List of works - Niels Galjart

A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability

scientific article

A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability

article

A plus-end raft to control microtubule dynamics and function

scientific article

ACTG2 variants impair actin polymerization in sporadic Megacystis Microcolon Intestinal Hypoperistalsis Syndrome.

scientific article

Acetylcholine receptor (AChR) clustering is regulated both by glycogen synthase kinase 3β (GSK3β)-dependent phosphorylation and the level of CLIP-associated protein 2 (CLASP2) mediating the capture of microtubule plus-ends

scientific article

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.

scientific article

Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network

scientific article

Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport ⬇️

scientific article published on November 17, 2003

Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex

scientific article

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex

scientific article

CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles

scientific article

CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta

scientific article

CLIP-170 facilitates the formation of kinetochore-microtubule attachments

scientific article

CLIPs and CLASPs and cellular dynamics

scientific article

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin

scientific article

CTCF contributes in a critical way to spermatogenesis and male fertility.

scientific article published on 27 June 2016

CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.

scientific article published on 28 August 2017

CTCF induces histone variant incorporation, erases the H3K27me3 histone mark and opens chromatin

scientific article published on 7 October 2014

CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons

scientific article published on 26 July 2012

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

scientific journal article

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

scientific article

CTCF regulates cell cycle progression of alphabeta T cells in the thymus

scientific article published on 16 October 2008

CTCF regulates the local epigenetic state of ribosomal DNA repeats

scientific article

Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference

scientific article published on 01 August 2018

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl

scientific article published on 19 April 2017

Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization

scientific article

Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression.

scientific article published in January 2009

Cryo electron tomography of vitrified fibroblasts: microtubule plus ends in situ.

scientific article

Cytoplasmic linker proteins promote microtubule rescue in vivo ⬇️

scientific article

Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis

scientific article

Differential effects of matrix and growth factors on endothelial and fibroblast motility: application of a modified cell migration assay

scientific article

Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes

scientific article

Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation

scientific article published on 29 January 2019

Dual effect of CTCF loss on neuroprogenitor differentiation and survival.

scientific article published on February 2014

Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends

scientific article

Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension

scientific article

Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.

scientific article

EB1 and EB3 control CLIP dissociation from the ends of growing microtubules

scientific article

Functional analysis of CTCF during mammalian limb development

scientific article

Going solo: measuring the motions of microtubules with an in vitro assay for TIRF microscopy

scientific article published on January 2013

History-dependent catastrophes regulate axonal microtubule behavior

scientific article

Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process

scientific article published on 20 November 2012

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

scientific article published on 14 February 2010

Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.

scientific article published on 22 February 2018

Isolation of Functional Tubulin Dimers and of Tubulin-Associated Proteins from Mammalian Cells

scientific article

LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome

scientific article published on February 2004

LIS1, CLIP-170's key to the dynein/dynactin pathway

scientific article

MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells

scientific article

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function

scientific article published on 16 August 2006

Mammalian Navigators are microtubule plus-end tracking proteins that can reorganize the cytoskeleton to induce neurite-like extensions.

scientific article published in October 2009

Microtubule plus-end conformations and dynamics in the periphery of interphase mouse fibroblasts

scientific article published on 14 May 2008

Microtubule-binding proteins CLASP1 and CLASP2 interact with actin filaments

scientific article

Mitotic progression, arrest, exit or death is determined by centromere integrity and independent of de novo transcription

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

scientific article published on 06 August 2018

Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.

scientific article

Nicotinamide adenine dinucleotide (NAD)–regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus ⬇️

scientific article published on November 24, 2010

Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres

scientific article published on February 2017

Particle filtering for multiple object tracking in dynamic fluorescence microscopy images: application to microtubule growth analysis

scientific article

Phosphorylation controls autoinhibition of cytoplasmic linker protein-170

scientific article

Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.

scientific article published on 28 July 2009

Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway.

scientific article

Plus-end-tracking proteins and their interactions at microtubule ends

scientific article

Protein 4.1R binds to CLASP2 and regulates dynamics, organization and attachment of microtubules to the cell cortex

scientific article published on 13 August 2013

Purification of Biotinylated Proteins Using Single Walled Carbon Nanotube-Streptavidin Complexes

scientific article published on 01 February 2017

Purification of Mammalian Tubulins and Tubulin-Associated Proteins Using a P2A-Based Expression System

scientific article published on 01 January 2020

Rao-Blackwellized marginal particle filtering for multiple object tracking in molecular bioimaging

scientific article published in January 2007

Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF)

scientific article published on 30 April 2018

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility

scientific article

Severe presentation of WDR62 mutation: is there a role for modifying genetic factors?

scientific article published on 19 May 2014

TAPping into the treasures of tubulin using novel protein production methods

article

Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice

scientific article

Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.

scientific article

The +TIP Navigator-1 is an actin-microtubule crosslinker that regulates axonal growth cone motility

scientific article published on 01 September 2020

The DNA-Binding Protein CTCF Limits Proximal Vκ Recombination and Restricts κ Enhancer Interactions to the Immunoglobulin κ Light Chain Locus

article by Claudia Ribeiro de Almeida et al published October 2011 in Immunity

The DNA-binding factor Ctcf critically controls gene expression in macrophages.

scientific article published on 9 September 2013

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner

scientific article published on 18 June 2012

The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance

scientific article

The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis

scientific article

The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells

scientific article published on 02 April 2018

Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.

scientific article

Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).

scientific article published in April 2003

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules

scientific article

List of works by Niels Galjart

A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability

A defect in the CLIP1 gene (CLIP-170) can cause autosomal recessive intellectual disability

A plus-end raft to control microtubule dynamics and function

ACTG2 variants impair actin polymerization in sporadic Megacystis Microcolon Intestinal Hypoperistalsis Syndrome.

