List of works by Tom H Karlsen

A Cross-Sectional Study of the Prevalence of Gastrointestinal Symptoms and Pathology in Patients With Common Variable Immunodeficiency

scientific article published on 16 August 2016

A frequent PNPLA3 variant is a sex specific disease modifier in PSC patients with bile duct stenosis

scientific article

Abundant genetic overlap between blood lipids and immune-mediated diseases indicates shared molecular genetic mechanisms

scientific article published on 8 April 2015

Activation of biliary tree stem cells within peribiliary glands in primary sclerosing cholangitis.

scientific article published on 25 June 2015

Alterations of the bile microbiome in primary sclerosing cholangitis

scientific article published on 26 June 2019

Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis

scientific article published on 30 December 2020

Altered gut microbiota profile in common variable immunodeficiency associates with levels of lipopolysaccharide and markers of systemic immune activation

scientific article published on 16 March 2016

An ex vivo perfusion model to evaluate hyperacute rejection in a discordant pig-to-human combination

scientific article published on 01 January 1998

An interleukin-6 (IL-6) receptor polymorphism affecting serum levels of IL-6 does not increase the risk of cholangiocarcinoma in primary sclerosing cholangitis

scientific article published on 01 April 2008

Analysis of MAdCAM-1 and ICAM-1 polymorphisms in 365 Scandinavian patients with primary sclerosing cholangitis

scientific article (publication date: November 2006)

Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci

scientific article

Anti-GP2 IgA autoantibodies are associated with poor survival and cholangiocarcinoma in primary sclerosing cholangitis.

scientific article published on 12 July 2016

Antineutrophil antibodies define clinical and genetic subgroups in primary sclerosing cholangitis

scientific article published on 25 August 2016

Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci

scientific article published on 17 August 2017

Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease

scientific article published on 18 April 2016

Association Between HLA Haplotypes and Increased Serum Levels of IgG4 in Patients With Primary Sclerosing Cholangitis

scientific article

Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies

scientific article published on 25 April 2013

Association of CLEC16A with human common variable immunodeficiency disorder and role in murine B cells

scientific article published on 20 April 2015

Association of UCP2 -866 G/A polymorphism with chronic inflammatory diseases

scientific article published on 23 April 2009

Association to the Glypican-5 gene in multiple sclerosis

article

At the end of the beginning. Foreword

scientific article

Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis.

scientific article published on 11 June 2019

Bile Acid Profiles in Primary Sclerosing Cholangitis and their Ability to Predict Hepatic Decompensation

scientific article published on 23 November 2020

Boolean analysis reveals systematic interactions among low-abundance species in the human gut microbiome.

scientific article

Cancer After Liver Transplantation in Children and Young Adults: A Population-Based Study From 4 Nordic Countries

scientific article published on 01 September 2018

Catalytically impaired hMYH and NEIL1 mutant proteins identified in patients with primary sclerosing cholangitis and cholangiocarcinoma

scientific article published on 14 May 2009

Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis

scientific article published on 2 November 2015

Characterization of animal models for primary sclerosing cholangitis (PSC).

scientific article published on 19 February 2014

Cholangiocarcinoma in primary sclerosing cholangitis is associated with NKG2D polymorphisms

scientific article published on 01 January 2008

Cholangiocyte pathobiology.

scientific article

Cholangiocytes and the environment in primary sclerosing cholangitis: where is the link?

scientific article published on 21 July 2017

Cholangiocytes derived from human induced pluripotent stem cells for disease modeling and drug validation

scientific article published on 13 July 2015

Cholangiocytes in the pathogenesis of primary sclerosing cholangitis and development of cholangiocarcinoma.

scientific article published on 24 August 2017

Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis

scientific article published on 24 October 2018

Comparison of three oxygenator-coated and one total-circuit-coated extracorporeal devices

scientific article published on 01 March 1999

Comprehensive assessment of ECM turnover using serum biomarkers establishes PBC as a high-turnover autoimmune liver disease

scientific article published on 03 September 2020

Consistent alterations in faecal microbiomes of patients with primary sclerosing cholangitis independent of associated colitis

scientific article published on 28 June 2019

Continuous molecular adsorbent recirculating system treatment in 69 patients listed for liver transplantation

scientific article

Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin

scientific article published on 21 October 2019

Correction: Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic Mechanisms

scientific article published on 15 May 2015

Correction: Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

scientific article

Creating an effective clinical registry for rare diseases

scientific article

Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease

scientific article published on 20 January 2022

Deciphering the genetic predisposition to primary sclerosing cholangitis

scientific article published on 02 May 2011

Decreasing incidence of cancer after liver transplantation-A Nordic population-based study over 3 decades

scientific article

Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

scientific article

Development of a high-resolution NGS-based HLA-typing and analysis pipeline

scientific article published on 9 March 2015

Differences in long-term survival among liver transplant recipients and the general population: a population-based Nordic study.

