List of works - John P Sumpter

10th Anniversary Perspective: Reflections on endocrine disruption in the aquatic environment: from known knowns to unknown unknowns (and many things in between).

scientific article

5α-Dihydrotestosterone is a potent androgen in the fathead minnow (Pimephales promelas).

scientific article published on 24 February 2011

A rational approach to selecting and ranking some pharmaceuticals of concern for the aquatic environment and their relative importance compared with other chemicals

scientific article

A restatement of the natural science evidence base on the effects of endocrine disrupting chemicals on wildlife

scientific article published on 01 February 2019

Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals

scientific article

An alternative approach to risk rank chemicals on the threat they pose to the aquatic environment

scientific article published on 17 May 2017

Anti-anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects.

scientific article published on 7 April 2016

Are some invertebrates exquisitely sensitive to the human pharmaceutical fluoxetine?

scientific article published on 3 December 2013

Are we going about chemical risk assessment for the aquatic environment the wrong way?

scientific article published on July 2016

Assessing the concentrations and risks of toxicity from the antibiotics ciprofloxacin, sulfamethoxazole, trimethoprim and erythromycin in European rivers.

scientific article published on 21 January 2015

Assessing the concentrations of polar organic microcontaminants from point sources in the aquatic environment: measure or model?

scientific article published on August 2008

Benzotriazole is antiestrogenic in vitro but not in vivo.

scientific article published in November 2007

COMPREHENDing endocrine disrupters in aquatic environments.

scientific article

Changes in estrogenic and androgenic activities at different stages of treatment in wastewater treatment works

scientific article published in May 2002

Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas).

scientific article published on 31 July 2011

Chronic effects assessment and plasma concentrations of the beta-blocker propranolol in fathead minnows (Pimephales promelas).

scientific article published on 16 September 2009

Comments on Niemuth, N.J. and Klaper, R.D. 2015. Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish. Chemosphere 135, 38–45

scientific article published in December 2016

Comparative physiology, pharmacology and toxicology of beta-blockers: mammals versus fish

scientific article published on 16 February 2007

Corrigendum: Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish

scientific article published on 20 June 2016

Could the Quality of Published Ecotoxicological Research Be Better?

scientific article published on 6 August 2015

Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas).

scientific article published on 3 December 2007

Derivation of an aquatic predicted no-effect concentration for the synthetic hormone, 17 alpha-ethinyl estradiol.

scientific article published in October 2008

Diclofenac: New data on chronic toxicity and bioconcentration in fish

scientific article

Do concentrations of ethinylestradiol, estradiol, and diclofenac in European rivers exceed proposed EU environmental quality standards?

scientific article published on 10 October 2013

Do cytotoxic chemotherapy drugs discharged into rivers pose a risk to the environment and human health? An overview and UK case study

article

Do suspended sediments modulate the effects of octylphenol on rainbow trout?

scientific article published on 24 December 2008

Drug residues and endocrine disruptors in drinking water: risk for humans?

scientific article published on 31 August 2011

Ecotoxicology--a multidisciplinary, problem-driven science

scientific article published on 01 December 2004

Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 1. Reproductive and early developmental effects

scientific article

Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity

Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)

article

Endocrine (sexual) disruption is not a prominent feature in the pike (Esox lucius), a top predator, living in English waters.

scientific article published in June 2005

Endocrine Disrupters in the Aquatic Environment: An Overview

article

Endocrine disruption due to estrogens derived from humans predicted to be low in the majority of U.S. surface waters.

scientific article published on 27 April 2012

Estrogenic activity measured in a sewage treatment works treating industrial inputs containing high concentrations of alkylphenolic compounds--a case study

scientific article published in March 2002

Estrogenic activity of tropical fish food can alter baseline vitellogenin concentrations in male fathead minnow (Pimephales promelas).

scientific article published on 04 March 2011

Estrogenic potency of effluent from two sewage treatment works in the United Kingdom

article

Evidence of estrogenic mixture effects on the reproductive performance of fish

scientific article published in January 2007

Evidence of temperature-dependent effects on the estrogenic response of fish: implications with regard to climate change

scientific article

Evidence suggesting that di-n-butyl phthalate has antiandrogenic effects in fish

scientific article published on 2 April 2011

Exposure assessment of 17alpha-ethinylestradiol in surface waters of the United States and Europe.

scientific article published on December 2009

From dishwasher to tap? Xenobiotic substances benzotriazole and tolyltriazole in the environment

scientific article

From single chemicals to mixtures--reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow

scientific article published on 17 October 2015

Hypoxia does not influence the response of fish to a mixture of estrogenic chemicals.

