List of works - Thomas Desaive

3D kernel-density stochastic model for more personalized glycaemic control: development and in-silico validation

scientific article published on 22 October 2019

A graphical method for practical and informative identifiability analyses of physiological models: a case study of insulin kinetics and sensitivity.

scientific article

A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship

scientific article

A patient-specific airway branching model for mechanically ventilated patients

scientific article

Accurate end systole detection in dicrotic notch-less arterial pressure waveforms

scientific article published on 11 February 2020

Algorithmic processing of pressure waveforms to facilitate estimation of cardiac elastance

scientific article published on 15 June 2012

Alteration of right ventricular-pulmonary vascular coupling in a porcine model of progressive pressure overloading

scientific article published on 01 February 2008

An Assessment of the relationship between dicrotic notch timing and cardiac preload.

scientific article published on August 2015

Analysis of different model-based approaches for estimating dFRC for real-time application

scientific article published on 31 January 2013

Arterial dP/dtmax accurately reflects left ventricular contractility during shock when adequate vascular filling is achieved ⬇️

scientific article published on March 1, 2012

Assessing mechanical ventilation asynchrony through iterative airway pressure reconstruction

scientific article published on 03 February 2018

Assessing respiratory mechanics using pressure reconstruction method in mechanically ventilated spontaneous breathing patient

scientific article

Assessment of ventricular contractility and ventricular-arterial coupling with a model-based sensor.

scientific article published on 2 February 2012

Beat-by-Beat Estimation of the Left Ventricular Pressure-Volume Loop Under Clinical Conditions.

scientific article published on 25 October 2017

Beat-to-beat estimation of the continuous left and right cardiac elastance from metrics commonly available in clinical settings

scientific article published on 21 September 2012

Blood Glucose Levels of Subelite Athletes During 6 Days of Free Living

scientific article published on 14 June 2016

Blood pressure waveform contour analysis for assessing peripheral resistance changes in sepsis

scholarly article by Shaun Davidson et al published 20 November 2018 in BioMedical Engineering OnLine

Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion

scientific article published on 12 October 2006

Clinical detection and monitoring of acute pulmonary embolism: proof of concept of a computer-based method ⬇️

scientific article published on August 11, 2011

Clinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults

scientific article

Clinically applicable model-based method, for physiologically accurate flow waveform and stroke volume estimation

scientific article published on 08 October 2019

Continuous glucose control in the ICU: report of a 2013 round table meeting

scientific article

Continuous glucose monitoring in the ICU: clinical considerations and consensus.

scientific article published on 31 July 2017

Continuous stroke volume estimation from aortic pressure using zero dimensional cardiovascular model: proof of concept study from porcine experiments

scientific article

Data Entry Errors and Design for Model-Based Tight Glycemic Control in Critical Care ⬇️

scientific article published on January 1, 2012

Does the achievement of an intermediate glycemic target reduce organ failure and mortality? A post hoc analysis of the Glucontrol trial

scientific article

Early detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model

scientific article

Editorial

scholarly article by Geoff Chase et al published January 2017 in Control Engineering Practice

Effective arterial elastance as an index of pulmonary vascular load

scientific article published on 18 April 2008

Effects of Neurally Adjusted Ventilatory Assist (NAVA) levels in non-invasive ventilated patients: titrating NAVA levels with electric diaphragmatic activity and tidal volume matching

scientific article published on 02 July 2013

Evaluation of a model-based hemodynamic monitoring method in a porcine study of septic shock.

scientific article published on 25 March 2013

Evolution of insulin sensitivity and its variability in out-of-hospital cardiac arrest (OHCA) patients treated with hypothermia

scientific article

Expiratory model-based method to monitor ARDS disease state.

scientific article published on 26 June 2013

Extracorporeal CO2 removal and regional citrate anticoagulation in an experimental model of hypercapnic acidosis

scientific article published on 26 February 2019

Feasibility of titrating PEEP to minimum elastance for mechanically ventilated patients

scientific article

First pilot trial of the STAR-Liege protocol for tight glycemic control in critically ill patients

scientific article published on 31 August 2011

Generalisability of a Virtual Trials Method for Glycaemic Control in Intensive Care

scientific article published on 24 March 2017

Glucose Control in the ICU: A Continuing Story

scientific article published on 10 May 2016

Glucose control positively influences patient outcome: A retrospective study

scientific article published on 31 December 2014

Impact of sensor and measurement timing errors on model-based insulin sensitivity

article

Improved pressure contour analysis for estimating cardiac stroke volume using pulse wave velocity measurement.

