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List of works by Li-Huei Tsai

14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome

scientific article (publication date: July 2003)

3D mapping reveals network-specific amyloid progression and subcortical susceptibility in mice

scientific article published on 04 October 2019

A Developmental Switch in Microglial HDAC Function

scientific article published on 01 March 2018

A Jekyll and Hyde kinase: roles for Cdk5 in brain development and disease

scientific article published on June 2004

A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations.

scientific article published on 11 April 2018

A NUDEL-dependent mechanism of neurofilament assembly regulates the integrity of CNS neurons

scientific journal article

A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration

scientific article published on May 2013

A high-throughput screen for Wnt/β-catenin signaling pathway modulators in human iPSC-derived neural progenitors

scientific article

A hippocampal Cdk5 pathway regulates extinction of contextual fear

scientific article

A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory.

scientific article published on 21 December 2016

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

scientific article

A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains

scientific article

A tool for mapping microglial morphology, morphOMICs, reveals brain-region and sex-dependent phenotypes

scientific article published in 2022

ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects

scientific article published on 10 February 2014

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types

scientific article published on 01 June 2018

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

scientific article

APP processing is regulated by cytoplasmic phosphorylation ⬇️

scientific article published on October 13, 2003

ASPM regulates Wnt signaling pathway activity in the developing brain

scientific journal article

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

scientific article

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

scientific article

Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment

scientific journal article

Addendum: The schizophrenia risk gene product miR-137 alters presynaptic plasticity

article

Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity

scientific article published on May 2009

Alzheimer's disease: A protective factor for the ageing brain

scientific article published on 19 March 2014

Amyloid-independent mechanisms in Alzheimer's disease pathogenesis

scientific article

An epigenetic blockade of cognitive functions in the neurodegenerating brain

scientific article

Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia

scientific article published in Nature

Author Correction: Single-cell transcriptomic analysis of Alzheimer's disease

scientific article published on 01 July 2019

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex

scientific article

Axon selection: From a polarized cytoplasm to a migrating neuron

scientific article published on May 2011

BACE1 Suppression by RNA Interference in Primary Cortical Neurons ⬇️

scientific article published on November 3, 2003

Basolateral amygdala bidirectionally modulates stress-induced hippocampal learning and memory deficits through a p25/Cdk5-dependent pathway

scientific article published on 20 May 2015

Bridging physiology and pathology in AD.

scientific article published on June 2009

Calpain-mediated Cleavage of the Cyclin-dependent Kinase-5 Activator p39 to p29 ⬇️

scientific article (publication date: 8 March 2002)

Capzb2 interacts with beta-tubulin to regulate growth cone morphology and neurite outgrowth

scientific article

Cdk5 behind the wheel: a role in trafficking and transport?

scientific article

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

scientific article published in September 2004

Cdk5 is a New Rapid Synaptic Homeostasis Regulator Capable of Initiating the Early Alzheimer-Like Pathology

scientific article

Cdk5 is a dynamo at the synapse

scientific article published on 01 August 2003

Cdk5 is required for memory function and hippocampal plasticity via the cAMP signaling pathway.

scientific article published on 30 September 2011

Cdk5 phosphorylation of FAK regulates centrosome-associated miocrotubules and neuronal migration.

scientific article published on February 2004

Cdk5 phosphorylation of doublecortin ser297 regulates its effect on neuronal migration

scientific article published in January 2004

Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK

scientific journal article

Cdk5 selectively affects the migration of different populations of neurons in the developing spinal cord

scientific article

Cdk5 sinks into ALS.

scientific article

Cdk5, a therapeutic target for Alzheimer's disease?

scientific article published on March 2004

Cdk5: One of the links between senile plaques and neurofibrillary tangles? ⬇️

scientific article published on April 1, 2003

Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex

scientific journal article

Centrosome Motility Is Essential for Initial Axon Formation in the Neocortex ⬇️

scientific article published on August 4, 2010

Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool.

scientific article

Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

scientific article

Chromatin regulation of DNA damage repair and genome integrity in the central nervous system

scientific article

Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice.

