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List of works by Alexander N. Freiberg

A Unique BSL-3 Cryo-Electron Microscopy Laboratory at UTMB.

scientific article

A broad-spectrum antiviral targeting entry of enveloped viruses

scientific article

A catalytically and genetically optimized beta-lactamase-matrix based assay for sensitive, specific, and higher throughput analysis of native henipavirus entry characteristics

scientific article published on 31 July 2009

A mechanistic paradigm for broad-spectrum antivirals that target virus-cell fusion

scientific article published in 2013

A replication-incompetent Rift Valley fever vaccine: chimeric virus-like particles protect mice and rats against lethal challenge

scientific article

A single sublingual dose of an adenovirus-based vaccine protects against lethal Ebola challenge in mice and guinea pigs

scientific article

A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice

scientific article published in Scientific Reports

An assembly model of rift valley Fever virus

scientific article

An intersubunit active site between supercoiled parallel beta helices in the trimeric tailspike endorhamnosidase of Shigella flexneri Phage Sf6

scientific article

Antiviral effect of ranpirnase against Ebola virus

scientific article published on 24 June 2016

Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain

scientific article published on 20 October 2017

Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR.

scientific article published on June 2016

Bolstering Components of the Immune Response Compromised by Prior Exposure to Adenovirus: Guided Formulation Development for a Nasal Ebola Vaccine

scientific article published on 20 January 2015

Broad-Range Antiviral Activity of Hydrogen Sulfide Against Highly Pathogenic RNA Viruses

scientific article

Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virus

scientific article

Chemotactic and inflammatory responses in the liver and brain are associated with pathogenesis of Rift Valley fever virus infection in the mouse

scientific article (publication date: 2012)

Coagulation factors, fibrinogen and plasminogen activator inhibitor-1, are differentially regulated by yellow fever virus infection of hepatocytes

scientific article published on 29 April 2013

Combined chloroquine and ribavirin treatment does not prevent death in a hamster model of Nipah and Hendra virus infection

scientific article

Contribution of Human Lung Parenchyma and Leukocyte Influx to Oxidative Stress and Immune System-Mediated Pathology following Nipah Virus Infection

scientific article published on 24 May 2017

Cross-neutralisation of viruses of the tick-borne encephalitis complex following tick-borne encephalitis vaccination and/or infection

scientific article published on 13 March 2017

Cytokine response in mouse bone marrow derived macrophages after infection with pathogenic and non-pathogenic Rift Valley fever virus

scientific article

Detection of severe fever with thrombocytopenia syndrome virus by reverse transcription-cross-priming amplification coupled with vertical flow visualization

scientific article

Differential cytokine responses from primary human Kupffer cells following infection with wild-type or vaccine strain yellow fever virus

scientific article published on February 2011

Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors

scientific article published on 01 May 2020

Distinct virulence of Rift Valley fever phlebovirus strains from different genetic lineages in a mouse model

scientific article published on 21 December 2017

Efficacy and Immunogenicity of a Recombinant Vesicular Stomatitis Virus-Vectored Marburg Vaccine in Cynomolgus Macaques

scientific article published on 24 July 2024

Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection

scientific article published on 13 November 2017

Efficient and Robust Paramyxoviridae Reverse Genetics Systems.

scientific article published on 29 March 2017

Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of viral spread in small animal models of henipavirus infection.

scientific article

Establishment and characterization of plasmid-driven minigenome rescue systems for Nipah virus: RNA polymerase I- and T7-catalyzed generation of functional paramyxoviral RNA.

scientific article

Evidence for henipavirus spillover into human populations in Africa

scientific article

Evidence for ubiquitin-regulated nuclear and subnuclear trafficking among Paramyxovirinae matrix proteins

scientific article

Experimental Infection of Syrian Hamsters with Aerosolized Nipah virus

scientific article published on 01 October 2018

Favipiravir (T-705) inhibits Junín virus infection and reduces mortality in a guinea pig model of Argentine hemorrhagic fever

scientific article (publication date: 2013)

Favipiravir (T-705) protects against Nipah virus infection in the hamster model.

scientific article

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names

scientific article published on 26 September 2014

Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir

scientific article published in 2019

Folding and stability of the leucine-rich repeat domain of internalin B from Listeri monocytogenes

scientific article (publication date: 19 March 2004)

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

scientific article published on 26 August 2020

Genetic subpopulations of Rift Valley fever virus strains ZH548 and MP-12 and recombinant MP-12 strains

scientific article

Henipavirus infection of the central nervous system

scientific article published on 01 March 2019

Human neural stem cell-derived neuron/astrocyte co-cultures respond to La Crosse virus infection with proinflammatory cytokines and chemokines

article

ISG15 deficiency and increased viral resistance in humans but not mice

scientific article

Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening

scientific article

Imaging of Murine Whole Lung Fibrosis by Large Scale 3D Microscopy aided by Tissue Optical Clearing

scientific article

Inactivated or live-attenuated bivalent vaccines that confer protection against rabies and Ebola viruses

scientific article

Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol

scientific article

Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis

scientific article published on 25 January 2021

Modeling pre-existing immunity to adenovirus in rodents: immunological requirements for successful development of a recombinant adenovirus serotype 5-based ebola vaccine

scientific article published on 19 August 2013

Multiplexed digital mRNA profiling of the inflammatory response in the West Nile Swiss Webster mouse model

scientific article

Mutational analysis of positively charged amino acid residues of Uukuniemi phlebovirus nucleocapsid protein

scientific article published in July 2012

N-Glycans on the Rift Valley Fever Virus Envelope Glycoproteins Gn and Gc Redundantly Support Viral Infection via DC-SIGN.