scientific article published on 24 April 2017

Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas

In-parallel Ventilator Sharing During an Acute Shortage: Too Much Risk for a Wider Uptake

scientific article published on 03 August 2020

Incorporating pulse wave velocity into model-based pulse contour analysis method for estimation of cardiac stroke volume

scientific article published on 26 May 2020

Insulin Sensitivity, Its Variability and Glycemic Outcome: A model-based analysis of the difficulty in achieving tight glycemic control in critical care

Interface Design and Human Factors Considerations for Model-Based Tight Glycemic Control in Critical Care ⬇️

scientific article published on January 1, 2012

Interstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance

scientific article published on 30 January 2014

Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs

scientific article published on 01 July 2006

Letter to the Editor in response to "COVID-19: desperate times call for desperate measures"

scientific article published on 10 July 2020

Mathematical modeling of extracorporeal CO2 removal therapy : A validation carried out on ten pigs.

scientific article published on 09 August 2017

Mathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency

scientific article published on 24 September 2011

Measuring lung mechanics of expiratory tidal breathing with non-invasive breath occlusion

scientific article published on 14 May 2020

Minimally invasive estimation of ventricular dead space volume through use of Frank-Starling curves

scientific article

Minimally invasive, patient specific, beat-by-beat estimation of left ventricular time varying elastance

scientific article

Model-Based Prediction of the Patient-Specific Response to Adrenaline ⬇️

scientific article published on July 29, 2010

Model-Based Weaning Tests for VA-ECLS Therapy

scientific article published on 06 April 2020

Model-based PEEP optimisation in mechanical ventilation

scientific article published on 23 December 2011

Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial

scientific article published on 01 February 2020

Model-based computation of total stressed blood volume from a preload reduction manoeuvre

scientific article published on 10 April 2015

Model-based optimal PEEP in mechanically ventilated ARDS patients in the intensive care unit

scientific article

Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects.

scientific article published in January 2013

Modelling in anaesthesia and intensive care: a special section including papers from IFAC's 8. Symposium on Medical and Biological Systems in Budapest 2012.

scientific article published in December 2014

Modelling of the nonlinear end-systolic pressure-volume relation and volume-at-zero-pressure in porcine experiments

scientific article published on August 2015

Modelling the cardiovascular system

scientific article published on September 2007

Multi-input stochastic prediction of insulin sensitivity for tight glycaemic control using insulin sensitivity and blood glucose data

scientific article published on 21 August 2019

NAVA enhances tidal volume and diaphragmatic electro-myographic activity matching: a Range90 analysis of supply and demand.

scientific article published on 27 September 2012

Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to validation them.

scientific article published on 20 February 2018

Organ failure and tight glycemic control in the SPRINT study.

scientific article

Parameter estimation in a minimal model of cardio-pulmonary interactions

scientific article published on 23 May 2019

Patient-Specific Monitoring and Trend Analysis of Model-Based Markers of Fluid Responsiveness in Sepsis: A Proof-of-Concept Animal Study

scientific article published on 25 November 2019

Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice? ⬇️

scientific article published on May 5, 2011

Physiological relevance and performance of a minimal lung model: an experimental study in healthy and acute respiratory distress syndrome model piglets.

scientific article

Physiological trend analysis of a novel cardio-pulmonary model during a preload reduction manoeuvre

scientific article published on 17 April 2022

Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control

scientific article

Practical identifiability analysis of a minimal cardiovascular system model

scientific article

Pre-ejection period, the reason why the electrocardiogram Q-wave is an unreliable indicator of pulse wave initialization

scientific article published on 24 September 2018

Preface

Preload & Frank-Starling curves, from textbook to bedside: Clinically applicable non-additionally invasive model-based estimation in pigs

scientific article published in 2021

Re: Chung et al.'s Letter to the Editor in response to: Early detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model. Med Eng Phys 2014;36(September (9)):1101-5 by Morimont et al.

scientific article published on 29 May 2015

Reducing the impact of insulin sensitivity variability on glycaemic outcomes using separate stochastic models within the STAR glycaemic protocol

scientific article

Risk and reward: extending stochastic glycaemic control intervals to reduce workload

scientific article published on 29 April 2020

STAR development and protocol comparison.

