List of works by Holden T. Maecker

"MIATA"-minimal information about T cell assays

scientific article published on October 2009

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

A Novel Utility to Correct for Plate/Batch/Lot and Nonspecific Binding Artifacts in Luminex Data

scientific article published on 06 May 2020

A Prospective Clinical Trial Combining Radiation Therapy With Systemic Immunotherapy in Metastatic Melanoma

scientific article published on 15 July 2016

A Prospective, Phase 1 Trial of Nivolumab, Ipilimumab, and Radiotherapy in Patients with Advanced Melanoma

scientific article published on 23 March 2020

A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring

scientific article published on 06 March 2019

A harmonized approach to intracellular cytokine staining gating: Results from an international multiconsortia proficiency panel conducted by the Cancer Immunotherapy Consortium (CIC/CRI)

scientific article published on 20 June 2013

A model for harmonizing flow cytometry in clinical trials

scientific article

A pilot study of Ipilimumab in patients with stage IV melanoma receiving palliative radiation therapy

A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers".

scientific article

AS03 adjuvant enhances the magnitude, persistence, and clonal breadth of memory B cell responses to a plant-based COVID-19 vaccine in humans

scientific article published on 5 April 2024

Adjuvant immunization of HLA-A2-positive melanoma patients with a modified gp100 peptide induces peptide-specific CD8+ T-cell responses

scientific article published on April 2003

Algorithmic Tools for Mining High-Dimensional Cytometry Data

scientific article (publication date: August 2015)

An analytical workflow for investigating cytokine profiles

scientific article

An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging

scientific article published on 12 July 2021

An initial investigation of serum cytokine levels in patients with gadolinium retention

scientific article published on 01 September 2020

Analysis of the frequencies and of the memory T cell phenotypes of human CD8+ T cells specific for influenza A viruses.

scientific article published on 19 March 2003

Analyzing T-cell responses to cytomegalovirus by cytokine flow cytometry

scientific article published on May 2004

Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis

scientific article published on June 2017

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

scientific article published on 16 April 2013

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

scientific article published on 2 July 2013

Apoptosis and other immune biomarkers predict influenza vaccineresponsiveness.

scientific article published on 8 September 2014

Assessing basophil activation by using flow cytometry and mass cytometry in blood stored 24 hours before analysis.

scientific article published on 15 July 2016

Autoantibody profiling on a plasmonic nano-gold chip for the early detection of hypertensive heart disease.

scientific article published on 19 June 2017

Autoantibody-Positive Healthy Individuals Display Unique Immune Profiles That May Regulate Autoimmunity

scientific article published on 05 April 2016

Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype

scientific article published on 21 May 2020

Bacillus Calmette Guerin vaccination of human newborns induces a specific, functional CD8+ T cell response

scientific article published on 01 October 2006

Bacillus Calmette-Guérin vaccination of human newborns induces T cells with complex cytokine and phenotypic profiles

scientific article

Barcoding of live human peripheral blood mononuclear cells for multiplexed mass cytometry

scientific article published on 21 January 2015

Baseline Gastrointestinal Eosinophilia Is Common in Oral Immunotherapy Subjects With IgE-Mediated Peanut Allergy

scientific article published on 22 November 2018

Baseline immune profile by CyTOF can predict response to an investigational adjuvanted vaccine in elderly adults.

scientific article published on 5 June 2018

Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response

scientific article published on 21 April 2020

Comparison of CyTOF assays across sites: Results of a six-center pilot study.

scientific article published on 22 November 2017

Comprehensive Immune Monitoring of Clinical Trials to Advance Human Immunotherapy

scientific article published on 01 July 2019

Computationally efficient multidimensional analysis of complex flow cytometry data using second order polynomial histograms.

scientific article published on 11 June 2015

Continuous immunotypes describe human immune variation and predict diverse responses

scientific article published on 10 July 2017

Cord blood T cell subpopulations and associations with maternal cadmium and arsenic exposures

scientific article

Correction to: Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response

scientific article published on 13 May 2020

CyTOF Measurement of Immunocompetence Across Major Immune Cell Types.

