List of works - Matthew B. Frieman

A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses

scientific article

A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes

scientific article

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

scientific article published on 03 May 2021

Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion

scientific article

Animal models for COVID-19

scientific article published on 23 September 2020

Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis

scientific article

CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome

scientific article published on 26 October 2016

Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ

scientific article published on 7 February 2015

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

scientific article published on 15 October 2020

Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

scientific article published on 13 January 2018

Coronavirus interactions with the cellular autophagy machinery

scientific article published on 23 September 2020

Coronaviruses: important emerging human pathogens

scientific article published on 05 March 2014

Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation

scientific article published on February 2014

Defining the risk of SARS-CoV-2 variants on immune protection

scientific article published on 31 March 2022

Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding

scientific journal article

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

scientific article (publication date: July 2009)

Emergence of the Middle East respiratory syndrome coronavirus

scientific article published on 5 September 2013

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

scientific article published on 26 August 2020

Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus

scientific article

Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses

scientific article published on 19 May 2014

Evidence supporting a zoonotic origin of human coronavirus strain NL63

scientific article (publication date: December 2012)

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

scientific article published on 21 September 2021

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

scientific article published on 9 October 2015

Glycan microarray analysis of Candida glabrata adhesin ligand specificity

scientific article published in May 2008

Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection

scientific article

Integrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection

scientific article published on 15 November 2011

Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays

scientific article published on 09 December 2013

Mechanisms of severe acute respiratory syndrome pathogenesis and innate immunomodulation

scientific article

Metagenomic Analysis of the Viromes of Three North American Bat Species: Viral Diversity among Different Bat Species That Share a Common Habitat ⬇️

scientific article published on October 6, 2010

Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease

scientific article published on 9 November 2011

Novel influenza virus NS1 antagonists block replication and restore innate immune function

scientific article

One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus

scientific article published on 2 November 2016

Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection

scientific article published on 12 April 2017

Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza

scientific article published on 20 October 2011

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

scientific article published on 29 June 2015

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

scientific article published on 19 May 2014

SARS coronavirus accessory ORFs encode luxury functions

scientific article published on January 2006

SARS coronavirus and innate immunity

scientific article published on 23 April 2007

SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism

scientific article

SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors

scientific article published on 18 March 2015

Screening of FDA-Approved Drugs for Treatment of Emerging Pathogens

scientific article published on 21 August 2015

Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference

scientific article published on 16 September 2015

Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice

scientific article

Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling

scientific article published on 15 April 2009

The Global Virus Network: Challenging chikungunya

scientific article

The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling

scientific article published on 17 January 2014

The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

scientific article

The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses

scientific article published on 12 November 2020

The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death

scientific article

The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis

scientific article published on 5 April 2017

The ω‐site sequence of glycosylphosphatidylinositol‐anchored proteins in Saccharomyces cerevisiae can determine distribution between the membrane and the cell wall ⬇️

scientific article published on November 1, 2003

Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection

scientific article

Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling

scientific article

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus

scientific article published on 6 November 2013

Yeast based small molecule screen for inhibitors of SARS-CoV

scientific article

List of works by Matthew B. Frieman

A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses

A genome-wide screen for normally methylated human CpG islands that can identify novel imprinted genes

A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics

Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion

Animal models for COVID-19

Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis

CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome

Celastrol, a Chinese herbal compound, controls autoimmune inflammation by altering the balance of pathogenic and regulatory T cells in the target organ

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

Coronavirus interactions with the cellular autophagy machinery

Coronaviruses: important emerging human pathogens

Deficiency of melanoma differentiation-associated protein 5 results in exacerbated chronic postviral lung inflammation

Defining the risk of SARS-CoV-2 variants on immune protection

Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding

Early Upregulation of Acute Respiratory Distress Syndrome-Associated Cytokines Promotes Lethal Disease in an Aged-Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Infection

Emergence of the Middle East respiratory syndrome coronavirus

Emerging preclinical evidence does not support broad use of hydroxychloroquine in COVID-19 patients

Escape from human monoclonal antibody neutralization affects in vitro and in vivo fitness of severe acute respiratory syndrome coronavirus

Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses

Evidence supporting a zoonotic origin of human coronavirus strain NL63

Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail

Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

Glycan microarray analysis of Candida glabrata adhesin ligand specificity

Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection

Integrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection

Interferon-β and mycophenolic acid are potent inhibitors of Middle East respiratory syndrome coronavirus in cell-based assays

Mechanisms of severe acute respiratory syndrome pathogenesis and innate immunomodulation

Metagenomic Analysis of the Viromes of Three North American Bat Species: Viral Diversity among Different Bat Species That Share a Common Habitat ⬇️

Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease

Novel influenza virus NS1 antagonists block replication and restore innate immune function

One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus

Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection

Potential role for alternatively activated macrophages in the secondary bacterial infection during recovery from influenza

Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

SARS coronavirus accessory ORFs encode luxury functions

SARS coronavirus and innate immunity

SARS-CoV pathogenesis is regulated by a STAT1 dependent but a type I, II and III interferon receptor independent mechanism

SINC, a type III secreted protein of Chlamydia psittaci, targets the inner nuclear membrane of infected cells and uninfected neighbors

Screening of FDA-Approved Drugs for Treatment of Emerging Pathogens

Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference

Severe acute respiratory syndrome coronavirus group-specific open reading frames encode nonessential functions for replication in cell cultures and mice

Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling

The Global Virus Network: Challenging chikungunya

The ORF4b-encoded accessory proteins of Middle East respiratory syndrome coronavirus and two related bat coronaviruses localize to the nucleus and inhibit innate immune signalling

The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

The SKI complex is a broad-spectrum, host-directed antiviral drug target for coronaviruses, influenza, and filoviruses

The open reading frame 3a protein of severe acute respiratory syndrome-associated coronavirus promotes membrane rearrangement and cell death

The role of epidermal growth factor receptor (EGFR) signaling in SARS coronavirus-induced pulmonary fibrosis

The ω‐site sequence of glycosylphosphatidylinositol‐anchored proteins in Saccharomyces cerevisiae can determine distribution between the membrane and the cell wall ⬇️

Transcriptomic analysis reveals a mechanism for a prefibrotic phenotype in STAT1 knockout mice during severe acute respiratory syndrome coronavirus infection

Unique signatures of long noncoding RNA expression in response to virus infection and altered innate immune signaling

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus

Yeast based small molecule screen for inhibitors of SARS-CoV