List of works - Varman T Samuel

3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats

scientific article published on 20 October 2015

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

scientific article published on 26 August 2020

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

scientific article

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

scientific article

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

scientific article

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

scientific article published on 28 March 2019

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity

scientific article published on 09 January 2009

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.

scientific article published in March 2018

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

scientific article

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

scientific article

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

scientific article published on 31 May 2016

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

scientific article published on 9 January 2013

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance

scientific article published on 30 January 2013

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

scientific article

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice

scientific article

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

scientific article

Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ε

scientific article published on 23 August 2019

Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle

scientific article published on 5 May 2015

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

scholarly article by Andreas L. Birkenfeld et al published October 2011 in Cell Metabolism

Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity ⬇️

scientific article

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

scientific article

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

scientific article

Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content

scientific article published on 25 July 2013

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues

scientific article

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

scientific article published on 28 November 2011

Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice

scientific article published on November 2011

Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

scientific article published on 01 December 2019

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice

scientific article published on 19 December 2018

Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle

scientific article published on 06 June 2013

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

scientific article

Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes

scientific article published on 3 August 2012

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

scholarly article

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

scientific article

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

scientific article

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21.

scientific article

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

scientific article

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats

scientific article published on 25 September 2007

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

scientific article

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

scientific article

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

scientific journal article

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

scientific article

Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients

scientific article published in May 2012

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

scientific article

Lipid-induced insulin resistance: unravelling the mechanism

scientific article

Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure

scientific article published on 9 January 2012

MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice

scientific article published on 16 November 2009

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

scientific article published on 27 May 2004

Mechanisms for insulin resistance: common threads and missing links

scientific article (publication date: 2 March 2012)

Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice

scientific article published on 09 September 2020

Metabolic control analysis of hepatic glycogen synthesis in vivo

scientific article published on 18 March 2020

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

scientific article

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

scientific article

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

scientific article published on 15 July 2008

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

scientific article published on 11 April 2014

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

scientific article published on 29 August 2017

Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides

scientific article published on 01 November 2019

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability

scientific article

Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.

scientific article published on 31 December 2013

PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats

scientific article published on 01 January 2019

PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling

scientific article published on 04 September 2018

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

scientific article published on October 2013

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

scholarly article

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling

scientific article published on 23 January 2014

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

scientific article

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein

scientific article published on December 2009

Regulation of hepatic energy metabolism and gluconeogenesis by BAD

scientific article published on February 2014

Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes

scientific article

Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) transgenic mice.

scientific article

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

scientific article published on 16 February 2006

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

scientific article published on 25 January 2013

SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function ⬇️

scientific article

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

scientific article published on 09 July 2013

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

scientific article published on 7 December 2015

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice

scientific article published on 13 March 2015

Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol - PKCε - insulin receptorT1160 phosphorylation

scientific article published on 07 January 2021

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

scholarly article

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

scientific article published on 16 August 2010

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

scientific journal article

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

scientific article

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action

scientific article published in July 2006

Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance

scientific article published on 19 February 2013

Targeting steroid receptor coactivator 1 with antisense oligonucleotides increases insulin-stimulated skeletal muscle glucose uptake in chow-fed and high-fat-fed male rats

scientific article

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

scientific article published on 4 January 2016

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

scientific article published on June 2014

The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.

scientific article published on August 2010

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

scientific article

The role of the carbohydrate response element-binding protein in male fructose-fed rats

scientific article

Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance

scientific article

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.

scientific article published on 07 May 2013

Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance

scientific article

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

scientific article published on 17 April 2013

List of works by Varman T Samuel

3,5 Diiodo-L-Thyronine (T2) Does Not Prevent Hepatic Steatosis or Insulin Resistance in Fat-Fed Sprague Dawley Rats

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents.

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

Considering the Links Between Nonalcoholic Fatty Liver Disease and Insulin Resistance: Revisiting the Role of Protein Kinase C ε

Coordinated Regulation of Vasopressin Inactivation and Glucose Uptake by Action of TUG Protein in Muscle

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity ⬇️

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

Determination of mesenchymal stem cell fate by pigment epithelium-derived factor (PEDF) results in increased adiposity and reduced bone mineral content

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice

Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice

Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

Hepatic insulin resistance and increased hepatic glucose production in mice lacking Fgf21.

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

Insulin resistance is associated with elevated serum pigment epithelium-derived factor (PEDF) levels in morbidly obese patients

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

Lipid-induced insulin resistance: unravelling the mechanism

Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure

MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

Mechanisms for insulin resistance: common threads and missing links

Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice

Metabolic control analysis of hepatic glycogen synthesis in vivo

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

Nonalcoholic Fatty Liver Disease, Insulin Resistance, and Ceramides

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability

Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.

PEPCK1 Antisense Oligonucleotide Prevents Adiposity and Impairs Hepatic Glycogen Synthesis in High-Fat Male Fed Rats

PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein

Regulation of hepatic energy metabolism and gluconeogenesis by BAD

Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes

Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) transgenic mice.

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function ⬇️

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice

Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol - PKCε - insulin receptorT1160 phosphorylation

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.