scientific article published on 2 October 2017

Cytokine and chemokine patterns across 100 days after hematopoietic stem cell transplantation in children

scientific article

Cytokine flow cytometry

scientific article published in January 2004

Cytokine flow cytometry: a multiparametric approach for assessing cellular immune responses to viral antigens

scientific article published on March 2004

Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis

scientific article published on 17 May 2020

Cytokine profile in plasma of severe COVID-19 does not differ from ARDS and sepsis

scientific article published on 24 July 2020

Cytokine profiles in patients with toxoplasmic lymphadenitis in the setting of pregnancy

scientific article

Cytokine signature associated with disease severity in chronic fatigue syndrome patients

scientific article

Cytokine-Stimulated Phosphoflow of Whole Blood Using CyTOF Mass Cytometry

scientific article published on June 2015

Cytokine-stimulated Phosphoflow of PBMC Using CyTOF Mass Cytometry

2015 scientific article

Cytokines profile in hypertensive patients with left ventricular remodeling and dysfunction

scientific article published on 17 October 2015

Cytomegalovirus infection enhances the immune response to influenza.

scientific article

Daily cytokine fluctuations, driven by leptin, are associated with fatigue severity in chronic fatigue syndrome: evidence of inflammatory pathology

scientific article published on 9 April 2013

Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans

scientific article published on 12 October 2016

Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals

scientific article

Development and dynamics of robust T-cell responses to CML under imatinib treatment

scientific article published on 7 March 2008

Differences in multiple immune parameters between Indian and U.S. infants

scientific article published in PLoS ONE

Diminished B-Cell Response After Repeat Influenza Vaccination

scientific article published on 01 April 2019

Disease characteristics and serological responses in patients with differing severity of COVID-19 infection: A longitudinal cohort study in Dhaka, Bangladesh

scientific article published on 04 January 2022

Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients

scientific article published on 6 March 2018

Dynamics of CD4 and CD8 T cell responses to cytomegalovirus in healthy human donors

scientific article published on 14 June 2002

Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes.

scientific article

Early non-neutralizing, afucosylated antibody responses are associated with COVID-19 severity

scientific article published on 09 March 2022

Effect of Cryopreservation on Assays of Antigen-Specific T Cells: Comparison of Tetramer, Cytokine Flow Cytometry, and ELISPOT

article

Effects of serum and plasma matrices on multiplex immunoassays

scientific article published in May 2014

Epigenetic changes in tumor Fas levels determine immune escape and response to therapy

scientific article published in August 2002

Ex vivo analysis of T-cell function

scientific article

Experimental pain and opioid analgesia in volunteers at high risk for obstructive sleep apnea

scientific article

Faculty of 1000 evaluation for Activity of broad-spectrum T cells as treatment for AdV, EBV, CMV, BKV, and HHV6 infections after HSCT

Faculty of 1000 evaluation for Acyclovir Therapy Reduces the CD4+ T Cell Response against the Immunodominant pp65 Protein from Cytomegalovirus in Immune Competent Individuals

Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

scientific article published on 3 January 2024

Flow cytometry controls, instrument setup, and the determination of positivity

scientific article published on 01 September 2006

Food allergy and omics

scientific article published in January 2018

Functional T cell responses to tumor antigens in breast cancer patients have a distinct phenotype and cytokine signature.

scientific article published in August 2007

Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry

scientific article published on October 2013

Getting the Most from Your High-Dimensional Cytometry Data

scientific article published on 01 March 2019

Guidelines for Gating Flow Cytometry Data for Immunological Assays

scientific article published on 01 January 2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

scientific article published on 01 October 2019

Harmonization guidelines for HLA-peptide multimer assays derived from results of a large scale international proficiency panel of the Cancer Vaccine Consortium

scientific article

High-Parameter Immune Profiling with CyTOF

scientific article published on 01 January 2020

High-parametric evaluation of human invariant natural killer T cells to delineate heterogeneity in allo- and autoimmunity