scientific article published on 23 August 2012

STAR-Liège Clinical Trial Interim Results: Safe and Effective Glycemic Control for All

scientific article published on 01 July 2019

Safe doubling of ventilator capacity: a last resort proposal for last resorts

scientific article published on 14 May 2020

Second pilot trials of the STAR-Liege protocol for tight glycemic control in critically ill patients

scientific article

Simulation of left atrial function using a multi-scale model of the cardiovascular system

scientific article

State Analysis of Total Stressed Blood Volume and Arterial Elastance During Induced Sepsis

scientific article published on 01 July 2019

Stochastic integrated model-based protocol for volume-controlled ventilation setting

scientific article published on 11 February 2022

Stochastic targeted (STAR) glycemic control: design, safety, and performance

scientific article published in January 2012

Structural identifiability analysis of a cardiovascular system model

scientific article published on 9 March 2016

Study of ventricular interaction during pulmonary embolism using clinical identification in a minimum cardiovascular system model

scientific article published on 01 January 2007

Subject-specific cardiovascular system model-based identification and diagnosis of septic shock with a minimally invasive data set: animal experiments and proof of concept.

scientific article

The Clinical Utilisation of Respiratory Elastance Software (CURE Soft): a bedside software for real-time respiratory mechanics monitoring and mechanical ventilation management

scientific article

Tight glycemic control in critical care--the leading role of insulin sensitivity and patient variability: a review and model-based analysis.

scientific article published on 09 December 2010

Time-varying respiratory system elastance: a physiological model for patients who are spontaneously breathing

scientific article published on 22 January 2015

Tube-load model: A clinically applicable pulse contour analysis method for estimation of cardiac stroke volume

scientific article published on 26 March 2021

Untangling glycaemia and mortality in critical care

scientific article

Validation of a model-based virtual trials method for tight glycemic control in intensive care.

scientific article published on 14 December 2010

Validation of subject-specific cardiovascular system models from porcine measurements.

scientific article

Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control

scientific article published on 15 June 2012

Virtual patients for mechanical ventilation in the intensive care unit

scientific article published on 22 December 2020

Visualisation of time-varying respiratory system elastance in experimental ARDS animal models

scientific article

What makes tight glycemic control tight? The impact of variability and nutrition in two clinical studies

scientific article

When the value of gold is zero.

scientific article

List of works by Thomas Desaive

3D kernel-density stochastic model for more personalized glycaemic control: development and in-silico validation

A graphical method for practical and informative identifiability analyses of physiological models: a case study of insulin kinetics and sensitivity.

A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship

A patient-specific airway branching model for mechanically ventilated patients

Accurate end systole detection in dicrotic notch-less arterial pressure waveforms

Algorithmic processing of pressure waveforms to facilitate estimation of cardiac elastance

Alteration of right ventricular-pulmonary vascular coupling in a porcine model of progressive pressure overloading

An Assessment of the relationship between dicrotic notch timing and cardiac preload.

Analysis of different model-based approaches for estimating dFRC for real-time application

Arterial dP/dtmax accurately reflects left ventricular contractility during shock when adequate vascular filling is achieved ⬇️

Assessing mechanical ventilation asynchrony through iterative airway pressure reconstruction

Assessing respiratory mechanics using pressure reconstruction method in mechanically ventilated spontaneous breathing patient

Assessment of ventricular contractility and ventricular-arterial coupling with a model-based sensor.

Beat-by-Beat Estimation of the Left Ventricular Pressure-Volume Loop Under Clinical Conditions.

Beat-to-beat estimation of the continuous left and right cardiac elastance from metrics commonly available in clinical settings

Blood Glucose Levels of Subelite Athletes During 6 Days of Free Living

Blood pressure waveform contour analysis for assessing peripheral resistance changes in sepsis

Cardiovascular haemodynamics and ventriculo-arterial coupling in an acute pig model of coronary ischaemia-reperfusion

Clinical detection and monitoring of acute pulmonary embolism: proof of concept of a computer-based method ⬇️

Clinical review: Consensus recommendations on measurement of blood glucose and reporting glycemic control in critically ill adults

Clinically applicable model-based method, for physiologically accurate flow waveform and stroke volume estimation

Continuous glucose control in the ICU: report of a 2013 round table meeting

Continuous glucose monitoring in the ICU: clinical considerations and consensus.

Continuous stroke volume estimation from aortic pressure using zero dimensional cardiovascular model: proof of concept study from porcine experiments

Data Entry Errors and Design for Model-Based Tight Glycemic Control in Critical Care ⬇️

Does the achievement of an intermediate glycemic target reduce organ failure and mortality? A post hoc analysis of the Glucontrol trial

Early detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model

Editorial

Effective arterial elastance as an index of pulmonary vascular load

Effects of Neurally Adjusted Ventilatory Assist (NAVA) levels in non-invasive ventilated patients: titrating NAVA levels with electric diaphragmatic activity and tidal volume matching

Evaluation of a model-based hemodynamic monitoring method in a porcine study of septic shock.

