Search filters

List of works by Karen L Posey

An inducible cartilage oligomeric matrix protein mouse model recapitulates human pseudoachondroplasia phenotype

scientific article published on 17 September 2009

Antioxidant and anti-inflammatory agents mitigate pathology in a mouse model of pseudoachondroplasia

scientific article

Antisense Reduction of Mutant COMP Reduces Growth Plate Chondrocyte Pathology

scientific article published on 3 February 2017

Assessing the plasticity of DNA target site recognition of the PI-SceI homing endonuclease using a bacterial two-hybrid selection system

scientific article

COMP mutations: domain-dependent relationship between abnormal chondrocyte trafficking and clinical PSACH and MED phenotypes

scientific article published on 01 February 2008

Cartilage oligomeric matrix protein: COMPopathies and beyond.

scientific article published on 9 March 2018

Chondrocyte-specific pathology during skeletal growth and therapeutics in a murine model of pseudoachondroplasia

scientific article

Chop (Ddit3) is essential for D469del-COMP retention and cell death in chondrocytes in an inducible transgenic mouse model of pseudoachondroplasia

scientific article published on 7 December 2011

Computational identification and functional validation of regulatory motifs in cartilage-expressed genes.

scientific article published on 4 September 2007

D469del-COMP retention in chondrocytes stimulates caspase-independent necroptosis

scientific journal article

Evolution of divergent DNA recognition specificities in VDE homing endonucleases from two yeast species

scientific article published on 27 July 2004

Identification of a 3Kbp mechanoresponsive promoter region in the human cartilage oligomeric matrix protein gene.

scientific article

In vivo human Cartilage oligomeric matrix protein (COMP) promoter activity

scientific article published on 7 October 2005

Insertion of a reversible redox switch into a rare-cutting DNA endonuclease

scientific article published in February 2002

Mutant COMP shapes growth and development of skull and facial structures in mice and humans

scientific article published on 28 April 2020

Mutant cartilage oligomeric matrix cartilage (COMP) compromises bone integrity, joint function and the balance between adipogenesis and osteogenesis.

scientific article published on 5 January 2018

Novel mTORC1 Mechanism Suggests Therapeutic Targets for COMPopathies

scientific article published on 01 January 2019

Novel therapeutic interventions for pseudoachondroplasia

scientific article published on 21 March 2017

Pseudoachondroplasia/COMP - translating from the bench to the bedside

scientific article

RNAi reduces expression and intracellular retention of mutant cartilage oligomeric matrix protein

scientific article

Resveratrol induces dephosphorylation of Tau by interfering with the MID1-PP2A complex

scientific article

Role of TSP-5/COMP in pseudoachondroplasia

scientific article published on June 2004

Skeletal abnormalities in mice lacking extracellular matrix proteins, thrombospondin-1, thrombospondin-3, thrombospondin-5, and type IX collagen

scientific journal article

Thrombospondins and novel TSR-containing proteins, R-spondins, regulate bone formation and remodeling

scientific article published on June 2010

Paulina is supported by:

About Paulina

Help