scientific article published in January 2009

Identification and quantification of 5α-dihydrotestosterone in the teleost fathead minnow (Pimephales promelas) by gas chromatography-tandem mass spectrometry

scientific article

Immunoassays are not immune to errors: Examples from two studies of steroid output from freshwater trout farms

scientific article published on 30 July 2019

Impaired reproduction in three-spined sticklebacks exposed to ethinyl estradiol as juveniles.

scientific article published on 15 August 2007

Improving environmental risk assessment of human pharmaceuticals

scientific article published on 16 April 2015

Improving environmental risk assessments of chemicals: Steps towards evidence-based ecotoxicology

scientific article published on 03 May 2019

Improving the quality of wastewater to tackle trace organic contaminants: think before you act!

scientific article published on 20 March 2015

In Response: An academic perspective

scientific article published on 01 January 2016

In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol.

scientific article

In vivo ovarian uptake and processing of vitellogenin in the rainbow trout,Salmo gairdneri

article

Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish.

scientific article published on 26 February 2016

Isomer-specific degradation and endocrine disrupting activity of nonylphenols

scientific article

Key actions for a sustainable chemicals policy

scientific article published on 18 February 2020

Learning from the past and considering the future of chemicals in the environment

scientific article published on 01 January 2020

Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment

scientific article

Long-Term Temporal Changes in the Estrogenic Composition of Treated Sewage Effluent and Its Biological Effects on Fish

article

Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems.

scientific article

Metabolic and reproductive effects of relatively low concentrations of beclomethasone dipropionate, a synthetic glucocorticoid, on fathead minnows

scientific article published on 2 August 2013

Metabolism and environmental degradation of pyrethroid insecticides produce compounds with endocrine activities

article

Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study.

scientific article published on 10 December 2012

Modeling Effects of Mixtures of Endocrine Disrupting Chemicals at the River Catchment Scale

article

Populations of a cyprinid fish are self-sustaining despite widespread feminization of males

scientific article published on 13 January 2014

Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol

scientific article published on 27 April 2012

Predicting concentrations of the cytostatic drugs cyclophosphamide, carboplatin, 5-fluorouracil, and capecitabine throughout the sewage effluents and surface waters of Europe

scientific article published in September 2013

Prediction of environmental concentrations of glucocorticoids: the River Thames, UK, as an example

scientific article

Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow

scientific article published on 16 June 2007

Principles of sound ecotoxicology

scientific article published on 26 February 2014

Progesterone potentially degrades to potent androgens in surface waters

scientific article published on 6 December 2016

Progress and promises in toxicogenomics in aquatic toxicology: is technical innovation driving scientific innovation?

scientific article published on 13 June 2011

Protecting aquatic organisms from chemicals: the harsh realities

scientific article

Protecting the environment from psychoactive drugs: Problems for regulators illustrated by the possible effects of tramadol on fish behaviour

scientific article published on 06 February 2019

Putting pharmaceuticals into the wider context of challenges to fish populations in rivers.

scientific article

Quantitative cross-species extrapolation between humans and fish: the case of the anti-depressant fluoxetine

scientific article

Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially derived surfactants

scientific article published in March 2002

Relative potencies and combination effects of steroidal estrogens in fish

scientific article published in March 2003

Renewing and improving the environmental risk assessment of chemicals

scientific article published in 2022

Repeating history: pharmaceuticals in the environment.

scientific article

Reproductive responses in fathead minnow and Japanese medaka following exposure to a synthetic progestin, Norethindrone

scientific article published on August 2010

Route of exposure affects the oestrogenic response of fish to 4-tert-nonylphenol.

scientific article published in November 2003

Scientific integrity issues in Environmental Toxicology and Chemistry: Improving research reproducibility, credibility, and transparency

scientific article published on 28 February 2019

Selectivity of protein sequestration by vitellogenic oocytes of the rainbow trout,Salmo gairdneri

article

Several synthetic progestins with different potencies adversely affect reproduction of fish

scientific article published on 8 February 2013

Sexual disruption in a second species of wild cyprinid fish (the gudgeon,Gobio gobio) in United Kingdom Freshwaters

scholarly article by Ronny van Aerle published in December 2001

Stress status of gudgeon (Gobio gobio) from rivers in Switzerland with and without input of sewage treatment plant effluent.