scientific article

Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory

scientific article published on 22 June 2018

Cognitive Function in Health and Disease: The Role of Epigenetic Mechanisms ⬇️

scientific article published on January 1, 2012

Cognitive enhancement: A molecular memory booster

scientific article published in January 2011

Colocalization and fluorescence resonance energy transfer between cdk5 and AT8 suggests a close association in pre-neurofibrillary tangles and neurofibrillary tangles

scientific article

Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development

scientific article

Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease

scientific article

Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt

scientific article

Control of activating transcription factor 4 (ATF4) persistence by multisite phosphorylation impacts cell cycle progression and neurogenesis.

scientific article

Control of cortical neuron migration and layering: cell and non cell-autonomous effects of p35.

scientific article

Cortical neurons gradually attain a post-mitotic state.

scientific article published on 21 June 2016

Coupling PAF Signaling to Dynein Regulation

Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase

scientific article

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

scientific article

Cyclin-Dependent Kinases in Brain Development and Disease ⬇️

scientific article published on 05 July 2011

Cyclin-dependent kinase 5 and neuronal migration in the neocortex

scientific article published on September 2003

Cyclin-dependent kinase 5 permits efficient cytoskeletal remodeling--a hypothesis on neuronal migration

scientific article published on July 2006

Cyclin-dependent kinase 5 phosphorylates serine 31 of tyrosine hydroxylase and regulates its stability

scientific journal article

Cyclin-dependent kinase 5 phosphorylates the N-terminal domain of the postsynaptic density protein PSD-95 in neurons.

scientific article published in January 2004

Cyclin-dependent kinases: a family portrait.

scientific article

DNA damage and its links to neurodegeneration

scientific article published on July 2014

DNA methylation in cognition comes of age ⬇️

scientific article published on July 26, 2012

Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity

scientific article

Diaminothiazoles Modify Tau Phosphorylation and Improve the Tauopathy in Mouse Models* ⬇️

scientific article published on 04 June 2013

Disabled-1-regulated adhesion of migrating neurons to radial glial fiber contributes to neuronal positioning during early corticogenesis

scientific journal article

Disc1 regulates both β‐catenin‐mediated and noncanonical Wnt signaling during vertebrate embryogenesis ⬇️

scientific article published on August 22, 2011

Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling

scientific article

Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation

scientific article published on 11 January 2016

Dixdc1 is a critical regulator of DISC1 and embryonic cortical development ⬇️

scientific journal article

Doublecortin-like kinase controls neurogenesis by regulating mitotic spindles and M phase progression

scientific article published in January 2006

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

scientific article

Early remodeling of the neocortex upon episodic memory encoding.

scientific article

Editorial. Molecular and Cellular Cognition Society (MCCS) meetings

scientific article published on 22 October 2014

Efficient derivation of microglia-like cells from human pluripotent stem cells

scientific article published on 26 September 2016

Elimination of senescent cells prevents neurodegeneration in mice

scientific article published in Nature

Elimination of senescent cells prevents neurodegeneration in mice

article published in 2018

Epigenetic Regulation of Gene Expression in Physiological and Pathological Brain Processes ⬇️

scientific article published on April 1, 2011

Epigenetic modifications in the nervous system and their impact upon cognitive impairments

scientific article

Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.

scientific article

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.

scientific article published on 17 December 2018

Examining the Role of HDACs in DNA Double-Strand Break Repair in Neurons

scientific article published on 01 January 2019

Exifone Is a Potent HDAC1 Activator with Neuroprotective Activity in Human Neuronal Models of Neurodegeneration

scientific article published on 08 January 2021

Forebrain-specific deletion of Cdk5 in pyramidal neurons results in mania-like behavior and cognitive impairment ⬇️

scientific article published on July 11, 2013

Functional dissection of Alzheimer's disease brain gene expression signatures in humans and mouse models

article

Functional integration of dopaminergic neurons directly converted from mouse fibroblasts

scientific article published on 20 October 2011

G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitors

scientific article published on July 2005

GC Box-binding Transcription Factors Control the Neuronal Specific Transcription of the Cyclin-dependent Kinase 5 Regulator p35 ⬇️