scientific article published on 05 January 2015

Different HLA class II associations in ulcerative colitis patients with and without primary sclerosing cholangitis

scientific article published on 15 February 2007

Effects of coffee consumption, smoking, and hormones on risk for primary sclerosing cholangitis

scientific article published on 25 September 2013

Effects on Complement, Granulocytes and Platelets of a Leukocyte-Depletion Filter During in vitro Extracorporeal Circulation ⬇️

scientific article published on 01 January 1997

Electrostatic modifications of the human leukocyte antigen-DR P9 peptide-binding pocket and susceptibility to primary sclerosing cholangitis

scientific article

Elevated interleukin-8 in bile of patients with primary sclerosing cholangitis.

scientific article published on 11 February 2016

Elevated trimethylamine-N-oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function

scientific article

Emerging therapies in primary sclerosing cholangitis: pathophysiological basis and clinical opportunities

scientific article published on 28 March 2020

Enhanced liver fibrosis score predicts transplant-free survival in primary sclerosing cholangitis

scientific article published on 28 April 2015

Enhanced liver fibrosis test predicts transplant-free survival in primary sclerosing cholangitis, a multi-centre study

scientific article published on 7 March 2017

Erratum: Corrigendum: Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scholarly article published in Nature Genetics

Establishment of a surgical bile duct injection technique giving direct access to the bile ducts for studies of the murine biliary tree

scientific article

Extended analysis of a genome-wide association study in primary sclerosing cholangitis detects multiple novel risk loci

scientific article

Extracorporeal membrane oxygenation using a centrifugal pump and a servo regulator to prevent negative inlet pressure

scientific article published on 01 May 1997

FUT2 and FUT3 genotype determines CA19-9 cut-off values for detection of cholangiocarcinoma in patients with primary sclerosing cholangitis

article

Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System

scientific article published on 04 March 2019

Fine mapping and replication of genetic risk loci in primary sclerosing cholangitis

scientific article published on 04 May 2012

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump

scientific article published on 01 January 2019

Gallbladder polyps in primary sclerosing cholangitis: not so benign

scientific article

Genetic Discoveries Highlight Environmental Factors as Key Drivers of Liver Disease.

scientific article published on 3 May 2017

Genetic Risk and the Development of Autoimmune Liver Disease

scientific article

Genetic Risks Link Autoimmune Hepatitis to Other Autoimmune Liver Disease

scientific article published on 25 June 2014

Genetic and transcriptional analysis of inflammatory bowel disease-associated pathways in patients with GUCY2C-linked familial diarrhea

scientific article published on 24 October 2018

Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis

scientific article published on 4 August 2017

Genetic associations in Italian primary sclerosing cholangitis: heterogeneity across Europe defines a critical role for HLA-C

scientific article published on 04 March 2010

Genetic polymorphisms associated with inflammatory bowel disease do not confer risk for primary sclerosing cholangitis

scientific article published on 13 November 2006

Genetics in PSC: what do the "risk genes" teach us?

scientific article published on June 2015

Genetics in primary sclerosing cholangitis

scientific article published on December 2011

Genetics in primary sclerosing cholangitis.

scientific article published on May 2012

Genetics of Primary Sclerosing Cholangitis

article

Genetics of cholestatic liver disease in 2010.

scientific article published on May 2010

Genetics of liver disease: From pathophysiology to clinical practice

scientific article

Genetics of primary sclerosing cholangitis and pathophysiological implications

scientific article published on 15 March 2017

Genome-wide Pleiotropy Between Parkinson Disease and Autoimmune Diseases

scientific article published on 05 June 2017

Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota.

scientific article

Genome-wide association analysis in primary sclerosing cholangitis

scientific article

Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4

scientific journal article

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

scientific journal article

Genome-wide association studies--a summary for the clinical gastroenterologist

scientific article

Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).

scientific article

Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2

scientific article

Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease

scientific article

Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci.

scientific article

Genomic characterization of cholangiocarcinoma in primary sclerosing cholangitis reveals novel therapeutic opportunities

scientific article published on 10 January 2020

Guanylate Cyclase C Activation Shapes the Intestinal Microbiota in Patients with Familial Diarrhea and Increased Susceptibility for Crohn's Disease

scientific article

Gut and Liver B Cells of Common Clonal Origin in Primary Sclerosing Cholangitis-Inflammatory Bowel Disease

Gut and liver T-cells of common clonal origin in primary sclerosing cholangitis-inflammatory bowel disease

scientific article

HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry.

scientific article published on 11 July 2017

HLA variants related to primary sclerosing cholangitis influence rejection after liver transplantation.

