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List of works by Ryan T Strachan

A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1 ⬇️

scientific article published on August 21, 2011

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library

scientific article

Allosteric modulation of β-arrestin-biased angiotensin II type 1 receptor signaling by membrane stretch

scientific article

Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

scientific article published on 13 July 2016

Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice ⬇️

scientific article published on April 1, 2012

Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors.

scientific article published on 20 May 2015

Conformation Guides Molecular Efficacy in Docking Screens of Activated β-2 Adrenergic G Protein Coupled Receptor ⬇️

scientific article published on March 21, 2013

Conformationally selective RNA aptamers allosterically modulate the β2-adrenoceptor.

scientific article

Discovery of Human Signaling Systems: Pairing Peptides to G Protein-Coupled Receptors

scientific article published on 01 October 2019

Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin.

scientific article published on August 2011

Divergent transducer-specific molecular efficacies generate biased agonism at a G protein-coupled receptor (GPCR)

scientific article

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

scientific article

Genetic deletion of p90 ribosomal S6 kinase 2 alters patterns of 5-hydroxytryptamine 2A serotonin receptor functional selectivity

scientific article

Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling

scientific article published on 7 September 2017

Novel characteristics of the biological properties of the yeast Saccharomyces cerevisiae eukaryotic initiation factor 2A.

scientific article

PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?

scientific article published on 07 June 2018

Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways

scientific article

Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling

scientific article

Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies.

scientific article published on 06 December 2013

Ribosomal S6 kinase 2 directly phosphorylates the 5-hydroxytryptamine 2A (5-HT2A) serotonin receptor, thereby modulating 5-HT2A signaling

scientific article published on 22 December 2008

Screening the receptorome: an efficient approach for drug discovery and target validation

scientific article

Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice.

scientific article

Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.

scientific article published on 3 January 2018

TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

scientific article published on 04 May 2020

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells

scientific article published on 04 July 2019

VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells

scientific article published on 01 August 2019

p90 Ribosomal S6 kinase 2, a novel GPCR kinase, is required for growth factor-mediated attenuation of GPCR signaling

scientific article

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