List of works - Wojciech Stec

A novel class of DNA analogs bearing 5'-C-phosphonothymidine units: synthesis and physicochemical and biochemical properties

scientific article

A simple procedure for synthesis of diastereoisomers of thymidine cyclic 3',5'-phosphate derivatives

scientific article published on 01 January 1987

Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases.

scientific article published in July 2003

Alkyl phosphotriester modified oligodeoxyribonucleotides. V. Synthesis and absolute configuration of Rp and Sp diastereomers of an ethyl phosphotriester (Et) modified EcoRI recognition sequence, d[GGAA(Et)TTCC]. A synthetic approach to regio- and st

scientific article

An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.

scientific article published in September 2009

An oxathiaphospholane approach to one-pot phosphorothioylation of isoprenoid alcohols

scientific article

Analogues of acyclic nucleosides derived from tris-(hydroxymethyl)phosphine oxide or bis-(hydroxymethyl)phosphinic acid coupled to DNA nucleobases.

scientific article

Analysis of oligo(deoxynucleoside phosphorothioate)s and their diastereomeric composition

scientific article

Antibodies to recombinant fragment 212-276 of protein C specifically recognize the intact human molecule.

scientific article

Antitumor activity of optical isomers of cyclophosphamide, ifosfamide and trofosfamide as compared to clinically used racemates

scientific article published on 01 January 1986

Attempted stereoselective synthesis of P-chiral analogues of oligodeoxyribonucleotides

scientific article published on 01 January 1989

Backbone-modified oligonucleotides containing a butanediol-1,3 moiety as a 'vicarious segment' for the deoxyribosyl moiety--synthesis and enzyme studies

scientific article published on April 1990

Base-Dependent Regioselective and P-Stereocontrolled Hydrolysis of Nucleoside 3‘-O-(O-2,4,6-Trimethylbenzoyl Methanephosphonothioate)s

Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent

scientific article

Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors

scientific article published on 24 February 2004

Catalytic phosphoryl interactions of topoisomerase IB.

scientific article

Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.

scientific article published on 19 March 2016

ChemInform Abstract: New Examples of Mixed Seleno-sulfides; Reactions with Triphenylphosphine

Chemo-and Stereoselectivity of Nucleophilic Substitution in Mixed Phosphorus-Carboxylic Anhydrides

Chemoselective activation of nucleoside 3'-O-methylphosphonothioates with 1,3,5-triazinyl morpholinium salts.

scientific article published on 4 October 2007

Chiral phosphorothioates as probes of protein interactions with individual DNA phosphoryl oxygens: essential interactions of EcoRI endonuclease with the phosphate at pGAATTC.

scientific article

Comparison of the cleavage profiles of oligonucleotide duplexes with or without phosphorothioate linkages by using a chemical nuclease probe.

scientific article published on 19 March 2004

Cryo-EM structure of the human α1β3γ2 GABA receptor in a lipid bilayer

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum

scientific article published on 01 August 1985

Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation

scientific article published on 6 January 2018

DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel

scientific article published on 23 October 2001

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication

scientific article

Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement ⬇️

scientific article published on January 1, 2001

Diastereomerically pure nucleoside‐5′‐O‐(2‐thio‐4,4‐pentamethylene‐1,3,2‐oxathiaphospholane)s—Substrates for synthesis of P‐chiral derivatives of nucleoside‐5′‐O‐phosphorothioates ⬇️

scientific article published on 06 October 2010

Diastereomers of thymidine 3'-O-(methanephosphonothioate): synthesis, absolute configuration and reaction with 3'-methoxyacetylthymidine under conditions of triester approach to oligonucleotide synthesis

scientific article published on January 1987

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.

scientific article published on 24 July 2013

DrosophilaSOCS Proteins ⬇️

scientific article published on December 13, 2011

Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition? ⬇️

scientific article published on October 1, 2003

Effect of P‐chirality of oligo(deoxyribonucleoside phosphorothioate)s on the activity of terminal deoxyribonucleotidyl transferase ⬇️

scientific article published on August 28, 1998

Efficient One-Pot Synthesis of 2‘-Deoxyribonucleoside 3‘-O- and 5‘-O-Phosphorodithioates ⬇️

scientific article published on 01 April 1997

Efficient inhibition of β‐secretase gene expression in HEK293 cells by tRNAVal‐driven and CTE‐helicase associated hammerhead ribozymes ⬇️

scientific article published on October 1, 2003

Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis

scientific article

Fhit proteins can also recognize substrates other than dinucleoside polyphosphates.