scientific article published on November 27, 2001

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

scientific article published on 07 May 2019

Gamma Entrainment: Impact on Neurocircuits, Glia, and Therapeutic Opportunities

scientific article published on 10 December 2019

Gamma frequency entrainment attenuates amyloid load and modifies microglia

scientific article published on December 2016

Glutamate Receptors in Alzheimer's Disease: Mechanisms and Therapies

scientific article published on 16 May 2016

Guiding neuronal cell migrations

scientific article published on February 2010

HDAC1 modulates OGG1-initiated oxidative DNA damage repair in the aging brain and Alzheimer's disease

scientific article published on 18 May 2020

HDAC2 expression in parvalbumin interneurons regulates synaptic plasticity in the mouse visual cortex

scientific article

HDAC2 negatively regulates memory formation and synaptic plasticity.

scientific article

Histone acetylation: molecular mnemonics on the chromatin.

scientific article

Histone deacetylase 3 associates with MeCP2 to regulate FOXO and social behavior.

scientific article published on 18 July 2016

Histone deacetylases in memory and cognition

scientific article published on 09 December 2014

Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis

scientific article

How MicroRNAs Are Involved in Splitting the Mind

scientific article published on 9 March 2016

Human induced pluripotent stem cells: now open to discovery

scientific article published in July 2014

Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein

scientific article published on 30 November 2020

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

scientific article

In the loop: how chromatin topology links genome structure to function in mechanisms underlying learning and memory

scientific article published on 23 December 2016

Inhibition of p25/Cdk5 Attenuates Tauopathy in Mouse and iPSC Models of Frontotemporal Dementia

scientific article

Interaction of FUS and HDAC1 regulates DNA damage response and repair in neurons.

scientific article published on 15 September 2013

JAKMIP1: Translating the Message for Social Behavior

scientific article published in December 2015

Layering defect in p35 deficiency is linked to improper neuronal-glial interaction in radial migration

scientific article published on 09 November 2003

Li-Huei Tsai: I well remember. Interview by Caitlin Sedwick

scientific article published on December 2012

Life is a journey: a genetic look at neocortical development

scientific article

Linking cell cycle reentry and DNA damage in neurodegeneration

scientific article published in July 2009

Loss of Protein Arginine Methyltransferase 8 Alters Synapse Composition and Function, Resulting in Behavioral Defects

scientific article

Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment

scientific article

Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons.

scientific article

Mapping the epigenomic and transcriptomic interplay during memory formation and recall in the hippocampal engram ensemble

scientific article published on 05 October 2020

Mechanism of CDK5/p25 binding by CDK inhibitors

scientific article

Mechanisms of age-related cognitive change and targets for intervention: epigenetics.

scientific article

Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

scientific article published on 01 July 2020

MethyLock: DNA Demethylation Is the Epigenetic Key to Axon Regeneration

scientific article published in April 2017

MicroRNAs in learning, memory, and neurological diseases: Figure 1 ⬇️

scientific article published on August 16, 2012

MicroTUB(B3)ules and brain development

scientific article published in January 2010

Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells

scientific article

Modeling Alzheimer's disease with iPSC-derived brain cells

scientific article published on 07 August 2019

Molecular biology: Local metabolites linked to memory

scientific article published on 31 May 2017

Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition

scientific article published on 14 March 2019

Ndel1 controls the dynein-mediated transport of vimentin during neurite outgrowth

scientific article published on 26 February 2008

Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning

scientific article published on 01 October 2004

Negative regulation of Vps34 by Cdk mediated phosphorylation

scientific article

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

scientific article

Neuronal differentiation: 5-HT6R can do it alone

scientific article published in July 2014

Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1

scientific journal article

Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load

scientific article published on 01 August 2018

Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

scientific article (publication date: June 2017)

Nucleokinesis illuminated

scientific article

Nucleokinesis in neuronal migration

scientific article

On the resilience of remote traumatic memories against exposure therapy-mediated attenuation.

scientific article

Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory

scientific article published in December 2005

PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4

scientific article published on 01 October 2020

Par-4 links dopamine signaling and depression

scientific article published in July 2005

Partial rescue of the p35-/- brain phenotype by low expression of a neuronal-specific enolase p25 transgene.