scientific article published on April 2014

Hepatic stem/progenitor cell activation differs between primary sclerosing and primary biliary cholangitis.

scientific article published on 14 December 2017

High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

scientific article

High-throughput T-cell receptor sequencing across chronic liver diseases reveals distinct disease-associated repertoires.

scientific article published on 7 August 2015

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease

scientific article

Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes

scientific article published on 06 January 2014

Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies

scientific article published on 9 January 2018

Immunosuppression after liver transplantation for primary sclerosing cholangitis influences activity of inflammatory bowel disease.

scientific article

Impaired intention-to-treat survival after listing for liver transplantation in children with biliary atresia compared to other chronic liver diseases: 20 years' experience from the Nordic countries.

scientific article published on 13 December 2016

Imputation of KIR Types from SNP Variation Data

scientific article

In vitro evaluation of new surface coatings for extracorporeal circulation

scientific article published on 01 January 1999

Indications and Outcomes in Liver Transplantation in Patients With Primary Sclerosing Cholangitis in Norway

scientific article published on 19 October 2015

Investigation of cholangiocarcinoma associated NKG2D polymorphisms in colorectal carcinoma

scientific article published on 01 July 2008

Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis

scientific article published in June 2009

Knockout of the primary sclerosing cholangitis-risk gene Fut2 causes liver disease in mice

scientific article published on 5 January 2017

Lipid antigens in bile from patients with chronic liver diseases activate natural killer T cells

scientific article published on 21 October 2020

Liver transplantation for cholangiocarcinoma: Selection is essential for acceptable results

scientific article published on 15 November 2010

Liver transplantation in Norway through 25 years

scientific article published in December 2009

Liver transplantation in patients with primary antibody deficiency

scientific article

Liver transplantation in the Nordic countries - An intention to treat and post-transplant analysis from The Nordic Liver Transplant Registry 1982-2013.

scientific article published on June 2015

Liver transplantation with deceased ABO-incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications

scientific article published on 01 July 2015

Lysyl oxidase-like protein 2 (LOXL2) Modules Barrier Function in Cholangiocytes In Cholestasis.

scientific article published on 27 April 2018

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

scientific journal article

Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure

scientific article

Mutational characterization of the bile acid receptor TGR5 in primary sclerosing cholangitis

scientific article

Natural killer T cells mediate inflammation in the bile ducts

scientific article published on 16 August 2018

Neoplastic transformation of peribiliary stem cell niche in cholangiocarcinoma arisen in primary sclerosing cholangitis

scientific article published on 04 January 2019

New susceptibility loci for severe COVID-19 by detailed GWAS analysis in European populations

scholarly article published 23 July 2021

Nlrp3 Activation Induces Il-18 Synthesis and Affects the Epithelial Barrier Function in Reactive Cholangiocytes.

scientific article published on 29 November 2016

No Evidence That Azathioprine Increases Risk of Cholangiocarcinoma in Patients With Primary Sclerosing Cholangitis.

scientific article

No association between the TUCAN (CARD8) Cys10Stop mutation and inflammatory bowel disease in a large retrospective German and a clinically well-characterized Norwegian sample.

scientific article

Novel insights into autoimmune liver diseases provided by genome-wide association studies

scientific article published on 07 August 2013

Novel serum and bile protein markers predict primary sclerosing cholangitis disease severity and prognosis

scientific article published on February 2017

Novel target genes and a valid biomarker panel identified for cholangiocarcinoma

scientific article

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

scientific article published on 06 August 2019

Overview of methodologies for T-cell receptor repertoire analysis

scientific article published on 10 July 2017

Particular genetic variants of ligands for natural killer cell receptors may contribute to the HLA associated risk of primary sclerosing cholangitis

scientific article published on 27 February 2007

Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis

scientific article published on 5 March 2017

Patients with Cholangiocarcinoma Present Specific RNA Profiles in Serum and Urine Extracellular Vesicles Mirroring the Tumor Expression: Novel Liquid Biopsy Biomarkers for Disease Diagnosis

scientific article published on 14 March 2020

Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis

scientific article published on 24 October 2016

Polymorphisms in the steroid and xenobiotic receptor gene influence survival in primary sclerosing cholangitis

scientific article published on 01 September 2006

Prevalence of Sclerosing Cholangitis Detected by Magnetic Resonance Cholangiography in Patients With Long-term Inflammatory Bowel Disease

scientific article published on 21 June 2016

Primary Sclerosing Cholangitis Risk Estimate Tool (PREsTo) Predicts Outcomes of the Disease: A Derivation and Validation Study Using Machine Learning

