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List of works by Age Utt

A Chikungunya virus trans-replicase system reveals the importance of delayed non-structural polyprotein processing for efficient replication complex formation in mosquito cells.

scientific article published on 25 April 2018

ADP-ribosyl-binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

article published in the Proceedings of the National Academy of Sciences of the United States of America

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue.

scientific article published on 15 November 2016

Correction for Thaa et al., Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.

scientific article published on 28 March 2016

Correction for Utt et al., Mutations Conferring a Noncytotoxic Phenotype on Chikungunya Virus Replicons Compromise Enzymatic Properties of Nonstructural Protein 2.

scientific article published on 12 August 2016

Cross-utilisation of template RNAs by alphavirus replicases

scientific article published on 04 September 2020

Decreased Virulence of Ross River Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein Is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs

scientific article published on 21 August 2018

Design and Use of Chikungunya Virus Replication Templates Utilizing Mammalian and Mosquito RNA Polymerase I-Mediated Transcription

scientific article published on 28 August 2019

Design and Validation of Novel Chikungunya Virus Protease Inhibitors

scientific article published on 10 October 2016

Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization.

scientific article published on 2 September 2015

Identification of Alphavirus Inhibitors by Using Virus-Based Assays and a Chikungunya Replicon Cell Line

scientific article published in 2011

Inhibitors of alphavirus entry and replication identified with a stable Chikungunya replicon cell line and virus-based assays

scientific article

Mutating chikungunya virus non-structural protein produces potent live-attenuated vaccine candidate.

scientific article published in June 2019

Mutations conferring a noncytotoxic phenotype on chikungunya virus replicons compromise enzymatic properties of nonstructural protein 2

scientific article

Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template

scientific article published on 12 July 2017

RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication

scientific article

Sensitivity of Alphaviruses to G3BP Deletion Correlates with Efficiency of Replicase Polyprotein Processing

scientific article published on 17 March 2020

Structural insights into RNA recognition by the Chikungunya virus nsP2 helicase

scientific article published on 18 April 2019

VCP/p97 Is a Proviral Host Factor for Replication of Chikungunya Virus and Other Alphaviruses

scientific article published on 24 September 2019

Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein

scientific article

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