scientific article published on 23 May 2016

Natural History and Pathogenesis of Wild-Type Marburg Virus Infection in STAT2 Knockout Hamsters

scholarly article by Colm Atkins et al published 22 November 2018 in Journal of Infectious Diseases

Niemann-Pick C1 Heterogeneity of Bat Cells Controls Filovirus Tropism

scientific article published on 01 January 2020

Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway

scientific article

Oligomerization of Uukuniemi virus nucleocapsid protein

scientific article published on 10 August 2010

Optimized P2A for reporter gene insertion into Nipah virus results in efficient ribosomal skipping and wild-type lethality

scientific article published on 18 January 2016

PHOSPHORYLATED VP30 OF MARBURG VIRUS IS A REPRESSOR OF TRANSCRIPTION

scientific article published on 12 October 2018

Peptidoglycan associated cyclic lipopeptide disrupts viral infectivity

scientific article published on 14 May 2019

Peptidoglycan-Associated Cyclic Lipopeptide Disrupts Viral Infectivity

scientific article published on 29 October 2019

Phage tailspike proteins with beta-solenoid fold as thermostable carbohydrate binding materials

scientific article

Phosphoinositide-3 Kinase-Akt Pathway Controls Cellular Entry of Ebola Virus

scientific article

Polyphenylene carboxymethylene (PPCM) in vitro antiviral efficacy against Ebola virus in the context of a sexually transmitted infection

scientific article published on 24 July 2019

Pyronaridine Tetraphosphate Efficacy Against Ebola Virus Infection in Guinea Pig

scientific article published on 16 July 2020

Recent advances in the development of antiviral therapeutics for Rift Valley fever virus infection.

scientific article published on 23 October 2017

Recent progress in henipavirus research: Molecular biology, genetic diversity, animal models ⬇️

scientific article published on May 27, 2012

Recombinant Rift Valley fever vaccines induce protective levels of antibody in baboons and resistance to lethal challenge in mice

scientific article

Repurposing Quinacrine against Ebola Virus Infection In Vivo

scientific article published on 23 August 2019

Rift Valley Fever Virus MP-12 Vaccine Is Fully Attenuated by a Combination of Partial Attenuations in the S, M, and L Segments.

scientific article

Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains neuroinvasiveness in mice

scientific article published on 20 March 2013

Role of protein phosphatase 1 in dephosphorylation of Ebola virus VP30 protein and its targeting for the inhibition of viral transcription

scientific article

SAR studies of 4-acyl-1,6-dialkylpiperazin-2-one arenavirus cell entry inhibitors

scientific article published on 24 August 2019

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species

scientific article published on 29 December 2020

Single-particle cryo-electron microscopy of Rift Valley fever virus

scientific article

Spike mutation D614G alters SARS-CoV-2 fitness

scientific article published on 26 October 2020

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

scientific article published on 02 September 2020

Spike mutation D614G alters SARS-CoV-2 fitness and neutralization susceptibility

scientific article published on 10 September 2020

T-705 (favipiravir) inhibition of arenavirus replication in cell culture

scientific article

The Dominant-Negative Inhibition of Double-Stranded RNA-Dependent Protein Kinase PKR Increases the Efficacy of Rift Valley Fever Virus MP-12 Vaccine.

scientific article published in November 2013

The Host E3-Ubiquitin Ligase TRIM6 Ubiquitinates the Ebola Virus VP35 Protein and Promotes Virus Replication

scientific article

The Lack of Maturation of Ebola Virus-Infected Dendritic Cells Results from the Cooperative Effect of at Least Two Viral Domains

article by Ndongala M. Lubaki et al published 1 November 2013 in Journal of Virology

The Matrix Protein of Nipah Virus Targets the E3-Ubiquitin Ligase TRIM6 to Inhibit the IKKε Kinase-Mediated Type-I IFN Antiviral Response

scientific article

The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine

scientific article

The lack of maturation of Ebola virus-infected dendritic cells results from the cooperative effect of at least two viral domains

scientific article published on 24 April 2013

The tailspike protein of Shigella phage Sf6. A structural homolog of Salmonella phage P22 tailspike protein without sequence similarity in the beta-helix domain.

scientific article

Three-Dimensional Organization of Rift Valley Fever Virus Revealed by Cryoelectron Tomography

scientific article

Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytium formation in endothelial cells

scientific article

Ubiquitin-regulated nuclear-cytoplasmic trafficking of the Nipah virus matrix protein is important for viral budding

scientific article

VAMP8 Contributes to the TRIM6-Mediated Type I Interferon Antiviral Response during West Nile Virus Infection

scientific article published on 06 January 2020

Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA

scientific article published on 5 November 2013

Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae

scientific article published on 29 January 2013

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