scientific article published on 01 March 2020

Host-microbe multiomic profiling reveals age-dependent immune dysregulation associated with COVID-19 immunopathology

scientific article published on 17 April 2024

Human CD81 directly enhances Th1 and Th2 cell activation, but preferentially induces proliferation of Th2 cells upon long-term stimulation

scientific article

IFN priming is necessary but not sufficient to turn on a migratory dendritic cell program in lupus monocytes

scientific article

IL-2 production correlates with effector cell differentiation in HIV-specific CD8+ T cells

scientific article

IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

scientific article published on 9 January 2024

Immune Checkpoint Function of CD85j in CD8 T Cell Differentiation and Aging.

scientific article

Immune Profiles to Predict Response to Desensitization Therapy in Highly HLA-Sensitized Kidney Transplant Candidates

scientific article

Immune biomarkers link air pollution exposure to blood pressure in adolescents

scientific article published on 16 October 2020

Immune dysfunction and micrometastases in women with breast cancer

scientific article published in May 2005

Immune monitoring technology primer: flow and mass cytometry

scientific article published on 15 September 2015

Immune responses in the draining lymph nodes against cancer: implications for immunotherapy

scientific article published on June 2006

Immunodynamics: a cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials

scientific article

Immunologic Network and Response to Intramyocardial CD34+ Stem Cell Therapy in Patients With Dilated Cardiomyopathy.

scientific article published on 8 April 2015

Immunologic effects of forest fire exposure show increases in IL-1β and CRP

scientific article published on 28 February 2020

Immunological response in normal healthy twins across age

scholarly article published 2010

Immunotherapy biomarkers 2016: overcoming the barriers.

scientific article published on 21 March 2017

Impact of cryopreservation on tetramer, cytokine flow cytometry, and ELISPOT

scientific article

Impaired Immune Health in Survivors of Diffuse Large B-Cell Lymphoma

scientific article published on 21 February 2020

In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort

scientific article

Increased brain size and glial cell number in CD81-null mice

scientific article published in November 2002

Influence of frequent infectious exposures on general and varicella-zoster virus-specific immune responses in pediatricians

scientific article published on 15 January 2014

Insulin Growth Factor Phenotypes in Heart Failure With Preserved Ejection Fraction, an INSPIRE Registry and CATHGEN Study

scientific article published in 2022

Integrated longitudinal multiomics study identifies immune programs associated with acute COVID-19 severity and mortality

scientific article published in May 2024

Interleukin 4 is inactivated via selective disulfide-bond reduction by extracellular thioredoxin

scientific article published on 13 August 2018

Intracellular Cytokine Staining on PBMCs Using CyTOF™ Mass Cytometry

scientific article published in January 2015

JAK-STAT Activity in Peripheral Blood Cells and Kidney Tissue in IgA Nephropathy

scientific article published on 30 April 2020

JAK-STAT signaling is activated in the kidney and peripheral blood cells of patients with focal segmental glomerulosclerosis

scientific article published on 06 August 2018

Large-Scale and Comprehensive Immune Profiling and Functional Analysis of Normal Human Aging

scientific article published on 21 July 2015

Long term survivors and immune biomarker analysis of Phase IIa, randomized study of GVAX pancreas and crs-207 immunotherapy in patients with metastatic pancreatic cancer

scientific article published on 4 November 2015

Loss of receptor on tuberculin-reactive T-cells marks active pulmonary tuberculosis

scientific article

MYC functions as a switch for natural killer cell-mediated immune surveillance of lymphoid malignancies

scientific article published on 05 June 2020

Mass Cytometry Assays for Antigen-Specific T Cells Using CyTOF.

scientific article

Mass Cytometry Defines Virus-Specific CD4<sup>+</sup> T Cells in Influenza Vaccination

scientific article published on 11 December 2020

Mass cytometry as a platform for the discovery of cellular biomarkers to guide effective rheumatic disease therapy

scientific article

Mass cytometry: protocol for daily tuning and running cell samples on a CyTOF mass cytometer.

