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List of works by Michael M. C. Lai

A Nucleolar Protein, Ribosomal RNA Processing 1 Homolog B (RRP1B), Enhances the Recruitment of Cellular mRNA in Influenza Virus Transcription

scientific article

A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication

scientific article

Activation of anti-hepatitis C virus responses via Toll-like receptor 7.

scientific article

Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft

scientific article

Association of hepatitis C virus replication complexes with microtubules and actin filaments is dependent on the interaction of NS3 and NS5A

scientific article

Attenuation of 40S Ribosomal Subunit Abundance Differentially Affects Host and HCV Translation and Suppresses HCV Replication ⬇️

scientific article published on June 28, 2012

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

scientific article

Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts

scientific article published on July 2004

Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection

scientific article

Dengue Virus Impairs Mitochondrial Fusion by Cleaving Mitofusins

scientific article (publication date: December 2015)

Detection and characterization of small and large HDV antigens

scientific article published in January 2004

Detection of a Novel Unglycosylated Form of Hepatitis C Virus E2 Envelope Protein That Is Located in the Cytosol and Interacts with PKR ⬇️

scientific article published on February 1, 2002

Enzymatic characterization of the full-length and C-terminally truncated hepatitis C virus RNA polymerases: function of the last 21 amino acids of the C terminus in template binding and RNA synthesis

scientific article published on August 2004

Establishment of B-cell lymphoma cell lines persistently infected with hepatitis C virus in vivo and in vitro: the apoptotic effects of virus infection

scientific article

Genomic but not antigenomic hepatitis delta virus RNA is preferentially exported from the nucleus immediately after synthesis and processing

scientific article published on April 2002

HCV core expression in hepatocytes protects against autoimmune liver injury and promotes liver regeneration in mice

scientific article published in October 2006

HCV infection enhances Th17 commitment, which could affect the pathogenesis of autoimmune diseases

scientific article

HCV-induced autophagosomes are generated via homotypic fusion of phagophores that mediate HCV RNA replication

scientific article published on 19 September 2017

Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein

scientific article

Hepatitis C Virus Causes Uncoupling of Mitotic Checkpoint and Chromosomal Polyploidy through the Rb Pathway

scientific article

Hepatitis C Virus Genotype 1b Core Protein Does Not Exert Immunomodulatory Effects on Virus-Induced Cellular Immunity ⬇️

scientific article published on February 1, 2002

Hepatitis C Virus Inhibits DNA Damage Repair through Reactive Oxygen and Nitrogen Species and by Interfering with the ATM-NBS1/Mre11/Rad50 DNA Repair Pathway in Monocytes and Hepatocytes ⬇️

scientific article published on October 25, 2010

Hepatitis C Virus RNA Replication Occurs on a Detergent-Resistant Membrane That Cofractionates with Caveolin-2

scientific article

Hepatitis C Virus Triggers Mitochondrial Permeability Transition with Production of Reactive Oxygen Species, Leading to DNA Damage and STAT3 Activation

scientific article

Hepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells

scientific article

Hepatitis C virus IRES-dependent translation is insensitive to an eIF2alpha-independent mechanism of inhibition by interferon in hepatocyte cell lines

scientific article published in June 2002

Hepatitis C virus NS3/4A protein interacts with ATM, impairs DNA repair and enhances sensitivity to ionizing radiation.

scientific article

Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins

scientific article

Hepatitis C virus core protein regulates p300/CBP co-activation function. Possible role in the regulation of NF-AT1 transcriptional activity

scientific article

Hepatitis C virus egress and release depend on endosomal trafficking of core protein

scientific article

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2.

scientific article

Hepatitis C virus induces a mutator phenotype: enhanced mutations of immunoglobulin and protooncogenes

scholarly article

Hepatitis C virus induces toll-like receptor 4 expression, leading to enhanced production of beta interferon and interleukin-6

scientific article

Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes

scientific article published on August 2004

Hepatitis C virus infection of T cells inhibits proliferation and enhances fas-mediated apoptosis by down-regulating the expression of CD44 splicing variant 6.

scientific article

Hepatitis C virus infects T cells and affects interferon-gamma signaling in T cell lines

scientific article published on 18 December 2006

Hepatitis C virus nonstructural 5B protein regulates tumor necrosis factor alpha signaling through effects on cellular IkappaB kinase

scientific article

Hepatitis C virus proteins: direct link to hepatic oxidative stress, steatosis, carcinogenesis and more

scientific article published in February 2002

Hepatitis C virus translation preferentially depends on active RNA replication

scientific article

Hepatitis Delta Virus RNA Encoding the Large Delta Antigen Cannot Sustain Replication due to Rapid Accumulation of Mutations Associated with RNA Editing ⬇️

scientific article published on November 1, 2003

Hepatitis Delta Virus RNA Replication ⬇️

scientific article published on November 6, 2009

Hepatitis delta virus RNA transfection for the cell culture model

scientific article published in January 2004

Hepatitis delta virus antigen is methylated at arginine residues, and methylation regulates subcellular localization and RNA replication

scientific article published on December 2004

High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity

scientific article

Household transmission of respiratory viruses - assessment of viral, individual and household characteristics in a population study of healthy Australian adults.

scientific article

How Dengue Virus Circumvents Innate Immunity

Human VAP-B is involved in hepatitis C virus replication through interaction with NS5A and NS5B

scientific article

Human monoclonal antibody to hepatitis C virus E1 glycoprotein that blocks virus attachment and viral infectivity

scientific article

Identification of RNA ligands that bind hepatitis C virus polymerase selectively and inhibit its RNA synthesis from the natural viral RNA templates

scientific article

Identification of a ribavirin-resistant NS5B mutation of hepatitis C virus during ribavirin monotherapy ⬇️

scientific article published on October 1, 2003

Immunogenicity of a monovalent 2009 influenza A(H1N1) vaccine in infants and children: a randomized trial.

