List of works - Panayotis K Thanos

Addiction by Any Other Name is Still Addiction: Embracing Molecular Neurogenetic/Epigenetic Basis of Reward Deficiency

scientific article published on 01 January 2020

Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice.

scientific article

Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse

scientific article published on 30 July 2018

Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects

scientific article published on 27 August 2019

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

scientific article

Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant rats

scientific article

Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats

scientific article

Chronic mild stress increases alcohol intake in mice with low dopamine D2 receptor levels ⬇️

scientific article published on November 12, 2012

Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?

scientific article

D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice

scientific article published on 30 December 2008

D-cycloserine facilitates extinction of cocaine self-administration in C57 mice

scientific article

DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking

scientific article

DRD4 genotype predicts longevity in mouse and human

scientific article published on January 2013

Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement

scientific article published on 26 October 2012

Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task.

scientific article

Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior.

scientific article published on 15 March 2016

Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking

scientific article published on 9 February 2005

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

scientific article

Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate

scientific article

Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome

scientific article

Dopamine-related frontostriatal abnormalities in obesity and binge-eating disorder: emerging evidence for developmental psychopathology

scientific article published on June 2012

D‐cycloserine facilitates extinction of cocaine self‐administration in rats ⬇️

scientific article published on March 28, 2011

Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents

scientific article published on 5 June 2007

Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z.

scientific article

Evidence That Sleep Deprivation Downregulates Dopamine D2R in Ventral Striatum in the Human Brain ⬇️

scientific article published on May 9, 2012

Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation

scientific article

Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels.

scientific article published on 19 February 2018

Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography.

scientific article published on January 2008

Gastric bypass increases ethanol and water consumption in diet-induced obese rats

scientific article published on December 2012

Gastric distention activates satiety circuitry in the human brain

scientific article

Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry

scholarly article

Genetic addiction risk score (GARS) ™, a predictor of vulnerability to opioid dependence

scientific article published on January 2018

Hypothesizing Las Vegas and Sutherland Springs Mass Shooters Suffer from Reward Deficiency Syndrome: "Born Bad"

scientific article published on 30 December 2017

Imaging of brain dopamine pathways: implications for understanding obesity

scientific article

Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression

scientific article

In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET.

scientific article published on November 2002

Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors

scientific article published on 27 November 2018

Inverse association between BMI and prefrontal metabolic activity in healthy adults

scientific article published on 23 October 2008

Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice

scientific article

Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions

scientific article published on September 2008

Limbic activation to novel versus familiar food cues predicts food preference and alcohol intake

scientific article published on 15 March 2013

Loss of Dopamine D2 Receptors Induces Atrophy in the Temporal and Parietal Cortices and the Caudal Thalamus of Ethanol‐Consuming Mice ⬇️

scientific article published on October 21, 2011

Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors

scientific article published on 13 June 2008

Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cues.

scientific article published on 20 December 2012

Obesity-resistant S5B rats showed greater cocaine conditioned place preference than the obesity-prone OM rats

scientific article

PET imaging predicts future body weight and cocaine preference

scientific article published on 26 August 2011

Positron emission tomography as a tool for studying alcohol abuse

scientific article published on January 2008

Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity.

scientific article published in May 2003

Roux-en-Y Gastric Bypass Alters Brain Activity in Regions that Underlie Reward and Taste Perception.

scientific article published on 3 June 2015

Roux-en-Y gastric bypass in rat reduces mu-opioid receptor levels in brain regions associated with stress and energy regulation.

scientific article published on 20 June 2019

Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review

scientific article

Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity

scientific article published on 28 June 2018

Substance use disorder a bio-directional subset of reward deficiency syndrome

scientific article published in June 2017

The Benefits of Genetic Addiction Risk Score (GARS™) Testing in Substance Use Disorder (SUD)

scientific article published on 15 January 2018

The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis

scientific article published on 22 August 2017

The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice

scientific article published on May 2008

The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity

scientific article published on 08 February 2008

The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography

scientific article published on 20 June 2020

Translational neuroimaging in drug addiction and obesity

scientific article

Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.

scientific article

Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks

scientific article

List of works by Panayotis K Thanos

Addiction by Any Other Name is Still Addiction: Embracing Molecular Neurogenetic/Epigenetic Basis of Reward Deficiency

Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice.

Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse

Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects

Bromocriptine administration reduces hyperphagia and adiposity and differentially affects dopamine D2 receptor and transporter binding in leptin-receptor-deficient Zucker rats and rats with diet-induced obesity

Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant rats

Chronic forced exercise during adolescence decreases cocaine conditioned place preference in Lewis rats

Chronic mild stress increases alcohol intake in mice with low dopamine D2 receptor levels ⬇️

Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?

D-cycloserine accelerates the extinction of cocaine-induced conditioned place preference in C57bL/c mice

D-cycloserine facilitates extinction of cocaine self-administration in C57 mice

DRD2 gene transfer into the nucleus accumbens core of the alcohol preferring and nonpreferring rats attenuates alcohol drinking

DRD4 genotype predicts longevity in mouse and human

Daily treadmill exercise attenuates cocaine cue-induced reinstatement and cocaine induced locomotor response but increases cocaine-primed reinstatement

Dissociation between spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats in baseline performance and methylphenidate response on measures of attention, impulsivity and hyperactivity in a Visual Stimulus Position Discrimination Task.

Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior.

Dopamine D2R DNA transfer in dopamine D2 receptor-deficient mice: effects on ethanol drinking

Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine

Dopamine D4 receptors modulate brain metabolic activity in the prefrontal cortex and cerebellum at rest and in response to methylphenidate

Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome

Dopamine-related frontostriatal abnormalities in obesity and binge-eating disorder: emerging evidence for developmental psychopathology

D‐cycloserine facilitates extinction of cocaine self‐administration in rats ⬇️

Effects of chronic oral methylphenidate on cocaine self-administration and striatal dopamine D2 receptors in rodents

Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z.

Evidence That Sleep Deprivation Downregulates Dopamine D2R in Ventral Striatum in the Human Brain ⬇️

Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation

Fatty acid binding protein deletion prevents stress-induced preference for cocaine and dampens stress-induced corticosterone levels.

Food restriction markedly increases dopamine D2 receptor (D2R) in a rat model of obesity as assessed with in-vivo muPET imaging ([11C] raclopride) and in-vitro ([3H] spiperone) autoradiography.

Gastric bypass increases ethanol and water consumption in diet-induced obese rats

Gastric distention activates satiety circuitry in the human brain

Gastric stimulation in obese subjects activates the hippocampus and other regions involved in brain reward circuitry

Genetic addiction risk score (GARS) ™, a predictor of vulnerability to opioid dependence

Hypothesizing Las Vegas and Sutherland Springs Mass Shooters Suffer from Reward Deficiency Syndrome: "Born Bad"

Imaging of brain dopamine pathways: implications for understanding obesity

Impaired periamygdaloid-cortex prodynorphin is characteristic of opiate addiction and depression

In vivo comparative imaging of dopamine D2 knockout and wild-type mice with (11)C-raclopride and microPET.

Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors

Inverse association between BMI and prefrontal metabolic activity in healthy adults

Leptin increases striatal dopamine D2 receptor binding in leptin-deficient obese (ob/ob) mice

Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions

Limbic activation to novel versus familiar food cues predicts food preference and alcohol intake

Loss of Dopamine D2 Receptors Induces Atrophy in the Temporal and Parietal Cortices and the Caudal Thalamus of Ethanol‐Consuming Mice ⬇️

Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors

Obese rats with deficient leptin signaling exhibit heightened sensitivity to olfactory food cues.

Obesity-resistant S5B rats showed greater cocaine conditioned place preference than the obesity-prone OM rats

PET imaging predicts future body weight and cocaine preference

Positron emission tomography as a tool for studying alcohol abuse

Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity.

Roux-en-Y Gastric Bypass Alters Brain Activity in Regions that Underlie Reward and Taste Perception.

Roux-en-Y gastric bypass in rat reduces mu-opioid receptor levels in brain regions associated with stress and energy regulation.

Similarity between obesity and drug addiction as assessed by neurofunctional imaging: a concept review

Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity

Substance use disorder a bio-directional subset of reward deficiency syndrome

The Benefits of Genetic Addiction Risk Score (GARS™) Testing in Substance Use Disorder (SUD)

The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis

The effects of cocaine on regional brain glucose metabolism is attenuated in dopamine transporter knockout mice

The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity

The functional networks of a novel environment: Neural activity mapping in awake unrestrained rats using positron emission tomography

Translational neuroimaging in drug addiction and obesity

Upregulation of cannabinoid type 1 receptors in dopamine D2 receptor knockout mice is reversed by chronic forced ethanol consumption.

Whole-brain circuit dissection in free-moving animals reveals cell-specific mesocorticolimbic networks