scientific article published in September 2003

Synthetic glucocorticoids in the environment: first results on their potential impacts on fish

scientific article published on 15 February 2011

THE STRESS RESPONSE AND ITS CONSEQUENCES IN CULTURED FISH ⬇️

scientific article published in 1991

Targeting the environmental risk assessment of pharmaceuticals: Facts and fantasies

scientific article published on 01 July 2010

Testing the "read-across hypothesis" by investigating the effects of ibuprofen on fish

scientific article published on 25 August 2016

The British river of the future: how climate change and human activity might affect two contrasting river ecosystems in England

scientific article

The challenge: Do pharmaceuticals present a risk to the environment, and what needs to be done to answer the question?

article published in 2014

The consequences of exposure to mixtures of chemicals: Something from 'nothing' and 'a lot from a little' when fish are exposed to steroid hormones

scientific article published on 01 December 2017

The consequences of feminization in breeding groups of wild fish.

scientific article

The development of a radioimmunoassay for carp, Cyprinus carpio, vitellogenin

article

The ecotoxicology of hormonally active micropollutants.

scientific article published in January 2008

The influence of a surfactant, linear alkylbenzene sulfonate, on the estrogenic response to a mixture of (xeno)estrogens in vitro and in vivo

scientific article published on 14 October 2008

The occurrence, causes, and consequences of estrogens in the aquatic environment

scientific article published in February 2013

The read-across hypothesis and environmental risk assessment of pharmaceuticals.

scientific article published on 30 September 2013

The role of the North Atlantic Oscillation in controlling U.K. butterfly population size and phenology

scientific article

The value of repeating studies and multiple controls: replicated 28-day growth studies of rainbow trout exposed to clofibric acid

scientific article published on 23 October 2010

Towards improved behavioural testing in aquatic toxicology: Acclimation and observation times are important factors when designing behavioural tests with fish

scientific article published on 14 April 2017

Uptake and Metabolism of Human Pharmaceuticals by Fish: A Case Study with the Opioid Analgesic Tramadol

scientific article published on 4 October 2017

Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry.

scientific article

Using risk-ranking of metals to identify which poses the greatest threat to freshwater organisms in the UK.

scientific article published on 31 July 2014

Utility of a juvenile fathead minnow screening assay for detecting (anti-)estrogenic substances.

scientific article published in February 2002

What Makes a Concentration Environmentally Relevant? Critique and a Proposal

scientific article published on 28 September 2017

What makes a good scientist? Karl Fent as an example

scientific article published on 11 May 2019

What training and skills will the ecotoxicologists of the future require?

scientific article published on 09 December 2016

Widespread Sexual Disruption in Wild Fish

article

List of works by John P Sumpter

10th Anniversary Perspective: Reflections on endocrine disruption in the aquatic environment: from known knowns to unknown unknowns (and many things in between).

5α-Dihydrotestosterone is a potent androgen in the fathead minnow (Pimephales promelas).

A rational approach to selecting and ranking some pharmaceuticals of concern for the aquatic environment and their relative importance compared with other chemicals

A restatement of the natural science evidence base on the effects of endocrine disrupting chemicals on wildlife

Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals

An alternative approach to risk rank chemicals on the threat they pose to the aquatic environment

Anti-anxiety drugs and fish behavior: Establishing the link between internal concentrations of oxazepam and behavioral effects.

Are some invertebrates exquisitely sensitive to the human pharmaceutical fluoxetine?

Are we going about chemical risk assessment for the aquatic environment the wrong way?

Assessing the concentrations and risks of toxicity from the antibiotics ciprofloxacin, sulfamethoxazole, trimethoprim and erythromycin in European rivers.

Assessing the concentrations of polar organic microcontaminants from point sources in the aquatic environment: measure or model?

Benzotriazole is antiestrogenic in vitro but not in vivo.

COMPREHENDing endocrine disrupters in aquatic environments.

Changes in estrogenic and androgenic activities at different stages of treatment in wastewater treatment works

Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas).

Chronic effects assessment and plasma concentrations of the beta-blocker propranolol in fathead minnows (Pimephales promelas).

Comments on Niemuth, N.J. and Klaper, R.D. 2015. Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish. Chemosphere 135, 38–45

Comparative physiology, pharmacology and toxicology of beta-blockers: mammals versus fish

Corrigendum: Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish

Could the Quality of Published Ecotoxicological Research Be Better?

Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas).

Derivation of an aquatic predicted no-effect concentration for the synthetic hormone, 17 alpha-ethinyl estradiol.

Diclofenac: New data on chronic toxicity and bioconcentration in fish

Do concentrations of ethinylestradiol, estradiol, and diclofenac in European rivers exceed proposed EU environmental quality standards?