scientific article

Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase

scientific article

Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft

scientific article

Involvement of creatine kinase B in hepatitis C virus genome replication through interaction with the viral NS4A protein

scientific article

Is avian influenza A (H7N9) virus staggering its way to humans?

scientific article published on 3 June 2013

Large hepatitis delta antigen is not a suppressor of hepatitis delta virus RNA synthesis once RNA replication is established ⬇️

scientific article published on October 2002

Modification of small hepatitis delta virus antigen by SUMO protein

scientific article

Molecular pathogenesis of Gilbert's syndrome: decreased TATA-binding protein binding affinity of UGT1A1 gene promoter

scientific article published on April 2007

Multiple type A/B heterogeneous nuclear ribonucleoproteins (hnRNPs) can replace hnRNP A1 in mouse hepatitis virus RNA synthesis

scientific article published on October 2003

Murine Retroviral Pseudotype Virus Containing Hepatitis B Virus Large and Small Surface Antigens Confers Specific Tropism for Primary Human Hepatocytes: a Potential Liver-Specific Targeting System ⬇️

scientific article published on January 1, 2002

Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release

scientific article

Mutagenic and inhibitory effects of ribavirin on hepatitis C virus RNA polymerase

scientific article published in September 2003

Nonstructural 5A protein of hepatitis C virus modulates tumor necrosis factor alpha-stimulated nuclear factor kappa B activation

scientific article

Nonstructural protein 5A is incorporated into hepatitis C virus low-density particle through interaction with core protein and microtubules during intracellular transport

scientific article

Palmitoylation and Polymerization of Hepatitis C Virus NS4B Protein

scientific article (publication date: June 2006)

Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A

scientific article

Polo-like-kinase 1: A key cellular target for anti-HBV therapy?

scientific article published on 27 July 2017

Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5′ Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome ⬇️

scientific article published on June 1, 2011

Polypyrimidine-tract-binding protein affects transcription but not translation of mouse hepatitis virus RNA.

scientific article published on November 2002

Polypyrimidine-tract-binding protein is a component of the HCV RNA replication complex and necessary for RNA synthesis

scientific article published on 12 May 2006

Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entry

scientific article published on 07 October 2013

Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2), a Host Membrane-Deforming Protein, Is Critical for Membranous Web Formation in Hepatitis C Virus Replication ⬇️

scientific article published on November 30, 2011

Quantitative RT-PCR Analysis of Influenza Virus Endocytic Escape

scientific article published on 01 January 2018

RNA replication without RNA-dependent RNA polymerase: surprises from hepatitis delta virus

scientific article

RNA-templated replication of hepatitis delta virus: genomic and antigenomic RNAs associate with different nuclear bodies

scientific article

Rab5 and class III phosphoinositide 3-kinase Vps34 are involved in hepatitis C virus NS4B-induced autophagy.

scientific article

Reactive oxygen species suppress hepatitis C virus RNA replication in human hepatoma cells

scientific article published on January 2004

Redox modulation of the hepatitis C virus replication complex is calcium dependent

scientific article published on 12 August 2006

Rolling circle replication of hepatitis delta virus RNA is carried out by two different cellular RNA polymerases

scientific article

SARS virus: the beginning of the unraveling of a new coronavirus

scientific article published on November 2003

SUMO Modification Stabilizes Dengue Virus Nonstructural Protein 5 To Support Virus Replication

scientific article published on 17 February 2016

SYNCRIP (synaptotagmin-binding, cytoplasmic RNA-interacting protein) is a host factor involved in hepatitis C virus RNA replication

scientific article

SYNCRIP, a member of the heterogeneous nuclear ribonucleoprotein family, is involved in mouse hepatitis virus RNA synthesis

scientific article

The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6.

scientific article published on 21 March 2009

The C-terminal transmembrane domain of hepatitis C virus (HCV) RNA polymerase is essential for HCV replication in vivo

scientific article published on April 2004

The hepatitis C virus persistence: how to evade the immune system? ⬇️

scientific article published on April 1, 2003

The ubiquitin-proteasome system facilitates the transfer of murine coronavirus from endosome to cytoplasm during virus entry

scientific article published on January 2005

Transcription of subgenomic mRNA of hepatitis delta virus requires a modified hepatitis delta antigen that is distinct from antigenomic RNA synthesis

scientific article published on 23 July 2008

Transient activation of the PI3K-AKT pathway by hepatitis C virus to enhance viral entry

scientific article

Treatment of HCV-related mantle-cell lymphoma with ribavirin and pegylated interferon Alfa

scientific article published in November 2003

Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication

scientific article

Ubiquitination of the Cytoplasmic Domain of Influenza A Virus M2 Protein is Crucial for Production of Infectious Virus Particles

scientific article published on 22 November 2017

Using an Old Drug to Target a New Drug Site: Application of Disulfiram to Target the Zn-Site in HCV NS5A Protein.

scientific article

Virus detection and its association with symptoms during influenza-like illness in a sample of healthy adults enrolled in a randomised controlled vaccine trial ⬇️

scientific article published on 19 June 2012

Zinc Finger-Containing Cellular Transcription Corepressor ZBTB25 Promotes Influenza Virus RNA Transcription and Is a Target for Zinc Ejector Drugs

scientific article published on 2 August 2017

[Hepatitis C virus replication associated with lipid rafts]

scientific article published on 01 April 2006

c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair.

scientific article

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