List of works by William G Dunphy

Absence of BLM leads to accumulation of chromosomal DNA breaks during both unperturbed and disrupted S phases

scientific article

Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase

scientific article

Ataxia-telangiectasia mutated (ATM)-dependent activation of ATR occurs through phosphorylation of TopBP1 by ATM.

scientific article

Aven-dependent activation of ATM following DNA damage

scientific article published on 19 June 2008

Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

scientific article

Claspin, a Chk1-regulatory protein, monitors DNA replication on chromatin independently of RPA, ATR, and Rad17.

scientific article

Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts

scientific article (publication date: October 2000)

CtIP interacts with TopBP1 and Nbs1 in the response to double-stranded DNA breaks (DSBs) in Xenopus egg extracts

scientific article published on February 2011

Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication ⬇️

scientific article

Dissection of c-MOS degron

scientific article

Drf1-dependent kinase interacts with Claspin through a conserved protein motif

scientific article

How cells activate ATR.

scientific article

Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome

scientific article

Interaction of Chk1 with Treslin negatively regulates the initiation of chromosomal DNA replication.

scientific article

MTBP, the partner of Treslin, contains a novel DNA-binding domain that is essential for proper initiation of DNA replication.

scientific article published on 6 September 2017

Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses

scientific article

Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2.

scientific article published on October 2005

Phosphorylated claspin interacts with a phosphate-binding site in the kinase domain of Chk1 during ATR-mediated activation

scientific article published on 8 September 2003

Phosphorylation of Chk1 by ATM- and Rad3-related (ATR) in Xenopus egg extracts requires binding of ATRIP to ATR but not the stable DNA-binding or coiled-coil domains of ATRIP.

scientific article

RPA-coated single-stranded DNA promotes the ETAA1-dependent activation of ATR

scientific article published on 12 April 2019

Rad17 plays a central role in establishment of the interaction between TopBP1 and the Rad9-Hus1-Rad1 complex at stalled replication forks

scientific article

Redox priming promotes Aurora A activation during mitosis

scientific article published on 21 July 2020

Repeated phosphopeptide motifs in Claspin mediate the regulated binding of Chk1

scientific article (publication date: February 2003)

Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts

scientific article published on 15 March 2012

Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.

scientific article

Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis

scientific article published on November 2006

Roles of replication fork-interacting and Chk1-activating domains from Claspin in a DNA replication checkpoint response

scientific article

SUMOylation of the C-terminal domain of DNA topoisomerase IIα regulates the centromeric localization of Claspin.

scientific article

Site-specific phosphorylation of a checkpoint mediator protein controls its responses to different DNA structures

scientific article

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

scientific article

The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATM

scientific article published on 11 March 2009

The Rad9-Hus1-Rad1 checkpoint clamp regulates interaction of TopBP1 with ATR.

scientific article published on 18 July 2007

Treslin collaborates with TopBP1 in triggering the initiation of DNA replication

scientific article

Xenopus DNA2 is a helicase/nuclease that is found in complexes with replication proteins And-1/Ctf4 and Mcm10 and DSB response proteins Nbs1 and ATM

scientific article

Xenopus Drf1, a regulator of Cdc7, displays checkpoint-dependent accumulation on chromatin during an S-phase arrest

scientific article published in August 2003

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