Evolution of insulin sensitivity and its variability in out-of-hospital cardiac arrest (OHCA) patients treated with hypothermia

Expiratory model-based method to monitor ARDS disease state.

Extracorporeal CO2 removal and regional citrate anticoagulation in an experimental model of hypercapnic acidosis

Feasibility of titrating PEEP to minimum elastance for mechanically ventilated patients

First pilot trial of the STAR-Liege protocol for tight glycemic control in critically ill patients

Generalisability of a Virtual Trials Method for Glycaemic Control in Intensive Care

Glucose Control in the ICU: A Continuing Story

Glucose control positively influences patient outcome: A retrospective study

Impact of sensor and measurement timing errors on model-based insulin sensitivity

Improved pressure contour analysis for estimating cardiac stroke volume using pulse wave velocity measurement.

Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas

In-parallel Ventilator Sharing During an Acute Shortage: Too Much Risk for a Wider Uptake

Incorporating pulse wave velocity into model-based pulse contour analysis method for estimation of cardiac stroke volume

Insulin Sensitivity, Its Variability and Glycemic Outcome: A model-based analysis of the difficulty in achieving tight glycemic control in critical care

Interface Design and Human Factors Considerations for Model-Based Tight Glycemic Control in Critical Care ⬇️

Interstitial insulin kinetic parameters for a 2-compartment insulin model with saturable clearance

Large-pore membrane hemofiltration increases cytokine clearance and improves right ventricular-vascular coupling during endotoxic shock in pigs

Letter to the Editor in response to "COVID-19: desperate times call for desperate measures"

Mathematical modeling of extracorporeal CO2 removal therapy : A validation carried out on ten pigs.

Mathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency

Measuring lung mechanics of expiratory tidal breathing with non-invasive breath occlusion

Minimally invasive estimation of ventricular dead space volume through use of Frank-Starling curves

Minimally invasive, patient specific, beat-by-beat estimation of left ventricular time varying elastance

Model-Based Prediction of the Patient-Specific Response to Adrenaline ⬇️

Model-Based Weaning Tests for VA-ECLS Therapy

Model-based PEEP optimisation in mechanical ventilation

Model-based PEEP titration versus standard practice in mechanical ventilation: a randomised controlled trial

Model-based computation of total stressed blood volume from a preload reduction manoeuvre

Model-based optimal PEEP in mechanically ventilated ARDS patients in the intensive care unit

Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects.

Modelling in anaesthesia and intensive care: a special section including papers from IFAC's 8. Symposium on Medical and Biological Systems in Budapest 2012.

Modelling of the nonlinear end-systolic pressure-volume relation and volume-at-zero-pressure in porcine experiments

Modelling the cardiovascular system

Multi-input stochastic prediction of insulin sensitivity for tight glycaemic control using insulin sensitivity and blood glucose data

NAVA enhances tidal volume and diaphragmatic electro-myographic activity matching: a Range90 analysis of supply and demand.

Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to validation them.

Organ failure and tight glycemic control in the SPRINT study.

Parameter estimation in a minimal model of cardio-pulmonary interactions

Patient-Specific Monitoring and Trend Analysis of Model-Based Markers of Fluid Responsiveness in Sepsis: A Proof-of-Concept Animal Study

Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice? ⬇️

Physiological relevance and performance of a minimal lung model: an experimental study in healthy and acute respiratory distress syndrome model piglets.

Physiological trend analysis of a novel cardio-pulmonary model during a preload reduction manoeuvre

Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control

Practical identifiability analysis of a minimal cardiovascular system model

Pre-ejection period, the reason why the electrocardiogram Q-wave is an unreliable indicator of pulse wave initialization

Preface

Preload &amp; Frank-Starling curves, from textbook to bedside: Clinically applicable non-additionally invasive model-based estimation in pigs

Re: Chung et al.'s Letter to the Editor in response to: Early detection of abnormal left ventricular relaxation in acute myocardial ischemia with a quadratic model. Med Eng Phys 2014;36(September (9)):1101-5 by Morimont et al.

Preload & Frank-Starling curves, from textbook to bedside: Clinically applicable non-additionally invasive model-based estimation in pigs