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List of works by Mariola Fotin-Mleczek

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A CD14 domain with lipopolysaccharide-binding and -neutralizing activity

scientific article published on February 2006

A Comprehensive Model for the Cellular Uptake of Cationic Cell-penetrating Peptides

article

A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects

scientific article published on 11 January 2017

A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile

scientific article published on 8 January 2015

A novel, disruptive vaccination technology: self-adjuvanted RNActive(®) vaccines

scientific article published on 04 June 2013

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

scientific article published on 15 February 2019

A randomized, double-blind, placebo-controlled, Phase I/II trial of RNActive®-vaccine cv9104 in patients with metastatic castrate-refractory prostate cancer (mcrpc): first results of the Phase I part

scientific article published on 6 November 2014

A stepwise dissection of the intracellular fate of cationic cell-penetrating peptides

scientific article published on 5 January 2004

A targeted protease substrate for a quantitative determination of protease activities in the endolysosomal pathway

scientific article

Abscopal effects of radiotherapy and combined mRNA-based immunotherapy in a syngeneic, OVA-expressing thymoma mouse model.

scientific article published on 16 January 2018

Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response

scientific article

Apoptotic crosstalk of TNF receptors: TNF-R2-induces depletion of TRAF2 and IAP proteins and accelerates TNF-R1-dependent activation of caspase-8

scientific article published on 01 July 2002

Break on through to the other side-biophysics and cell biology shed light on cell-penetrating peptides

scientific article

Caspase-mediated cleavage converts the tumor necrosis factor (TNF) receptor-associated factor (TRAF)-1 from a selective modulator of TNF receptor signaling to a general inhibitor of NF-kappaB activation

scientific article published on 22 April 2003

Cationic cell-penetrating peptides interfere with TNF signalling by induction of TNF receptor internalization

scientific article

Detection of protein-protein interactions using a green fluorescent protein-based mammalian two-hybrid system

scientific article published on July 2000

Developing mRNA-vaccine technologies

scientific article published on 12 October 2012

Distinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy

scientific article

Endocytosis and cationic cell-penetrating peptides--a merger of concepts and methods

scientific article

Endogenous membrane tumor necrosis factor (TNF) is a potent amplifier of TNF receptor 1-mediated apoptosis

scientific article published on 8 July 2002

Highly potent mRNA based cancer vaccines represent an attractive platform for combination therapies supporting an improved therapeutic effect ⬇️

scientific article published on June 1, 2012

Messenger RNA-based vaccines with dual activity induce balanced TLR-7 dependent adaptive immune responses and provide antitumor activity

scientific article published in January 2011

No RISC, no fun: assembly of receptor-induced signalling complexes in the tumor necrosis factor system.

scientific article published on September 2000

Phase Ib evaluation of a self-adjuvanted protamine formulated mRNA-based active cancer immunotherapy, BI1361849 (CV9202), combined with local radiation treatment in patients with stage IV non-small cell lung cancer

scholarly article by Alexandros Papachristofilou et al published 8 February 2019 in Journal for Immunotherapy of Cancer

Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer

scientific article

Protein expression from exogenous mRNA: uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway.

scientific article

RNA-based adjuvant CV8102 enhances the immunogenicity of a licensed rabies vaccine in a first-in-human trial

scientific article published on 21 February 2019

RNAdjuvant®, a novel, highly-potent RNA-based adjuvant, combines strong immunostimulatory capacities with a favorable safety profile

scientific article published on 4 November 2015

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

scientific article published on 25 July 2017

Self-adjuvanted RNActive® vaccine induces local immune responses at the injection site leading to potent adaptive immunity in mice and humans

article

Self-adjuvanted RNActive® vaccines provide a promising platform for combination therapies with checkpoint inhibitors.

scientific article published on 6 November 2014

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

scientific article published on 16 June 2015

Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity

scientific article

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

scientific article published on 8 June 2015

Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation

scientific article published on 13 October 2003

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

scientific article published on 19 October 2017

mRNA mediates passive vaccination against infectious agents, toxins, and tumors.

scientific article published on 9 August 2017

mRNA-based vaccines synergize with radiation therapy to eradicate established tumors

scientific article published on 15 August 2014

mRNA: A Novel Avenue to Antibody Therapy?

scientific article published on 06 March 2019

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