scientific article published on 28 December 2018

Primary sclerosing cholangitis

scientific article published in The Lancet

Primary sclerosing cholangitis

scientific article published on 01 October 2010

Primary sclerosing cholangitis - a comprehensive review

article

Primary sclerosing cholangitis - the Norwegian experience

scientific article published on 12 April 2015

Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations

scientific article

Primary sclerosing cholangitis is associated with extended HLA-DR3 and HLA-DR6 haplotypes

scientific article

Publisher Correction: Whole-genome sequencing of a sporadic primary immunodeficiency cohort

scientific article published on 17 July 2020

Rare variants at 16p11.2 are associated with common variable immunodeficiency

scientific article published on 10 February 2015

Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids

scientific article

Recurrence and rejection in liver transplantation for primary sclerosing cholangitis

scientific article published in January 2012

Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population

scientific article

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

scientific article published on 27 April 2008

Review article: controversies in the management of primary biliary cirrhosis and primary sclerosing cholangitis

scientific article published on 29 December 2013

Rifaximin alters gut microbiota profile, but does not affect systemic inflammation - a randomized controlled trial in common variable immunodeficiency

scientific article published in Scientific Reports

Role of endoscopy in primary sclerosing cholangitis: European Society of Gastrointestinal Endoscopy (ESGE) and European Association for the Study of the Liver (EASL) Clinical Guideline.

scientific article published on 18 April 2017

Rosuvastatin alters the genetic composition of the human gut microbiome

scientific article published on 25 March 2020

SNP discovery performance of two second-generation sequencing platforms in the NOD2 gene region

scientific article

SNPexp - A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels

scientific article

Second-line and Third-line therapy for Autoimmune Hepatitis A position statement from the European Reference Network on Hepatological Diseases and the International Autoimmune Hepatitis Group

scientific article published on 21 July 2020

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

scientific article published on 5 October 2008

Serological markers of extracellular matrix remodeling predict transplant-free survival in primary sclerosing cholangitis

scientific article published on 30 May 2018

Serum metabolomic profiling highlights pathways associated with liver fat content in a general population sample

scientific article published on 5 April 2017

Small duct primary sclerosing cholangitis without inflammatory bowel disease is genetically different from large duct disease

scientific article

Surrogate endpoints for clinical trials in primary sclerosing cholangitis: Review and results from an International PSC Study Group consensus process

scientific article published on 29 September 2015

TGR5 sequence variation in primary sclerosing cholangitis

scientific article published on 17 June 2011

The 32-base pair deletion of the chemokine receptor 5 gene (CCR5-Delta32) is not associated with primary sclerosing cholangitis in 363 Scandinavian patients

scientific article published on 01 July 2006

The 6 C's of Primary Sclerosing Cholangitis

scientific article published on 07 July 2020

The ABO blood group locus and a chromosome 3 gene cluster associate with SARS-CoV-2 respiratory failure in an Italian-Spanish genome-wide association analysis

scientific article (preprint)

The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis

scientific article

The EASL International Liver Foundation: A growing pup with missions that are distinct yet integrated with those of its mother

scientific article published on 18 December 2018

The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases

scientific article published on 07 December 2007

The First European Evidence-based Consensus on Extra-intestinal Manifestations in Inflammatory Bowel Disease

scientific article

The Influence of the Autoimmunity-Associated Ancestral HLA Haplotype AH8.1 on the Human Gut Microbiota: A Cross-Sectional Study

scientific article published on 24 July 2015

The Lancet-EASL Commission on liver diseases in Europe: overcoming unmet needs, stigma, and inequities

scientific article published on 27 July 2018

The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts

scientific article published in November 2017

The biliary epithelium presents antigens to and activates natural killer T cells

scientific article

The genetics of complex cholestatic disorders

scientific article

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

scientific article

The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation

scientific article published on 5 October 2016

The role of natural killer T cells in a mouse model with spontaneous bile duct inflammation

scientific article published on February 2017

The utility of genome-wide association studies in hepatology

scientific article published on May 2010

Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9

scientific article

To MMP or not to MMP: a role for matrix metalloproteinase 3 in primary sclerosing cholangitis?

scientific article published on 15 February 2011

Transplantation With Livers From Deceased Donors Older Than 75 Years.

scientific article published on 24 April 2015

Update on primary sclerosing cholangitis

scientific article

Update on primary sclerosing cholangitis

scientific article published on 20 February 2010

Update on primary sclerosing cholangitis genetics

scientific article published on May 2014

Urine proteomic analysis differentiates cholangiocarcinoma from primary sclerosing cholangitis and other benign biliary disorders.

scientific article published on 12 May 2012

Whole Genome Sequencing of Primary Immunodeficiency reveals a role for common and rare variants in coding and non-coding sequences

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

scientific article published on 06 May 2020

Paulina is supported by:

About Paulina

Help