scientific article published on 9 August 2008

High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing α4β3δ subunits.

scientific article published on 19 January 2018

IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis.

scientific article

Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues

scientific article

Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model

scientific article published on September 2002

Inhibition of plasminogen activator inhibitor release in endothelial cell cultures by antisense oligodeoxyribonucleotides with a 5'-end lipophilic modification.

scientific article

Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases ⬇️

scientific article published on July 16, 1984

Interaction of cAMP Derivatives with the 'Stable' CAMP-Binding Site in the CAMP-Dependent Protein Kinase Type I ⬇️

scientific article published on 01 February 1982

Interactions of cellular histidine triad nucleotide binding protein 1 with nucleosides 5'-O-monophosphorothioate and their derivatives - Implication for desulfuration process in the cell

scientific article published on 06 September 2014

Investigations on stimulation of lac transcription in vivo in Escherichia coli by cAMP analogues. Biological activities and structure-activity correlations

scientific article published on 01 January 1984

Low Incidence along with Low mRNA Levels of EGFRvIII in Prostate and Colorectal Cancers Compared to Glioblastoma

scientific article published on January 2017

Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10-23.

scientific article published on 22 January 2007

Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran.

scientific article published on 10 December 2015

Mechanisms of coupling between DNA recognition specificity and catalysis in EcoRI endonuclease

scientific article

Membrane-bound tumour necrosis factor alpha: immunocytochemical and ultrastructural studies of human monocytes and monocytic cell line and its induction by tumour cells in vitro

scientific article published on January 1, 1992

Mixed Phosphorus-Carboxylic Anhydrides as Synthons for Stereoselective Synthesis of [RP]-Dinucleoside (3',5')-Methanephosphonates

Mixed Phosphorus-Carboxylic Anhydrides as Synthons for Stereoselective Synthesis of [RP]-Dinucleoside (3',5)-Methanephosphonates

Modulation of beta-secretase gene expression by action of catalytic nucleic acids

scientific article published on 01 January 2002

Modulation of plasminogen activator inhibitor type-1 biosynthesis in vitro and in vivo with oligo(nucleoside phosphorothioate)s and related constructs ⬇️

scientific article published on October 1, 1997

NMR studies of backbone-alkylated DNA: duplex stability, absolute stereochemistry, and chemical shift anomalies of prototypal isopropyl phosphotriester modified octanucleotides, (Rp,Rp)- and (Sp,Sp)-(d-[GGA(iPr)ATTCC])2 and -(d-[GGAA(iPr)TTCC])2

scientific article published on 01 April 1987

Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.

scientific article

New examples of mixed seleno-sulfides; reactions with triphenylphosphine

scientific article

Novel cost-effective methanephosphonoanilidothioate approach to the stereoselective synthesis of dinucleoside (3',5')-methanephosphonates

scientific article published on 01 August 1997

Novel internucleotide 3'-NH-P(CH3)(O)-O-5' linkage. Oligo(deoxyribonucleoside methanephosphonamidates); synthesis, structure and hybridization properties.

scientific article

Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates).

scientific article

Nucleophilic N1-->N3 rearrangement of 5'-O-trityl-O2,3'-cycloanhydrothymidine

scientific article published on 01 October 2000

Nucleotide pyrophosphatase/phosphodiesterase 1 is responsible for degradation of antisense phosphorothioate oligonucleotides

scientific article published on 01 January 2007

Octa(thymidine methanephosphonates) of partially defined stereochemistry: synthesis and effect of chirality at phosphorus on binding to pentadecadeoxyriboadenylic acid

scientific article

Oligomeric building block approach to the synthesis of diastereomerically pure pentathymidine 3',5'-methanephosphonates

scientific article published on 01 March 2000

On the quality control of antisense oligonucleotides

scientific article published on 01 January 1996

One-pot synthesis of nucleoside 3′-O-(S-phenyl methanephosphonothioates)

Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope

Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope This work was financially supported by the State Committee for Scientific Research (KBN, Pol

scientific article published on 01 February 2001

Oxathiaphospholane Method of Stereocontrolled Synthesis of Diribonucleoside 3‘,5‘-Phosphorothioates ⬇️

scientific article published on September 20, 1996

Oxathiaphospholane approach to the synthesis of oligodeoxyribonucleotides containing stereodefined internucleotide phosphoroselenoate function

scientific article published on 01 September 2005

P-chirality-dependent immune activation by phosphorothioate CpG oligodeoxynucleotides

scientific article published in January 2003

Phosphorothioate oligodeoxyribonucleotides antisense to PAI-1 mRNA increase fibrinolysis and modify experimental thrombosis in rats

scientific article published on 01 February 1998

Potassium peroxymonosulfate (oxone)--an efficient oxidizing agent for phosphothio compounds

scientific article published on 01 October 1998

Recent advances in the elucidation of the mechanisms of action of ribozymes

scientific article (publication date: May 2001)

Regulation of PAI-1 concentration in platelets by systemic administration of antisense oligonucleotides to rats.

scientific article

Retention of configuration in the action of human plasma 3'-exonuclease on oligo(deoxynucleoside phosphorothioate). A new method for assignment of absolute configuration at phosphorus in isotopomeric deoxyadenosine 5'-O-[(18)O]phosphorothioate.

scientific article

Significance of stereochemistry of 3'-terminal phosphorothioate-modified primer in DNA polymerase-mediated chain extension

scientific article

Specificity of cyclic GMP activation of a multi-substrate cyclic nucleotide phosphodiesterase from rat liver

scientific article published on 01 April 1981

Stabilities of lead(II) complexes formed in aqueous solution with methyl thiophosphate (MeOPS(2-)), uridine 5'- O-thiomonophosphate (UMPS(2-)) or adenosine 5'- O-thiomonophosphate (AMPS(2-)).

scientific article

Stability of stereoregular oligo(nucleoside phosphorothioate)s in human plasma: diastereoselectivity of plasma 3'-exonuclease

scientific article published on 01 February 1997

Stereochemical Course of Escherichia coli RNase H.

scientific article published in 2003

Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5'-O-phosphorothioyl)glycerols

scientific article published in May 2003

Stereochemical course of Escherichia coli RNase H.

scientific article

Stereochemistry of cleavage of internucleotide bonds by Serratia marcescens endonuclease

scientific article

Stereochemistry of rHint1 hydrolase assisted cleavage of P-N bond in nucleoside 5'-O-phosphoramidothioates

scientific article

Stereocontrolled synthesis of LNA dinucleoside phosphorothioate by the oxathiaphospholane approach

scientific article published in April 2001

Stereodefined phosphorothioate analogues of DNA: relative thermodynamic stability of the model PS-DNA/DNA and PS-DNA/RNA complexes

scientific article published on 01 October 2002

Stereodependent Inhibition of Plasminogen Activator Inhibitor Type 1 by Phosphorothioate Oligonucleotides: Proof of Sequence Specificity in Cell Culture andIn VivoRat Experiments ⬇️

scientific article published on 01 December 1997

Stereodifferentiation--the effect of P chirality of oligo(nucleoside phosphorothioates) on the activity of bacterial RNase H.

scientific article published on December 1995

Stereoselective Synthesis of [Rp]-Dinucleoside (3′,5′)-Methanephosphonates

Stereoselective formation of a P–P bond in the reaction of 2-alkoxy-2-thio-1,3,2-oxathiaphospholanes with O,O-dialkyl H-phosphonates and H-thiophosphonates ⬇️

scientific article published on October 14, 2010

Stereoselective synthesis of P-homochiral oligo(thymidine methanephosphonates).

scientific article published on December 1988

Stereospecific synthesis of P-chiral analogs of oligonucleotides

scientific article published on 01 January 1993

Stereospecific synthesis of chiral metabolites of ifosfamide and their determination in the urine

scientific article published on May 1983

Structural effect of complete [Rp]-phosphorothioate and phosphorodithioate substitutions in the DNA strand of a model antisense inhibitor-target RNA complex

scientific article published in January 1999

Structural study of a DNA.RNA hybrid duplex with a chiral phosphorothioate moiety by NMR: extraction of distance and torsion angle constraints and imino proton exchange rates

scientific article published in September 1994

Structure and dynamics of a DNA.RNA hybrid duplex with a chiral phosphorothioate moiety: NMR and molecular dynamics with conventional and time-averaged restraints

scientific article

Synthesis and an antiviral activity evaluation of nucleoside 5´-O-(N-acyl) phosphoramidates.

