophic lateral sclerosis patients: a crowdsourcing approach

Systemic pharmacokinetics and cerebrospinal fluid uptake of intravenous ceftriaxone in patients with amyotrophic lateral sclerosis

scientific article

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice.

scientific article

The Combined Assessment of Function and Survival (CAFS): A new endpoint for ALS clinical trials ⬇️

scientific article published on January 17, 2013

The PRO-ACT database: design, initial analyses, and predictive features

scientific article

The Role of Environmental Toxins in Amyotrophic Lateral Sclerosis Risk

scientific article

The effects of dexpramipexole (KNS-760704) in individuals with amyotrophic lateral sclerosis ⬇️

scientific article published on November 20, 2011

The natural history of ALS is changing: improved survival

scientific article published on October 2009

Therapeutic targets for amyotrophic lateral sclerosis: current treatments and prospects for more effective therapies

scientific article

Therapy development for ALS: lessons learned and path forward

scientific article published on June 2008

Thrombopoietin is ineffective in a mouse model of motor neuron disease

article

Toward more efficient clinical trials for amyotrophic lateral sclerosis

scientific article published on May 2010

Transcranial magnetic stimulation of the brain: guidelines for pain treatment research

scientific article

Translating preclinical insights into effective human trials in ALS.

scientific article published on 4 April 2006

Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials

scientific article published on 29 June 2016

Trial of celecoxib in amyotrophic lateral sclerosis

scientific article published on 01 July 2006

Understanding the use of NIV in ALS: results of an international ALS specialist survey

scientific article published on 16 April 2018

Urate Levels Predict Survival in ALS: Analysis of the Expanded PRO-ACT Database

scientific article published on 31 August 2017

Uric acid levels predict survival in men with amyotrophic lateral sclerosis ⬇️

scientific article published on February 10, 2012

VITALITY-ALS, a phase III trial of tirasemtiv, a selective fast skeletal muscle troponin activator, as a potential treatment for patients with amyotrophic lateral sclerosis: study design and baseline characteristics

scientific article published on 6 February 2018

Validation of a new strength measurement device for amyotrophic lateral sclerosis clinical trials ⬇️

scientific article published on 01 January 2012

Vanadium, aluminum, magnesium and manganese are not elevated in hair samples in amyotrophic lateral sclerosis

scholarly article by Galen Royce-Nagel et al published 3 May 2010 in Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders

Vitamin D levels are associated with gross motor function in amyotrophic lateral sclerosis

scientific article published on 05 April 2017

Vitamin E intake and risk of amyotrophic lateral sclerosis

scientific article

What does body mass index measure in amyotrophic lateral sclerosis and why should we care?

scientific article published on April 2012

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