Acetylcholine receptor (AChR) clustering is regulated both by glycogen synthase kinase 3β (GSK3β)-dependent phosphorylation and the level of CLIP-associated protein 2 (CLASP2) mediating the capture of microtubule plus-ends

Agrin regulates CLASP2-mediated capture of microtubules at the neuromuscular junction synaptic membrane.

Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network

Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport ⬇️

Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex

CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex

CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles

CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta

CLIP-170 facilitates the formation of kinetochore-microtubule attachments

CLIPs and CLASPs and cellular dynamics

CTCF binding and higher order chromatin structure of the H19 locus are maintained in mitotic chromatin

CTCF contributes in a critical way to spermatogenesis and male fertility.

CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.

CTCF induces histone variant incorporation, erases the H3K27me3 histone mark and opens chromatin

CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons

CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus

CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation

CTCF regulates cell cycle progression of alphabeta T cells in the thymus

CTCF regulates the local epigenetic state of ribosomal DNA repeats

Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference

Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl

Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization

Critical role for the transcription regulator CCCTC-binding factor in the control of Th2 cytokine expression.

Cryo electron tomography of vitrified fibroblasts: microtubule plus ends in situ.

Cytoplasmic linker proteins promote microtubule rescue in vivo ⬇️

Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis

Differential effects of matrix and growth factors on endothelial and fibroblast motility: application of a modified cell migration assay

Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes

Distinct Functions for Mammalian CLASP1 and -2 During Neurite and Axon Elongation

Dual effect of CTCF loss on neuroprogenitor differentiation and survival.

Dynamic behavior of GFP-CLIP-170 reveals fast protein turnover on microtubule plus ends

Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension

Dynein, Lis1 and CLIP-170 counteract Eg5-dependent centrosome separation during bipolar spindle assembly.

EB1 and EB3 control CLIP dissociation from the ends of growing microtubules

Functional analysis of CTCF during mammalian limb development

Going solo: measuring the motions of microtubules with an in vitro assay for TIRF microscopy

History-dependent catastrophes regulate axonal microtubule behavior

Host microtubule plus-end binding protein CLASP1 influences sequential steps in the Trypanosoma cruzi infection process

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities.

Isolation of Functional Tubulin Dimers and of Tubulin-Associated Proteins from Mammalian Cells

LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome

LIS1, CLIP-170's key to the dynein/dynactin pathway

MAP1B regulates microtubule dynamics by sequestering EB1/3 in the cytosol of developing neuronal cells

Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function

Mammalian Navigators are microtubule plus-end tracking proteins that can reorganize the cytoskeleton to induce neurite-like extensions.

Microtubule plus-end conformations and dynamics in the periphery of interphase mouse fibroblasts

Microtubule-binding proteins CLASP1 and CLASP2 interact with actin filaments

Mitotic progression, arrest, exit or death is determined by centromere integrity and independent of de novo transcription

Mitotic progression, arrest, exit or death relies on centromere structural integrity, rather than de novo transcription

Motor-independent targeting of CLASPs to kinetochores by CENP-E promotes microtubule turnover and poleward flux.

Nicotinamide adenine dinucleotide (NAD)–regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus ⬇️

Ninein is essential for apico-basal microtubule formation and CLIP-170 facilitates its redeployment to non-centrosomal microtubule organizing centres

Particle filtering for multiple object tracking in dynamic fluorescence microscopy images: application to microtubule growth analysis

Phosphorylation controls autoinhibition of cytoplasmic linker protein-170

Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.

Plasma membrane recruitment of dephosphorylated beta-catenin upon activation of the Wnt pathway.

Plus-end-tracking proteins and their interactions at microtubule ends

Protein 4.1R binds to CLASP2 and regulates dynamics, organization and attachment of microtubules to the cell cortex

Purification of Biotinylated Proteins Using Single Walled Carbon Nanotube-Streptavidin Complexes

Purification of Mammalian Tubulins and Tubulin-Associated Proteins Using a P2A-Based Expression System

Rao-Blackwellized marginal particle filtering for multiple object tracking in molecular bioimaging

Remote Memory and Cortical Synaptic Plasticity Require Neuronal CCCTC-Binding Factor (CTCF)

Role of CLASP2 in microtubule stabilization and the regulation of persistent motility

Severe presentation of WDR62 mutation: is there a role for modifying genetic factors?

TAPping into the treasures of tubulin using novel protein production methods

Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice

Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.

The +TIP Navigator-1 is an actin-microtubule crosslinker that regulates axonal growth cone motility

The DNA-Binding Protein CTCF Limits Proximal Vκ Recombination and Restricts κ Enhancer Interactions to the Immunoglobulin κ Light Chain Locus

The DNA-binding factor Ctcf critically controls gene expression in macrophages.

The male germ cell gene regulator CTCFL is functionally different from CTCF and binds CTCF-like consensus sites in a nucleosome composition-dependent manner

The microtubule plus-end tracking protein CLASP2 is required for hematopoiesis and hematopoietic stem cell maintenance

The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis

The transcriptional regulator CCCTC-binding factor limits oxidative stress in endothelial cells