scientific article

Synthesis and interaction with thymidylate synthase of 5'-dithiophosphate and 5'-fluorothiophosphate of thymidine

scientific article published on 01 January 1998

Synthesis of nucleoside alpha-thiotriphosphates via an oxathiaphospholane approach

scientific article published on 01 May 2005

Synthesis of phosphorothioate oligonucleotides with stereodefined phosphorothioate linkages

scientific article published on October 2003

Synthesis, biochemical and biological studies on oligonucleotides bearing a lipophilic dimethoxytrityl group

scientific article published on January 1, 1998

The First Stereocontrolled Solid-Phase Synthesis of Di-, Tri-, and Tetra[adenosine (2‘,5‘) phosphorothioate]s ⬇️

scientific article published on 01 October 1998

The cytotoxicity of anti-PAI-1 oligonucleotides and their conjugates

scientific article published on June 1999

The effect of divalent cations on the catalytic activity of the human plasma 3'-exonuclease

scientific article published on 30 June 2010

The epidermal growth factor-like domain from tissue plasminogen activator. Cloning in E. coli, purification and ESR studies of its interaction with human blood platelets.

scientific article

The mononucleotide-dependent, nonantisense mechanism of action of phosphodiester and phosphorothioate oligonucleotides depends upon the activity of an ecto-5'-nucleotidase

scientific article published on August 2001

The role of tumor necrosis factor in the regulation of antigen presentation by human monocytes

scientific article published on 01 January 1990

The synthesis of di- and oligo-nucleotides containing a phosphorodithioate internucleotide linkage with one of the sulfur atoms in a 5'-bridging position

scientific article published on 30 March 2009

The synthesis of dithymidine boranophosphate by the oxathiaphospholane approach ⬇️

scientific article published on October 1, 2001

The synthesis of unsymmetrical S1-(3′-O-thymidine-O-methanephosphonyl)-S2-p-nitrophenyl disulfides and their reactions with triphenylphosphine

The α-thio and/or β-γ-hypophosphate analogs of ATP as cofactors of T4 DNA ligase

scholarly article by Roza Pawlowska published in August 2016

Transport and metabolism of N6- and C8-substituted analogs of adenosine 3′,5′-cyclic monophosphate and adenosine 3′5′-cyclic phosphorothioate by the isolated perfused rat kidney ⬇️

scientific article published on March 28, 1983

Unusual thermal stability of RNA/[RP-PS]-DNA/RNA triplexes containing a homopurine DNA strand

scientific article

List of works by Wojciech Stec

A novel class of DNA analogs bearing 5'-C-phosphonothymidine units: synthesis and physicochemical and biochemical properties

A simple procedure for synthesis of diastereoisomers of thymidine cyclic 3',5'-phosphate derivatives

Adenosine-5'-O-phosphorylated and adenosine-5'-O-phosphorothioylated polyols as strong inhibitors of (symmetrical) and (asymmetrical) dinucleoside tetraphosphatases.

Alkyl phosphotriester modified oligodeoxyribonucleotides. V. Synthesis and absolute configuration of Rp and Sp diastereomers of an ethyl phosphotriester (Et) modified EcoRI recognition sequence, d[GGAA(Et)TTCC]. A synthetic approach to regio- and st

An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.

An oxathiaphospholane approach to one-pot phosphorothioylation of isoprenoid alcohols

Analogues of acyclic nucleosides derived from tris-(hydroxymethyl)phosphine oxide or bis-(hydroxymethyl)phosphinic acid coupled to DNA nucleobases.

Analysis of oligo(deoxynucleoside phosphorothioate)s and their diastereomeric composition

Antibodies to recombinant fragment 212-276 of protein C specifically recognize the intact human molecule.

