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List of works by Lei Wei

2010 Riley Heart Center Symposium on Cardiac Development: cardiomyocyte injury and protection

scientific article

Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

scholarly article

Amelioration of albuminuria in ROCK1 knockout mice with streptozotocin-induced diabetic kidney disease

scientific article published on 04 October 2011

Apoptosis in Anthracycline Cardiomyopathy

scientific article published on November 2011

Cardiac-specific and ligand-inducible target gene expression in transgenic mice.

scientific article published on April 2005

Cardiomyocyte death in doxorubicin-induced cardiotoxicity

scientific article

Cyclic mechanical strain inhibits skeletal myogenesis through activation of focal adhesion kinase, Rac-1 GTPase, and NF-kappaB transcription factor

scientific article

Disruption of ROCK1 gene attenuates cardiac dilation and improves contractile function in pathological cardiac hypertrophy

scientific article published on 08 December 2007

Disruption of ROCK1 gene restores autophagic flux and mitigates doxorubicin-induced cardiotoxicity.

scientific article published on 8 February 2018

Disruption of Rho signaling results in progressive atrioventricular conduction defects while ventricular function remains preserved.

scientific article published on 19 March 2004

Disruption of both ROCK1 and ROCK2 genes in cardiomyocytes promotes autophagy and reduces cardiac fibrosis during aging

scientific article published on 08 March 2019

Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1

scientific article

Dissecting the roles of ROCK isoforms in stress-induced cell detachment

scientific article published on 18 April 2013

Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment

scientific article published on 07 February 2013

Double-inducible gene activation system for caspase 3 and 9 in epidermis

scientific article published on April 2007

Downregulation of doxorubicin-induced myocardial apoptosis accompanies postnatal heart maturation

scientific article published on 10 February 2012

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

scientific article

Induction and reversal of cardiac phenotype of human hypertrophic cardiomyopathy mutation cardiac troponin T-Q92 in switch on-switch off bigenic mice

scientific article published on December 2004

Inhibition of Rho family GTPases by Rho GDP dissociation inhibitor disrupts cardiac morphogenesis and inhibits cardiomyocyte proliferation.

scientific article published in April 2002

Inhibitory cardiac transcription factor, SRF-N, is generated by caspase 3 cleavage in human heart failure and attenuated by ventricular unloading

scientific article published on 21 July 2003

Lysophospholipid signaling in cardiac myocyte hypertrophy

scientific article published in April 2004

Mechanism of fibrotic cardiomyopathy in mice expressing truncated Rho-associated coiled-coil protein kinase 1.

scientific article published on 25 January 2012

Novel Insights into the Roles of Rho Kinase in Cancer

scientific article

Novel phosphorylation target in the serum response factor MADS box regulates alpha-actin transcription

scientific article

ROCK inhibitor Y-27632 suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells and increases their cloning efficiency

scientific article

ROCK1 deficiency enhances protective effects of antioxidants against apoptosis and cell detachment

scientific article (publication date: 2014)

ROCK1 functions as a critical regulator of stress erythropoiesis and survival by regulating p53.

scientific article

ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability

scientific article

ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance

scientific article published on 10 December 2013

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

scientific article

ROCK1 via LIM kinase regulates growth, maturation and actin based functions in mast cells

scientific article published on 02 March 2016

ROCK2 inhibition enhances the thermogenic program in white and brown fat tissue in mice

scientific article published on 25 November 2019

Regulation of JAK/STAT signalling by SOCS in the myocardium.

scientific article published on 22 October 2012

Regulation of the actin cytoskeleton by Rho kinase controls antigen presentation by CD1d.

scientific article

Rho kinase as a therapeutic target in cardiovascular disease

scientific article

Rho kinase in the regulation of cell death and survival

scientific article published on 9 March 2007

Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3, and BCR-ABL.

scientific article published on September 2011

Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation

scientific article published on 30 April 2009

Rho kinases in cardiovascular physiology and pathophysiology: the effect of fasudil

scientific article published on October 2013

Rho-kinase in development and heart failure: insights from genetic models

scientific article

RhoA GTPase regulates L-type Ca2+ currents in cardiac myocytes

scientific article

Rnd3/RhoE Modulates Hypoxia-Inducible Factor 1α/Vascular Endothelial Growth Factor Signaling by Stabilizing Hypoxia-Inducible Factor 1α and Regulates Responsive Cardiac Angiogenesis

scientific article published on 18 January 2016

Serum response factor MADS box serine-162 phosphorylation switches proliferation and myogenic gene programs

scholarly article

Signaling mechanism of renal fibrosis in unilateral ureteral obstructive kidney disease in ROCK1 knockout mice

scientific article published on 27 September 2006

Spatial variability in T-tubule and electrical remodeling of left ventricular epicardium in mouse hearts with transgenic Gαq overexpression-induced pathological hypertrophy

scientific article published on 21 June 2012

Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis

scientific article published on 01 May 2006

Targeted disruption of ROCK1 causes insulin resistance in vivo.

scientific article published on 10 March 2009

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