scientific article published in April 2003

Phosphoproteomic analysis with a solid-phase capture-release-tag approach

scientific article published in July 2005

Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration

scientific article published on 01 December 2020

Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5.

scientific article

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity ⬇️

scientific article published on April 27, 2011

Profiling DNA break sites and transcriptional changes in response to contextual fear learning

scientific article published on 01 July 2021

Putting a notch in our understanding of nuclear migration

scientific article published in September 2008

Pyramidal neuron polarity axis is defined at the bipolar stage

scientific article

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease

article

Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected].

scientific article published in April 2013

Reconstruction of the human blood-brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

scientific article published on 08 June 2020

Reelin Improves Cognition and Extends the Lifespan of Mutant Ndel1 Mice with Postnatal CA1 Hippocampus Deterioration

scientific article published on 24 April 2020

Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.

scientific article

Regulation of N-type Voltage-Gated Calcium Channels and Presynaptic Function by Cyclin-Dependent Kinase 5 ⬇️

scientific article published on August 23, 2012

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration

scientific article (publication date: 12 April 2016)

S-nitrosylation of E3 ubiquitin-protein ligase RNF213 alters non-canonical Wnt/Ca+2 signaling in the P301S mouse model of tauopathy

scientific article published on 29 January 2019

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

scientific article published on 14 July 2013

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

scientific journal article

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer's Disease Phenotypes

scientific article

Serine 732 phosphorylation of FAK by Cdk5 is important for microtubule organization, nuclear movement, and neuronal migration

scientific journal article

Single-cell dissection of the human brain vasculature

scientific article

Single-cell transcriptomic analysis of Alzheimer's disease

scientific article published on 01 May 2019

Spindle regulation in neural precursors of flies and mammals

scientific article published on 17 January 2007

Striatal dysregulation of Cdk5 alters locomotor responses to cocaine, motor learning, and dendritic morphology

journal article published in 2008

Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-secretase (BACE1)

scientific article published on November 2011

TFP5, a Peptide Inhibitor of Aberrant and Hyperactive Cdk5/p25, Attenuates Pathological Phenotypes and Restores Synaptic Function in CK-p25Tg Mice

scientific article

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.

scientific article

Targeting p35/Cdk5 signalling via CIP-peptide promotes angiogenesis in hypoxia

scientific article

Targeting the correct HDAC(s) to treat cognitive disorders

scientific article published on October 25, 2010

Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

scientific article published on October 2017

Tet1 is critical for neuronal activity-regulated gene expression and memory extinction

scientific article

The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System

scientific article

The Top3β way to untangle RNA.

scientific article published in September 2013

The Transcription Factor Sp3 Cooperates with HDAC2 to Regulate Synaptic Function and Plasticity in Neurons

scientific article published in August 2017

The complexity of neuroinflammation at single-cell resolution

scientific article published on 01 May 2019

The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner

scientific article

The hippocampus grows up.

scientific article

The intracellular domain of CX3CL1 regulates adult neurogenesis and Alzheimer's amyloid pathology

scientific article published on 17 June 2019

The potential of HDAC inhibitors as cognitive enhancers.

scientific article published on January 2013

The road to restoring neural circuits for the treatment of Alzheimer's disease

scientific article published on 9 November 2016

The role of Cdk5 in neuroendocrine thyroid cancer

scientific article

The schizophrenia risk gene product miR-137 alters presynaptic plasticity.

scientific article

Transient enhancement of proliferation of neural progenitors and impairment of their long-term survival in p25 transgenic mice.

scientific article published on 06 June 2016

Trekking across the brain: the journey of neuronal migration

scientific article published on January 2007

Unraveling the Paradox of Statins with Human Neurons: New Leads in Alzheimer's Disease

scientific article published on 01 March 2019

What is memory? The present state of the engram.

scientific article

[Using reprogramming techniques of human somatic cells to understand genetic risk variations associated with psychiatric disorders]

scientific article published in December 2013

p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

scientific article

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