Antitumor activity of optical isomers of cyclophosphamide, ifosfamide and trofosfamide as compared to clinically used racemates

Attempted stereoselective synthesis of P-chiral analogues of oligodeoxyribonucleotides

Backbone-modified oligonucleotides containing a butanediol-1,3 moiety as a 'vicarious segment' for the deoxyribosyl moiety--synthesis and enzyme studies

Base-Dependent Regioselective and P-Stereocontrolled Hydrolysis of Nucleoside 3‘-O-(O-2,4,6-Trimethylbenzoyl Methanephosphonothioate)s

Binding of phosphorothioate oligodeoxynucleotides to basic fibroblast growth factor, recombinant soluble CD4, laminin and fibronectin is P-chirality independent

Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors

Catalytic phosphoryl interactions of topoisomerase IB.

Cell line with endogenous EGFRvIII expression is a suitable model for research and drug development purposes.

ChemInform Abstract: New Examples of Mixed Seleno-sulfides; Reactions with Triphenylphosphine

Chemo-and Stereoselectivity of Nucleophilic Substitution in Mixed Phosphorus-Carboxylic Anhydrides

Chemoselective activation of nucleoside 3'-O-methylphosphonothioates with 1,3,5-triazinyl morpholinium salts.

Chiral phosphorothioates as probes of protein interactions with individual DNA phosphoryl oxygens: essential interactions of EcoRI endonuclease with the phosphate at pGAATTC.

Comparison of the cleavage profiles of oligonucleotide duplexes with or without phosphorothioate linkages by using a chemical nuclease probe.

Cryo-EM structure of the human α1β3γ2 GABA receptor in a lipid bilayer

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum

Cyclic trans-phosphorylation in a homodimer as the predominant mechanism of EGFRvIII action and regulation

DNAzymes to beta 1 and beta 3 mRNA down-regulate expression of the targeted integrins and inhibit endothelial cell capillary tube formation in fibrin and matrigel

Design, synthesis, and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication

Di-, tri- and tetra-5'-O-phosphorothioadenosyl substituted polyols as inhibitors of Fhit: Importance of the α-β bridging oxygen and β phosphorus replacement ⬇️

Diastereomerically pure nucleoside‐5′‐O‐(2‐thio‐4,4‐pentamethylene‐1,3,2‐oxathiaphospholane)s—Substrates for synthesis of P‐chiral derivatives of nucleoside‐5′‐O‐phosphorothioates ⬇️

Diastereomers of thymidine 3'-O-(methanephosphonothioate): synthesis, absolute configuration and reaction with 3'-methoxyacetylthymidine under conditions of triester approach to oligonucleotide synthesis

Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.

DrosophilaSOCS Proteins ⬇️

Dynamic NMR Structures of [Rp]- and [Sp]-Phosphorothioated DNA-RNA Hybrids: Is Flexibility Required for RNase H Recognition? ⬇️

Effect of P‐chirality of oligo(deoxyribonucleoside phosphorothioate)s on the activity of terminal deoxyribonucleotidyl transferase ⬇️

Efficient One-Pot Synthesis of 2‘-Deoxyribonucleoside 3‘-O- and 5‘-O-Phosphorodithioates ⬇️

Efficient inhibition of β‐secretase gene expression in HEK293 cells by tRNAVal‐driven and CTE‐helicase associated hammerhead ribozymes ⬇️

Evaluation of influence of Ap4A analogues on Fhit-positive HEK293T cells; cytotoxicity and ability to induce apoptosis

Fhit proteins can also recognize substrates other than dinucleoside polyphosphates.

High-level production and purification in a functional state of an extrasynaptic gamma-aminobutyric acid type A receptor containing α4β3δ subunits.

IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis.

Inhibition of ADP-triggered blood platelet aggregation by diadenosine polyphosphate analogues

Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model

Inhibition of plasminogen activator inhibitor release in endothelial cell cultures by antisense oligodeoxyribonucleotides with a 5'-end lipophilic modification.

Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases ⬇️

Interaction of cAMP Derivatives with the 'Stable' CAMP-Binding Site in the CAMP-Dependent Protein Kinase Type I ⬇️

Interactions of cellular histidine triad nucleotide binding protein 1 with nucleosides 5'-O-monophosphorothioate and their derivatives - Implication for desulfuration process in the cell

Investigations on stimulation of lac transcription in vivo in Escherichia coli by cAMP analogues. Biological activities and structure-activity correlations

Low Incidence along with Low mRNA Levels of EGFRvIII in Prostate and Colorectal Cancers Compared to Glioblastoma

Mapping of the functional phosphate groups in the catalytic core of deoxyribozyme 10-23.

