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List of works by Alexandra Schäfer

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

scientific article published on 23 September 2020

A Newcastle Disease Virus (NDV) Expressing a Membrane-Anchored Spike as a Cost-Effective Inactivated SARS-CoV-2 Vaccine

scientific article published on 17 December 2020

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2

scientific article published on 19 August 2020

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

scientific article published on 26 January 2022

A compendium of multi-omics data illuminating host responses to lethal human virus infections

scientific article published in 2024

A mouse-adapted SARS-CoV-2 model for the evaluation of COVID-19 medical countermeasures

scientific article published on 08 May 2020

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

scientific article published on 27 August 2020

Acute SARS-CoV-2 Infection is Highly Cytopathic, Elicits a Robust Innate Immune Response and is Efficiently Prevented by EIDD-2801

scientific article published on 24 September 2020

Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in Mice.

scientific article

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 and multiple endemic, epidemic and bat coronavirus

scientific article (preprint)

An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

scientific article published on 06 April 2020

Antibody potency, effector function and combinations in protection from SARS-CoV-2 infection in vivo

scientific article published on 15 September 2020

Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

scientific article published on 01 March 2021

Baseline T cell immune phenotypes predict virologic and disease control upon SARS-CoV infection

scientific article published on 21 September 2020

Cell and animal models of SARS-CoV-2 pathogenesis and immunity

scientific article published on 01 September 2020

Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus monkey rhadinovirus

scientific article published on 23 April 2007

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

scientific article published on 10 January 2020

Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross

scientific article published on 01 April 2020

Cross-reactive coronavirus antibodies with diverse epitope specificities and extra-neutralization functions

scientific article published on 20 December 2020

Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform

scientific article published on 14 March 2018

Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion

scientific article

Early activation of the host complement system is required to restrict central nervous system invasion and limit neuropathology during Venezuelan equine encephalitis virus infection ⬇️

scientific article published on December 28, 2011

Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2

scientific article published on 31 October 2020

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

scientific article published on 12 August 2020

Epigenetic Landscape during Coronavirus Infection

scientific article published on 15 February 2017

Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed

scientific article

Foamy virus Bet proteins function as novel inhibitors of the APOBEC3 family of innate antiretroviral defense factors

scientific article published on July 2005

High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models

scientific article published on 04 September 2020

Human APOBEC3B is a potent inhibitor of HIV-1 infectivity and is resistant to HIV-1 Vif.

scientific article published in September 2005

Immune Predictors of Mortality After Ribonucleic Acid Virus Infection

scientific article published on 01 March 2020

MERS-CoV and H5N1 influenza virus antagonize antigen presentation by altering the epigenetic landscape

scientific article published on 16 January 2018

Newcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidate

scientific article published on 21 November 2020

Pathogenic influenza viruses and coronaviruses utilize similar and contrasting approaches to control interferon-stimulated gene responses.

scientific article

Potently neutralizing and protective human antibodies against SARS-CoV-2

scientific article published on 15 July 2020

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

scientific article published on 22 May 2020

Release of severe acute respiratory syndrome coronavirus nuclear import block enhances host transcription in human lung cells

scientific article published on 30 January 2013

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

scientific article published on 07 July 2020

Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice

scientific article published on 28 April 2020

Replicon particles of Venezuelan equine encephalitis virus as a reductionist murine model for encephalitis

scientific article published on 18 February 2009

SARS-CoV-2 D614G Variant Exhibits Enhanced Replication ex vivo and Earlier Transmission in vivo

scientific article published on 29 September 2020

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

scientific article

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

scientific article published on 27 May 2020

SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

scientific article

SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

scientific article published in 2022

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

scientific article published on 11 June 2020

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

scientific article published on 05 August 2020

SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats ()

scholarly article by Neeltje van Doremalen et al published 19 December 2018 in Viruses

Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor

scientific article

Systems approaches to Coronavirus pathogenesis

scientific article

The Role of the Blood-Brain Barrier during Venezuelan Equine Encephalitis Virus Infection ⬇️

scientific article published on August 17, 2011

The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

scientific article

The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus

scientific article

Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection

scientific article published on 26 May 2015

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