scientific article published on 2 November 2012

Maximizing the retention of antigen specific lymphocyte function after cryopreservation

scientific article published on 21 October 2005

Monitoring the immune competence of cancer patients to predict outcome

scientific article published on February 2014

Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients

scientific article published on 20 June 2023

Multicolor flow cytometric analysis in SIV-infected rhesus macaque

scientific article

Multiparameter Intracellular Cytokine Staining

scientific article published in January 2018

Multiparameter Phenotyping of Human PBMCs Using Mass Cytometry

scientific article published on January 2015

Multiparameter flow cytometry monitoring of T cell responses

scientific article

Multiparameter intracellular cytokine staining

scientific article published on January 2011

Mycophenolate mofetil reduces STAT3 phosphorylation in systemic lupus erythematosus patients

scholarly article by Samantha Slight-Webb et al published 24 January 2019 in JCI insight

Network for biomarker immunoprofiling for cancer immunotherapy: Cancer Immune Monitoring and Analysis Centers and Cancer Immunologic Data Commons (CIMAC-CIDC)

scientific article published on 08 January 2021

New technologies for autoimmune disease monitoring

scientific article published on August 2010

New tools for classification and monitoring of autoimmune diseases

scientific article published on 31 May 2012

Novel technologies and emerging biomarkers for personalized cancer immunotherapy

scientific article

Opening the Door on the CMV Immune Response in Aging

scientific article published on 12 February 2017

Optimal preparation of rhesus macaque blood for cytokine flow cytometric analysis ⬇️

scientific article published on May 1, 2003

Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3).

scientific article

Pembrolizumab in Relapsed and Refractory Mycosis Fungoides and Sézary Syndrome: A Multicenter Phase II Study

scientific article published on 18 September 2019

Penalized Supervised Star Plots: Example Application in Influenza-Specific CD4+ T Cells

scientific article published on 30 January 2019

Performance of plate-based cytokine flow cytometry with automated data analysis

scientific article

Persistent and selective deficiency of CD4+ T cell immunity to cytomegalovirus in immunocompetent young children

scientific article published in March 2004

Phenotype and in vitro function of mature MDDC generated from cryopreserved PBMC of cancer patients are equivalent to those from healthy donors

scientific article published on 3 May 2007

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

scientific article published in 2022

Phenotyping of Live Human PBMC using CyTOF™ Mass Cytometry

2015 scientific article

Platelet transcriptome identifies progressive markers and potential therapeutic targets in chronic myeloproliferative neoplasms

scientific article published on 19 October 2021

Platinum-conjugated antibodies for application in mass cytometry

scientific article published on 10 September 2015

Poor predictive value of cytomegalovirus (CMV)-specific T cell assays for the development of CMV retinitis in patients with AIDS.

scientific article published on February 2008

Precision and linearity targets for validation of an IFNgamma ELISPOT, cytokine flow cytometry, and tetramer assay using CMV peptides

scientific article

Predicting CD137 upregulation on NK cells in patients receiving monoclonal antibody therapy

scientific article published on 4 November 2015

Predictors of clinical response to immunotherapy with or without radiotherapy

scientific article

Protective immunity to cytomegalovirus (CMV) retinitis in AIDS is associated with CMV-specific T cells that express interferon- gamma and interleukin-2 and have a CD8+ cell early maturational phenotype

scientific article published on 26 October 2006

Quality assurance of intracellular cytokine staining assays: Analysis of multiple rounds of proficiency testing ⬇️

scientific article published on August 19, 2010

Recommendations from the iSBTc-SITC/FDA/NCI Workshop on Immunotherapy Biomarkers

scientific article

Reply to Roerink et al: Methods for recruitment, serum separation, and storage were the same for patients and controls.

