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List of works by Lynn G Feun

A Phase II Trial of Tricyclic Nucleoside Phosphate in Patients with Advanced Squamous Cell Carcinoma of the Cervix

article

A case of intracranial hemorrhage caused by combined dabrafenib and trametinib therapy for metastatic melanoma

scientific article published on 12 October 2014

A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma

scientific article published in April 2003

Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells ⬇️

scientific article published on March 29, 2012

Advanced Extramammary Paget's Disease of the Groin, Penis, and Scrotum.

scientific article published on 6 July 2014

Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction

scientific article published on 26 August 2013

Arginine deprivation in cancer therapy

scientific article published in January 2015

Arginine deprivation therapy for malignant melanoma ⬇️

scientific article published on December 27, 2012

Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy.

scientific article

Autophagic Mechanism in Anti-Cancer Immunity: Its Pros and Cons for Cancer Therapy

scientific article

BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma

scientific article published on 11 January 2016

Bilateral ocular manifestations of aggressive cutaneous metastatic melanoma.

scientific article

CS-03UTILIZING COLLAGEN AND DISCOIDIN DOMAIN RECEPTOR SIGNALING AS A NEWTHERAPEUTIC STRATEGY IN HUMAN MALIGNANT GLIOMA.

scientific article published in November 2014

Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

scientific article published on 7 September 2017

Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation.

scientific article published on 28 September 2016

Clinical trial of CPT-11 and VM-26/VP-16 for patients with recurrent malignant brain tumors

scientific article published on 19 October 2006

Collaboration Between RSK-EphA2 and Gas6-Axl RTK Signaling in Arginine Starvation Response That Confers Resistance to EGFR Inhibitors

scientific article published on 27 December 2019

Combination of arginine deprivation with TRAIL treatment as a targeted-therapy for mesothelioma.

scientific article published on December 2014

Cyclosporine A, alpha-lnterferon and interleukin-2 following chemotherapy with BCNU, DTIC, cisplatin, and tamoxifen: a phase II study in advanced melanoma

scientific article

Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation

scientific article published on 2 November 2017

Double-Blind Phase III Randomized Trial of the Antiprogestin Agent Mifepristone in the Treatment of Unresectable Meningioma: SWOG S9005.

scientific article

Exploiting ROS and metabolic differences to kill cisplatin resistant lung cancer

scientific article published on 02 May 2017

Extended remission of a recurrent median nerve malignant peripheral nerve sheath tumor after multimodal treatment. Case report

scientific article

First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma

scientific article published on 01 October 2019

Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins

scientific article

Liver transplantation for hepatocellular carcinoma in the model for end-stage liver disease era.

scientific article published on May 2010

Merkel cell carcinomas

scientific article published on June 2007

Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated with spermatocyte and adipocyte differentiation

scientific article

N',N'-Dimethyl-N',N'-bis(phenylcarbonothioyl) Propanedihydrazide (Elesclomol) Selectively Kills Cisplatin Resistant Lung Cancer Cells through Reactive Oxygen Species (ROS).

scientific article published on January 2009

Optical coherence tomography imaging of melanoma skin cancer

scientific article published on 11 December 2018

Overcoming cisplatin resistance by mTOR inhibitor in lung cancer

scientific article

Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine

scientific article published on July 2003

Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies

scientific article published in October 2005

Pegylated arginine deiminase: a novel anticancer enzyme agent

scientific article

Phase 2 study of pembrolizumab and circulating biomarkers to predict anticancer response in advanced, unresectable hepatocellular carcinoma

scientific article published on 28 June 2019

Phase I and pharmacokinetic study of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) using a single intravenous dose schedule

scientific article

Phase II study of darinaparsin in patients with advanced hepatocellular carcinoma.

scientific article published on 30 June 2009

Phase II trial of Paclitaxel and Dacarbazine with filgrastim administration in advanced malignant melanoma

scientific article published in January 2002

Phase II trial of SOM230 (pasireotide LAR) in patients with unresectable hepatocellular carcinoma

scientific article published on 12 January 2018

Phase III randomized controlled trial comparing the survival of patients with unresectable hepatocellular carcinoma treated with nolatrexed or doxorubicin.

scientific article

Pilot Study of Intrahepatic Artery Chemotherapy in Combination with Sorafenib in Hepatocellular Carcinoma

scientific article published on July 2016

Pilot study of estramustine added to radiosurgery and radiotherapy for treatment of high grade glioma

scientific article published in March 2004

Preoperative evaluation for patients with choroidal/ciliary body melanomas: what is necessary?

scientific article published on 01 June 2011

Procollagen alpha 1 type 1: a potential aide in histopathological grading of glioma

scientific article published on January 2005

Procollagen-Like Protein as a Molecular Target in the Treatment of Primary Brain Tumor.

scientific article

Prolonged Complete Response With Combined Dabrafenib and Trametinib After BRAF Inhibitor Failure in BRAF-Mutant Glioblastoma

scientific article published on 03 February 2020

Recombinant leukocyte interferon, doxorubicin, and 5FUDR in patients with hepatocellular carcinoma-A phase II trial

scientific article published on 9 January 2003

Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4.

scientific article

Results from a randomized phase III study comparing combined treatment with histamine dihydrochloride plus interleukin-2 versus interleukin-2 alone in patients with metastatic melanoma

scientific article published in January 2002

Single-cell analysis reveals new evolutionary complexity in uveal melanoma

scientific article published on 24 January 2020

TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation

scientific article

Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes ⬇️

scientific article published on August 1, 2010

Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin

scientific article published on March 2015

Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy

scientific article published on 25 May 2015

Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer

scientific article published on 18 October 2019

The Florida Melanoma Trial I: A Prospective Multicenter Phase I/II Trial of Postoperative Hypofractionated Adjuvant Radiotherapy with Concurrent Interferon-Alfa-2b in the Treatment of Advanced Stage III Melanoma with Long-Term Toxicity Follow-Up

article

The Relationship of Thioredoxin-1 and Cisplatin Resistance: Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells ⬇️

scientific article published on January 16, 2012

The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines

scientific article

The relationship of arginine deprivation, argininosuccinate synthetase and cell death in melanoma

scientific article published on 15 June 2007

Topoisomerase I Inhibitors in the Treatment of Primary CNS Malignancies: An Update on Recent Trends ⬇️

scientific article published on November 1, 2010

Topoisomerase I inhibitors for the treatment of brain tumors

scientific article published on May 2008

Unilateral Fourth Nerve Palsy due to Presumed Metastatic Melanoma

scientific article published on 24 January 2020

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