Do cytotoxic chemotherapy drugs discharged into rivers pose a risk to the environment and human health? An overview and UK case study

Do suspended sediments modulate the effects of octylphenol on rainbow trout?

Drug residues and endocrine disruptors in drinking water: risk for humans?

Ecotoxicology--a multidisciplinary, problem-driven science

Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 1. Reproductive and early developmental effects

Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity

Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)

Endocrine (sexual) disruption is not a prominent feature in the pike (Esox lucius), a top predator, living in English waters.

Endocrine Disrupters in the Aquatic Environment: An Overview

Endocrine disruption due to estrogens derived from humans predicted to be low in the majority of U.S. surface waters.

Estrogenic activity measured in a sewage treatment works treating industrial inputs containing high concentrations of alkylphenolic compounds--a case study

Estrogenic activity of tropical fish food can alter baseline vitellogenin concentrations in male fathead minnow (Pimephales promelas).

Estrogenic potency of effluent from two sewage treatment works in the United Kingdom

Evidence of estrogenic mixture effects on the reproductive performance of fish

Evidence of temperature-dependent effects on the estrogenic response of fish: implications with regard to climate change

Evidence suggesting that di-n-butyl phthalate has antiandrogenic effects in fish

Exposure assessment of 17alpha-ethinylestradiol in surface waters of the United States and Europe.

From dishwasher to tap? Xenobiotic substances benzotriazole and tolyltriazole in the environment

From single chemicals to mixtures--reproductive effects of levonorgestrel and ethinylestradiol on the fathead minnow

Hypoxia does not influence the response of fish to a mixture of estrogenic chemicals.

Identification and quantification of 5α-dihydrotestosterone in the teleost fathead minnow (Pimephales promelas) by gas chromatography-tandem mass spectrometry

Immunoassays are not immune to errors: Examples from two studies of steroid output from freshwater trout farms

Impaired reproduction in three-spined sticklebacks exposed to ethinyl estradiol as juveniles.

Improving environmental risk assessment of human pharmaceuticals

Improving environmental risk assessments of chemicals: Steps towards evidence-based ecotoxicology

Improving the quality of wastewater to tackle trace organic contaminants: think before you act!

In Response: An academic perspective

In vivo and in vitro liver and gill EROD activity in rainbow trout (Oncorhynchus mykiss) exposed to the beta-blocker propranolol.

In vivo ovarian uptake and processing of vitellogenin in the rainbow trout,Salmo gairdneri

Internal exposure dynamics drive the Adverse Outcome Pathways of synthetic glucocorticoids in fish.

Isomer-specific degradation and endocrine disrupting activity of nonylphenols

Key actions for a sustainable chemicals policy

Learning from the past and considering the future of chemicals in the environment

Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment

Long-Term Temporal Changes in the Estrogenic Composition of Treated Sewage Effluent and Its Biological Effects on Fish

Medicating the environment: assessing risks of pharmaceuticals to wildlife and ecosystems.

Metabolic and reproductive effects of relatively low concentrations of beclomethasone dipropionate, a synthetic glucocorticoid, on fathead minnows

Metabolism and environmental degradation of pyrethroid insecticides produce compounds with endocrine activities

Mode of action of human pharmaceuticals in fish: the effects of the 5-alpha-reductase inhibitor, dutasteride, on reproduction as a case study.

Modeling Effects of Mixtures of Endocrine Disrupting Chemicals at the River Catchment Scale

Populations of a cyprinid fish are self-sustaining despite widespread feminization of males

Predicted-no-effect concentrations for the steroid estrogens estrone, 17β-estradiol, estriol, and 17α-ethinylestradiol

Predicting concentrations of the cytostatic drugs cyclophosphamide, carboplatin, 5-fluorouracil, and capecitabine throughout the sewage effluents and surface waters of Europe

Prediction of environmental concentrations of glucocorticoids: the River Thames, UK, as an example

Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow

Principles of sound ecotoxicology

Progesterone potentially degrades to potent androgens in surface waters

Progress and promises in toxicogenomics in aquatic toxicology: is technical innovation driving scientific innovation?

Protecting aquatic organisms from chemicals: the harsh realities

Protecting the environment from psychoactive drugs: Problems for regulators illustrated by the possible effects of tramadol on fish behaviour

Putting pharmaceuticals into the wider context of challenges to fish populations in rivers.

Quantitative cross-species extrapolation between humans and fish: the case of the anti-depressant fluoxetine

Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially derived surfactants

Relative potencies and combination effects of steroidal estrogens in fish

Renewing and improving the environmental risk assessment of chemicals