Search filters

List of works by Janine N. Copp

A giant leap in sequence space reveals the intracellular complexities of evolving a new function

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

scientific article

Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy

scientific article published on 20 August 2019

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.

scientific article published on 20 February 2017

Error-prone PCR and effective generation of gene variant libraries for directed evolution

scientific article

Evaluating the abilities of diverse nitroaromatic prodrug metabolites to exit a model Gram negative vector for bacterial-directed enzyme-prodrug therapy

scientific article published on 21 October 2018

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

scientific article published on 13 November 2020

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

scientific article published on 15 September 2020

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

scientific article published on 25 April 2020

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

scientific article published on October 2015

Rapid and flexible biochemical assays for evaluating 4'-phosphopantetheinyl transferase activity.

scientific article

Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy

scientific article

Site-saturation mutagenesis by overlap extension PCR.

scientific article

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

scientific article

Paulina is supported by:

About Paulina

Help