scientific article published on 30 October 2017

Results and harmonization guidelines from two large-scale international Elispot proficiency panels conducted by the Cancer Vaccine Consortium (CVC/SVI)

scientific article

Results of a cytomegalovirus (CMV)-specific CD8+/interferon- gamma+ cytokine flow cytometry assay correlate with clinical evidence of protective immunity in patients with AIDS with CMV retinitis

scientific article published on 31 March 2004

Reversal of epigenetic aging and immunosenescent trends in humans

scientific article published on 08 September 2019

SIMON, an Automated Machine Learning System, Reveals Immune Signatures of Influenza Vaccine Responses

scientific article published on 14 June 2019

SITC cancer immunotherapy resource document: a compass in the land of biomarker discovery

scientific article published on 01 December 2020

Selecting fluorochrome conjugates for maximum sensitivity

scientific article

Selective developmental defects of cord blood antigen-presenting cell subsets.

scientific article published in November 2004

Similarities in the Markers of Inflammation Between Men With Syphilis and Women With Increased Risk of HIV Acquisition

scientific article published on 22 September 2015

Standardization and optimization of multiparameter intracellular cytokine staining

scientific article

Standardization of cytokine flow cytometry assays

scientific article

Standardizing Flow Cytometry Immunophenotyping Analysis from the Human ImmunoPhenotyping Consortium

scientific article

Standardizing immunophenotyping for the Human Immunology Project

scientific article

Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1.

scientific article published on 7 January 2004

Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER)

scientific article published on 19 October 2020

Successful immunotherapy induces previously unidentified allergen-specific CD4+ T-cell subsets

scientific article published on 25 January 2016

Sustained outcomes in oral immunotherapy for peanut allergy (POISED study): a large, randomised, double-blind, placebo-controlled, phase 2 study

scientific article published on 12 September 2019

Systems approach to uncover signaling networks in primary immunodeficiency diseases

scientific article published on 12 April 2017

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

scientific article

T cell immunity to HIV: defining parameters of protection

scientific article published on April 2003

TNF-α detection using a flow cytometric assay to determine cellular responses to anthrax vaccine ⬇️

scientific article published on November 1, 2003

The FluPRINT dataset, a multidimensional analysis of the influenza vaccine imprint on the immune system

scientific article published on 21 October 2019

The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors

scientific article

The Stanford Data Miner: a novel approach for integrating and exploring heterogeneous immunological data

scientific article

The phenotypic distribution and functional profile of tuberculin-specific CD4 T-cells characterizes different stages of TB infection.

scientific article published on 7 September 2012

The role of the reporting framework MIATA within current efforts to advance immune monitoring

scholarly article by Sylvia Janetzki et al published July 2014 in Journal of Immunological Methods

The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination

scientific article published on 25 June 2021

Thinking outside the gate: single-cell assessments in multiple dimensions

scientific article published on April 2015

Transcriptional changes in peanut-specific CD4+ T cells over the course of oral immunotherapy

scientific article published on 09 August 2020

Tuberculin-specific T cells are reduced in active pulmonary tuberculosis compared to LTBI or status post BCG vaccination

scientific article

Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study

scientific article published on 11 January 2019

Value of Circulating Cytokine Profiling During Submaximal Exercise Testing in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

scientific article published on 9 February 2018

Value of Neutrophil to Lymphocyte Ratio and Its Trajectory in Patients Hospitalized With Acute Heart Failure and Preserved Ejection Fraction

scientific article published on 26 October 2019

Variation in the human immune system is largely driven by non-heritable influences

scientific article

Vitamin d deficiency in a multiethnic healthy control cohort and altered immune response in vitamin D deficient European-American healthy controls

scientific article

Wild immunology assessed by multidimensional mass cytometry.

scientific article published on 12 July 2016

[Selecting reagents for multicolor BD flow cytometry]

scientific article published on 01 January 2009

flowCL: ontology-based cell population labelling in flow cytometry

scientific article

gp100(209-2M) peptide immunization of human lymphocyte antigen-A2+ stage I-III melanoma patients induces significant increase in antigen-specific effector and long-term memory CD8+ T cells

scientific article published on January 2004

mTOR inhibition improves immune function in the elderly

scientific article

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