Mechanisms of JAK/STAT pathway negative regulation by the short coreceptor Eye Transformer/Latran.

Mechanisms of coupling between DNA recognition specificity and catalysis in EcoRI endonuclease

Membrane-bound tumour necrosis factor alpha: immunocytochemical and ultrastructural studies of human monocytes and monocytic cell line and its induction by tumour cells in vitro

Mixed Phosphorus-Carboxylic Anhydrides as Synthons for Stereoselective Synthesis of [RP]-Dinucleoside (3',5')-Methanephosphonates

Mixed Phosphorus-Carboxylic Anhydrides as Synthons for Stereoselective Synthesis of [RP]-Dinucleoside (3',5)-Methanephosphonates

Modulation of beta-secretase gene expression by action of catalytic nucleic acids

Modulation of plasminogen activator inhibitor type-1 biosynthesis in vitro and in vivo with oligo(nucleoside phosphorothioate)s and related constructs ⬇️

NMR studies of backbone-alkylated DNA: duplex stability, absolute stereochemistry, and chemical shift anomalies of prototypal isopropyl phosphotriester modified octanucleotides, (Rp,Rp)- and (Sp,Sp)-(d-[GGA(iPr)ATTCC])2 and -(d-[GGAA(iPr)TTCC])2

Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.

New examples of mixed seleno-sulfides; reactions with triphenylphosphine

Novel cost-effective methanephosphonoanilidothioate approach to the stereoselective synthesis of dinucleoside (3',5')-methanephosphonates

Novel internucleotide 3'-NH-P(CH3)(O)-O-5' linkage. Oligo(deoxyribonucleoside methanephosphonamidates); synthesis, structure and hybridization properties.

Novel route to oligo(deoxyribonucleoside phosphorothioates). Stereocontrolled synthesis of P-chiral oligo(deoxyribonucleoside phosphorothioates).

Nucleophilic N1-->N3 rearrangement of 5'-O-trityl-O2,3'-cycloanhydrothymidine

Nucleotide pyrophosphatase/phosphodiesterase 1 is responsible for degradation of antisense phosphorothioate oligonucleotides

Octa(thymidine methanephosphonates) of partially defined stereochemistry: synthesis and effect of chirality at phosphorus on binding to pentadecadeoxyriboadenylic acid

Oligomeric building block approach to the synthesis of diastereomerically pure pentathymidine 3',5'-methanephosphonates

On the quality control of antisense oligonucleotides

One-pot synthesis of nucleoside 3′-O-(S-phenyl methanephosphonothioates)

Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope

Oxathiaphospholane Approach to the Synthesis of P-Chiral, Isotopomeric Deoxy(ribonucleoside phosphorothioate)s and Phosphates Labeled with an Oxygen Isotope This work was financially supported by the State Committee for Scientific Research (KBN, Pol

Oxathiaphospholane Method of Stereocontrolled Synthesis of Diribonucleoside 3‘,5‘-Phosphorothioates ⬇️

Oxathiaphospholane approach to the synthesis of oligodeoxyribonucleotides containing stereodefined internucleotide phosphoroselenoate function

P-chirality-dependent immune activation by phosphorothioate CpG oligodeoxynucleotides

Phosphorothioate oligodeoxyribonucleotides antisense to PAI-1 mRNA increase fibrinolysis and modify experimental thrombosis in rats

Potassium peroxymonosulfate (oxone)--an efficient oxidizing agent for phosphothio compounds

Recent advances in the elucidation of the mechanisms of action of ribozymes

Regulation of PAI-1 concentration in platelets by systemic administration of antisense oligonucleotides to rats.

Retention of configuration in the action of human plasma 3'-exonuclease on oligo(deoxynucleoside phosphorothioate). A new method for assignment of absolute configuration at phosphorus in isotopomeric deoxyadenosine 5'-O-[(18)O]phosphorothioate.

Significance of stereochemistry of 3'-terminal phosphorothioate-modified primer in DNA polymerase-mediated chain extension